Tetrodotoxin-resistant sodium channels in sensory neurons generate slow resurgent currents that are enhanced by inflammatory mediators

Journal of Neuroscience

Volumn 34, Issue 21, 2014, Pages 7190-7197

  Tan, Zhi Yong ^a   Piekarz, Andrew D ^b   Priest, Birgit T ^b   Knopp, Kelly L ^b   Krajewski, Jeffrey L ^b   McDermott, Jeff S ^b   Nisenbaum, Eric S ^b   Cummins, Theodore R ^a  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b ELI LILLY AND COMPANY   (United States)

Author keywords

Action potential; Hyperexcitability; Nociceptor; Resurgent sodium current; Sodium current; Voltage clamp

Indexed keywords

SODIUM CHANNEL; TETRODOTOXIN;

ACTION POTENTIAL; ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; COMPUTER SIMULATION; CONTROLLED STUDY; DORSAL ROOT; ELECTROPHYSIOLOGY; IMMUNOPRECIPITATION; INFLAMMATION; KINETICS; MALE; MEMBRANE DEPOLARIZATION; MEMBRANE POTENTIAL; NERVE EXCITABILITY; NONHUMAN; PRIORITY JOURNAL; RAT; SENSORY NERVE CELL; VOLTAGE CLAMP TECHNIQUE; WESTERN BLOTTING;

ACTION POTENTIAL; HYPEREXCITABILITY; NOCICEPTOR; RESURGENT SODIUM CURRENT; SODIUM CURRENT; VOLTAGE CLAMP;

ANILINE COMPOUNDS; ANIMALS; BIOPHYSICS; CELLS, CULTURED; ELECTRIC STIMULATION; FURANS; GANGLIA, SPINAL; IMMUNOPRECIPITATION; INFLAMMATION MEDIATORS; LIDOCAINE; MEMBRANE POTENTIALS; NAV1.8 VOLTAGE-GATED SODIUM CHANNEL; PATCH-CLAMP TECHNIQUES; PEPTIDES; PROTEIN SUBUNITS; RATS; RATS, SPRAGUE-DAWLEY; SENSORY RECEPTOR CELLS; SODIUM CHANNEL BLOCKERS; TETRODOTOXIN;

EID: 84901008873     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.5011-13.2014     Document Type: Article

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