Combined MUC1-specific nanobody-tagged PEG-polyethylenimine polyplex targeting and transcriptional targeting of tBid transgene for directed killing of MUC1 over-expressing tumour cells

Journal of Controlled Release

Volumn 156, Issue 1, 2011, Pages 85-91

  Sadeqzadeh, Elham ^a   Rahbarizadeh, Fatemeh ^a   Ahmadvand, Davoud ^b   Rasaee, Mohammad J ^a   Parhamifar, Ladan ^b   Moghimi, S Moein ^b  

^a TARBIAT MODARES UNIVERSITY   (Iran)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

Cancer nanomedicines; MUC1; Nanobody; Poly(ethylene glycol); Polyethylenimine; Transcriptional targeting

Indexed keywords

CELL CULTURE; CELL DEATH; DISEASES; ETHYLENE GLYCOL; POLYETHYLENE GLYCOLS; POLYOLS; TUMORS;

MUC1; NANOBODY; NECROTIC CELL DEATHS; PHYSICOCHEMICAL CHARACTERISTICS; POLYETHYLENIMINES; SINGLE-DOMAIN ANTIBODIES; TRANSCRIPTIONAL TARGETING; TRANSGENE EXPRESSION;

MOLECULAR BIOLOGY;

CASPASE 3; MACROGOL; MUCIN 1; POLYETHYLENEIMINE; POLYETHYLENIMINE POLYPLEX; PROTEIN BID; SYNAPSIN I; UNCLASSIFIED DRUG;

ANTIGEN SPECIFICITY; APOPTOSIS; ARTICLE; CANCER CELL; CELL DAMAGE; CELL DEATH; CELL KILLING; CELL SURFACE; CELL VIABILITY; CONTROLLED STUDY; CROSS REACTION; ENZYME ACTIVITY; EPITHELIUM CELL; GENE EXPRESSION; GENETIC TRANSCRIPTION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IN VIVO STUDY; NUCLEOTIDE SEQUENCE; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN GLYCOSYLATION; SEQUENCE TAGGED SITE;

EID: 80855148160     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2011.06.022     Document Type: Article

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