Antisense-mediated knockdown of Nav1.8, but not Nav1.9, generates inhibitory effects on complete freund's adjuvant-induced inflammatory pain in rat

PLoS ONE

Volumn 6, Issue 5, 2011, Pages

  Yu, Yao Qing ^a   Zhao, Feng ^a   Guan, Su Min ^b   Chen, Jun ^a,c  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^b FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^c CAPITAL MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ANTISENSE OLIGODEOXYNUCLEOTIDE; FREUND ADJUVANT; MESSENGER RNA; SODIUM CHANNEL NAV1.8; SODIUM CHANNEL NAV1.9; TETRODOTOXIN; ANTISENSE OLIGONUCLEOTIDE; SCN11A PROTEIN, RAT; SENSORY NEURON SPECIFIC (SNS) SODIUM CHANNEL; SODIUM CHANNEL;

ANALGESIA; ANIMAL BEHAVIOR; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTISENSE THERAPY; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; DRUG MECHANISM; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; HEAT SENSITIVITY; IMMUNOHISTOCHEMISTRY; INFLAMMATION; MALE; NEUROMODULATION; NONHUMAN; PAIN; PAIN THRESHOLD; PROTEIN EXPRESSION; RAT; SENSORY NERVE CONDUCTION; SODIUM CURRENT; SPINAL GANGLION; UPREGULATION; WESTERN BLOTTING; ANIMAL; CHANNEL GATING; DRUG EFFECT; GENE SILENCING; GENETICS; HYPERSENSITIVITY; INTRASPINAL DRUG ADMINISTRATION; METABOLISM; NERVE CELL; PATHOLOGY; SPRAGUE DAWLEY RAT;

RATTUS;

ANIMALS; DOWN-REGULATION; FREUND'S ADJUVANT; GANGLIA, SPINAL; GENE EXPRESSION PROFILING; GENE KNOCKDOWN TECHNIQUES; HYPERSENSITIVITY; INFLAMMATION; INJECTIONS, SPINAL; ION CHANNEL GATING; MALE; NEURONS; OLIGONUCLEOTIDES, ANTISENSE; PAIN; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; SODIUM CHANNELS;

EID: 79955878897     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0019865     Document Type: Article

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