Senescence induced by RECQL4 dysfunction contributes to Rothmund-Thomson syndrome features in mice

Cell Death and Disease

Volumn 5, Issue 5, 2014, Pages

  Lu, H ^a   Fang, E F ^a   Sykora, P ^a   Kulikowicz, T ^a   Zhang, Y ^b   Becker, K G ^b   Croteau, D L ^a   Bohr, V A ^a  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

^b NATIONAL INSTITUTE ON AGING   (United States)

Author keywords

Premature aging; RecQ helicase; RECQ4; RECQL4; Rothmund Thomson syndrome; Senescence

Indexed keywords

ANTIBIOTIC AGENT; BETA GALACTOSIDASE; BLOOM SYNDROME HELICASE; PROTEIN P16; PROTEIN P21; RECQ HELICASE; RECQ PROTEIN LIKE 1; RECQ PROTEIN LIKE 4; RECQ PROTEIN LIKE 5; UNCLASSIFIED DRUG; WERNER SYNDROME PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD CELL; BONE MARROW CELL; CELL PROLIFERATION; CLINICAL FEATURE; CONTROLLED STUDY; DNA DAMAGE; FEMALE; FIBROBLAST; FLOW CYTOMETRY; HAIR FOLLICLE; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN FUNCTION; ROTHMUND THOMSON SYNDROME; SENESCENCE;

AGE FACTORS; AGING; ANIMALS; BONE MARROW CELLS; CELL AGING; CELL PROLIFERATION; CELLS, CULTURED; CYCLIN-DEPENDENT KINASE INHIBITOR P16; CYCLIN-DEPENDENT KINASE INHIBITOR P21; DISEASE MODELS, ANIMAL; DNA DAMAGE; EXODEOXYRIBONUCLEASES; FIBROBLASTS; GENETIC PREDISPOSITION TO DISEASE; HAIR FOLLICLE; HUMANS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; PHENOTYPE; PROTEIN STRUCTURE, TERTIARY; RECQ HELICASES; RNA INTERFERENCE; ROTHMUND-THOMSON SYNDROME; TRANSFECTION;

EID: 84900990161     PISSN: None     EISSN: 20414889     Source Type: Journal    
DOI: 10.1038/cddis.2014.168     Document Type: Article

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