Production of Resurgent Current in NaV1.6-Null Purkinje Neurons by Slowing Sodium Channel Inactivation with β-Pompilidotoxin

Journal of Neuroscience

Volumn 24, Issue 1, 2004, Pages 35-42

  Grieco, Tina M ^a   Raman, Indira M ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

Author keywords

CA3; Cerebellum; Med; Open channel block; Scn8a; Sodium current

Indexed keywords

ALKALINE PHOSPHATASE; BETA POMPILIDOTOXIN; SODIUM CHANNEL; SODIUM ION; TETRODOTOXIN; UNCLASSIFIED DRUG; VOLTAGE GATED SODIUM CHANNEL;

ACTION POTENTIAL; ANIMAL CELL; ARTICLE; CEREBELLUM; CONTROLLED STUDY; MOUSE; MUTATION; NERVE CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PURKINJE CELL; REPOLARIZATION; SODIUM CHANNEL NAV1.6; SODIUM CURRENT; WILD TYPE;

ANIMALS; CELLS, CULTURED; ELECTRIC CONDUCTIVITY; INSECT PROTEINS; KINETICS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NERVE TISSUE PROTEINS; NEUROTOXINS; PATCH-CLAMP TECHNIQUES; PHOSPHORYLATION; PURKINJE CELLS; PYRAMIDAL CELLS; SODIUM CHANNEL BLOCKERS; SODIUM CHANNELS; WASP VENOMS;

EID: 0842344423     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.3807-03.2004     Document Type: Article

References (29)

1. Boiko T, Van Wart A, Caldwell JH, Levinson SR, Trimmer JS, Matthews G (2003) Functional specialization of the axon initial segment by isoform-specific sodium channel targeting. J Neurosci 23:2306-2313.
2. Burgess DL, Kohrman DC, Galt J, Plummer NW, Jones JM, Spear B, Meisler MH (1995) Mutation of a new sodium channel gene, Scn8a, in the mouse mutant "motor endplate disease." Nat Genet 10:461-465.
3. V1.6 is localized at nodes of Ranvier, dendrites, and synapses. Proc Natl Acad Sci USA 97:5616-5620.
4. +-dependent mechanism. J Neurosci 21:759-770.
5. Do MT, Bean BP (2003) Subthreshold sodium currents and pacemaking of subthalamic neurons: modulation by slow inactivation. Neuron 39:109-120.
6. Felts PA, Yokoyama S, Dib-Hajj S, Black JA, Waxman SG (1997) Sodium channel alpha-subunit mRNAs I, II, III, NaG, Na6 and hNE (PN1): different expression patterns in developing rat nervous system. Brain Res Mol Brain Res 45:71-82.
7. Grieco TM, Afshari F, Raman IM (2002) A role for phosphorylation in the maintenance of resurgent sodium current in cerebellar Purkinje neurons. J Neurosci 22:3100-3107.
8. Isom LL, De Jongh KS, Patton DE, Reber BF, Offord J, Charbonneau H, Walsh K, Goldin AL, Catterall WA (1992) Primary structure and functional expression of the beta 1 subunit of the rat brain sodium channel. Science 256:839-842.
9. Isom LL, Scheuer T, Brownstein AB, Ragsdale DS, Murphy BJ, Catterall WA (1995) Functional co-expression of the beta 1 and type IIA alpha sub-units of sodium channels in a mammalian cell line. J Biol Chem 270:3306-3312.
10. + channel. Nature 423:42-48.
11. Khaliq ZM, Gouwens NW, Raman IM (2003) The contribution of resurgent sodium current to high-frequency firing in Purkinje neurons: an experimental and modeling study. J Neurosci 23:4899-4912.
12. Kinoshita E, Maejima H, Yamaoka K, Konno K, Kawai N, Shimizu E, Yokote S, Nakayama H, Seyama I (2001) Novel wasp toxin discriminates between neuronal and cardiac sodium channels. Mol Pharmacol 59:1457-1463.
13. 5 dopamine receptor activation differentially modulates rapidly inactivating and persistent sodium currents in prefrontal cortex pyramidal neurons. J Neurosci 21:2268-2277.
14. Mossadeghi B, Slater NT (1998) Persistent and resurgent sodium currents in cerebellar unipolar brush cells. Soc Neurosci Abstr 24:1078.
15. Pan F, Beam KG (1999) The absence of resurgent current in mouse spinal neurons. Brain Res 849:162-168.
16. Qu Y, Curtis R, Lawson D, Gilbride K, Ge P, DiStefano PS, Silos-Santiago I, Catterall WA, Scheuer T (2001) Differential modulation of sodium channel gating and persistent sodium currents by the beta1, beta2, and beta3 subunits. Mol Cell Neurosci 18:570-580.
17. Raman IM, Bean BP (1997) Resurgent sodium current and action potential formation in dissociated cerebellar Purkinje neurons. J Neurosci 17:4517-4526.
18. Raman IM, Bean BP (2001) Inactivation and recovery of sodium currents in cerebellar Purkinje neurons: evidence for two mechanisms. Biophys J 80:729-737.
19. Raman IM, Sprunger LK, Meisler MH, Bean BP (1997) Altered subthreshold sodium current and disrupted firing patterns in Purkinje neurons of Scn8a mutant mice. Neuron 19:881-891.
20. Raman IM, Gustafson AE, Padgett D (2000) Ionic currents and spontaneous firing in neurons isolated from the cerebellar nuclei. J Neurosci 20:9004-9016.
21. Ratcliffe CM, Qu Y, McCormick KA, Tibbs VC, Dixon JE, Scheuer T, Catterall WA (2000) A sodium channel signaling complex: modulation by associated receptor protein tyrosine phosphatase beta. Nat Neurosci 3:437-444.
22. Regan LJ (1991) Voltage-dependent calcium currents in Purkinje cells from rat cerebellar vermis. J Neurosci 11:2259-2269.
23. Shah BS, Stevens EB, Pinnock RD, Dixon AK, Lee K (2001) Developmental expression of the novel voltage-gated sodium channel auxiliary subunit beta 3, in rat CNS. J Physiol (Lond) 534:763-776.
24. Smith MR, Smith RD, Plummer NM, Meisler MH, Goldin AL (1998) Functional analysis of the mouse Scn8a sodium channel. J Neurosci 18:6093-6102.
25. Smith RD, Goldin AL (1998) Functional analysis of the rat I sodium channel in Xenopus oocytes. J Neurosci 18:811-820.
26. Stühmer W, Conti F, Suzuki H, Wang XD, Noda M, Yahagi N, Kubo H, Numa S (1989) Structural parts involved in activation and inactivation of the sodium channel. Nature 339:597-603.
27. Vassilev PM, Scheuer T, Catterall WA (1988) Identification of an intracellular peptide segment involved in sodium channel inactivation. Science 241:1658-1661.
28. Vassilev P, Scheuer T, Catterall WA (1989) Inhibition of inactivation of single sodium channels by a site-directed antibody. Proc Natl Acad Sci USA 86:8147-8151.
29. Vega-Saenz de Miera E, Rudy B, Sugimori M, Llinás R (1997) Molecular characterization of the sodium channel subunits expressed in mammalian cerebellar Purkinje neurons. Proc Natl Acad Sci USA 94:7059-7064.