In vitro analysis and in vivo tumor targeting of a humanized, grafted Nanobody in mice using pinhole SPECT/micro-CT

Journal of Nuclear Medicine

Volumn 51, Issue 7, 2010, Pages 1099-1106

  Vaneycken, Ilse ^a,b   Govaert, Jochen ^a,c   Vincke, Cécile ^a,c   Caveliers, Vicky ^a,b   Lahoutte, Tony ^a,b   De Baetselier, Patrick ^a,c   Raes, Geert ^a,c   Bossuyt, Axel ^a,b   Muyldermans, Serge ^a,c   Devoogdt, Nick ^a,c  

^a VRIJE UNIVERSITEIT BRUSSEL   (Belgium)

^b UNIVERSITY HOSPITAL BRUSSELS   (Belgium)

^c DEPARTMENT OF PLANT SYSTEMS BIOLOGY   (Belgium)

Author keywords

99mTc Nanobody; Animal imaging; Biodistribution; CEA; Humanization; Oncology; SPECT CT

Indexed keywords

CARCINOEMBRYONIC ANTIGEN; TECHNETIUM 99M; CARRIER PROTEIN; DIAGNOSTIC AGENT; RADIOPHARMACEUTICAL AGENT; TECHNETIUM DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN BINDING; ARTICLE; CANCER CELL CULTURE; CARCINOMA CELL; CHEMICAL ANALYSIS; CHO CELL; COLON CARCINOMA; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; GEL PERMEATION CHROMATOGRAPHY; HUMAN; HUMAN CELL; IMAGE ANALYSIS; IMMOBILIZED METAL AFFINITY CHROMATOGRAPHY; IN VITRO STUDY; IN VIVO STUDY; MICRO-COMPUTED TOMOGRAPHY; MOLECULAR IMAGING; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PURIFICATION; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; TUMOR XENOGRAFT; AMINO ACID SEQUENCE; ANIMAL; ANTIBODY SPECIFICITY; COMPUTER ASSISTED EMISSION TOMOGRAPHY; CRICETULUS; DRUG DELIVERY SYSTEM; HAMSTER; IMAGE PROCESSING; IMMUNOLOGY; ISOTOPE LABELING; MOLECULAR GENETICS; SYNTHESIS; TISSUE DISTRIBUTION; TUMOR CELL LINE;

AMINO ACID SEQUENCE; ANIMALS; ANTIBODY SPECIFICITY; CARCINOEMBRYONIC ANTIGEN; CARRIER PROTEINS; CELL LINE, TUMOR; CHO CELLS; CRICETINAE; CRICETULUS; DRUG DELIVERY SYSTEMS; ENZYME-LINKED IMMUNOSORBENT ASSAY; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; ISOTOPE LABELING; MICE; MOLECULAR SEQUENCE DATA; RADIOPHARMACEUTICALS; TECHNETIUM COMPOUNDS; TISSUE DISTRIBUTION; TOMOGRAPHY, EMISSION-COMPUTED; TOMOGRAPHY, EMISSION-COMPUTED, SINGLE-PHOTON;

EID: 77955000361     PISSN: 01615505     EISSN: None     Source Type: Journal    
DOI: 10.2967/jnumed.109.069823     Document Type: Article

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