Exogenous hydrogen sulfide alleviates high glucose-induced cardiotoxicity via inhibition of leptin signaling in H9c2 cells

Molecular and Cellular Biochemistry

Volumn 391, Issue 1-2, 2014, Pages 147-155

  Zhuang, Xiao Dong ^a   Hu, Xun ^a   Long, Ming ^a   Dong, Xiao Bian ^a   Liu, Dong Hong ^a   Liao, Xin Xue ^a  

^a SUN YAT SEN UNIVERSITY   (China)

Author keywords

H9c2 cells; High glucose; Hydrogen sulfide; Leptin; P38 mitogen activated protein kinase

Indexed keywords

GLUCOSE; HYDROGEN SULFIDE; LEPTIN; LEPTIN RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE P38; REACTIVE OXYGEN METABOLITE; PROTECTIVE AGENT;

ANIMAL CELL; APOPTOSIS; ARTICLE; CARDIOTOXICITY; CELL DAMAGE; CELL PROTECTION; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; ENZYME PHOSPHORYLATION; HEART MUSCLE CELL; INTRACELLULAR SIGNALING; MITOCHONDRIAL MEMBRANE POTENTIAL; NONHUMAN; RAT; ANIMAL; CARDIAC MUSCLE CELL; CELL DEATH; CELL LINE; CELL SURVIVAL; DRUG EFFECTS; HEART MITOCHONDRION; METABOLISM; PATHOLOGY; PHOSPHORYLATION; SIGNAL TRANSDUCTION;

ANIMALS; CARDIOTOXICITY; CELL DEATH; CELL LINE; CELL SURVIVAL; CYTOPROTECTION; GLUCOSE; HYDROGEN SULFIDE; LEPTIN; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA, HEART; MYOCYTES, CARDIAC; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PROTECTIVE AGENTS; RATS; REACTIVE OXYGEN SPECIES; RECEPTORS, LEPTIN; SIGNAL TRANSDUCTION;

EID: 84900836139     PISSN: 03008177     EISSN: 15734919     Source Type: Journal    
DOI: 10.1007/s11010-014-1997-3     Document Type: Article

References (43)

1. van der Heijden AA, Van'T RE, Bot SD et al (2013) Risk of a recurrent cardiovascular event in individuals with type 2 diabetes or intermediate hyperglycemia: The Hoorn Study. Diabetes Care 36:3498-3502
2. Thangaraj A, Thomas PA, Geraldine P (2013) Ameliorative effect of naringenin on hyperglycemia mediated inflammation in hepatic and pancreatic tissues of Wistar rats with streptozotocin-nicotinamide-induced experimental diabetes mellitus. Free Radic Res 47:783-803
3. Corvera S, Gealekman O (2014) Adipose tissue angiogenesis: impact on obesity and type-2 diabetes. Biochim Biophys Acta 1842:463-472
4. Miguel-Soca PE (2013) Links between obesity and diabetes mellitus. Semergen 39:402
5. Friedman JM, Halaas JL (1998) Leptin and the regulation of body weight in mammals. Nature 395:763-770
6. Ricci R, Bevilacqua F (2012) The potential role of leptin and adiponectin in obesity: a comparative review. Vet J 191:292-298
7. Fonfara S, Hetzel U, Tew SR, Dukes-McEwan J, Cripps P, Clegg PD (2011) Leptin expression in dogs with cardiac disease and congestive heart failure. J Vet Intern Med 25:1017-1024
8. Matsui H, Motooka M, Koike H et al (2007) Ischemia/reperfusion in rat heart induces leptin and leptin receptor gene expression. Life Sci 80:672-680
9. Cheng YS, Dai DZ, Dai Y (2009) Stress-induced cardiac insufficiency relating to abnormal leptin and FKBP12.6 is ameliorated by CPU0213, an endothelin receptor antagonist, which is not affected by the CYP3A suppressing effect of erythromycin. J Pharm Pharmacol 61:569-576
10. Rajapurohitam V, Kilic A, Javadov S, Karmazyn M (2012) Role of NF-kappaB and p38 MAPK activation in mediating angiotensin II and endothelin-1-induced stimulation in leptin production and cardiomyocyte hypertrophy. Mol Cell Biochem 366:287-297
11. Xu W, Wu W, Chen J et al (2013) Exogenous hydrogen sulfide protects H9c2 cardiac cells against high glucose-induced injury by inhibiting the activities of the p38 MAPK and ERK1/2 pathways. Int J Mol Med 32:917-925
12. Stein A, Bailey SM (2013) Redox biology of hydrogen sulfide: implications for physiology, pathophysiology, and pharmacology. Redox Biol 1:32-39
13. Guettler C, Kubes P (2013) Hydrogen sulfide, another simple gas with complex biology. Am J Physiol Gastrointest Liver Physiol 304:G1066-G1069
14. Lu F, Xing J, Zhang X et al (2013) Exogenous hydrogen sulfide prevents cardiomyocyte apoptosis from cardiac hypertrophy induced by isoproterenol. Mol Cell Biochem 38:41-50
15. Predmore BL, Kondo K, Bhushan S et al (2012) The polysulfide diallyl trisulfide protects the ischemic myocardium by preservation of endogenous hydrogen sulfide and increasing nitric oxide bioavailability. Am J Physiol Heart Circ Physiol 302:H2410-H2418
16. Wei H, Zhang R, Jin H et al (2010) Hydrogen sulfide attenuates hyperhomocysteinemia-induced cardiomyocytic endoplasmic reticulum stress in rats. Antioxid Redox Signal 12:1079-1091
17. Lan A, Liao X, Mo L et al (2011) Hydrogen sulfide protects against chemical hypoxia-induced injury by inhibiting ROS-activated ERK1/2 and p38MAPK signaling pathways in PC12 cells. PLoS ONE 6:e25921
18. Dong XB, Yang CT, Zheng DD et al (2012) Inhibition of ROS-activated ERK1/2 pathway contributes to the protection of H2S against chemical hypoxia-induced injury in H9c2 cells. Mol Cell Biochem 362:149-157
19. Peake BF, Nicholson CK, Lambert JP et al (2013) Hydrogen sulfide preconditions the db/db diabetic mouse heart against ischemia-reperfusion injury by activating Nrf2 signaling in an Erk-dependent manner. Am J Physiol Heart Circ Physiol 304:H1215-H1224
20. Lee GH, Proenca R, Montez JM et al (1996) Abnormal splicing of the leptin receptor in diabetic mice. Nature 379:632-635
21. Tartaglia LA, Dembski M, Weng X et al (1995) Identification and expression cloning of a leptin receptor, OB-R. Cell 83:1263-1271
22. Shin EJ, Schram K, Zheng XL, Sweeney G (2009) Leptin attenuates hypoxia/reoxygenation-induced activation of the intrinsic pathway of apoptosis in rat H9c2 cells. J Cell Physiol 221:490-497
23. Pemberton CJ (2008) Leptin-induced cardiac hypertrophy: RhoAing a lipid raft down a protective p38 MAPK signalling stream? Cardiovasc Res 77:4-5
24. Samuelsson AM, Clark J, Rudyk O et al (2013) Experimental hyperleptinemia in neonatal rats leads to selective leptin responsiveness, hypertension, and altered myocardial function. Hypertension 62:627-633
25. Balasubramaniyan V, Nalini N (2007) Effect of leptin on peroxidation and antioxidant defense in ethanol-supplemented Mus musculus heart. Fundam Clin Pharmacol 21:245-253
26. Zeidan A, Javadov S, Chakrabarti S, Karmazyn M (2008) Leptin-induced cardiomyocyte hypertrophy involves selective caveolae and RhoA/ROCK-dependent p38 MAPK translocation to nuclei. Cardiovasc Res 77:64-72
27. Schram K, De Girolamo S, Madani S, Munoz D, Thong F, Sweeney G (2010) Leptin regulates MMP-2, TIMP-1 and collagen synthesis via p38 MAPK in HL-1 murine cardiomyocytes. Cell Mol Biol Lett 15:551-563
28. Purdham DM, Zou MX, Rajapurohitam V, Karmazyn M (2004) Rat heart is a site of leptin production and action. Am J Physiol Heart Circ Physiol 287:H2877-H2884
29. Denroche HC, Levi J, Wideman RD et al (2011) Leptin therapy reverses hyperglycemia in mice with streptozotocin-induced diabetes, independent of hepatic leptin signaling. Diabetes 60:1414-1423
30. Meek TH, Matsen ME, Dorfman MD et al (2013) Leptin Action in the ventromedial hypothalamic nucleus is sufficient, but not necessary, to normalize diabetic hyperglycemia. Endocrinology 154:3067-3076
31. Kojima S, Asakawa A, Amitani H et al (2009) Central leptin gene therapy, a substitute for insulin therapy to ameliorate hyperglycemia and hyperphagia, and promote survival in insulin-deficient diabetic mice. Peptides 30:962-966
32. Procaccini C, Lourenco EV, Matarese G, La Cava A (2009) Leptin signaling: a key pathway in immune responses. Curr Signal Transduct Ther 4:22-30
33. Tsai KH, Wang WJ, Lin CW et al (2012) NADPH oxidase-derived superoxide anion-induced apoptosis is mediated via the JNK-dependent activation of NF-kappaB in cardiomyocytes exposed to high glucose. J Cell Physiol 227:1347-1357
34. Donato JJ, Frazao R, Elias CF (2010) The PI3K signaling pathway mediates the biological effects of leptin. Arq Bras Endocrinol Metabol 54:591-602
35. Zhang W, Niu M, Yan K et al (2013) Stat3 pathway correlates with the roles of leptin in mouse liver fibrosis and sterol regulatory element binding protein-1c expression of rat hepatic stellate cells. Int J Biochem Cell Biol 45:736-744
36. Zhang J, Deng Z, Liao J et al (2013) Leptin attenuates cerebral ischemia injury through the promotion of energy metabolism via the PI3 K/Akt pathway. J Cereb Blood Flow Metab 33:567-574
37. van den Brink GR, O'Toole T, Hardwick JC et al (2000) Leptin signaling in human peripheral blood mononuclear cells, activation of p38 and p42/44 mitogen-activated protein (MAP) kinase and p70 S6 kinase. Mol Cell Biol Res Commun 4:144-150
38. Zhuo Y, Chen PF, Zhang AZ, Zhong H, Chen CQ, Zhu YZ (2009) Cardioprotective effect of hydrogen sulfide in ischemic reperfusion experimental rats and its influence on expression of survivin gene. Biol Pharm Bull 32:1406-1410
39. Whiteman M, Gooding KM, Whatmore JL et al (2010) Adiposity is a major determinant of plasma levels of the novel vasodilator hydrogen sulphide. Diabetologia 53:1722-1726
40. Yusuf M, Kwong HB, Hsu A, Whiteman M, Bhatia M, Moore PK (2005) Streptozotocin-induced diabetes in the rat is associated with enhanced tissue hydrogen sulfide biosynthesis. Biochem Biophys Res Commun 333:1146-1152
41. Ahmad FU, Sattar MA, Rathore HA et al (2012) Exogenous hydrogen sulfide (H2S) reduces blood pressure and prevents the progression of diabetic nephropathy in spontaneously hypertensive rats. Ren Fail 34:203-210
42. Gao Y, Yao X, Zhang Y et al (2011) The protective role of hydrogen sulfide in myocardial ischemia-reperfusion-induced injury in diabetic rats. Int J Cardiol 152:177-183
43. Suzuki K, Olah G, Modis K et al (2011) Hydrogen sulfide replacement therapy protects the vascular endothelium in hyperglycemia by preserving mitochondrial function. Proc Natl Acad Sci USA 108:13829-13834