Antibody discovery from immune competent and immune transplanted mice

Current Drug Discovery Technologies

Volumn 11, Issue 1, 2014, Pages 65-73

  Harman, Benjamin C ^a   Giles Komar, Jill ^a   Rycyzyn, Michael A ^a  

^a JANSSEN RESEARCH AND DEVELOPMENT   (Belgium)

Author keywords

Antibody; Drug discovery; Humanized mice; Hybridoma; Immune response

Indexed keywords

ANTIBODY; CD27 ANTIGEN; CD5 ANTIGEN; COLONY STIMULATING FACTOR 1; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; GROWTH FACTOR; HUMAN IMMUNOGLOBULIN; IMMUNOGLOBULIN ANTIBODY; IMMUNOGLOBULIN G2; IMMUNOGLOBULIN M; INTERLEUKIN 15; INTERLEUKIN 7; MONOCLONAL ANTIBODY; T LYMPHOCYTE RECEPTOR;

ANTIBODY PRODUCTION; ANTIBODY RESPONSE; ARTICLE; B LYMPHOCYTE; CELL MATURATION; DENDRITIC CELL; HUMAN; HYBRIDOMA; IMMUNE RESPONSE; IMMUNOCOMPETENT CELL; INNATE IMMUNITY; LEUKOCYTE; MAJOR HISTOCOMPATIBILITY COMPLEX; MICROENVIRONMENT; NATURAL KILLER CELL; NOD SCID MOUSE; NONHUMAN; PRIORITY JOURNAL; SCID MOUSE;

ANIMALS; ANTIBODIES, MONOCLONAL; DRUG DISCOVERY; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMANS; HYBRIDOMAS; MICE;

EID: 84900856994     PISSN: 15701638     EISSN: 18756220     Source Type: Journal    
DOI: 10.2174/15701638113109990036     Document Type: Article

References (76)

1. Kohler G, Milstein C. Continuous cultures of fused cells secreting antibody of predefined specificity. Nature 1975; 256(5517): 495-7.
2. Fursov N, Johnston E, Duffy K, et al. Generation and characterization of rat anti-mouse ST2L monoclonal antibodies. Hybridoma (Larchmt) 2011; 30(2): 153-62.
3. Metlay JP, Witmer-Pack MD, Agger R, Crowley MT, Lawless D, Steinman RM. The distinct leukocyte integrins of mouse spleen dendritic cells as identified with new hamster monoclonal antibodies. J Exp Med 1990; 171(5): 1753-71.
4. James DE, Kreutz FT, Biggs DF, Suresh MR. Production of murine/guinea pig and rat/guinea pig heterohybridomas. Hybridoma 1996; 15(5): 387-9.
5. Yao X, Qian FC, Dai LC, Min LS. Preparation and preliminary characterization of rabbit monoclonal antibodies against human midkine. Hybridoma (Larchmt) 2011; 30(1): 87-93.
6. Olsson L, Kaplan HS. Human-human hybridomas producing monoclonal antibodies of predefined antigenic specificity. Proc Natl Acad Sci USA 1980; 77(9): 5429-31.
7. Samoilovich SR, Dugan CB, Macario AJ. Hybridoma technology: New developments of practical interest. J Immunol Methods 1987; 101(2): 153-70.
8. Zimmermann U, Pilwat G, Richter HP. Electric-field-stimulated fusion: Increased field stability of cells induced by pronase. Naturwissenschaften 1981; 68(11): 577-9.
9. Bischoff R, Eisert RM, Schedel I, Vienken J, Zimmerman U. Human hybridoma cells produced by electro-fusion. FEBS Lett 1982; 147(1): 64-8.
10. Karsten U, Stolley P, Walther I, et al. Direct comparison of electric field-mediated and PEG-mediated cell fusion for the generation of antibody producing hybridomas. Hybridoma 1988; 7(6): 627-33.
11. Sgro C. Side-effects of a monoclonal antibody, muromonab CD3/orthoclone OKT3: Bibliographic review. Toxicology 1995; 105(1): 23-9.
12. Boulianne GL, Hozumi N, Shulman MJ. Production of functional chimaeric mouse/human antibody. Nature 1984; 312(5995): 643-6.
13. Morrison SL, Johnson MJ, Herzenberg LA, Oi VT. Chimeric human antibody molecules: Mouse antigen-binding domains with human constant region domains. Proc Natl Acad Sci USA 1984; 81(21): 6851-5.
14. Hwang WY, Foote J. Immunogenicity of engineered antibodies. Methods 2005; 36(1): 3-10.
15. Baert F, Noman M, Vermeire S, et al. Influence of immunogenicity on the long-term efficacy of infliximab in Crohn's disease. N Engl J Med 2003; 348(7): 601-8.
16. Taylor LD, Carmack CE, Schramm SR, et al. A transgenic mouse that expresses a diversity of human sequence heavy and light chain immunoglobulins. Nucleic Acids Res 1992; 20(23): 6287-95.
17. Green LL, Hardy MC, Maynard-Currie CE, et al. Antigen-specific human monoclonal antibodies from mice engineered with human Ig heavy and light chain YACs. Nat Genet 1994; 7(1): 13-21.
18. Mendez MJ, Green LL, Corvalan JR, et al. Functional transplant of megabase human immunoglobulin loci recapitulates human antibody response in mice. Nat Genet 1997; 15(2): 146-56.
19. Tomizuka K, Shinohara T, Yoshida H, et al. Double transchromosomic mice: Maintenance of two individual human chromosome fragments containing Ig heavy and kappa loci and expression of fully human antibodies. Proc Natl Acad Sci USA 2000; 97(2): 722-7.
20. Ishida I, Tomizuka K, Yoshida H, et al. Production of human monoclonal and polyclonal antibodies in TransChromo animals. Cloning Stem Cells 2002; 4(1): 91-102.
21. Little M. Recombinant antibodies for immunotherapy. 2009, New York: Cambridge University Press. pp. 100-108.
22. Mosier DE, Gulizia RJ, Baird SM, Wilson DB. Transfer of a functional human immune system to mice with severe combined immunodeficiency. Nature 1988; 335(6187): 256-9.
23. Greiner DL, Shultz LD, Yates J, et al. Improved engraftment of human spleen cells in NOD/LtSz-scid/scid mice as compared with C.B-17-scid/scid mice. Am J Pathol 1995; 146(4): 888-902.
24. Shultz LD, Schweitzer PA, Christianson SW, et al. Multiple defects in innate and adaptive immunologic function in NOD/LtSzscid mice. J Immunol 1995; 154(1): 180-91.
25. Bosma M, Schuler W, Bosma G. The scid mouse mutant. Curr Top Microbiol Immunol 1988; 137: 197-202.
26. Carballido JM, Namikawa R, Carballido-Perrig N, Antonenko S, Roncarolo MG, de Vries JE. Generation of primary antigenspecific human T-and B-cell responses in immunocompetent SCID-hu mice. Nat Med 2000; 6(1): 103-6.
27. Mombaerts P, Iacomini J, Johnson RS, Herrup K, Tonegawa S, Papaioannou VE. RAG-1-deficient mice have no mature B and T lymphocytes. Cell 1992; 68(5): 869-77.
28. Shinkai Y, Rathbun G, Lam KP, et al. RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement. Cell 1992; 68(5): 855-67.
29. Ito M, Hiramatsu H, Kobayashi K, et al. NOD/SCID/gamma(c)(null) mouse: An excellent recipient mouse model for engraftment of human cells. Blood 2002; 100(9): 3175-82.
30. Watanabe S, Terashima K, Ohta S, et al. Hematopoietic stem cellengrafted NOD/SCID/IL2Rgamma null mice develop human lymphoid systems and induce long-lasting HIV-1 infection with specific humoral immune responses. Blood 2007; 109(1): 212-8.
31. Chen Q, Khoury M, Chen J. Expression of human cytokines dramatically improves reconstitution of specific human-blood lineage cells in humanized mice. Proc Natl Acad Sci USA 2009; 106(51): 21783-8.
32. Wunderlich M, Chou FS, Link KA, et al. AML xenograft efficiency is significantly improved in NOD/SCID-IL2RG mice constitutively expressing human SCF, GM-CSF and IL-3. Leukemia 2010; 24(10): 1785-8.
33. Shultz LD, Saito Y, Najima Y, et al. Generation of functional human T-cell subsets with HLA-restricted immune responses in HLA class I expressing NOD/SCID/IL2r gamma(null) humanized mice. Proc Natl Acad Sci USA 2010; 107(29): 13022-7.
34. Danner R, Chaudhari SN, Rosenberger J, et al. Expression of HLA class II molecules in humanized NOD.Rag1KO.IL2RgcKO mice is critical for development and function of human T and B cells. PLoS One 2011; 6(5): E19826.
35. Strowig T, Rongvaux A, Rathinam C, et al. Transgenic expression of human signal regulatory protein alpha in Rag2-/-gamma(c)-/-mice improves engraftment of human hematopoietic cells in humanized mice. Proc Natl Acad Sci USA 2011; 108(32): 13218-23.
36. Shultz LD, Ishikawa F, Greiner DL. Humanized mice in translational biomedical research. Nat Rev Immunol 2007; 7(2): 118-30.
37. Peschon JJ, Morrissey PJ, Grabstein KH, et al. Early lymphocyte expansion is severely impaired in interleukin 7 receptor-deficient mice. J Exp Med 1994; 180(5): 1955-60.
38. Lodolce JP, Boone DL, Chai S, et al. IL-15 receptor maintains lymphoid homeostasis by supporting lymphocyte homing and proliferation. Immunity 1998; 9(5): 669-76.
39. Ishikawa F, Yasukawa M, Lyons B, et al. Development of functional human blood and immune systems in NOD/SCID/IL2 receptor {gamma} chain(null) mice. Blood 2005; 106(5): 1565-73.
40. King MA, Covassin L, Brehm MA, et al. Human peripheral blood leucocyte non-obese diabetic-severe combined immunodeficiency interleukin-2 receptor gamma chain gene mouse model of xenogeneic graft-versus-host-like disease and the role of host major histocompatibility complex. Clin Exp Immunol 2009; 157(1): 104-18.
41. Watanabe Y, Takahashi T, Okajima A, et al. The analysis of the functions of human B and T cells in humanized NOD/shiscid/gammac(null) (NOG) mice (hu-HSC NOG mice). Int Immunol 2009; 21(7): 843-58.
42. Choi B, Chun E, Kim M, et al. Human B cell development and antibody production in humanized NOD/SCID/IL-2Rgamma(null) (NSG) mice conditioned by busulfan. J Clin Immunol 2011; 31(2): 253-64.
43. Ippolito GC, Hoi KH, Reddy ST, et al. Antibody repertoires in humanized NOD-scid-IL2Rgamma(null) mice and human B cells reveals human-like diversification and tolerance checkpoints in the mouse. PLoS One 2012; 7(4): E35497.
44. Becker PD, Legrand N, van Geelen CM, et al. Generation of human antigen-specific monoclonal IgM antibodies using vaccinated "human immune system" mice. PLoS One 2010; 5(10): E13137.
45. Shultz LD, Lyons BL, Burzenski LM, et al. Human lymphoid and myeloid cell development in NOD/LtSz-scid IL2R gamma null mice engrafted with mobilized human hemopoietic stem cells. J Immunol 2005; 174(10): 6477-89.
46. Matsumura T, Kametani Y, Ando K, et al. Functional CD5+ B cells develop predominantly in the spleen of NOD/SCID/gammac(null) (NOG) mice transplanted either with human umbilical cord blood, bone marrow, or mobilized peripheral blood CD34+ cells. Exp Hematol 2003; 31(9): 789-97.
47. Lee J, Kuchen S, Fischer R, Chang S, Lipsky PE. Identification and characterization of a human CD5+ pre-naive B cell population. J Immunol 2009; 182(7): 4116-26.
48. Singh M, Singh P, Gaudray G, et al. An improved protocol for efficient engraftment in NOD/LTSZ-SCIDIL-2Rgammanull mice allows HIV replication and development of anti-HIV immune responses. PLoS One 2012; 7(6): E38491.
49. Lepus CM, Gibson TF, Gerber SA, et al. Comparison of human fetal liver, umbilical cord blood, and adult blood hematopoietic stem cell engraftment in NOD-scid/gammac-/-, Balb/c-Rag1-/-gammac-/-, and C.B-17-scid/bg immunodeficient mice. Hum Immunol 2009; 70(10): 790-802.
50. Schmidt MR, Appel MC, Giassi LJ, et al. Human BLyS facilitates engraftment of human PBL derived B cells in immunodeficient mice. PLoS One 2008; 3(9): E3192.
51. Kracker S, Radbruch A. Immunoglobulin class switching: In vitro induction and analysis. Methods Mol Biol 2004; 271: 149-59.
52. Metcalf D. The molecular biology and functions of the granulocyte-macrophage colony-stimulating factors. Blood 1986; 67(2): 257-67.
53. Mosmann TR, Yokota T, Kastelein R, Zurawski SM, Arai N, Takebe Y. Species-specificity of T cell stimulating activities of IL 2 and BSF-1 (IL 4): Comparison of normal and recombinant, mouse and human IL 2 and BSF-1 (IL 4). J Immunol 1987; 138(6): 1813-6.
54. Fixe P, Praloran V. Macrophage colony-stimulating-factor (M-CSF or CSF-1) and its receptor: Structure-function relationships. Eur Cytokine Netw 1997; 8(2): 125-36.
55. Stevenson LM, Jones DG. Cross-reactivity amongst recombinant haematopoietic cytokines from different species for sheep bonemarrow eosinophils. J Comp Pathol 1994; 111(1): 99-106.
56. Nicolini FE, Cashman JD, Hogge DE, Humphries RK, Eaves CJ. NOD/SCID mice engineered to express human IL-3, GM-CSF and Steel factor constitutively mobilize engrafted human progenitors and compromise human stem cell regeneration. Leukemia 2004; 18(2): 341-7.
57. Brehm MA, Racki WJ, Leif J, et al. Engraftment of human HSCs in nonirradiated newborn NOD-scid IL2rgamma null mice is enhanced by transgenic expression of membrane-bound human SCF. Blood 2012; 119(12): 2778-88.
58. Tanaka S, Saito Y, Kunisawa J, et al. Development of mature and functional human myeloid subsets in hematopoietic stem cellengrafted NOD/SCID/IL2rgammaKO mice. J Immunol 2012; 188(12): 6145-55.
59. Barata JT, Silva A, Abecasis M, Carlesso N, Cumano A, Cardoso AA. Molecular and functional evidence for activity of murine IL-7 on human lymphocytes. Exp Hematol 2006; 34(9): 1133-42.
60. Brown EJ, Frazier WA. Integrin-associated protein (CD47) and its ligands. Trends Cell Biol 2001; 11(3): 130-5.
61. Melkus MW, Estes JD, Padgett-Thomas A, et al. Humanized mice mount specific adaptive and innate immune responses to EBV and TSST-1. Nat Med 2006; 12(11): 1316-22.
62. Wege AK, Melkus MW, Denton PW, Estes JD, Garcia JV. et al. Functional and phenotypic characterization of the humanized BLT mouse model. Curr Top Microbiol Immunol 2008; 324: 149-65.
63. Brainard DM, Seung E, Frahm N, et al. Induction of robust cellular and humoral virus-specific adaptive immune responses in human immunodeficiency virus-infected humanized BLT mice. J Virol 2009; 83(14): 7305-21.
64. Jaiswal S, Pazoles P, Woda M, et al. Enhanced humoral and HLAA2-restricted dengue virus-specific T-cell responses in humanized BLT NSG mice. Immunology 2012; 136(3): 334-43.
65. Cao X, Shores EW, Hu-Li J, et al. Defective lymphoid development in mice lacking expression of the common cytokine receptor gamma chain. Immunity 1995; 2(3): 223-38.
66. DiSanto JP, Müller W, Guy-Grand D, Fischer A, Rajewsky K. Lymphoid development in mice with a targeted deletion of the interleukin 2 receptor gamma chain. Proc Natl Acad Sci USA 1995; 92(2): 377-81.
67. Ohbo K, Suda T, Hashiyama M, et al. Modulation of hematopoiesis in mice with a truncated mutant of the interleukin-2 receptor gamma chain. Blood 1996; 87(3): 956-67.
68. Cupedo T, Mebius RE. Cellular interactions in lymph node development. J Immunol 2005; 174(1): 21-5.
69. Finke D. Fate and function of lymphoid tissue inducer cells. Curr Opin Immunol 2005; 17(2): 144-50.
70. Eberl G, Marmon S, Sunshine MJ, Rennert PD, Choi Y, Littman DR. An essential function for the nuclear receptor RORgamma(t) in the generation of fetal lymphoid tissue inducer cells. Nat Immunol 2004; 5(1): 64-73.
71. Spits H, Cupedo T. Innate lymphoid cells: Emerging insights in development, lineage relationships, and function. Annu Rev Immunol 2012; 30: 647-75.
72. Suematsu S, Watanabe T. Generation of a synthetic lymphoid tissue-like organoid in mice. Nat Biotechnol 2004; 22(12): 1539-45.
73. Okamoto N, Chihara R, Shimizu C, Nishimoto S, Watanabe T. Artificial lymph nodes induce potent secondary immune responses in naive and immunodeficient mice. J Clin Invest 2007; 117(4): 997-1007.
74. Strowig T, Gurer C, Ploss A, et al. Priming of protective T cell responses against virus-induced tumors in mice with human immune system components. J Exp Med 2009; 206(6): 1423-34.
75. Leyendeckers H, Odendahl M, Löhndorf A, et al. Correlation analysis between frequencies of circulating antigen-specific IgGbearing memory B cells and serum titers of antigen-specific IgG. Eur J Immunol 1999; 29(4): 1406-17.
76. Pinna D, Corti D, Jarrossay D, Sallusto F, Lanzavecchia A. Clonal dissection of the human memory B-cell repertoire following infection and vaccination. Eur J Immunol 2009; 39(5): 1260-70.