Dose-dependent effect of CDPPB, the mGluR5 positive allosteric modulator, on recognition memory is associated with GluR1 and CREB phosphorylation in the prefrontal cortex and hippocampus

Neuropharmacology

Volumn 57, Issue 5-6, 2009, Pages 531-538

  Uslaner, Jason M ^a   Parmentier Batteur, Sophie ^a   Flick, Rosemarie B ^a   Surles, Nathaniel O ^a   Lam, June S H ^a   McNaughton, Caitlyn H ^a   Jacobson, Marlene A ^a   Hutson, Pete H ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Cognition; Glutamate; Metabotropic; NMDA; Novel object recognition; Schizophrenia

Indexed keywords

3 CYANO N (1,3 DIPHENYL 1H PYRAZOL 5 YL)BENZAMIDE; AMINO ACID RECEPTOR AFFECTING AGENT; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE II; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; GLUTAMATE RECEPTOR 1; METABOTROPIC RECEPTOR 5; METABOTROPIC RECEPTOR 5 POSITIVE ALLOSTERIC MODULATOR; N METHYL DEXTRO ASPARTIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 1; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2B; NEUROLEPTIC AGENT; UNCLASSIFIED DRUG;

ALLOSTERISM; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFICACY; DRUG MECHANISM; DRUG MEGADOSE; DRUG SYNTHESIS; HIPPOCAMPUS; LOW DRUG DOSE; MALE; MEMORY CONSOLIDATION; MEMORY DISORDER; NERVE CELL PLASTICITY; NONHUMAN; PREFRONTAL CORTEX; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; RECALL; SCHIZOPHRENIA;

ANIMALS; BENZAMIDES; BRAIN; CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASE TYPE 2; CENTRAL NERVOUS SYSTEM AGENTS; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; DIZOCILPINE MALEATE; DOSE-RESPONSE RELATIONSHIP, DRUG; HIPPOCAMPUS; MALE; MEMORY DISORDERS; NEURONAL PLASTICITY; PHOSPHORYLATION; PREFRONTAL CORTEX; PYRAZOLES; RATS; RATS, WISTAR; RECEPTORS, AMPA; RECEPTORS, N-METHYL-D-ASPARTATE; RECOGNITION (PSYCHOLOGY);

EID: 69649104858     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2009.07.022     Document Type: Article

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