Activation of hif1α by the prolylhydroxylase inhibitor dimethyoxalyglycine decreases radiosensitivity

PLoS ONE

Volumn 6, Issue 10, 2011, Pages

  Ayrapetov, Marina K ^a   Xu, Chang ^a   Sun, Yingli ^b   Zhu, Kaya ^a   Parmar, K ^a   D'Andrea, Alan D ^a   Price, Brendan D ^a  

^a DANA FARBER CANCER INSTITUTE   (United States)

^b Chinese Academy of Sciences and China National Center for Bioinformation   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATASE; DIMETHYLOXALYLGLYCINE; GLYCINE DERIVATIVE; HISTONE DEACETYLASE; HISTONE H3; HISTONE METHYLTRANSFERASE; HYPOXIA INDUCIBLE FACTOR 1ALPHA; OXYGENASE INHIBITOR; PROCOLLAGEN PROLINE 2 OXOGLUTARATE 4 DIOXYGENASE; PROTEIN CHD4; PROTEIN MTA3; UNCLASSIFIED DRUG; AUTOANTIGEN; CHD4 PROTEIN, HUMAN; DICARBOXYLIC AMINO ACID; ENZYME INHIBITOR; HIF1A PROTEIN, HUMAN; MESSENGER RNA; MTA3 PROTEIN, HUMAN; OXALYLGLYCINE; RADIOPROTECTIVE AGENT; TUMOR PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOACCUMULATION; CELL PROTECTION; CONTROLLED STUDY; DRUG EFFECT; EMBRYO; ENZYME INHIBITION; FIBROBLAST; HISTONE METHYLATION; HUMAN; HUMAN CELL; IONIZING RADIATION; MALE; MOUSE; NONHUMAN; PROTEIN DEPLETION; RADIATION INJURY; RADIATION PROTECTION; RADIOSENSITIVITY; WHOLE BODY RADIATION; ANIMAL; CELL STRAIN HEK293; DRUG ANTAGONISM; GENETICS; METABOLISM; RADIATION DOSE; RADIATION EXPOSURE; TUMOR CELL LINE; UPREGULATION;

MUS;

AMINO ACIDS, DICARBOXYLIC; ANIMALS; AUTOANTIGENS; CELL LINE, TUMOR; ENZYME INHIBITORS; FIBROBLASTS; HEK293 CELLS; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; MI-2 NUCLEOSOME REMODELING AND DEACETYLASE COMPLEX; MICE; NEOPLASM PROTEINS; PROCOLLAGEN-PROLINE DIOXYGENASE; RADIATION TOLERANCE; RADIATION-PROTECTIVE AGENTS; RNA, MESSENGER; UP-REGULATION;

EID: 80053984327     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0026064     Document Type: Article

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