Anticancer drug oxaliplatin induces acute cooling-aggravated neuropathy via sodium channel subtype Na V1.6-resurgent and persistent current

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 17, 2012, Pages 6704-6709

  Sittl, Ruth ^a   Lampert, Angelika ^b   Huth, Tobias ^b   Schuy, E Theresa ^b   Link, Andrea S ^b   Fleckenstein, Johannes ^a   Alzheimer, Christian ^b   Grafe, Peter ^a   Carr, Richard W ^a,c  

^a UNIVERSITY OF MUNICH   (Germany)

^b UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^c UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Abnormal axonal excitability; Chemotherapy; Peripheral nerve; Repetitive action potential discharge

Indexed keywords

OXALIPLATIN; SODIUM CHANNEL NAV1.6;

ACTION POTENTIAL; ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; COOLING; ELECTRIC CURRENT; HUMAN; HUMAN TISSUE; MALE; MOUSE; MYELINATION; NERVE FIBER; NONHUMAN; PERIPHERAL NEUROPATHY; PRIORITY JOURNAL; SODIUM CURRENT; SPINAL GANGLION;

ANIMALS; ANTINEOPLASTIC AGENTS; AXONS; GANGLIA, SPINAL; HUMANS; MICE; NERVE TISSUE PROTEINS; NEURONS; ORGANOPLATINUM COMPOUNDS; PERIPHERAL NERVOUS SYSTEM DISEASES; SODIUM CHANNELS;

EID: 84860138977     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1118058109     Document Type: Article

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