Klotho to treat kidney fibrosis

Journal of the American Society of Nephrology

Volumn 24, Issue 5, 2013, Pages 687-689

  Sanchez Niño, Maria D ^a,b   Sanz, Ana B ^b,c   Ortiz, Alberto ^b,c,d,e  

^a HOSPITAL UNIVERSITARIO LA PAZ IDIPAZ   (Spain)

^b Fundación Renal and Red de Investigación Renal REDinREN   (Spain)

^c 28400 Madrid   (Spain)

^d AUTONOMOUS UNIVERSITY OF MADRID   (Spain)

^e Section of Nephrology   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN; FIBROBLAST GROWTH FACTOR 23; INSULIN; KLOTHO PROTEIN; POTASSIUM CHANNEL; RENAL OUTER MEDULLARY POTASSIUM CHANNEL; SOMATOMEDIN C; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 2; TRANSFORMING GROWTH FACTOR BETA1; TRANSIENT RECEPTOR POTENTIAL CHANNEL 5; TRANSIENT RECEPTOR POTENTIAL CHANNEL 6; UNCLASSIFIED DRUG; WNT PROTEIN;

CHRONIC KIDNEY DISEASE; DOWN REGULATION; EDITORIAL; GENE EXPRESSION; HUMAN; HYPOPHOSPHATEMIA; KIDNEY EPITHELIUM; KIDNEY FIBROSIS; KIDNEY TUBULE; NONHUMAN; PRIORITY JOURNAL; PROTEINURIA; RENAL PROTECTION; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM;

EID: 84877094343     PISSN: 10466673     EISSN: 15333450     Source Type: Journal    
DOI: 10.1681/ASN.2013030294     Document Type: Editorial

References (15)

1. Kuro-o M, Matsumura Y, Aizawa H, Kawaguchi H, Suga T, Utsugi T, Ohyama Y, Kurabayashi M, Kaname T, Kume E, Iwasaki H, Iida A, Shiraki- Iida T, Nishikawa S, Nagai R, Nabeshima YI: Mutation of themouse klotho gene leads to a syndrome resembling ageing. Nature 390: 45-51, 1997 (Pubitemid 27494749)
2. Hu MC, Moe OW: Klotho as a potential biomarker and therapy for acute kidney injury. Nat Rev Nephrol 8: 423-429, 2012
3. Izquierdo MC, Perez-Gomez MV, Sanchez-Niño MD, Sanz AB, Ruiz-Andres O, Poveda J, Moreno JA, Egido J, Ortiz A: Klotho, phosphate and infl ammation/ageing in chronic kidney disease. Nephrol Dial Transplant 27[Suppl 4]: iv6- iv10, 2012
4. Zhou L, Li Y, Zhou D, Tan RJ, Liu Y: Loss of Klotho contributes to kidney injury by releasing repressions of Wnt/β-catenin signaling. J Am Soc Nephrol 8: 771 - 785, 2013
5. Hu MC, Shi M, Zhang J, Quiñones H, Grif fith C, Kuro-o M, Moe OW: Klotho deficiency causes vascular calcification in chronic kidney disease. J Am Soc Nephrol 22: 124-136, 2011
6. Ohnishi M, Razzaque MS: Dietary and genetic evidence for phosphate toxicity accelerating mammalian aging. FASEB J 24: 3562-3571, 2010
7. Sugiura H, Yoshida T, Shiohira S, Kohei J, Mitobe M, Kurosu H, Kuro-o M, Nitta K, Tsuchiya K: Reduced Klotho expression level in kidney aggravates renal interstitial fibrosis. Am J Physiol Renal Physiol 302: F1252-F1264, 2012
8. Moreno JA, Izquierdo MC, Sanchez-Niño MD, Suárez-Alvarez B, Lopez-Larrea C, Jakubowski A, Blanco J, Ramirez R, Selgas R, Ruiz-Ortega M, Egido J, Ortiz A, Sanz AB: The in flammatory cytokines TWEAK and TNFα reduce renal klotho expression through NFκB. J Am Soc Nephrol 22: 1315-1325, 2011
9. Thurston RD, Larmonier CB,Majewski PM, Ramalingam R, Midura-Kiela M, Laubitz D, Vandewalle A, Besselsen DG, Mühlbauer M, Jobin C, Kiela PR, Ghishan FK: Tumor necrosis factor and interferon-gamma down-regulate Klotho in mice with colitis. Gastroenterology 138: 1384-1394, 1394, e1-e2, 2010
10. Doi S, Zou Y, Togao O, Pastor JV, John GB, Wang L, Shiizaki K, Gotschall R, Schiavi S, Yorioka N, Takahashi M, Boothman DA, Kuro-o M: Klotho inhibits transforming growth factor-beta1 (TGF-beta1) signaling and suppresses renal fibrosis and cancer metastasis in mice. J Biol Chem 286: 8655-8665, 2011
11. Haruna Y, Kashihara N, Satoh M, Tomita N, Namikoshi T, Sasaki T, Fujimori T, Xie P, Kanwar YS: Amelioration of progressive renal injury by genetic manipulation of Klotho gene. Proc Natl Acad Sci U S A 104: 2331-2336, 2007 (Pubitemid 46391397)
12. Mitani H, Ishizaka N, Aizawa T, Ohno M, Usui S, Suzuki T, Amaki T, Mori I, Nakamura Y, Sato M, Nangaku M, Hirata Y, Nagai R: In vivo klotho gene transfer ameliorates angiotensin II-induced renal damage. Hypertension 39: 838-843, 2002 (Pubitemid 34437536)
13. Liu H, Fergusson MM, Castilho RM, Liu J, Cao L, Chen J, Malide D, Rovira II, Schimel D, Kuo CJ, Gutkind JS, Hwang PM, Finkel T: Augmented Wnt signaling in a mammalian model of accelerated aging. Science 317: 803-806, 2007 (Pubitemid 47257917)
14. Satoh M, Nagasu H, Morita Y, Yamaguchi TP, Kanwar YS, Kashihara N: Klotho protects against mouse renal fibrosis by inhibiting Wnt signaling. Am J Physiol Renal Physiol 303: F1641-F1651, 2012
15. Zoccali C, Ruggenenti P, Perna A, Leonardis D, Tripepi R, Tripepi G, Mallamaci F, Remuzzi G; REIN Study Group: Phosphate may promote CKD progression and attenuate renoprotective effect of ACE inhibition. J Am Soc Nephrol 22: 1923-1930, 2011