Development of mature and functional human myeloid subsets in hematopoietic stem cell-engrafted NOD/SCID/IL2rγKO mice

Journal of Immunology

Volumn 188, Issue 12, 2012, Pages 6145-6155

  Tanaka, Satoshi ^a,b,c   Saito, Yoriko ^b   Kunisawa, Jun ^a   Kurashima, Yosuke ^a   Wake, Taichi ^a   Suzuki, Nahoko ^b   Shultz, Leonard D ^d   Kiyono, Hiroshi ^a,e   Ishikawa, Fumihiko ^b  

^a UNIVERSITY OF TOKYO   (Japan)

^b RIKEN Center for Integrative Medical Sciences   (Japan)

^c Nippon Becton Dickinson Company   (Japan)

^d JACKSON LABORATORY   (United States)

^e JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CD34 ANTIGEN; CD38 ANTIGEN; RECOMBINANT GAMMA INTERFERON; RECOMBINANT GRANULOCYTE COLONY STIMULATING FACTOR; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BASOPHIL; CELL DIFFERENTIATION; CELL FUNCTION; CELL LINEAGE; CELL MATURATION; CELL PHAGOCYTOSIS; CELL STIMULATION; CELL STRUCTURE; CELLULAR IMMUNITY; CONFOCAL MICROSCOPY; CONTROLLED STUDY; ENGRAFTMENT; FLOW CYTOMETRY; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; INNATE IMMUNITY; MACROPHAGE FUNCTION; MAST CELL; MONOCYTE; MOUSE; MYELOPOIESIS; NEUTROPHIL; NONHUMAN; PLASMACYTOID DENDRITIC CELL; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SALMONELLA TYPHIMURIUM; TISSUE DISTRIBUTION;

ANIMALS; FLOW CYTOMETRY; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMANS; INTERLEUKIN RECEPTOR COMMON GAMMA SUBUNIT; MICE; MICE, INBRED NOD; MICE, KNOCKOUT; MICE, SCID; MICROSCOPY, CONFOCAL; MYELOID CELLS; PHAGOCYTOSIS; TRANSPLANTATION, HETEROLOGOUS;

EID: 84862596451     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1103660     Document Type: Article

References (44)

1. Mosier, D. E., R. J. Gulizia, S. M. Baird, and D. B. Wilson. 1988. Transfer of a functional human immune system to mice with severe combined immunodeficiency. Nature 335: 256-259.
2. McCune, J. M., R. Namikawa, H. Kaneshima, L. D. Shultz, M. Lieberman, and I. L. Weissman. 1988. The SCID-hu mouse: murine model for the analysis of human hematolymphoid differentiation and function. Science 241: 1632-1639.
3. Greiner, D. L., R. A. Hesselton, and L. D. Shultz. 1998. SCID mouse models of human stem cell engraftment. Stem Cells 16: 166-177. (Pubitemid 28235161)
4. Shultz, L. D., P. A. Schweitzer, S. W. Christianson, B. Gott, I. B. Schweitzer, B. Tennent, S. McKenna, L. Mobraaten, T. V. Rajan, D. L. Greiner, et al. 1995. Multiple defects in innate and adaptive immunologic function in NOD/LtSz-scid mice. J. Immunol. 154: 180-191.
5. Takenaka, K., T. K. Prasolava, J. C. Wang, S. M. Mortin-Toth, S. Khalouei, O. I. Gan, J. E. Dick, and J. S. Danska. 2007. Polymorphism in Sirpa modulates engraftment of human hematopoietic stem cells. Nat. Immunol. 8: 1313-1323. (Pubitemid 350138972)
6. Oldenborg, P. A., A. Zheleznyak, Y. F. Fang, C. F. Lagenaur, H. D. Gresham, and F. P. Lindberg. 2000. Role of CD47 as a marker of self on red blood cells. Science 288: 2051-2054. (Pubitemid 30397687)
7. Hiramatsu, H., R. Nishikomori, T. Heike, M. Ito, K. Kobayashi, K. Katamura, and T. Nakahata. 2003. Complete reconstitution of human lymphocytes from cord blood CD34+ cells using the NOD/SCID/gammacnull mice model. Blood 102: 873-880. (Pubitemid 36917778)
8. Ito, M., H. Hiramatsu, K. Kobayashi, K. Suzue, M. Kawahata, K. Hioki, Y. Ueyama, Y. Koyanagi, K. Sugamura, K. Tsuji, et al. 2002. NOD/SCID/gamma (c)(null) mouse: an excellent recipient mouse model for engraftment of human cells. Blood 100: 3175-3182. (Pubitemid 35217065)
9. Ishikawa, F., M. Yasukawa, B. Lyons, S. Yoshida, T. Miyamoto, G. Yoshimoto, T. Watanabe, K. Akashi, L. D. Shultz, and M. Harada. 2005. Development of functional human blood and immune systems in NOD/SCID/IL2 receptor gamma chain(null) mice. Blood 106: 1565-1573. (Pubitemid 41208567)
10. Shultz, L. D., B. L. Lyons, L. M. Burzenski, B. Gott, X. Chen, S. Chaleff, M. Kotb, S. D. Gillies, M. King, J. Mangada, et al. 2005. Human lymphoid and myeloid cell development in NOD/LtSz-scid IL2R gamma null mice engrafted with mobilized human hemopoietic stem cells. J. Immunol. 174: 6477-6489. (Pubitemid 40663843)
11. Traggiai, E., L. Chicha, L. Mazzucchelli, L. Bronz, J. C. Piffaretti, A. Lanzavecchia, and M. G. Manz. 2004. Development of a human adaptive immune system in cord blood cell-transplanted mice. Science 304: 104-107. (Pubitemid 38451466)
12. Legrand, N., K. Weijer, and H. Spits. 2006. Experimental models to study development and function of the human immune system in vivo. J. Immunol. 176: 2053-2058. (Pubitemid 43201649)
13. McDermott, S. P., K. Eppert, E. R. Lechman, M. Doedens, and J. E. Dick. 2010. Comparison of human cord blood engraftment between immunocompromised mouse strains. Blood 116: 193-200.
14. Ishikawa, F., A. G. Livingston, J. R. Wingard, S. Nishikawa, and M. Ogawa. 2002. An assay for long-term engrafting human hematopoietic cells based on newborn NOD/SCID/beta2-microglobulin(null) mice. Exp. Hematol. 30: 488-494. (Pubitemid 34556741)
15. Mega, J., J. R. McGhee, and H. Kiyono. 1992. Cytokine- and Ig-producing T cells in mucosal effector tissues: analysis of IL-5- and IFN-gamma-producing T cells, T cell receptor expression, and IgA plasma cells from mouse salivary gland-associated tissues. J. Immunol. 148: 2030-2039.
16. Schulz, K. R., E. A. Danna, P. O. Krutzik, and G. P. Nolan. 2007. Single-cell phospho-protein analysis by flow cytometry. Curr. Protoc. Immunol. Chapter 8: Unit 8.17.
17. Niedergang, F., J. C. Sirard, C. T. Blanc, and J. P. Kraehenbuhl. 2000. Entry and survival of Salmonella typhimurium in dendritic cells and presentation of recombinant antigens do not require macrophage-specific virulence factors. Proc. Natl. Acad. Sci. USA 97: 14650-14655. (Pubitemid 32016630)
18. Baker, S. J., S. G. Rane, and E. P. Reddy. 2007. Hematopoietic cytokine receptor signaling. Oncogene 26: 6724-6737. (Pubitemid 47585098)
19. Semerad, C. L., F. Liu, A. D. Gregory, K. Stumpf, and D. C. Link. 2002. G-CSF is an essential regulator of neutrophil trafficking from the bone marrow to the blood. Immunity 17: 413-423. (Pubitemid 35223531)
20. Kawai, T., and S. Akira. 2010. The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors. Nat. Immunol. 11: 373-384.
21. Opitz, B., V. van Laak, J. Eitel, and N. Suttorp. 2010. Innate immune recognition in infectious and noninfectious diseases of the lung. Am. J. Respir. Crit. Care Med. 181: 1294-1309.
22. Wissinger, E., J. Goulding, and T. Hussell. 2009. Immune homeostasis in the respiratory tract and its impact on heterologous infection. Semin. Immunol. 21: 147-155.
23. Savina, A., and S. Amigorena. 2007. Phagocytosis and antigen presentation in dendritic cells. Immunol. Rev. 219: 143-156. (Pubitemid 47390005)
24. Arinobu, Y., H. Iwasaki, M. F. Gurish, S. Mizuno, H. Shigematsu, H. Ozawa, D. G. Tenen, K. F. Austen, and K. Akashi. 2005. Developmental checkpoints of the basophil/mast cell lineages in adult murine hematopoiesis. Proc. Natl. Acad. Sci. USA 102: 18105-18110. (Pubitemid 41798509)
25. Hallgren, J., and M. F. Gurish. 2007. Pathways of murine mast cell development and trafficking: tracking the roots and routes of the mast cell. Immunol. Rev. 217: 8-18. (Pubitemid 46718137)
26. Kambe, N., H. Hiramatsu, M. Shimonaka, H. Fujino, R. Nishikomori, T. Heike, M. Ito, K. Kobayashi, Y. Ueyama, N. Matsuyoshi, et al. 2004. Development of both human connective tissue-type and mucosal-type mast cells in mice from hematopoietic stem cells with identical distribution pattern to human body. Blood 103: 860-867. (Pubitemid 38129543)
27. Manz, M. G. 2007. Human-hemato-lymphoid-system mice: opportunities and challenges. Immunity 26: 537-541. (Pubitemid 46756351)
28. Brooimans, R. A., J. Kraan, W. van Putten, J. J. Cornelissen, B. Löwenberg, and J. W. Gratama. 2009. Flow cytometric differential of leukocyte populations in normal bone marrow: influence of peripheral blood contamination. Cytometry B Clin. Cytom. 76B: 18-26.
29. Björnsson, S., S. Wahlström, E. Norström, I. Bernevi, U. O'Neill, E. Johansson, H. Runström, and P. Simonsson. 2008. Total nucleated cell differential for blood and bone marrow using a single tube in a five-color flow cytometer. Cytometry B Clin. Cytom. 74: 91-103. (Pubitemid 351578736)
30. Rathinam, C., W. T. Poueymirou, J. Rojas, A. J. Murphy, D. M. Valenzuela, G. D. Yancopoulos, A. Rongvaux, E. E. Eynon, M. G. Manz, and R. A. Flavell. 2011. Efficient differentiation and function of human macrophages in humanized CSF-1 mice. Blood 118: 3119-3128.
31. Rongvaux, A., T. Willinger, H. Takizawa, C. Rathinam, W. Auerbach, A. J. Murphy, D. M. Valenzuela, G. D. Yancopoulos, E. E. Eynon, S. Stevens, et al. 2011. Human thrombopoietin knockin mice efficiently support human hematopoiesis in vivo. Proc. Natl. Acad. Sci. USA 108: 2378-2383.
32. Willinger, T., A. Rongvaux, H. Takizawa, G. D. Yancopoulos, D. M. Valenzuela, A. J. Murphy, W. Auerbach, E. E. Eynon, S. Stevens, M. G. Manz, and R. A. Flavell. 2011. Human IL-3/GM-CSF knock-in mice support human alveolar macrophage development and human immune responses in the lung. Proc. Natl. Acad. Sci. USA 108: 2390-2395.
33. Takagi, S., Y. Saito, A. Hijikata, S. Tanaka, T. Watanabe, T. Hasegawa, S. Mochizuki, J. Kunisawa, H. Kiyono, H. Koseki, et al. 2012. Membrane-bound human SCF/KL promotes in vivo human hematopoietic engraftment and myeloid differentiation. Blood 119: 2768-2777.
34. Umeda, S., K. Takahashi, M. Naito, L. D. Shultz, and K. Takagi. 1996. Neonatal changes of osteoclasts in osteopetrosis (op/op) mice defective in production of functional macrophage colony-stimulating factor (M-CSF) protein and effects of M-CSF on osteoclast development and differentiation. J. Submicrosc. Cytol. Pathol. 28: 13-26.
35. Hu, X., and L. B. Ivashkiv. 2009. Cross-regulation of signaling pathways by interferon-gamma: implications for immune responses and autoimmune diseases. Immunity 31: 539-550.
36. McLemore, M. L., S. Grewal, F. Liu, A. Archambault, J. Poursine-Laurent, J. Haug, and D. C. Link. 2001. STAT-3 activation is required for normal G-CSF-dependent proliferation and granulocytic differentiation. Immunity 14: 193-204. (Pubitemid 32206521)
37. Kimura, A., M. A. Rieger, J. M. Simone, W. Chen, M. C. Wickre, B. M. Zhu, P. S. Hoppe, J. J. O'Shea, T. Schroeder, and L. Hennighausen. 2009. The transcription factors STAT5A/B regulate GM-CSF-mediated granulopoiesis. Blood 114: 4721-4728.
38. Elo, L. L., H. Järvenpää, S. Tuomela, S. Raghav, H. Ahlfors, K. Laurila, B. Gupta, R. J. Lund, J. Tahvanainen, R. D. Hawkins, et al. 2010. Genome-wide profiling of interleukin-4 and STAT6 transcription factor regulation of human Th2 cell programming. Immunity 32: 852-862.
39. Saraiva, M., J. R. Christensen, M. Veldhoen, T. L. Murphy, K. M. Murphy, and A. O'Garra. 2009. Interleukin-10 production by Th1 cells requires interleukin- 12-induced STAT4 transcription factor and ERK MAP kinase activation by high antigen dose. Immunity 31: 209-219.
40. Graham, S. M., and M. English. 2009. Non-typhoidal salmonellae: a management challenge for children with community-acquired invasive disease in tropical African countries. Lancet 373: 267-269.
41. Liu, J., X. Guan, and X. Ma. 2007. Regulation of IL-27 p28 gene expression in macrophages through MyD88- and interferon-gamma-mediated pathways. J. Exp. Med. 204: 141-152. (Pubitemid 46148764)
42. MacNamara, K. C., K. Oduro, O. Martin, D. D. Jones, M. McLaughlin, K. Choi, D. L. Borjesson, and G. M. Winslow. 2011. Infection-induced myelopoiesis during intracellular bacterial infection is critically dependent upon IFN-γ signaling. J. Immunol. 186: 1032-1043.
43. Jambo, K. C., E. Sepako, R. S. Heyderman, and S. B. Gordon. 2010. Potential role for mucosally active vaccines against pneumococcal pneumonia. Trends Microbiol. 18: 81-89.
44. Legrand, N., A. Ploss, R. Balling, P. D. Becker, C. Borsotti, N. Brezillon, J. Debarry, Y. de Jong,H. Deng, J. P.Di Santo, et al. 2009. Humanized mice formodeling human infectious disease: challenges, progress, and outlook. Cell Host Microbe 6: 5-9.