Klotho attenuates high glucose-induced fibronectin and cell hypertrophy via the ERK1/2-p38 kinase signaling pathway in renal interstitial fibroblasts

Molecular and Cellular Endocrinology

Volumn 390, Issue 1-2, 2014, Pages 45-53

  Huang, Jau Shyang ^a   Chuang, Chao Tang ^b   Liu, Mei Hsin ^b   Lin, Sheng Hsuan ^b   Guh, Jinn Yuh ^b,c   Chuang, Lea Yea ^b  

^a CHUNG HWA UNIVERSITY OF MEDICAL TECHNOLOGY   (Taiwan)

^b KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

^c KAOHSIUNG MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

Author keywords

Cell hypertrophy; Diabetic nephropathy; Klotho; Renal fibrosis; Transforming growth factor

Indexed keywords

FIBRONECTIN; GLUCOSE; KLOTHO PROTEIN; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; SMAD2 PROTEIN; SMAD3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA; BETA GLUCURONIDASE; COLLAGEN; MADH2 PROTEIN, RAT; MADH3 PROTEIN, RAT; PROTEIN SERINE THREONINE KINASE; TRANSFORMING GROWTH FACTOR BETA RECEPTOR; TRANSFORMING GROWTH FACTOR-BETA TYPE II RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOLOGICAL ACTIVITY; CONTROLLED STUDY; DIABETES MELLITUS; ENZYME ACTIVATION; ENZYME ACTIVITY; FIBROBLAST; KIDNEY HYPERTROPHY; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT; SIGNAL TRANSDUCTION; ANIMAL; BIOSYNTHESIS; CELL LINE; COMPLICATION; DIABETIC NEPHROPATHY; EXPERIMENTAL DIABETES MELLITUS; GENE EXPRESSION; HYPERTROPHY; KIDNEY CORTEX; METABOLISM; PATHOLOGY; PHYSIOLOGY; SPRAGUE DAWLEY RAT;

ANIMALS; CELL LINE; COLLAGEN; DIABETES MELLITUS, EXPERIMENTAL; DIABETIC NEPHROPATHIES; FIBROBLASTS; FIBRONECTINS; GENE EXPRESSION; GLUCOSE; GLUCURONIDASE; HYPERTROPHY; KIDNEY CORTEX; MALE; MAP KINASE SIGNALING SYSTEM; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PROTEIN-SERINE-THREONINE KINASES; RATS, SPRAGUE-DAWLEY; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; SMAD2 PROTEIN; SMAD3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA;

EID: 84901024350     PISSN: 03037207     EISSN: 18728057     Source Type: Journal    
DOI: 10.1016/j.mce.2014.04.001     Document Type: Article

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