Generation of a synthetic lymphoid tissue-like organoid in mice

Nature Biotechnology

Volumn 22, Issue 12, 2004, Pages 1539-1545

  Suematsu, Sachiko ^a   Watanabe, Takeshi ^a  

^a RIKEN YOKOHAMA INSTITUTE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGENS; BIOLOGICAL ORGANS; CELLS; IMMUNOLOGY;

CELL-CELL INTERACTIONS; GERMINAL CENTERS; LYMPHOID ORGANS; STROMAL CELLS;

TISSUE;

IMMUNOGLOBULIN G; IMMUNOGLOBULIN G ANTIBODY;

ANIMAL CELL; ANIMAL TISSUE; ANTIBODY PRODUCING CELL; ANTIGEN SPECIFICITY; ARTICLE; B LYMPHOCYTE; BIOCOMPATIBILITY; CELL COMPARTMENTALIZATION; CELL TRANSPLANTATION; COMBINED IMMUNODEFICIENCY; CONTROLLED STUDY; CYTOARCHITECTURE; ENDOTHELIUM CELL; FOLLICULAR DENDRITIC CELL; GERMINAL CENTER; LYMPHOID TISSUE; MOUSE; NONHUMAN; PRIORITY JOURNAL; STROMA CELL; SYNTHESIS; T LYMPHOCYTE; TISSUE ENGINEERING; TISSUE STRUCTURE;

ANIMALS; BIOPROSTHESIS; CELL DIFFERENTIATION; CELL LINE; FEASIBILITY STUDIES; LYMPH NODES; LYMPHOCYTES; MICE; MICE, INBRED BALB C; MICE, SCID; ORGANOIDS; STROMAL CELLS; THYMUS GLAND; TISSUE ENGINEERING;

ANIMALIA;

EID: 11144268883     PISSN: 10870156     EISSN: None     Source Type: Journal    
DOI: 10.1038/nbt1039     Document Type: Article

References (34)

1. Fu, Y.-X. & Chaplin, D.D. Development and maturation of secondary lymphoid tissues. Annu. Rev. Immunol. 17, 399-433 (1999).
2. Nishikawa, S.-I., Hashi, H., Honda, K., Fraser, S. & Yoshida, H. Inflammation, a prototype for organogenesis of the lymphopoietic/hematopoietic system: Commentary. Curr. Opin. Immunol. 12, 342-345 (2000).
3. Mebius, R.E. Organogenesis of lymphoid tissues. Nat. Rev. Immunol. 3, 292-303 (2003).
4. Ansel, K.M. & Cyster, J.G. Chemokines in lymphopoiesis and lymphoid organ development. Curr. Opin. Immunol. 13, 172-179 (2001).
5. Cyster, J.G. Chemokines and cell migration in secondary lymphoid organs. Science 286, 2098-2102 (1999).
6. De Togni, P. et al. Abnormal development of peripheral lymphoid organs in mice deficient in lymphotoxin. Science 264, 703-707 (1994).
7. Banks, T.A. et al. Lymphotoxin-a-deficient mice. Effects on secondary lymphoid organ development and humoral immune responsiveness. J. Immunol. 155, 1685-1693 (1995).
8. Koni, P.A. et al. Distinct roles in lymphoid organogenesis for lymphotoxins α and β revealed in lymphotoxin β-deficient mice. Immunity, 491-500 (1997).
9. Fütterer, A., Mink, K., Luz, A., Kosco-Vilbois, M.H. & Pfeffer, K. The lymphotoxin β receptor controls organogenesis and affinity maturation in peripheral lymphoid tissues. Immunity 9, 59-70 (1998).
10. Rennert, P.D., Browning, J.L., Mebius, R., Mackay, F. & Hochman, P.S. Surface lymphotoxin α/β complex is required for the development of peripheral lymphoid organs. J. Exp. Med. 184, 1999-2006 (1996).
11. Rennert, P.D., James, D., Mackay, F., Browning, J.L. & Hochman, P.S. Lymph node genesis is induced by signaling through the lymphotoxin β receptor. Immunity 9, 71-79(1998).
12. Endres, R. et al. Mature follicular dendritic cell networks depend on expression of lymphotoxin β receptor by radioresistant stromal cells and of lymphotoxin β and tumor necrosis factor by B cells. J. Exp. Med. 189, 159-168 (1999).
13. Ngo, V.M. et al. Lymphotoxin α/β and tumor necrosis factor are required for stromal cell expression of homing chemokines in B and Tcell areas of the spleen. J. Exp. Med. 189, 403-412 (1999).
14. Luther, S.A., Tang, H.L., Hyman, P.L., Farr, A.G. & Cyster, J.G. Coexpression of the chemokines ELC and SLC by T zone stromal cells and deletion of the ELC gene in the plt/plt mouse. Proc. Natl. Acad. Sci. USA 97, 12694-12699 (2000).
15. Gunn, M.D. et al. Mice lacking expression of secondary lymphoid organ chemokine have defects in lymphocyte homing and dendritic cell localization. J. Exp. Med. 189, 451-460 (1999).
16. Vassileva, G. et al. The reduced expression of 6Ckine in the plt mouse results from the deletion of one of two 6Ckine genes. J. Exp. Med. 190, 1183-1188 (1999).
17. Nakano, H. & Gunn, M-D. Gene duplications at the chemokine locus on mouse chromosome 4: multiple strain-specific haplotypes and the deletion of secondary lymphoid-organ chemokine and EBI-1 ligand chemokine genes in the plt mutation. J. Immunol. 166, 361-369 (2001).
18. Gunn, M.D. et al. A chemokine expressed in lymphoid high endothelial venules promotes the adhesion and chemotaxis of naive T lymphocytes. Proc. Natl. Acad. Sci. USA 95, 258-263 (1998).
19. Okada, T. et al. Chemokine requirements for B cell entry to lymph nodes and Peyer's patches. J. Exp. Med. 196, 65-75 (2002).
20. Baekkevold, E.S. et al. The CCR7 ligand ELC (CCL19) is transcytosed in high endothelial venules and mediates T cell recruitment. J. Exp. Med. 193, 1105-1111 (2001).
21. Ebisuno, Y. et al. Cutting edge: the B cell chemokine CXC chemokine ligand 13/B lymphocyte chemoattractant is expressed in the high endothelial venules of lymph nodes and Peyer's patches and affects B cell trafficking across high endothelial venules. J. Immunol. 171, 1642-1646 (2003).
22. Kratz, A., Campos-Neto, A., Hanson, M. & Ruddle, N. Chronic inflammation caused by lymphotoxin is lymphoid neogenesis. J. Exp. Med. 183, 1461-1472 (1996).
23. Fan, L., Reilly, C.R., Luo, Y., Dorf, M.E. & Lo, D. Cutting edge: ectopic expression of the chemokine TCA4/SLC is sufficient to trigger lymphoid neogenesis. J. Immunol. 164, 3955-3959 (2000).
24. Chen, S.C. et al. Ectopic expression of the murine chemokines CCL21a and CCL21b induces the formation of lymph node-like structures in pancreas, but not skin of transgenic mice. J. Immunol. 168, 1001-1008 (2002).
25. Luther, S.A., Lopez, T., Bai, W., Hanahan, D. & Cyster, J.G. BLC expression in pancreatic islets causes B cell recruitment and lymphotoxin-dependent lymphoid neogenesis. Immunity 12, 471-481 (2000).
26. Luther, S.A. et al. Differing activities of homeostatic chemokines CCL19, CCL21, and CXCL12 in lymphocyte and dendritic cell recruitment and lymphoid neogenesis. J. Immunol. 169, 424-433 (2002).
27. Drayton, D.L., Ying, X., Lee, J., Lesslauer, W. & Ruddle, N.H. Ectopic LTαβ directs lymphoid organ neogenesis with concomitant expression of peripheral node addressin and a HEV-restricted sulfotransferase. J. Exp. Med. 197, 1153-1163 (2003).
28. Schrama, D. et al. Targeting of lymphotoxin-α to the tumor elicits an efficient immune response associated with induction of peripheral lymphoid-like tissue. Immunity 14, 111-121 (2001).
29. Nakashima, M. et al. Selective elimination of double-positive immaturethymocytes by athymic epithelial cell line. Eur. J. Immunol. 20, 47-53 (1990).
30. Banchereau, J. & Steinman, R.M. Dendritic cells and the control of immunity. Nature 392, 245-252 (1998).
31. Guermonprez, P., Valladeau, J., Zitvogel, L., Thery, C. & Amigorena, S. Antigen presentation and T cell stimulation by dendritic cells. Annu. Rev. Immunol. 20, 621-667 (2002).
32. Steinman, R.M., Hawiger, D. & Nussenzweig, M.C. Tolerogenic dendritic cells. Annu. Rev. Immunol. 21, 685-711 (2003).
33. Niwa, H., Yamamura, K. & Miyazaki, J. Efficient selection for high-expression transfectants with a novel eukaryotic vector. Gene 108, 193-199 (1991).
34. Lutz, M.B. et al. An advanced culture method for generating large quantities of highly pure dendritic cells from mouse bone marrow. J. Immunol. Methods 223, 77-92 (1999).