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Volumn 38, Issue 8, 2011, Pages 1119-1127

Effect of chelator conjugation level and injection dose on tumor and organ uptake of 111In-labeled MORAb-009, an anti-mesothelin antibody

Author keywords

111In anti mesothelin antibody ( 111In MORAb 009); Biodistribution; Chelator conjugation; Dose effect

Indexed keywords

2 (4 ISOTHIOCYANATOBENZYL)CYCLOHEXYLDIETHYLENETRIAMINE PENTAACETIC ACID AMATUXIMAB CONJUGATE; AMATUXIMAB; AMATUXIMAB IN 111; CHELATING AGENT; MESOTHELIN; RADIOPHARMACEUTICAL AGENT; UNCLASSIFIED DRUG;

EID: 82655181976     PISSN: 09698051     EISSN: 18729614     Source Type: Journal    
DOI: 10.1016/j.nucmedbio.2011.05.003     Document Type: Article
Times cited : (29)

References (30)
  • 2
    • 0029564367 scopus 로고
    • Phase I study of intravenous Lu-labeled CC49 murine monoclonal antibody in patients with advanced adenocarcinoma
    • Mulligan T., Carrasquillo J.A., Chung Y., Milenic D.E., Schlom J., Feuerstein I., et al. Phase I study of intravenous Lu-labeled CC49 murine monoclonal antibody in patients with advanced adenocarcinoma. Clin Cancer Res 1995, 1:1447-1454.
    • (1995) Clin Cancer Res , vol.1 , pp. 1447-1454
    • Mulligan, T.1    Carrasquillo, J.A.2    Chung, Y.3    Milenic, D.E.4    Schlom, J.5    Feuerstein, I.6
  • 3
    • 0028840870 scopus 로고
    • Radioimmunotherapy of interleukin-2R alpha-expressing adult T-cell leukemia with yttrium-90-labeled anti-Tac
    • Waldmann T.A., White J.D., Carrasquillo J.A., Reynolds J.C., Paik C.H., Gansow O.A., et al. Radioimmunotherapy of interleukin-2R alpha-expressing adult T-cell leukemia with yttrium-90-labeled anti-Tac. Blood 1995, 86:4063-4075.
    • (1995) Blood , vol.86 , pp. 4063-4075
    • Waldmann, T.A.1    White, J.D.2    Carrasquillo, J.A.3    Reynolds, J.C.4    Paik, C.H.5    Gansow, O.A.6
  • 6
    • 0035478728 scopus 로고    scopus 로고
    • Pivotal study of iodine I-131 tositumomab for chemotherapy-refractory low-grade or transformed low-grade B-cell non-Hodgkin's lymphomas
    • Kaminski M.S., Zelenetz A.D., Press O.W., Saleh M., Leonard J., Fehrenbacher L., et al. Pivotal study of iodine I-131 tositumomab for chemotherapy-refractory low-grade or transformed low-grade B-cell non-Hodgkin's lymphomas. J Clin Oncol 2001, 19:3918-3928.
    • (2001) J Clin Oncol , vol.19 , pp. 3918-3928
    • Kaminski, M.S.1    Zelenetz, A.D.2    Press, O.W.3    Saleh, M.4    Leonard, J.5    Fehrenbacher, L.6
  • 7
    • 0037093241 scopus 로고    scopus 로고
    • Randomized controlled trial of yttrium-90-labeled ibritumomab tiuxetan radioimmunotherapy versus rituximab immunotherapy for patients with relapsed or refractory low-grade, follicular, or transformed B-cell non-Hodgkin's lymphoma
    • Witzig T.E., Gordon L.I., Cabanillas F., Czuczman M.S., Emmanouilides C., Joyce R., et al. Randomized controlled trial of yttrium-90-labeled ibritumomab tiuxetan radioimmunotherapy versus rituximab immunotherapy for patients with relapsed or refractory low-grade, follicular, or transformed B-cell non-Hodgkin's lymphoma. J Clin Oncol 2002, 20:2453-2463.
    • (2002) J Clin Oncol , vol.20 , pp. 2453-2463
    • Witzig, T.E.1    Gordon, L.I.2    Cabanillas, F.3    Czuczman, M.S.4    Emmanouilides, C.5    Joyce, R.6
  • 9
    • 0022515047 scopus 로고
    • Chelating agents for the binding of metal ions to antibodies
    • Meares C.F. Chelating agents for the binding of metal ions to antibodies. Int J Rad Appl Instrum B 1986, 13:311-318.
    • (1986) Int J Rad Appl Instrum B , vol.13 , pp. 311-318
    • Meares, C.F.1
  • 10
    • 0024316503 scopus 로고
    • Nature of the bifunctional chelating agent used for radioimmunotherapy with yttrium-90 monoclonal antibodies: critical factors in determining in vivo survival and organ toxicity
    • Kozak R.W., Raubitschek A., Mirzadeh S., Brechbiel M.W., Junghans R.P., Gansow O.A., et al. Nature of the bifunctional chelating agent used for radioimmunotherapy with yttrium-90 monoclonal antibodies: critical factors in determining in vivo survival and organ toxicity. Cancer Res 1989, 49:2639-2644.
    • (1989) Cancer Res , vol.49 , pp. 2639-2644
    • Kozak, R.W.1    Raubitschek, A.2    Mirzadeh, S.3    Brechbiel, M.W.4    Junghans, R.P.5    Gansow, O.A.6
  • 11
    • 0025237122 scopus 로고
    • Yttrium-90-labeled monoclonal antibody for therapy: labeling by a new macrocyclic bifunctional chelating agent
    • Deshpande S.V., DeNardo S.J., Kukis D.L., Moi M.K., McCall M.J., DeNardo G.L., et al. Yttrium-90-labeled monoclonal antibody for therapy: labeling by a new macrocyclic bifunctional chelating agent. J Nucl Med 1990, 31:473-479.
    • (1990) J Nucl Med , vol.31 , pp. 473-479
    • Deshpande, S.V.1    DeNardo, S.J.2    Kukis, D.L.3    Moi, M.K.4    McCall, M.J.5    DeNardo, G.L.6
  • 13
    • 0028279425 scopus 로고
    • Evaluation of the serum stability and in vivo biodistribution of CHX-DTPA and other ligands for yttrium labeling of monoclonal antibodies
    • Camera L., Kinuya S., Garmestani K., Wu C., Brechbiel M.W., Pai L.H., et al. Evaluation of the serum stability and in vivo biodistribution of CHX-DTPA and other ligands for yttrium labeling of monoclonal antibodies. J Nucl Med 1994, 35:882-889.
    • (1994) J Nucl Med , vol.35 , pp. 882-889
    • Camera, L.1    Kinuya, S.2    Garmestani, K.3    Wu, C.4    Brechbiel, M.W.5    Pai, L.H.6
  • 14
    • 0029294701 scopus 로고
    • Electrophoretic method for the quantitative determination of a benzyl-DTPA ligand in DTPA monoclonal antibody conjugates
    • Pham D.T., Kaspersen F.M., Bos E.S. Electrophoretic method for the quantitative determination of a benzyl-DTPA ligand in DTPA monoclonal antibody conjugates. Bioconjug Chem 1995, 6:313-315.
    • (1995) Bioconjug Chem , vol.6 , pp. 313-315
    • Pham, D.T.1    Kaspersen, F.M.2    Bos, E.S.3
  • 15
    • 0035083298 scopus 로고    scopus 로고
    • An improved method for conjugating monoclonal antibodies with N-hydroxysulfosuccinimidyl DOTA
    • Lewis M.R., Kao J.Y., Anderson A.L., Shively J.E., Raubitschek A. An improved method for conjugating monoclonal antibodies with N-hydroxysulfosuccinimidyl DOTA. Bioconjug Chem 2001, 12:320-324.
    • (2001) Bioconjug Chem , vol.12 , pp. 320-324
    • Lewis, M.R.1    Kao, J.Y.2    Anderson, A.L.3    Shively, J.E.4    Raubitschek, A.5
  • 17
    • 0021067628 scopus 로고
    • Optimization of the DTPA mixed-anhydride reaction with antibodies at low concentration
    • Paik C.H., Murphy P.R., Eckelman W.C., Volkert W.A., Reba R.C. Optimization of the DTPA mixed-anhydride reaction with antibodies at low concentration. J Nucl Med 1983, 24:932-936.
    • (1983) J Nucl Med , vol.24 , pp. 932-936
    • Paik, C.H.1    Murphy, P.R.2    Eckelman, W.C.3    Volkert, W.A.4    Reba, R.C.5
  • 18
    • 0028814493 scopus 로고
    • Effect of the extent of chelate substitution on the immunoreactivity and biodistribution of 2IT-BAT-Lym-1 immunoconjugates
    • Kukis D.L., DeNardo G.L., DeNardo S.J., Mirick G.R., Miers L.A., Greiner D.P., et al. Effect of the extent of chelate substitution on the immunoreactivity and biodistribution of 2IT-BAT-Lym-1 immunoconjugates. Cancer Res 1995, 55:878-884.
    • (1995) Cancer Res , vol.55 , pp. 878-884
    • Kukis, D.L.1    DeNardo, G.L.2    DeNardo, S.J.3    Mirick, G.R.4    Miers, L.A.5    Greiner, D.P.6
  • 19
    • 33749429154 scopus 로고    scopus 로고
    • 177Lu-DOTA-labeled aglycosylated monoclonal anti-L1-CAM antibody chCE7: influence of the number of chelators on the in vitro and in vivo properties
    • 177Lu-DOTA-labeled aglycosylated monoclonal anti-L1-CAM antibody chCE7: influence of the number of chelators on the in vitro and in vivo properties. Nucl Med Biol 2006, 33:883-889.
    • (2006) Nucl Med Biol , vol.33 , pp. 883-889
    • Knogler, K.1    Grunberg, J.2    Novak-Hofer, I.3    Zimmermann, K.4    Schubiger, P.A.5
  • 20
    • 0026503664 scopus 로고
    • Isolation and characterization of a monoclonal antibody, K1, reactive with ovarian cancers and normal mesothelium
    • Chang K., Pastan I., Willingham M.C. Isolation and characterization of a monoclonal antibody, K1, reactive with ovarian cancers and normal mesothelium. Int J Cancer 1992, 50:373-381.
    • (1992) Int J Cancer , vol.50 , pp. 373-381
    • Chang, K.1    Pastan, I.2    Willingham, M.C.3
  • 21
    • 0030069718 scopus 로고    scopus 로고
    • Molecular cloning of mesothelin, a differentiation antigen present on mesothelium, mesotheliomas, and ovarian cancers
    • Chang K., Pastan I. Molecular cloning of mesothelin, a differentiation antigen present on mesothelium, mesotheliomas, and ovarian cancers. Proc Natl Acad Sci U S A 1996, 93:136-140.
    • (1996) Proc Natl Acad Sci U S A , vol.93 , pp. 136-140
    • Chang, K.1    Pastan, I.2
  • 22
    • 37449006756 scopus 로고    scopus 로고
    • Preclinical evaluation of MORAb-009, a chimeric antibody targeting tumor-associated mesothelin
    • Hassan R., Ebel W., Routhier E.L., Patel R., Kline J.B., Zhang J., et al. Preclinical evaluation of MORAb-009, a chimeric antibody targeting tumor-associated mesothelin. Cancer Immun 2007, 7:20.
    • (2007) Cancer Immun , vol.7 , pp. 20
    • Hassan, R.1    Ebel, W.2    Routhier, E.L.3    Patel, R.4    Kline, J.B.5    Zhang, J.6
  • 23
    • 78650339895 scopus 로고    scopus 로고
    • Phase I clinical trial of the chimeric anti-mesothelin monoclonal antibody MORAb-009 in patients with mesothelin expressing cancers
    • Hassan R., Cohen S.J., Phillips M., Pastan I., Sharon E., Kelly R.J., et al. Phase I clinical trial of the chimeric anti-mesothelin monoclonal antibody MORAb-009 in patients with mesothelin expressing cancers. Clin Cancer Res 2010, 16:6132-6138.
    • (2010) Clin Cancer Res , vol.16 , pp. 6132-6138
    • Hassan, R.1    Cohen, S.J.2    Phillips, M.3    Pastan, I.4    Sharon, E.5    Kelly, R.J.6
  • 24
    • 31544439933 scopus 로고    scopus 로고
    • Detection and quantitation of serum mesothelin, a tumor marker for patients with mesothelioma and ovarian cancer
    • Hassan R., Remaley A.T., Sampson M.L., Zhang J., Cox D.D., Pingpank J., et al. Detection and quantitation of serum mesothelin, a tumor marker for patients with mesothelioma and ovarian cancer. Clin Cancer Res 2006, 12:447-453.
    • (2006) Clin Cancer Res , vol.12 , pp. 447-453
    • Hassan, R.1    Remaley, A.T.2    Sampson, M.L.3    Zhang, J.4    Cox, D.D.5    Pingpank, J.6
  • 25
    • 36749029362 scopus 로고    scopus 로고
    • Immunotoxin and Taxol synergy results from a decrease in shed mesothelin levels in the extracellular space of tumors
    • Zhang Y., Xiang L., Hassan R., Pastan I. Immunotoxin and Taxol synergy results from a decrease in shed mesothelin levels in the extracellular space of tumors. Proc Natl Acad Sci USA 2007, 104:17099-17104.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 17099-17104
    • Zhang, Y.1    Xiang, L.2    Hassan, R.3    Pastan, I.4
  • 26
    • 0017184389 scopus 로고
    • A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
    • Bradford M.M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 1976, 72:248-254.
    • (1976) Anal Biochem , vol.72 , pp. 248-254
    • Bradford, M.M.1
  • 27
    • 0026889408 scopus 로고
    • Spectrophotometric method for the determination of a bifunctional DTPA ligand in DTPA-monoclonal antibody conjugates
    • Pippin C.G., Parker T.A., McMurry T.J., Brechbiel M.W. Spectrophotometric method for the determination of a bifunctional DTPA ligand in DTPA-monoclonal antibody conjugates. Bioconjug Chem 1992, 3:342-345.
    • (1992) Bioconjug Chem , vol.3 , pp. 342-345
    • Pippin, C.G.1    Parker, T.A.2    McMurry, T.J.3    Brechbiel, M.W.4
  • 28
    • 0022556055 scopus 로고
    • Determination of the true immunoreactive fraction of monoclonal antibodies after radiolabeling
    • Lindmo T., Bunn P.A. Determination of the true immunoreactive fraction of monoclonal antibodies after radiolabeling. Methods Enzymol 1986, 121:678-691.
    • (1986) Methods Enzymol , vol.121 , pp. 678-691
    • Lindmo, T.1    Bunn, P.A.2
  • 29
    • 0033521739 scopus 로고    scopus 로고
    • 111Indium labeled monoclonal antibody K1: biodistribution study in nude mice bearing a human carcinoma xenograft expressing mesothelin
    • 111Indium labeled monoclonal antibody K1: biodistribution study in nude mice bearing a human carcinoma xenograft expressing mesothelin. Int J Cancer 1999, 80:559-563.
    • (1999) Int J Cancer , vol.80 , pp. 559-563
    • Hassan, R.1    Wu, C.2    Brechbiel, M.W.3    Margulies, I.4    Kreitman, R.J.5    Pastan, I.6
  • 30
    • 67349134673 scopus 로고    scopus 로고
    • A simplified suite of methods to evaluate chelator conjugation of antibodies: effects on hydrodynamic radius and biodistribution
    • Al-Ejeh F., Darby J.M., Thierry B., Brown M.P. A simplified suite of methods to evaluate chelator conjugation of antibodies: effects on hydrodynamic radius and biodistribution. Nucl Med Biol 2009, 36:395-402.
    • (2009) Nucl Med Biol , vol.36 , pp. 395-402
    • Al-Ejeh, F.1    Darby, J.M.2    Thierry, B.3    Brown, M.P.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.