메뉴 건너뛰기




Volumn 5 APR, Issue , 2014, Pages

Role of pancreatic stellate cells in chemoresistance in pancreatic cancer

Author keywords

Chemoresistance; Fibrosis; Hypoxia; Pancreatic cancer; Pancreatic stellate cells; Stroma

Indexed keywords

ANGIOTENSIN 1 RECEPTOR ANTAGONIST; GEMCITABINE; LOSARTAN; PACLITAXEL; RECOMBINANT HYALURONIDASE;

EID: 84900991814     PISSN: None     EISSN: 1664042X     Source Type: Journal    
DOI: 10.3389/fphys.2014.00141     Document Type: Review
Times cited : (121)

References (95)
  • 1
    • 84883143193 scopus 로고    scopus 로고
    • Stromal disrupting effects of nab-paclitaxel in pancreatic cancer
    • doi: 10.1038/bjc.2013.415
    • Alvarez, R., Musteanu, M., Garcia-Garcia, E., Lopez-Casas, P. P., Megias, D., Guerra, C., et al. (2013). Stromal disrupting effects of nab-paclitaxel in pancreatic cancer. Br. J. Cancer 109, 926-933. doi: 10.1038/bjc.2013.415
    • (2013) Br. J. Cancer , vol.109 , pp. 926-933
    • Alvarez, R.1    Musteanu, M.2    Garcia-Garcia, E.3    Lopez-Casas, P.P.4    Megias, D.5    Guerra, C.6
  • 2
    • 33646414215 scopus 로고    scopus 로고
    • Autocrine loop between TGF-beta1 and IL-1beta through Smad3- and ERK-dependent pathways in rat pancreatic stellate cells
    • doi: 10.1152/ajpcell.00465.2005
    • Aoki, H., Ohnishi, H., Hama, K., Ishijima, T., Satoh, Y., Hanatsuka, K., et al. (2006a). Autocrine loop between TGF-beta1 and IL-1beta through Smad3- and ERK-dependent pathways in rat pancreatic stellate cells. Am. J. Physiol. Cell Physiol. 290, C1100-C1108. doi: 10.1152/ajpcell.00465.2005
    • (2006) Am. J. Physiol. Cell Physiol. , vol.290
    • Aoki, H.1    Ohnishi, H.2    Hama, K.3    Ishijima, T.4    Satoh, Y.5    Hanatsuka, K.6
  • 3
    • 33748039410 scopus 로고    scopus 로고
    • Existence of autocrine loop between interleukin-6 and transforming growth factor-beta1 in activated rat pancreatic stellate cells
    • doi: 10.1002/jcb.20906
    • Aoki, H., Ohnishi, H., Hama, K., Shinozaki, S., Kita, H., Yamamoto, H., et al. (2006b). Existence of autocrine loop between interleukin-6 and transforming growth factor-beta1 in activated rat pancreatic stellate cells. J. Cell. Biochem. 99, 221-228. doi: 10.1002/jcb.20906
    • (2006) J. Cell. Biochem. , vol.99 , pp. 221-228
    • Aoki, H.1    Ohnishi, H.2    Hama, K.3    Shinozaki, S.4    Kita, H.5    Yamamoto, H.6
  • 4
    • 0031842971 scopus 로고    scopus 로고
    • Periacinar stellate shaped cells in rat pancreas: identification, isolation, and culture
    • doi: 10.1136/gut.43.1.128
    • Apte, M. V., Haber, P. S., Applegate, T. L., Norton, I. D., McCaughan, G. W., Korsten, M. A., et al. (1998). Periacinar stellate shaped cells in rat pancreas: identification, isolation, and culture. Gut. 43, 128-133. doi: 10.1136/gut.43.1.128
    • (1998) Gut. , vol.43 , pp. 128-133
    • Apte, M.V.1    Haber, P.S.2    Applegate, T.L.3    Norton, I.D.4    McCaughan, G.W.5    Korsten, M.A.6
  • 5
    • 0032954505 scopus 로고    scopus 로고
    • Pancreatic stellate cells are activated by proinflammatory cytokines: implications for pancreatic fibrogenesis
    • doi: 10.1136/gut.44.4.534
    • Apte, M. V., Haber, P. S., Darby, S. J., Rodgers, S. C., McCaughan, G. W., Korsten, M. A., et al. (1999). Pancreatic stellate cells are activated by proinflammatory cytokines: implications for pancreatic fibrogenesis. Gut. 44, 534-541. doi: 10.1136/gut.44.4.534
    • (1999) Gut. , vol.44 , pp. 534-541
    • Apte, M.V.1    Haber, P.S.2    Darby, S.J.3    Rodgers, S.C.4    McCaughan, G.W.5    Korsten, M.A.6
  • 6
    • 4644317795 scopus 로고    scopus 로고
    • Desmoplastic reaction in pancreatic cancer: role of pancreatic stellate cells
    • doi: 10.1097/00006676-200410000-00002
    • Apte, M. V., Park, S., Phillips, P. A., Santucci, N., Goldstein, D., Kumar, R. K., et al. (2004). Desmoplastic reaction in pancreatic cancer: role of pancreatic stellate cells. Pancreas 29, 179-187. doi: 10.1097/00006676-200410000-00002
    • (2004) Pancreas , vol.29 , pp. 179-187
    • Apte, M.V.1    Park, S.2    Phillips, P.A.3    Santucci, N.4    Goldstein, D.5    Kumar, R.K.6
  • 7
    • 33747607470 scopus 로고    scopus 로고
    • Battle-scarred pancreas: role of alcohol and pancreatic stellate cells in pancreatic fibrosis
    • doi: 10.1111/j.1440-1746.2006.04587.x
    • Apte, M. V., Pirola, R. C., and Wilson, J. S. (2006). Battle-scarred pancreas: role of alcohol and pancreatic stellate cells in pancreatic fibrosis. J. Gastroenterol. Hepatol. 21(Suppl. 3), S97-S101. doi: 10.1111/j.1440-1746.2006.04587.x
    • (2006) J. Gastroenterol. Hepatol. , vol.21 , Issue.SUPPL. 3
    • Apte, M.V.1    Pirola, R.C.2    Wilson, J.S.3
  • 8
    • 67650999217 scopus 로고    scopus 로고
    • Epithelial to mesenchymal transition contributes to drug resistance in pancreatic cancer
    • doi: 10.1158/0008-5472.can-08-2819
    • Arumugam, T., Ramachandran, V., Fournier, K. F., Wang, H., Marquis, L., Abbruzzese, J. L., et al. (2009). Epithelial to mesenchymal transition contributes to drug resistance in pancreatic cancer. Cancer Res. 69, 5820-5828. doi: 10.1158/0008-5472.can-08-2819
    • (2009) Cancer Res. , vol.69 , pp. 5820-5828
    • Arumugam, T.1    Ramachandran, V.2    Fournier, K.F.3    Wang, H.4    Marquis, L.5    Abbruzzese, J.L.6
  • 9
    • 17144404527 scopus 로고    scopus 로고
    • Pancreatic carcinoma cells induce fibrosis by stimulating proliferation and matrix synthesis of stellate cells
    • doi: 10.1053/j.gastro.2004.12.036
    • Bachem, M. G., Schunemann, M., Ramadani, M., Siech, M., Beger, H., Buck, A., et al. (2005). Pancreatic carcinoma cells induce fibrosis by stimulating proliferation and matrix synthesis of stellate cells. Gastroenterology 128, 907-921. doi: 10.1053/j.gastro.2004.12.036
    • (2005) Gastroenterology , vol.128 , pp. 907-921
    • Bachem, M.G.1    Schunemann, M.2    Ramadani, M.3    Siech, M.4    Beger, H.5    Buck, A.6
  • 10
    • 84861828232 scopus 로고    scopus 로고
    • The biological kinship of hypoxia with CSC and EMT and their relationship with deregulated expression of miRNAs and tumor aggressiveness
    • doi: 10.1016/j.bbcan.2012.04.008
    • Bao, B., Azmi, A. S., Ali, S., Ahmad, A., Li, Y., Banerjee, S., et al. (2012). The biological kinship of hypoxia with CSC and EMT and their relationship with deregulated expression of miRNAs and tumor aggressiveness. Biochim. Biophys. Acta. 1826, 272-296. doi: 10.1016/j.bbcan.2012.04.008
    • (2012) Biochim. Biophys. Acta. , vol.1826 , pp. 272-296
    • Bao, B.1    Azmi, A.S.2    Ali, S.3    Ahmad, A.4    Li, Y.5    Banerjee, S.6
  • 11
    • 0036883940 scopus 로고    scopus 로고
    • Pancreatic cancer biology and genetics
    • doi: 10.1038/nrc949
    • Bardeesy, N., and Depinho, R. A. (2002). Pancreatic cancer biology and genetics. Nat. Rev. Cancer 2, 897-909. doi: 10.1038/nrc949
    • (2002) Nat. Rev. Cancer , vol.2 , pp. 897-909
    • Bardeesy, N.1    Depinho, R.A.2
  • 12
    • 39749114978 scopus 로고    scopus 로고
    • Hypoxia and metabolism. Hypoxia, DNA repair and genetic instability
    • doi: 10.1038/nrc2344
    • Bristow, R. G., and Hill, R. P. (2008). Hypoxia and metabolism. Hypoxia, DNA repair and genetic instability. Nat. Rev. Cancer 8, 180-192. doi: 10.1038/nrc2344
    • (2008) Nat. Rev. Cancer , vol.8 , pp. 180-192
    • Bristow, R.G.1    Hill, R.P.2
  • 13
    • 3042561471 scopus 로고    scopus 로고
    • Tumor hypoxia correlates with metastatic tumor growth of pancreatic cancer in an orthotopic murine model
    • doi: 10.1016/j.jss.2004.02.014
    • Buchler, P., Reber, H. A., Lavey, R. S., Tomlinson, J., Buchler, M. W., Friess, H., et al. (2004). Tumor hypoxia correlates with metastatic tumor growth of pancreatic cancer in an orthotopic murine model. J. Surg. Res. 120, 295-303. doi: 10.1016/j.jss.2004.02.014
    • (2004) J. Surg. Res. , vol.120 , pp. 295-303
    • Buchler, P.1    Reber, H.A.2    Lavey, R.S.3    Tomlinson, J.4    Buchler, M.W.5    Friess, H.6
  • 14
    • 84884259884 scopus 로고    scopus 로고
    • Emerging targets in pancreatic cancer: epithelial-mesenchymal transition and cancer stem cells
    • doi: 10.2147/ott.s34670
    • Castellanos, J. A., Merchant, N. B., and Nagathihalli, N. S. (2013). Emerging targets in pancreatic cancer: epithelial-mesenchymal transition and cancer stem cells. Onco. Targets. Ther. 6, 1261-1267. doi: 10.2147/ott.s34670
    • (2013) Onco. Targets. Ther. , vol.6 , pp. 1261-1267
    • Castellanos, J.A.1    Merchant, N.B.2    Nagathihalli, N.S.3
  • 15
    • 77956676464 scopus 로고    scopus 로고
    • "Contextual" synthetic lethality and/or loss of heterozygosity: tumor hypoxia and modification of DNA repair
    • doi: 10.1158/1078-0432.ccr-10-0527
    • Chan, N., and Bristow, R. G. (2010). "Contextual" synthetic lethality and/or loss of heterozygosity: tumor hypoxia and modification of DNA repair. Clin. Cancer Res. 16, 4553-4560. doi: 10.1158/1078-0432.ccr-10-0527
    • (2010) Clin. Cancer Res. , vol.16 , pp. 4553-4560
    • Chan, N.1    Bristow, R.G.2
  • 16
    • 79954582454 scopus 로고    scopus 로고
    • Hypoxia predicts aggressive growth and spontaneous metastasis formation from orthotopically grown primary xenografts of human pancreatic cancer
    • doi: 10.1158/0008-5472.can-10-4049
    • Chang, Q., Jurisica, I., Do, T., and Hedley, D. W. (2011). Hypoxia predicts aggressive growth and spontaneous metastasis formation from orthotopically grown primary xenografts of human pancreatic cancer. Cancer Res. 71, 3110-3120. doi: 10.1158/0008-5472.can-10-4049
    • (2011) Cancer Res. , vol.71 , pp. 3110-3120
    • Chang, Q.1    Jurisica, I.2    Do, T.3    Hedley, D.W.4
  • 17
    • 84885129359 scopus 로고    scopus 로고
    • Angiotensin inhibition enhances drug delivery and potentiates chemotherapy by decompressing tumour blood vessels
    • doi: 10.1038/ncomms3516
    • Chauhan, V. P., Martin, J. D., Liu, H., Lacorre, D. A., Jain, S. R., Kozin, S. V., et al. (2013). Angiotensin inhibition enhances drug delivery and potentiates chemotherapy by decompressing tumour blood vessels. Nat. Commun. 4, 2516. doi: 10.1038/ncomms3516
    • (2013) Nat. Commun. , vol.4 , pp. 2516
    • Chauhan, V.P.1    Martin, J.D.2    Liu, H.3    Lacorre, D.A.4    Jain, S.R.5    Kozin, S.V.6
  • 18
    • 70349266564 scopus 로고    scopus 로고
    • Oxygen consumption can regulate the growth of tumors, a new perspective on the Warburg effect
    • doi: 10.1371/journal.pone.0007033
    • Chen, Y., Cairns, R., Papandreou, I., Koong, A., and Denko, N. C. (2009). Oxygen consumption can regulate the growth of tumors, a new perspective on the Warburg effect. PLoS ONE 4:e7033. doi: 10.1371/journal.pone.0007033
    • (2009) PLoS ONE , vol.4
    • Chen, Y.1    Cairns, R.2    Papandreou, I.3    Koong, A.4    Denko, N.C.5
  • 19
    • 84864943044 scopus 로고    scopus 로고
    • Why the stroma matters in breast cancer: insights into breast cancer patient outcomes through the examination of stromal biomarkers
    • doi: 10.4161/cam.20567
    • Conklin, M. W., and Keely, P. J. (2012). Why the stroma matters in breast cancer: insights into breast cancer patient outcomes through the examination of stromal biomarkers. Cell Adh. Migr. 6, 249-260. doi: 10.4161/cam.20567
    • (2012) Cell Adh. Migr. , vol.6 , pp. 249-260
    • Conklin, M.W.1    Keely, P.J.2
  • 20
    • 79251517097 scopus 로고    scopus 로고
    • Glucose metabolism gene polymorphisms and clinical outcome in pancreatic cancer
    • doi: 10.1002/cncr.25612
    • Dong, X., Tang, H., Hess, K. R., Abbruzzese, J. L., and Li, D. (2011). Glucose metabolism gene polymorphisms and clinical outcome in pancreatic cancer. Cancer 117, 480-491. doi: 10.1002/cncr.25612
    • (2011) Cancer , vol.117 , pp. 480-491
    • Dong, X.1    Tang, H.2    Hess, K.R.3    Abbruzzese, J.L.4    Li, D.5
  • 21
    • 60649087564 scopus 로고    scopus 로고
    • Accelerated metastasis after short-term treatment with a potent inhibitor of tumor angiogenesis
    • doi: 10.1016/j.ccr.2009.01.021
    • Ebos, J. M., Lee, C. R., Cruz-Munoz, W., Bjarnason, G. A., Christensen, J. G., and Kerbel, R. S. (2009). Accelerated metastasis after short-term treatment with a potent inhibitor of tumor angiogenesis. Cancer Cell 15, 232-239. doi: 10.1016/j.ccr.2009.01.021
    • (2009) Cancer Cell , vol.15 , pp. 232-239
    • Ebos, J.M.1    Lee, C.R.2    Cruz-Munoz, W.3    Bjarnason, G.A.4    Christensen, J.G.5    Kerbel, R.S.6
  • 22
    • 84876408848 scopus 로고    scopus 로고
    • Hypoxia enhances the interaction between pancreatic stellate cells and cancer cells via increased secretion of connective tissue growth factor
    • doi: 10.1016/j.jss.2012.06.051
    • Eguchi, D., Ikenaga, N., Ohuchida, K., Kozono, S., Cui, L., Fujiwara, K., et al. (2013). Hypoxia enhances the interaction between pancreatic stellate cells and cancer cells via increased secretion of connective tissue growth factor. J. Surg. Res. 181, 225-233. doi: 10.1016/j.jss.2012.06.051
    • (2013) J. Surg. Res. , vol.181 , pp. 225-233
    • Eguchi, D.1    Ikenaga, N.2    Ohuchida, K.3    Kozono, S.4    Cui, L.5    Fujiwara, K.6
  • 23
    • 84855201311 scopus 로고    scopus 로고
    • StellaTUM: current consensus and discussion on pancreatic stellate cell research
    • doi: 10.1136/gutjnl-2011-301220
    • Erkan, M., Adler, G., Apte, M. V., Bachem, M. G., Buchholz, M., Detlefsen, S., et al. (2012). StellaTUM: current consensus and discussion on pancreatic stellate cell research. Gut. 61, 172-178. doi: 10.1136/gutjnl-2011-301220
    • (2012) Gut. , vol.61 , pp. 172-178
    • Erkan, M.1    Adler, G.2    Apte, M.V.3    Bachem, M.G.4    Buchholz, M.5    Detlefsen, S.6
  • 24
    • 21744434389 scopus 로고    scopus 로고
    • Loss of BNIP3 expression is a late event in pancreatic cancer contributing to chemoresistance and worsened prognosis
    • doi: 10.1038/sj.onc.1208642
    • Erkan, M., Kleeff, J., Esposito, I., Giese, T., Ketterer, K., Buchler, M. W., et al. (2005). Loss of BNIP3 expression is a late event in pancreatic cancer contributing to chemoresistance and worsened prognosis. Oncogene 24, 4421-4432. doi: 10.1038/sj.onc.1208642
    • (2005) Oncogene , vol.24 , pp. 4421-4432
    • Erkan, M.1    Kleeff, J.2    Esposito, I.3    Giese, T.4    Ketterer, K.5    Buchler, M.W.6
  • 25
    • 52149094275 scopus 로고    scopus 로고
    • The activated stroma index is a novel and independent prognostic marker in pancreatic ductal adenocarcinoma
    • doi: 10.1016/j.cgh.2008.05.006
    • Erkan, M., Michalski, C. W., Rieder, S., Reiser-Erkan, C., Abiatari, I., Kolb, A., et al. (2008). The activated stroma index is a novel and independent prognostic marker in pancreatic ductal adenocarcinoma. Clin. Gastroenterol. Hepatol. 6, 1155-1161. doi: 10.1016/j.cgh.2008.05.006
    • (2008) Clin. Gastroenterol. Hepatol. , vol.6 , pp. 1155-1161
    • Erkan, M.1    Michalski, C.W.2    Rieder, S.3    Reiser-Erkan, C.4    Abiatari, I.5    Kolb, A.6
  • 26
    • 65949114866 scopus 로고    scopus 로고
    • Cancer-stellate cell interactions perpetuate the hypoxia-fibrosis cycle in pancreatic ductal adenocarcinoma
    • doi: 10.1593/neo.81618
    • Erkan, M., Reiser-Erkan, C., Michalski, C. W., Deucker, S., Sauliunaite, D., Streit, S., et al. (2009). Cancer-stellate cell interactions perpetuate the hypoxia-fibrosis cycle in pancreatic ductal adenocarcinoma. Neoplasia 11, 497-508. doi: 10.1593/neo.81618
    • (2009) Neoplasia , vol.11 , pp. 497-508
    • Erkan, M.1    Reiser-Erkan, C.2    Michalski, C.W.3    Deucker, S.4    Sauliunaite, D.5    Streit, S.6
  • 27
    • 77957726424 scopus 로고    scopus 로고
    • Tumor microenvironment and progression of pancreatic cancer
    • Erkan, M., Reiser-Erkan, C., Michalski, C. W., and Kleeff, J. (2010). Tumor microenvironment and progression of pancreatic cancer. Exp. Oncol. 32, 128-131.
    • (2010) Exp. Oncol. , vol.32 , pp. 128-131
    • Erkan, M.1    Reiser-Erkan, C.2    Michalski, C.W.3    Kleeff, J.4
  • 28
    • 84866450512 scopus 로고    scopus 로고
    • The role of inflammatory cells in fostering pancreatic cancer cell growth and invasion
    • doi: 10.3389/fphys.2012.00270
    • Evans, A., and Costello, E. (2012). The role of inflammatory cells in fostering pancreatic cancer cell growth and invasion. Front. Physiol. 3:270. doi: 10.3389/fphys.2012.00270
    • (2012) Front. Physiol. , vol.3 , pp. 270
    • Evans, A.1    Costello, E.2
  • 29
    • 0038293080 scopus 로고    scopus 로고
    • Prognostic significance of tumor oxygenation in humans
    • doi: 10.1016/S0304-3835(03)00012-0
    • Evans, S. M., and Koch, C. J. (2003). Prognostic significance of tumor oxygenation in humans. Cancer Lett. 195, 1-16. doi: 10.1016/S0304-3835(03)00012-0
    • (2003) Cancer Lett. , vol.195 , pp. 1-16
    • Evans, S.M.1    Koch, C.J.2
  • 31
    • 24144461303 scopus 로고    scopus 로고
    • Connective tissue growth factor (CCN2) in rat pancreatic stellate cell function: integrin alpha5beta1 as a novel CCN2 receptor
    • doi: 10.1053/j.gastro.2005.06.067
    • Gao, R., and Brigstock, D. R. (2005). Connective tissue growth factor (CCN2) in rat pancreatic stellate cell function: integrin alpha5beta1 as a novel CCN2 receptor. Gastroenterology 129, 1019-1030. doi: 10.1053/j.gastro.2005.06.067
    • (2005) Gastroenterology , vol.129 , pp. 1019-1030
    • Gao, R.1    Brigstock, D.R.2
  • 32
    • 77952304593 scopus 로고    scopus 로고
    • Pancreatic stellate cells increase the invasion of human pancreatic cancer cells through the stromal cell-derived factor-1/CXCR4 axis
    • doi: 10.1159/000236012
    • Gao, Z., Wang, X., Wu, K., Zhao, Y., and Hu, G. (2010). Pancreatic stellate cells increase the invasion of human pancreatic cancer cells through the stromal cell-derived factor-1/CXCR4 axis. Pancreatology 10, 186-193. doi: 10.1159/000236012
    • (2010) Pancreatology , vol.10 , pp. 186-193
    • Gao, Z.1    Wang, X.2    Wu, K.3    Zhao, Y.4    Hu, G.5
  • 33
    • 21344438419 scopus 로고    scopus 로고
    • Up-regulation of gene expression by hypoxia is mediated predominantly by hypoxia-inducible factor 1 (HIF-1)
    • doi: 10.1002/path.1778
    • Greijer, A. E., Van Der Groep, P., Kemming, D., Shvarts, A., Semenza, G. L., Meijer, G. A., et al. (2005). Up-regulation of gene expression by hypoxia is mediated predominantly by hypoxia-inducible factor 1 (HIF-1). J. Pathol. 206, 291-304. doi: 10.1002/path.1778
    • (2005) J. Pathol. , vol.206 , pp. 291-304
    • Greijer, A.E.1    Van Der Groep, P.2    Kemming, D.3    Shvarts, A.4    Semenza, G.L.5    Meijer, G.A.6
  • 34
    • 84889643856 scopus 로고    scopus 로고
    • Alteration of pancreatic cancer cell functions by tumor-stromal cell interaction
    • doi: 10.3389/fphys.2013.00318
    • Hamada, S., Masamune, A., and Shimosegawa, T. (2013). Alteration of pancreatic cancer cell functions by tumor-stromal cell interaction. Front. Physiol. 4:318. doi: 10.3389/fphys.2013.00318
    • (2013) Front. Physiol. , vol.4 , pp. 318
    • Hamada, S.1    Masamune, A.2    Shimosegawa, T.3
  • 35
    • 77951755278 scopus 로고    scopus 로고
    • Pancreatic cancer
    • doi: 10.1056/NEJMra0901557
    • Hidalgo, M. (2010). Pancreatic cancer. N. Engl. J. Med. 362, 1605-1617. doi: 10.1056/NEJMra0901557
    • (2010) N. Engl. J. Med. , vol.362 , pp. 1605-1617
    • Hidalgo, M.1
  • 36
    • 84890936723 scopus 로고    scopus 로고
    • A phase Ib study of gemcitabine plus PEGPH20 (pegylated recombinant human hyaluronidase) in patients with stage IV previously untreated pancreatic cancer
    • Hingorani, S. R., Harris, W. P., Beck, J. T., Berdov, B. A., Wagner, S. A., and Pshevlotsky, E. M. (2013). A phase Ib study of gemcitabine plus PEGPH20 (pegylated recombinant human hyaluronidase) in patients with stage IV previously untreated pancreatic cancer. J. Clin. Oncol. 31:4010.
    • (2013) J. Clin. Oncol. , vol.31 , pp. 4010
    • Hingorani, S.R.1    Harris, W.P.2    Beck, J.T.3    Berdov, B.A.4    Wagner, S.A.5    Pshevlotsky, E.M.6
  • 37
    • 45849149957 scopus 로고    scopus 로고
    • High expression of HIF1a is a predictor of clinical outcome in patients with pancreatic ductal adenocarcinomas and correlated to PDGFA, VEGF, and bFGF
    • doi: 10.1593/neo08292
    • Hoffmann, A. C., Mori, R., Vallbohmer, D., Brabender, J., Klein, E., Drebber, U., et al. (2008). High expression of HIF1a is a predictor of clinical outcome in patients with pancreatic ductal adenocarcinomas and correlated to PDGFA, VEGF, and bFGF. Neoplasia 10, 674-679. doi: 10.1593/neo08292
    • (2008) Neoplasia , vol.10 , pp. 674-679
    • Hoffmann, A.C.1    Mori, R.2    Vallbohmer, D.3    Brabender, J.4    Klein, E.5    Drebber, U.6
  • 38
    • 38849141696 scopus 로고    scopus 로고
    • Cancer-associated stromal fibroblasts promote pancreatic tumor progression
    • doi: 10.1158/0008-5472.can-07-5714
    • Hwang, R. F., Moore, T., Arumugam, T., Ramachandran, V., Amos, K. D., Rivera, A., et al. (2008). Cancer-associated stromal fibroblasts promote pancreatic tumor progression. Cancer Res. 68, 918-926. doi: 10.1158/0008-5472.can-07-5714
    • (2008) Cancer Res. , vol.68 , pp. 918-926
    • Hwang, R.F.1    Moore, T.2    Arumugam, T.3    Ramachandran, V.4    Amos, K.D.5    Rivera, A.6
  • 39
    • 34548578994 scopus 로고    scopus 로고
    • The hypoxic environment in tumor-stromal cells accelerates pancreatic cancer progression via the activation of paracrine hepatocyte growth factor/c-Met signaling
    • doi: 10.1245/s10434-007-9435-3
    • Ide, T., Kitajima, Y., Miyoshi, A., Ohtsuka, T., Mitsuno, M., Ohtaka, K., et al. (2007). The hypoxic environment in tumor-stromal cells accelerates pancreatic cancer progression via the activation of paracrine hepatocyte growth factor/c-Met signaling. Ann. Surg. Oncol. 14, 2600-2607. doi: 10.1245/s10434-007-9435-3
    • (2007) Ann. Surg. Oncol. , vol.14 , pp. 2600-2607
    • Ide, T.1    Kitajima, Y.2    Miyoshi, A.3    Ohtsuka, T.4    Mitsuno, M.5    Ohtaka, K.6
  • 40
    • 84871157346 scopus 로고    scopus 로고
    • Hyaluronan impairs vascular function and drug delivery in a mouse model of pancreatic cancer
    • doi: 10.1136/gutjnl-2012-302529
    • Jacobetz, M. A., Chan, D. S., Neesse, A., Bapiro, T. E., Cook, N., Frese, K. K., et al. (2013). Hyaluronan impairs vascular function and drug delivery in a mouse model of pancreatic cancer. Gut. 62, 112-120. doi: 10.1136/gutjnl-2012-302529
    • (2013) Gut. , vol.62 , pp. 112-120
    • Jacobetz, M.A.1    Chan, D.S.2    Neesse, A.3    Bapiro, T.E.4    Cook, N.5    Frese, K.K.6
  • 41
    • 57449083295 scopus 로고    scopus 로고
    • Pancreatic islet and stellate cells are the main sources of endocrine gland-derived vascular endothelial growth factor/prokineticin-1 in pancreatic cancer
    • doi: 10.1159/000178888
    • Jiang, X., Abiatari, I., Kong, B., Erkan, M., De Oliveira, T., Giese, N. A., et al. (2009). Pancreatic islet and stellate cells are the main sources of endocrine gland-derived vascular endothelial growth factor/prokineticin-1 in pancreatic cancer. Pancreatology 9, 165-172. doi: 10.1159/000178888
    • (2009) Pancreatology , vol.9 , pp. 165-172
    • Jiang, X.1    Abiatari, I.2    Kong, B.3    Erkan, M.4    De Oliveira, T.5    Giese, N.A.6
  • 42
    • 33751169387 scopus 로고    scopus 로고
    • Hypoxia-inducible factor-1 (HIF-1)
    • doi: 10.1124/mol.106.027029
    • Ke, Q., and Costa, M. (2006). Hypoxia-inducible factor-1 (HIF-1). Mol. Pharmacol. 70, 1469-1480. doi: 10.1124/mol.106.027029
    • (2006) Mol. Pharmacol. , vol.70 , pp. 1469-1480
    • Ke, Q.1    Costa, M.2
  • 43
    • 78650175637 scopus 로고    scopus 로고
    • Pancreatic stellate cells promote epithelial-mesenchymal transition in pancreatic cancer cells
    • doi: 10.1016/j.bbrc.2010.11.040
    • Kikuta, K., Masamune, A., Watanabe, T., Ariga, H., Itoh, H., Hamada, S., et al. (2010). Pancreatic stellate cells promote epithelial-mesenchymal transition in pancreatic cancer cells. Biochem. Biophys. Res. Commun. 403, 380-384. doi: 10.1016/j.bbrc.2010.11.040
    • (2010) Biochem. Biophys. Res. Commun. , vol.403 , pp. 380-384
    • Kikuta, K.1    Masamune, A.2    Watanabe, T.3    Ariga, H.4    Itoh, H.5    Hamada, S.6
  • 44
    • 69949109921 scopus 로고    scopus 로고
    • Decreased blood flow with increased metabolic activity: a novel sign of pancreatic tumor aggressiveness
    • doi: 10.1158/1078-0432.ccr-09-0414
    • Komar, G., Kauhanen, S., Liukko, K., Seppanen, M., Kajander, S., Ovaska, J., et al. (2009). Decreased blood flow with increased metabolic activity: a novel sign of pancreatic tumor aggressiveness. Clin. Cancer Res. 15, 5511-5517. doi: 10.1158/1078-0432.ccr-09-0414
    • (2009) Clin. Cancer Res. , vol.15 , pp. 5511-5517
    • Komar, G.1    Kauhanen, S.2    Liukko, K.3    Seppanen, M.4    Kajander, S.5    Ovaska, J.6
  • 46
    • 23044455711 scopus 로고    scopus 로고
    • Differential and synergistic effects of platelet-derived growth factor-BB and transforming growth factor-beta1 on activated pancreatic stellate cells
    • doi: 10.1097/01.mpa.0000168222.05591.a0
    • Kordes, C., Brookmann, S., Haussinger, D., and Klonowski-Stumpe, H. (2005). Differential and synergistic effects of platelet-derived growth factor-BB and transforming growth factor-beta1 on activated pancreatic stellate cells. Pancreas 31, 156-167. doi: 10.1097/01.mpa.0000168222.05591.a0
    • (2005) Pancreas , vol.31 , pp. 156-167
    • Kordes, C.1    Brookmann, S.2    Haussinger, D.3    Klonowski-Stumpe, H.4
  • 47
    • 84875992738 scopus 로고    scopus 로고
    • Pirfenidone inhibits pancreatic cancer desmoplasia by regulating stellate cells
    • doi: 10.1158/0008-5472.can-12-3180
    • Kozono, S., Ohuchida, K., Eguchi, D., Ikenaga, N., Fujiwara, K., Cui, L., et al. (2013). Pirfenidone inhibits pancreatic cancer desmoplasia by regulating stellate cells. Cancer Res. 73, 2345-2356. doi: 10.1158/0008-5472.can-12-3180
    • (2013) Cancer Res. , vol.73 , pp. 2345-2356
    • Kozono, S.1    Ohuchida, K.2    Eguchi, D.3    Ikenaga, N.4    Fujiwara, K.5    Cui, L.6
  • 48
    • 77950635816 scopus 로고    scopus 로고
    • Pancreatic cancer: pathobiology, treatment options, and drug delivery
    • doi: 10.1208/s12248-010-9181-5
    • Li, J., Wientjes, M. G., and Au, J. L. (2010). Pancreatic cancer: pathobiology, treatment options, and drug delivery. AAPS J. 12, 223-232. doi: 10.1208/s12248-010-9181-5
    • (2010) AAPS J. , vol.12 , pp. 223-232
    • Li, J.1    Wientjes, M.G.2    Au, J.L.3
  • 49
    • 56449092747 scopus 로고    scopus 로고
    • Hypoxia stimulates pancreatic stellate cells to induce fibrosis and angiogenesis in pancreatic cancer
    • doi: 10.1152/ajpgi.90356.2008
    • Masamune, A., Kikuta, K., Watanabe, T., Satoh, K., Hirota, M., and Shimosegawa, T. (2008). Hypoxia stimulates pancreatic stellate cells to induce fibrosis and angiogenesis in pancreatic cancer. Am. J. Physiol. Gastrointest. Liver Physiol. 295, G709-G717. doi: 10.1152/ajpgi.90356.2008
    • (2008) Am. J. Physiol. Gastrointest. Liver Physiol. , vol.295
    • Masamune, A.1    Kikuta, K.2    Watanabe, T.3    Satoh, K.4    Hirota, M.5    Shimosegawa, T.6
  • 50
    • 0035903468 scopus 로고    scopus 로고
    • Independent function of two destruction domains in hypoxia-inducible factor-alpha chains activated by prolyl hydroxylation
    • doi: 10.1093/emboj/20.18.5197
    • Masson, N., Willam, C., Maxwell, P. H., Pugh, C. W., and Ratcliffe, P. J. (2001). Independent function of two destruction domains in hypoxia-inducible factor-alpha chains activated by prolyl hydroxylation. EMBO J. 20, 5197-5206. doi: 10.1093/emboj/20.18.5197
    • (2001) EMBO J. , vol.20 , pp. 5197-5206
    • Masson, N.1    Willam, C.2    Maxwell, P.H.3    Pugh, C.W.4    Ratcliffe, P.J.5
  • 51
    • 0036282292 scopus 로고    scopus 로고
    • Pancreatic stellate cells respond to inflammatory cytokines: potential role in chronic pancreatitis
    • doi: 10.1136/gut.50.4.535
    • Mews, P., Phillips, P., Fahmy, R., Korsten, M., Pirola, R., Wilson, J., et al. (2002). Pancreatic stellate cells respond to inflammatory cytokines: potential role in chronic pancreatitis. Gut. 50, 535-541. doi: 10.1136/gut.50.4.535
    • (2002) Gut. , vol.50 , pp. 535-541
    • Mews, P.1    Phillips, P.2    Fahmy, R.3    Korsten, M.4    Pirola, R.5    Wilson, J.6
  • 52
    • 84872066969 scopus 로고    scopus 로고
    • Current concepts and novel targets in advanced pancreatic cancer
    • doi: 10.1136/gutjnl-2012-303588
    • Michl, P., and Gress, T. M. (2013). Current concepts and novel targets in advanced pancreatic cancer. Gut. 62, 317-326. doi: 10.1136/gutjnl-2012-303588
    • (2013) Gut. , vol.62 , pp. 317-326
    • Michl, P.1    Gress, T.M.2
  • 53
    • 34247860855 scopus 로고    scopus 로고
    • Expression of glycolytic enzymes is increased in pancreatic cancerous tissues as evidenced by proteomic profiling by two-dimensional electrophoresis and liquid chromatography-mass spectrometry/mass spectrometry
    • doi: 10.3892/ijo.30.4.849
    • Mikuriya, K., Kuramitsu, Y., Ryozawa, S., Fujimoto, M., Mori, S., Oka, M., et al. (2007). Expression of glycolytic enzymes is increased in pancreatic cancerous tissues as evidenced by proteomic profiling by two-dimensional electrophoresis and liquid chromatography-mass spectrometry/mass spectrometry. Int. J. Oncol. 30, 849-855. doi: 10.3892/ijo.30.4.849
    • (2007) Int. J. Oncol. , vol.30 , pp. 849-855
    • Mikuriya, K.1    Kuramitsu, Y.2    Ryozawa, S.3    Fujimoto, M.4    Mori, S.5    Oka, M.6
  • 54
    • 0346157370 scopus 로고    scopus 로고
    • Tumor-stroma interaction of human pancreatic cancer: acquired resistance to anticancer drugs and proliferation regulation is dependent on extracellular matrix proteins
    • doi: 10.1097/00006676-200401000-00006
    • Miyamoto, H., Murakami, T., Tsuchida, K., Sugino, H., Miyake, H., and Tashiro, S. (2004). Tumor-stroma interaction of human pancreatic cancer: acquired resistance to anticancer drugs and proliferation regulation is dependent on extracellular matrix proteins. Pancreas 28, 38-44. doi: 10.1097/00006676-200401000-00006
    • (2004) Pancreas , vol.28 , pp. 38-44
    • Miyamoto, H.1    Murakami, T.2    Tsuchida, K.3    Sugino, H.4    Miyake, H.5    Tashiro, S.6
  • 55
    • 10744221950 scopus 로고    scopus 로고
    • Tumor stroma interactions induce chemoresistance in pancreatic ductal carcinoma cells involving increased secretion and paracrine effects of nitric oxide and interleukin-1beta
    • doi: 10.1158/0008-5472.CAN-03-1860
    • Muerkoster, S., Wegehenkel, K., Arlt, A., Witt, M., Sipos, B., Kruse, M. L., et al. (2004). Tumor stroma interactions induce chemoresistance in pancreatic ductal carcinoma cells involving increased secretion and paracrine effects of nitric oxide and interleukin-1beta. Cancer Res. 64, 1331-1337. doi: 10.1158/0008-5472.CAN-03-1860
    • (2004) Cancer Res. , vol.64 , pp. 1331-1337
    • Muerkoster, S.1    Wegehenkel, K.2    Arlt, A.3    Witt, M.4    Sipos, B.5    Kruse, M.L.6
  • 56
    • 78650224339 scopus 로고    scopus 로고
    • Inhibition of renin-angiotensin system affects prognosis of advanced pancreatic cancer receiving gemcitabine
    • doi: 10.1038/sj.bjc.6605955
    • Nakai, Y., Isayama, H., Ijichi, H., Sasaki, T., Sasahira, N., Hirano, K., et al. (2010). Inhibition of renin-angiotensin system affects prognosis of advanced pancreatic cancer receiving gemcitabine. Br. J. Cancer 103, 1644-1648. doi: 10.1038/sj.bjc.6605955
    • (2010) Br. J. Cancer , vol.103 , pp. 1644-1648
    • Nakai, Y.1    Isayama, H.2    Ijichi, H.3    Sasaki, T.4    Sasahira, N.5    Hirano, K.6
  • 57
    • 84884758616 scopus 로고    scopus 로고
    • A multicenter phase II trial of gemcitabine and candesartan combination therapy in patients with advanced pancreatic cancer: GECA2
    • doi: 10.1007/s10637-013-9972-5
    • Nakai, Y., Isayama, H., Ijichi, H., Sasaki, T., Takahara, N., Ito, Y., et al. (2013). A multicenter phase II trial of gemcitabine and candesartan combination therapy in patients with advanced pancreatic cancer: GECA2. Invest. New Drugs 31, 1294-1299. doi: 10.1007/s10637-013-9972-5
    • (2013) Invest. New Drugs , vol.31 , pp. 1294-1299
    • Nakai, Y.1    Isayama, H.2    Ijichi, H.3    Sasaki, T.4    Takahara, N.5    Ito, Y.6
  • 58
    • 84899954489 scopus 로고    scopus 로고
    • SPARC independent drug delivery and antitumour effects of nab-paclitaxel in genetically engineered mice
    • doi: 10.1136/gutjnl-2013-305559. [Epub ahead of print].
    • Neesse, A., Frese, K. K., Chan, D. S., Bapiro, T. E., Howat, W. J., Richards, F. M., et al. (2013). SPARC independent drug delivery and antitumour effects of nab-paclitaxel in genetically engineered mice. Gut. doi: 10.1136/gutjnl-2013-305559. [Epub ahead of print].
    • (2013) Gut
    • Neesse, A.1    Frese, K.K.2    Chan, D.S.3    Bapiro, T.E.4    Howat, W.J.5    Richards, F.M.6
  • 59
    • 79955828776 scopus 로고    scopus 로고
    • Stromal biology and therapy in pancreatic cancer
    • doi: 10.1136/gut.2010.226092
    • Neesse, A., Michl, P., Frese, K. K., Feig, C., Cook, N., Jacobetz, M. A., et al. (2011). Stromal biology and therapy in pancreatic cancer. Gut. 60, 861-868. doi: 10.1136/gut.2010.226092
    • (2011) Gut. , vol.60 , pp. 861-868
    • Neesse, A.1    Michl, P.2    Frese, K.K.3    Feig, C.4    Cook, N.5    Jacobetz, M.A.6
  • 60
    • 0141869043 scopus 로고    scopus 로고
    • Activin A is an autocrine activator of rat pancreatic stellate cells: potential therapeutic role of follistatin for pancreatic fibrosis
    • doi: 10.1136/gut.52.10.1487
    • Ohnishi, N., Miyata, T., Ohnishi, H., Yasuda, H., Tamada, K., Ueda, N., et al. (2003). Activin A is an autocrine activator of rat pancreatic stellate cells: potential therapeutic role of follistatin for pancreatic fibrosis. Gut. 52, 1487-1493. doi: 10.1136/gut.52.10.1487
    • (2003) Gut. , vol.52 , pp. 1487-1493
    • Ohnishi, N.1    Miyata, T.2    Ohnishi, H.3    Yasuda, H.4    Tamada, K.5    Ueda, N.6
  • 61
    • 67149143399 scopus 로고    scopus 로고
    • Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer
    • doi: 10.1126/science.1171362
    • Olive, K. P., Jacobetz, M. A., Davidson, C. J., Gopinathan, A., McIntyre, D., Honess, D., et al. (2009). Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer. Science 324, 1457-1461. doi: 10.1126/science.1171362
    • (2009) Science , vol.324 , pp. 1457-1461
    • Olive, K.P.1    Jacobetz, M.A.2    Davidson, C.J.3    Gopinathan, A.4    McIntyre, D.5    Honess, D.6
  • 62
    • 33845998896 scopus 로고    scopus 로고
    • The pancreatic stellate cell: a star on the rise in pancreatic diseases
    • doi: 10.1172/jci30082
    • Omary, M. B., Lugea, A., Lowe, A. W., and Pandol, S. J. (2007). The pancreatic stellate cell: a star on the rise in pancreatic diseases. J. Clin. Invest. 117, 50-59. doi: 10.1172/jci30082
    • (2007) J. Clin. Invest. , vol.117 , pp. 50-59
    • Omary, M.B.1    Lugea, A.2    Lowe, A.W.3    Pandol, S.J.4
  • 63
    • 60649106195 scopus 로고    scopus 로고
    • Antiangiogenic therapy elicits malignant progression of tumors to increased local invasion and distant metastasis
    • doi: 10.1016/j.ccr.2009.01.027
    • Paez-Ribes, M., Allen, E., Hudock, J., Takeda, T., Okuyama, H., Vinals, F., et al. (2009). Antiangiogenic therapy elicits malignant progression of tumors to increased local invasion and distant metastasis. Cancer Cell 15, 220-231. doi: 10.1016/j.ccr.2009.01.027
    • (2009) Cancer Cell , vol.15 , pp. 220-231
    • Paez-Ribes, M.1    Allen, E.2    Hudock, J.3    Takeda, T.4    Okuyama, H.5    Vinals, F.6
  • 64
    • 84893931572 scopus 로고    scopus 로고
    • 'Pancreatic stellate cells and fibrosis'
    • eds P. J. Grippo and H. G. Munshi (Trivandrum: Transworld Research Network).
    • Phillips, P. (2012). "Pancreatic stellate cells and fibrosis," in Pancreatic Cancer and Tumor Microenvironment, eds P. J. Grippo and H. G. Munshi (Trivandrum: Transworld Research Network).
    • (2012) Pancreatic Cancer and Tumor Microenvironment
    • Phillips, P.1
  • 65
    • 0037302934 scopus 로고    scopus 로고
    • Rat pancreatic stellate cells secrete matrix metalloproteinases: implications for extracellular matrix turnover
    • doi: 10.1136/gut.52.2.275
    • Phillips, P. A., McCarroll, J. A., Park, S., Wu, M. J., Pirola, R., Korsten, M., et al. (2003a). Rat pancreatic stellate cells secrete matrix metalloproteinases: implications for extracellular matrix turnover. Gut. 52, 275-282. doi: 10.1136/gut.52.2.275
    • (2003) Gut. , vol.52 , pp. 275-282
    • Phillips, P.A.1    McCarroll, J.A.2    Park, S.3    Wu, M.J.4    Pirola, R.5    Korsten, M.6
  • 66
    • 0037962905 scopus 로고    scopus 로고
    • Cell migration: a novel aspect of pancreatic stellate cell biology
    • doi: 10.1136/gut.52.5.677
    • Phillips, P. A., Wu, M. J., Kumar, R. K., Doherty, E., McCarroll, J. A., Park, S., et al. (2003b). Cell migration: a novel aspect of pancreatic stellate cell biology. Gut. 52, 677-682. doi: 10.1136/gut.52.5.677
    • (2003) Gut. , vol.52 , pp. 677-682
    • Phillips, P.A.1    Wu, M.J.2    Kumar, R.K.3    Doherty, E.4    McCarroll, J.A.5    Park, S.6
  • 67
    • 84858602107 scopus 로고    scopus 로고
    • Enzymatic targeting of the stroma ablates physical barriers to treatment of pancreatic ductal adenocarcinoma
    • doi: 10.1016/j.ccr.2012.01.007
    • Provenzano, P. P., Cuevas, C., Chang, A. E., Goel, V. K., Von Hoff, D. D., and Hingorani, S. R. (2012). Enzymatic targeting of the stroma ablates physical barriers to treatment of pancreatic ductal adenocarcinoma. Cancer Cell 21, 418-429. doi: 10.1016/j.ccr.2012.01.007
    • (2012) Cancer Cell , vol.21 , pp. 418-429
    • Provenzano, P.P.1    Cuevas, C.2    Chang, A.E.3    Goel, V.K.4    Von Hoff, D.D.5    Hingorani, S.R.6
  • 68
    • 74949144690 scopus 로고    scopus 로고
    • Epidemiology of pancreatic cancer: an overview
    • doi: 10.1038/nrgastro.2009.177
    • Raimondi, S., Maisonneuve, P., and Lowenfels, A. B. (2009). Epidemiology of pancreatic cancer: an overview. Nat. Rev. Gastroenterol. Hepatol. 6, 699-708. doi: 10.1038/nrgastro.2009.177
    • (2009) Nat. Rev. Gastroenterol. Hepatol. , vol.6 , pp. 699-708
    • Raimondi, S.1    Maisonneuve, P.2    Lowenfels, A.B.3
  • 69
    • 59349116750 scopus 로고    scopus 로고
    • Cancer stem cell marker expression in hepatocellular carcinoma and liver metastases is not sufficient as single prognostic parameter
    • doi: 10.1016/j.canlet.2008.10.015
    • Salnikov, A. V., Kusumawidjaja, G., Rausch, V., Bruns, H., Gross, W., Khamidjanov, A., et al. (2009). Cancer stem cell marker expression in hepatocellular carcinoma and liver metastases is not sufficient as single prognostic parameter. Cancer Lett. 275, 185-193. doi: 10.1016/j.canlet.2008.10.015
    • (2009) Cancer Lett. , vol.275 , pp. 185-193
    • Salnikov, A.V.1    Kusumawidjaja, G.2    Rausch, V.3    Bruns, H.4    Gross, W.5    Khamidjanov, A.6
  • 71
    • 33847384148 scopus 로고    scopus 로고
    • Pancreatic stellate cells are an important source of MMP-2 in human pancreatic cancer and accelerate tumor progression in a murine xenograft model and CAM assay
    • doi: 10.1242/jcs.03347
    • Schneiderhan, W., Diaz, F., Fundel, M., Zhou, S., Siech, M., Hasel, C., et al. (2007). Pancreatic stellate cells are an important source of MMP-2 in human pancreatic cancer and accelerate tumor progression in a murine xenograft model and CAM assay. J. Cell Sci. 120, 512-519. doi: 10.1242/jcs.03347
    • (2007) J. Cell Sci. , vol.120 , pp. 512-519
    • Schneiderhan, W.1    Diaz, F.2    Fundel, M.3    Zhou, S.4    Siech, M.5    Hasel, C.6
  • 72
    • 77954582720 scopus 로고    scopus 로고
    • Radiosensitization and stromal imaging response correlates for the HIF-1 inhibitor PX-478 given with or without chemotherapy in pancreatic cancer
    • doi: 10.1158/1535-7163.mct-09-0768
    • Schwartz, D. L., Bankson, J. A., Lemos, R. Jr., Lai, S. Y., Thittai, A. K., He, Y., et al. (2010). Radiosensitization and stromal imaging response correlates for the HIF-1 inhibitor PX-478 given with or without chemotherapy in pancreatic cancer. Mol. Cancer Ther. 9, 2057-2067. doi: 10.1158/1535-7163.mct-09-0768
    • (2010) Mol. Cancer Ther. , vol.9 , pp. 2057-2067
    • Schwartz, D.L.1    Bankson, J.A.2    Lemos Jr., R.3    Lai, S.Y.4    Thittai, A.K.5    He, Y.6
  • 73
    • 33745804793 scopus 로고    scopus 로고
    • Regulation of gene expression by HIF-1
    • discussion: 8-14, 33-16. doi: 10.1002/9780470035009.ch2
    • Semenza, G. L., Shimoda, L. A., and Prabhakar, N. R. (2006). Regulation of gene expression by HIF-1. Novartis Found. Symp. 272, 2-8. discussion: 8-14, 33-16. doi: 10.1002/9780470035009.ch2
    • (2006) Novartis Found. Symp. , vol.272 , pp. 2-8
    • Semenza, G.L.1    Shimoda, L.A.2    Prabhakar, N.R.3
  • 74
    • 0036098613 scopus 로고    scopus 로고
    • Expression of transforming growth factor-beta 1 by pancreatic stellate cells and its implications for matrix secretion and turnover in chronic pancreatitis
    • doi: 10.1016/S0002-9440(10)61125-X
    • Shek, F. W., Benyon, R. C., Walker, F. M., McCrudden, P. R., Pender, S. L., Williams, E. J., et al. (2002). Expression of transforming growth factor-beta 1 by pancreatic stellate cells and its implications for matrix secretion and turnover in chronic pancreatitis. Am. J. Pathol. 160, 1787-1798. doi: 10.1016/S0002-9440(10)61125-X
    • (2002) Am. J. Pathol. , vol.160 , pp. 1787-1798
    • Shek, F.W.1    Benyon, R.C.2    Walker, F.M.3    McCrudden, P.R.4    Pender, S.L.5    Williams, E.J.6
  • 75
    • 0842333201 scopus 로고    scopus 로고
    • Prognostic significance of HIF-1 alpha overexpression in human pancreatic cancer
    • Shibaji, T., Nagao, M., Ikeda, N., Kanehiro, H., Hisanaga, M., Ko, S., et al. (2003). Prognostic significance of HIF-1 alpha overexpression in human pancreatic cancer. Anticancer Res. 23, 4721-4727.
    • (2003) Anticancer Res. , vol.23 , pp. 4721-4727
    • Shibaji, T.1    Nagao, M.2    Ikeda, N.3    Kanehiro, H.4    Hisanaga, M.5    Ko, S.6
  • 76
    • 84878582822 scopus 로고    scopus 로고
    • Hypoxia triggers hedgehog-mediated tumor-stromal interactions in pancreatic cancer
    • doi: 10.1158/0008-5472.can-11-1433
    • Spivak-Kroizman, T. R., Hostetter, G., Posner, R., Aziz, M., Hu, C., Demeure, M. J., et al. (2013). Hypoxia triggers hedgehog-mediated tumor-stromal interactions in pancreatic cancer. Cancer Res. 73, 3235-3247. doi: 10.1158/0008-5472.can-11-1433
    • (2013) Cancer Res. , vol.73 , pp. 3235-3247
    • Spivak-Kroizman, T.R.1    Hostetter, G.2    Posner, R.3    Aziz, M.4    Hu, C.5    Demeure, M.J.6
  • 77
    • 0033526781 scopus 로고    scopus 로고
    • Characterization of an oxygen/redox-dependent degradation domain of hypoxia-inducible factor alpha (HIF-alpha) proteins
    • doi: 10.1006/bbrc.1999.0878
    • Srinivas, V., Zhang, L. P., Zhu, X. H., and Caro, J. (1999). Characterization of an oxygen/redox-dependent degradation domain of hypoxia-inducible factor alpha (HIF-alpha) proteins. Biochem. Biophys. Res. Commun. 260, 557-561. doi: 10.1006/bbrc.1999.0878
    • (1999) Biochem. Biophys. Res. Commun. , vol.260 , pp. 557-561
    • Srinivas, V.1    Zhang, L.P.2    Zhu, X.H.3    Caro, J.4
  • 78
    • 84866557942 scopus 로고    scopus 로고
    • Causes, consequences, and remedies for growth-induced solid stress in murine and human tumors
    • doi: 10.1073/pnas.1213353109
    • Stylianopoulos, T., Martin, J. D., Chauhan, V. P., Jain, S. R., Diop-Frimpong, B., Bardeesy, N., et al. (2012). Causes, consequences, and remedies for growth-induced solid stress in murine and human tumors. Proc. Natl. Acad. Sci. U.S.A. 109, 15101-15108. doi: 10.1073/pnas.1213353109
    • (2012) Proc. Natl. Acad. Sci. U.S.A. , vol.109 , pp. 15101-15108
    • Stylianopoulos, T.1    Martin, J.D.2    Chauhan, V.P.3    Jain, S.R.4    Diop-Frimpong, B.5    Bardeesy, N.6
  • 79
    • 34447266708 scopus 로고    scopus 로고
    • Expression of hypoxia-inducible factor-1 alpha and associated proteins in pancreatic ductal adenocarcinoma and their impact on prognosis
    • doi: 10.3892/ijo.30.6.1359
    • Sun, H. C., Qiu, Z. J., Liu, J., Sun, J., Jiang, T., Huang, K. J., et al. (2007). Expression of hypoxia-inducible factor-1 alpha and associated proteins in pancreatic ductal adenocarcinoma and their impact on prognosis. Int. J. Oncol. 30, 1359-1367. doi: 10.3892/ijo.30.6.1359
    • (2007) Int. J. Oncol. , vol.30 , pp. 1359-1367
    • Sun, H.C.1    Qiu, Z.J.2    Liu, J.3    Sun, J.4    Jiang, T.5    Huang, K.J.6
  • 80
    • 84863012236 scopus 로고    scopus 로고
    • Selective tumor hypoxia targeting by hypoxia-activated prodrug TH-302 inhibits tumor growth in preclinical models of cancer
    • doi: 10.1158/1078-0432.ccr-11-1980
    • Sun, J. D., Liu, Q., Wang, J., Ahluwalia, D., Ferraro, D., Wang, Y., et al. (2012). Selective tumor hypoxia targeting by hypoxia-activated prodrug TH-302 inhibits tumor growth in preclinical models of cancer. Clin. Cancer Res. 18, 758-770. doi: 10.1158/1078-0432.ccr-11-1980
    • (2012) Clin. Cancer Res. , vol.18 , pp. 758-770
    • Sun, J.D.1    Liu, Q.2    Wang, J.3    Ahluwalia, D.4    Ferraro, D.5    Wang, Y.6
  • 82
    • 78649638780 scopus 로고    scopus 로고
    • Enzymatic depletion of tumor hyaluronan induces antitumor responses in preclinical animal models
    • doi: 10.1158/1535-7163.mct-10-0470
    • Thompson, C. B., Shepard, H. M., O'Cconnor, P. M., Kadhim, S., Jiang, P., Osgood, R. J., et al. (2010). Enzymatic depletion of tumor hyaluronan induces antitumor responses in preclinical animal models. Mol. Cancer Ther. 9, 3052-3064. doi: 10.1158/1535-7163.mct-10-0470
    • (2010) Mol. Cancer Ther. , vol.9 , pp. 3052-3064
    • Thompson, C.B.1    Shepard, H.M.2    O'Cconnor, P.M.3    Kadhim, S.4    Jiang, P.5    Osgood, R.J.6
  • 83
    • 85027954516 scopus 로고    scopus 로고
    • Tumor-stromal interactions in pancreatic cancer
    • doi: 10.1016/j.pan.2012.11.311
    • Tod, J., Jenei, V., Thomas, G., and Fine, D. (2013). Tumor-stromal interactions in pancreatic cancer. Pancreatology 13, 1-7. doi: 10.1016/j.pan.2012.11.311
    • (2013) Pancreatology , vol.13 , pp. 1-7
    • Tod, J.1    Jenei, V.2    Thomas, G.3    Fine, D.4
  • 84
    • 80051700067 scopus 로고    scopus 로고
    • Pancreatic cancer
    • doi: 10.1016/s0140-6736(10)62307-0
    • Vincent, A., Herman, J., Schulick, R., Hruban, R. H., and Goggins, M. (2011). Pancreatic cancer. Lancet 378, 607-620. doi: 10.1016/s0140-6736(10)62307-0
    • (2011) Lancet , vol.378 , pp. 607-620
    • Vincent, A.1    Herman, J.2    Schulick, R.3    Hruban, R.H.4    Goggins, M.5
  • 85
    • 84886741654 scopus 로고    scopus 로고
    • Increased survival in pancreatic cancer with nab-paclitaxel plus gemcitabine
    • doi: 10.1056/NEJMoa1304369
    • Von Hoff, D. D., Ervin, T., Arena, F. P., Chiorean, E. G., Infante, J., Moore, M., et al. (2013). Increased survival in pancreatic cancer with nab-paclitaxel plus gemcitabine. N. Engl. J. Med. 369, 1691-1703. doi: 10.1056/NEJMoa1304369
    • (2013) N. Engl. J. Med. , vol.369 , pp. 1691-1703
    • Von Hoff, D.D.1    Ervin, T.2    Arena, F.P.3    Chiorean, E.G.4    Infante, J.5    Moore, M.6
  • 86
    • 83355169753 scopus 로고    scopus 로고
    • Gemcitabine plus nab-paclitaxel is an active regimen in patients with advanced pancreatic cancer: a phase I/II trial
    • doi: 10.1200/jco.2011.36.5742
    • Von Hoff, D. D., Ramanathan, R. K., Borad, M. J., Laheru, D. A., Smith, L. S., Wood, T. E., et al. (2011). Gemcitabine plus nab-paclitaxel is an active regimen in patients with advanced pancreatic cancer: a phase I/II trial. J. Clin. Oncol. 29, 4548-4554. doi: 10.1200/jco.2011.36.5742
    • (2011) J. Clin. Oncol. , vol.29 , pp. 4548-4554
    • Von Hoff, D.D.1    Ramanathan, R.K.2    Borad, M.J.3    Laheru, D.A.4    Smith, L.S.5    Wood, T.E.6
  • 87
    • 42049097658 scopus 로고    scopus 로고
    • Pancreatic stellate cells: partners in crime with pancreatic cancer cells
    • doi: 10.1158/0008-5472.can-07-2477
    • Vonlaufen, A., Joshi, S., Qu, C., Phillips, P. A., Xu, Z., Parker, N. R., et al. (2008a). Pancreatic stellate cells: partners in crime with pancreatic cancer cells. Cancer Res. 68, 2085-2093. doi: 10.1158/0008-5472.can-07-2477
    • (2008) Cancer Res. , vol.68 , pp. 2085-2093
    • Vonlaufen, A.1    Joshi, S.2    Qu, C.3    Phillips, P.A.4    Xu, Z.5    Parker, N.R.6
  • 88
    • 54249088477 scopus 로고    scopus 로고
    • Pancreatic stellate cells and pancreatic cancer cells: an unholy alliance
    • doi: 10.1158/0008-5472.can-08-1132
    • Vonlaufen, A., Phillips, P. A., Xu, Z., Goldstein, D., Pirola, R. C., Wilson, J. S., et al. (2008b). Pancreatic stellate cells and pancreatic cancer cells: an unholy alliance. Cancer Res. 68, 7707-7710. doi: 10.1158/0008-5472.can-08-1132
    • (2008) Cancer Res. , vol.68 , pp. 7707-7710
    • Vonlaufen, A.1    Phillips, P.A.2    Xu, Z.3    Goldstein, D.4    Pirola, R.C.5    Wilson, J.S.6
  • 89
    • 77956075711 scopus 로고    scopus 로고
    • Isolation of quiescent human pancreatic stellate cells: a promising in vitro tool for studies of human pancreatic stellate cell biology
    • doi: 10.1159/000260900
    • Vonlaufen, A., Phillips, P. A., Yang, L., Xu, Z., Fiala-Beer, E., Zhang, X., et al. (2010). Isolation of quiescent human pancreatic stellate cells: a promising in vitro tool for studies of human pancreatic stellate cell biology. Pancreatology 10, 434-443. doi: 10.1159/000260900
    • (2010) Pancreatology , vol.10 , pp. 434-443
    • Vonlaufen, A.1    Phillips, P.A.2    Yang, L.3    Xu, Z.4    Fiala-Beer, E.5    Zhang, X.6
  • 90
    • 78651108985 scopus 로고    scopus 로고
    • Pancreatic cancer: understanding and overcoming chemoresistance
    • doi: 10.1038/nrgastro.2010.188
    • Wang, Z., Li, Y., Ahmad, A., Banerjee, S., Azmi, A. S., Kong, D., et al. (2011). Pancreatic cancer: understanding and overcoming chemoresistance. Nat. Rev. Gastroenterol. Hepatol. 8, 27-33. doi: 10.1038/nrgastro.2010.188
    • (2011) Nat. Rev. Gastroenterol. Hepatol. , vol.8 , pp. 27-33
    • Wang, Z.1    Li, Y.2    Ahmad, A.3    Banerjee, S.4    Azmi, A.S.5    Kong, D.6
  • 91
    • 0038406495 scopus 로고    scopus 로고
    • Advanced pancreatic ductal cancer: fibrotic focus and beta-catenin expression correlate with outcome
    • doi: 10.1097/00006676-200305000-00003
    • Watanabe, I., Hasebe, T., Sasaki, S., Konishi, M., Inoue, K., Nakagohri, T., et al. (2003). Advanced pancreatic ductal cancer: fibrotic focus and beta-catenin expression correlate with outcome. Pancreas 26, 326-333. doi: 10.1097/00006676-200305000-00003
    • (2003) Pancreas , vol.26 , pp. 326-333
    • Watanabe, I.1    Hasebe, T.2    Sasaki, S.3    Konishi, M.4    Inoue, K.5    Nakagohri, T.6
  • 93
    • 78149315330 scopus 로고    scopus 로고
    • Role of pancreatic stellate cells in pancreatic cancer metastasis
    • doi: 10.2353/ajpath.2010.090899
    • Xu, Z., Vonlaufen, A., Phillips, P. A., Fiala-Beer, E., Zhang, X., Yang, L., et al. (2010). Role of pancreatic stellate cells in pancreatic cancer metastasis. Am. J. Pathol. 177, 2585-2596. doi: 10.2353/ajpath.2010.090899
    • (2010) Am. J. Pathol. , vol.177 , pp. 2585-2596
    • Xu, Z.1    Vonlaufen, A.2    Phillips, P.A.3    Fiala-Beer, E.4    Zhang, X.5    Yang, L.6
  • 94
    • 0141630677 scopus 로고    scopus 로고
    • Candesartan, an angiotensin II receptor antagonist, suppresses pancreatic inflammation and fibrosis in rats
    • doi: 10.1124/jpet.103.053322
    • Yamada, T., Kuno, A., Masuda, K., Ogawa, K., Sogawa, M., Nakamura, S., et al. (2003). Candesartan, an angiotensin II receptor antagonist, suppresses pancreatic inflammation and fibrosis in rats. J. Pharmacol. Exp. Ther. 307, 17-23. doi: 10.1124/jpet.103.053322
    • (2003) J. Pharmacol. Exp. Ther. , vol.307 , pp. 17-23
    • Yamada, T.1    Kuno, A.2    Masuda, K.3    Ogawa, K.4    Sogawa, M.5    Nakamura, S.6
  • 95
    • 34047216068 scopus 로고    scopus 로고
    • Review. Molecular background of chemoresistance in pancreatic cancer
    • Zalatnai, A., and Molnar, J. (2007). Review. Molecular background of chemoresistance in pancreatic cancer. In Vivo 21, 339-347.
    • (2007) In Vivo , vol.21 , pp. 339-347
    • Zalatnai, A.1    Molnar, J.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.