Use-dependent block by lidocaine but not amitriptyline is more pronounced in tetrodotoxin (TTX)-resistant Nav1.8 than in TTX-sensitive Na + channels

Journal of Pharmacology and Experimental Therapeutics

Volumn 320, Issue 1, 2007, Pages 354-364

  Leffler, Andreas ^a   Reiprich, Anne ^a   Mohapatra, Durga P ^a   Nau, Carla ^a  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AMITRIPTYLINE; LIDOCAINE; SODIUM CHANNEL; SODIUM CHANNEL NAV 1.8; TETRODOTOXIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DRUG MECHANISM; DRUG POTENCY; IC 50; MOUSE; NEUROPATHIC PAIN; NOCICEPTION; NONHUMAN; PRIORITY JOURNAL; SENSORY NERVE CELL; SPINAL CORD NERVE CELL; SPINAL GANGLION; VOLTAGE CLAMP;

AMITRIPTYLINE; ANIMALS; CELL LINE; DOSE-RESPONSE RELATIONSHIP, DRUG; LIDOCAINE; MICE; MICE, INBRED C57BL; NERVE TISSUE PROTEINS; PROTEIN SUBUNITS; RATS; SODIUM CHANNEL BLOCKERS; SODIUM CHANNELS; TETRODOTOXIN;

EID: 33845872615     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.106.109025     Document Type: Article

References (40)

1. Akopian AN, Sivilotti L, and Wood JN (1996) A tetrodotoxin-resistant voltage-gated sodium channel expressed by sensory neurons. Nature (Lond) 379:257-262.
2. Akopian AN, Souslova V, England S, Okuse K, Ogata N, Ure J, Smith A, Kerr BJ, McMahon SB, Boyce S, et al. (1999) The tetrodotoxin-resistant sodium channel SNS has a specialized function in pain pathways. Nat Neurosci 2:541-548.
3. Bean BP, Cohen CJ, and Tsien RW (1983) Lidocaine block of cardiac sodium channels. J Gen Physiol 81:613-642.
4. 2+ current in the action potentials of nociceptive sensory neurons. J Neurosci 22:10277-10290.
5. + current slow inactivation in adaptation of action potential firing in small-diameter dorsal root ganglion neurons. J Neurosci 23:10338-10350.
6. Catterall WA, Goldin AL, and Waxman SG (2003) International Union of Pharmacology: XXXIX. Compendium of voltage-gated ion channels: sodium channels. Pharmacol Rev 55:575-578.
7. Chevrier P, Vijayaragavan K, and Chahine M (2004) Differential modulation of Nav1.7 and Nav1.8 peripheral nerve sodium channels by the local anesthetic lidocaine. Br J Pharmacol 142:576-584.
8. v1.8. FEBS Lett 572:256-260.
9. Cummins TR, Dib-Hajj SD, Black JA, Akopian AN, Wood JN, and Waxman SG (1999) A novel persistent tetrodotoxin-resistant sodium current in SNS-null and wild-type small primary sensory neurons. J Neurosci 19:RC43.
10. Cummins TR and Waxman SG (1997) Downregulation of tetrodotoxin-resistant sodium currents and upregulation of a rapidly repriming tetrodotoxin-sensitive sodium current in small spinal sensory neurons after nerve injury. J Neurosci 17:3503-3514.
11. Devor M, Wall PD, and Catalan N (1992) Systemic lidocaine silences ectopic neuroma and DRG discharge without blocking nerve conduction. Pain 48:261-268.
12. Djouhri L, Fang X, Okuse K, Wood JN, Berry CM, and Lawson SN (2003) The TTX-resistant sodium channel Nav1.8 (SNS/PN3): expression and correlation with membrane properties in rat nociceptive primary afferent neurons. J Physiol (Lond) 550:739-752.
13. England S, Bevan S, and Docherty RJ (1996) PGE2 modulates the tetrodotoxin-resistant sodium current in neonatal rat dorsal root ganglion neurones via the cyclic AMP-protein kinase A cascade. J Physiol (Lond) 495:429-440.
14. Gold MS, Levine JD, and Correa AM (1998) Modulation of TTX-R INa by PKC and PKA and their role in PGE2-induced sensitization of rat sensory neurons in vitro. J Neurosci 18:10345-10355.
15. Gold MS, Weinreich D, Kim CS, Wang R, Treanor J, Porreca F, and Lai J (2003) Redistribution of Na(v)1.8 in uninjured axons enables neuropathic pain. J Neurosci 23:158-166.
16. John VH, Main MJ, Powell AJ, Gladwell ZM, Hick C, Sidhu HS, Clare JJ, Tate S, and Trezise DJ (2004) Heterologous expression and functional analysis of rat Nav1.8 (SNS) voltage-gated sodium channels in the dorsal root ganglion neuroblastoma cell line ND7-23. Neuropharmacology 46:425-438.
17. Kerr BJ, Souslova V, McMahon SB, and Wood JN (2001) A role for the TTX-resistant sodium channel Nav 1.8 in NGF-induced hyperalgesia, but not neuropathic pain. Neuroreport 12:3077-3080.
18. Lai J, Gold MS, Kim CS, Bian D, Ossipov MH, Hunter JC, and Porreca F (2002) Inhibition of neuropathic pain by decreased expression of the tetrodotoxin-resistant sodium channel, NaV1.8. Pain 95:143-152.
19. Lai J, Hunter JC, and Porreca F (2003) The role of voltage-gated sodium channels in neuropathic pain. Curr Opin Neurobiol 13:291-297.
20. Leuwer M, Haeseler G, Hecker H, Bufler J, Dengler R, and Aronson JK (2004) An improved model for the binding of lidocaine and structurally related local anaesthetics to fast-inactivated voltage-operated sodium channels, showing evidence of cooperativity. Br J Pharmacol 141:47-54.
21. Nassar MA, Levato A, Stirling LC, and Wood JN (2005) Neuropathic pain develops normally in mice lacking both Nav1.7 and Nav1.8. Mol Pain 1:24.
22. Nau C, Seaver M, Wang SY, and Wang GK (2000) Block of human heart hH1 sodium channels by amitriptyline. J Pharmacol Exp Ther 292:1015-1023.
23. + channels. J Membr Biol 201:1-8.
24. + channels modulate binding affinity and stereoselectivity of local anesthetic enantiomers. Mol Pharmacol 56:404-413.
25. Okuse K, Malik-Hall M, Baker MD, Poon WY, Kong H, Chao MV, and Wood JN (2002) Annexin II light chain regulates sensory neuron-specific sodium channel expression. Nature (Lond) 417:653-656.
26. Ong BH, Tomaselli GF, and Balser JR (2000) A structural rearrangement in the sodium channel pore linked to slow inactivation and use dependence. J Gen Physiol 116:653-662.
27. Priest BT, Murphy BA, Lindia JA, Diaz C, Abbadie C, Ritter AM, Liberator P, Iyer LM, Kash SF, Kohler MG, et al. (2005) Contribution of the tetrodotoxin-resistant voltage-gated sodium channel Nav1.9 to sensory transmission and nociceptive behavior. Proc Natl Acad Sci USA 102:9382-9387.
28. Qu Y, Curtis R, Lawson D, Gilbride K, Ge P, DiStefano PS, Silos-Santiago I, Catterall WA, and Scheuer T (2001) Differential modulation of sodium channel gating and persistent sodium currents by the beta1, beta2, and beta3 subunits. Mol Cell Neurosci 18:570-580.
29. + channels by local anesthetics. Science (Wash DC) 265:1724-1728.
30. Renganathan M, Cummins TR, and Waxman SG (2001) Contribution of Na(v)1.8 sodium channels to action potential electrogenesis in DRG neurons. J Neurophysiol 86:629-640.
31. Roy ML and Narahashi T (1992) Differential properties of tetrodotoxin-sensitive and tetrodotoxin-resistant sodium channels in rat dorsal root ganglion neurons. J Neurosci 12:2104-2111.
32. + channel Nav1.8 is essential for the expression of spontaneous activity in damaged sensory axons of mice. J Physiol (Lond) 550:921-926.
33. Rush AM, Brau ME, Elliott AA, and Elliott JR (1998) Electrophysiological properties of sodium current subtypes in small cells from adult rat dorsal root ganglia. J Physiol (Lond) 511:771-789.
34. + currents by lidocaine and bupivacaine reduce firing frequency in DRG neurons. J Neurophysiol 79:1746-1754.
35. + channels by amitriptyline via the local anesthetic receptor and its implication for neuropathic pain. Pain 110:166-174.
36. Waxman SG, Cummins TR, Dib-Hajj S, Fjell J, and Black JA (1999) Sodium channels, excitability of primary sensory neurons, and the molecular basis of pain. Muscle Nerve 22:1177-1187.
37. Wood JN, Bevan SJ, Coote PR, Dunn PM, Harmar A, Hogan P, Latchman DS, Morrison C, Rougon G, Theveniau M, et al. (1990) Novel cell lines display properties of nociceptive sensory neurons. Proc Biol Sci 241:187-194.
38. Wright SN, Wang SY, Kallen RG, and Wang GK (1997) Differences in steady-state inactivation between Na channel isoforms affect local anesthetic binding affinity. Biophys J 73:779-788.
39. Wright SN, Wang SY, Xiao YF, and Wang GK (1999) State-dependent cocaine block of sodium channel isoforms, chimeras, and channels coexpressed with the beta1 subunit. Biophys J 76:233-245.
40. Yu FH, Westenbroek RE, Silos-Santiago I, McCormick KA, Lawson D, Ge P, Ferriera H, Lilly J, DiStefano PS, Catterall WA, et al. (2003) Sodium channel beta4, a new disulfide-linked auxiliary subunit with similarity to beta2. J Neurosci 23:7577-7585.