Site-specific labeling of cysteine-tagged camelid single-domain antibody-fragments for use in molecular imaging

Bioconjugate Chemistry

Volumn 25, Issue 5, 2014, Pages 979-988

  Massa, Sam ^a   Xavier, Catarina ^a   De Vos, Jens ^a   Caveliers, Vicky ^a,b   Lahoutte, Tony ^a,b   Muyldermans, Serge ^a   Devoogdt, Nick ^a  

^a VRIJE UNIVERSITEIT BRUSSEL   (Belgium)

^b UNIVERSITY HOSPITAL BRUSSELS   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODIES; ANTIGENS; LEAD COMPOUNDS; MASS SPECTROMETRY; MOLECULAR IMAGING; PROBES;

ANTIBODY-FRAGMENT; ANTIGEN BINDING; BINDING DOMAIN; CLINICAL TRANSLATION; IMAGING PROBE; LABELINGS; PHARMACOKINETICS AND PHARMACODYNAMICS; PROPERTY; SINGLE-DOMAIN ANTIBODIES; SITE-SPECIFIC;

AMINO ACIDS;

CHX A'' PENTETIC ACID 2RS15D HEXAHISTIDINE IN 111; CYSTEINE; EPIDERMAL GROWTH FACTOR RECEPTOR 2; MALEIMIDE; MERCAPTAMINE; NANOBODY; PENTETIC ACID; PENTETIC ACID 2RS15D HLC IN 111; PENTETIC ACID BCII10 HLC IN 111; TRACER; UNCLASSIFIED DRUG; ERBB2 PROTEIN, HUMAN; MOLECULAR PROBE; TUMOR MARKER;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN BINDING; ARTICLE; BINDING AFFINITY; CARBOXY TERMINAL SEQUENCE; CONJUGATION; CONTROLLED STUDY; DIMERIZATION; DRUG DISTRIBUTION; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; ISOTOPE LABELING; MASS SPECTROMETRY; MOLECULAR IMAGING; MOUSE; NONHUMAN; RADIOCHEMISTRY; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; ANIMAL; ANTIGEN ANTIBODY REACTION; CAMEL; CHEMICAL STRUCTURE; CHEMISTRY; IMMUNOLOGY; MOLECULAR PROBE; NEOPLASMS, EXPERIMENTAL; NUDE MOUSE; PROTEIN ENGINEERING; TISSUE DISTRIBUTION; TUMOR CELL CULTURE;

ANIMALS; ANTIGEN-ANTIBODY REACTIONS; CAMELS; CYSTEINE; FEMALE; HUMANS; MICE; MICE, NUDE; MODELS, MOLECULAR; MOLECULAR IMAGING; MOLECULAR PROBES; NEOPLASMS, EXPERIMENTAL; PROTEIN ENGINEERING; RECEPTOR, ERBB-2; SINGLE-DOMAIN ANTIBODIES; TISSUE DISTRIBUTION; TUMOR CELLS, CULTURED; TUMOR MARKERS, BIOLOGICAL;

EID: 84900991913     PISSN: 10431802     EISSN: 15204812     Source Type: Journal    
DOI: 10.1021/bc500111t     Document Type: Article

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