Leptin Expression in Dogs with Cardiac Disease and Congestive Heart Failure

Journal of Veterinary Internal Medicine

Volumn 25, Issue 5, 2011, Pages 1017-1024

  Fonfara, S ^a   Hetzel, U ^a   Tew, S R ^a   Dukes Mcewan, J ^a   Cripps, P ^a   Clegg, P D ^a  

^a UNIVERSITY OF LIVERPOOL   (United Kingdom)

Author keywords

Body condition score; Myocardium; Real time PCR; Sex

Indexed keywords

LEPTIN; MESSENGER RNA;

ANIMAL; ANIMAL DISEASE; ARTICLE; BIOSYNTHESIS; BLOOD; CHEMISTRY; DOG; DOG DISEASE; ELECTROCARDIOGRAPHY; FEMALE; HEART DISEASE; HEART FAILURE; HEART MUSCLE; MALE; METABOLISM; PATHOLOGY; POLYMERASE CHAIN REACTION;

ANIMALS; DOG DISEASES; DOGS; ELECTROCARDIOGRAPHY; FEMALE; HEART DISEASES; HEART FAILURE; LEPTIN; MALE; MYOCARDIUM; POLYMERASE CHAIN REACTION; RNA, MESSENGER;

CANIS FAMILIARIS;

EID: 80053062917     PISSN: 08916640     EISSN: 19391676     Source Type: Journal    
DOI: 10.1111/j.1939-1676.2011.00782.x     Document Type: Article

References (49)

1. Brown RD, Ambler SK, Mitchell MD, et al. The cardiac fibroblast: Therapeutic target in myocardial remodeling and failure. Annu Rev Pharmacol Toxicol 2005;45:657-687.
2. Spinale FG. Myocardial matrix remodeling and the matrix metalloproteinases: Influence on cardiac form and function. Physiol Rev 2007;87:1285-1342.
3. Deschamps AM, Spinale FG. Disruptions and detours in the myocardial matrix highway and heart failure. Curr Heart Fail Rep 2005;2:10-17.
4. Anker SD, Chua TP, Ponikowski P, et al. Hormonal changes and catabolic/anabolic imbalance in chronic heart failure and their importance for cardiac cachexia. Circulation 1997;96:526-534.
5. Igel M, Becker W, Herberg L, et al. Hyperleptinemia, leptin resistance, and polymorphic leptin receptor in the New Zealand obese mouse. Endocrinology 1997;138:4234-4239.
6. Zhang Y, Proenca R, Maffei M, et al. Positional cloning of the mouse obese gene and its human homologue. Nature 1994;372:425-432.
7. Couillard C, Mauriege P, Prud'homme D, et al. Plasma leptin concentrations: Gender differences and associations with metabolic risk factors for cardiovascular disease. Diabetologia 1997;40:1178-1184.
8. Fernandez-Riejos P, Najib S, Santos-Alvarez J, et al. Role of leptin in the activation of immune cells. Mediators Inflamm 2010;2010:568343.
9. Filippatos GS, Tsilias K, Venetsanou K, et al. Leptin serum levels in cachectic heart failure patients. Relationship with tumor necrosis factor-alpha system. Int J Cardiol 2000;76:117-122.
10. Faggioni R, Fantuzzi G, Fuller J, et al. IL-1 beta mediates leptin induction during inflammation. Am J Physiol 1998;274:R204-208.
11. Schols AM, Creutzberg EC, Buurman WA, et al. Plasma leptin is related to proinflammatory status and dietary intake in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 1999;160:1220-1226.
12. Conde J, Scotece M, Gomez R, et al. At the crossroad between immunity and metabolism: Focus on leptin. Expert Rev Clin Immunol 2010;6:801-808.
13. Loffreda S, Yang SQ, Lin HZ, et al. Leptin regulates proinflammatory immune responses. FASEB J 1998;12:57-65.
14. Santos-Alvarez J, Goberna R, Sanchez-Margalet V. Human leptin stimulates proliferation and activation of human circulating monocytes. Cell Immunol 1999;194:6-11.
15. Ouchi N, Parker JL, Lugus JJ, et al. Adipokines in inflammation and metabolic disease. Nat Rev Immunol 2011;11:85-97.
16. Garofalo C, Surmacz E. Leptin and cancer. J Cell Physiol 2006;207:12-22.
17. Schulze PC, Kratzsch J. Leptin as a new diagnostic tool in chronic heart failure. Clin Chim Acta 2005;362:1-11.
18. Rajapurohitam V, Gan XT, Kirshenbaum LA, et al. The obesity-associated peptide leptin induces hypertrophy in neonatal rat ventricular myocytes. Circ Res 2003;93:277-279.
19. Purdham DM, Zou MX, Rajapurohitam V, et al. Rat heart is a site of leptin production and action. Am J Physiol Heart Circ Physiol 2004;287:H2877-H2884.
20. Karmazyn M, Purdham DM, Rajapurohitam V, et al. Leptin as a cardiac hypertrophic factor: A potential target for therapeutics. Trends Cardiovasc Med 2007;17:206-211.
21. Sierra-Honigmann MR, Nath AK, Murakami C, et al. Biological action of leptin as an angiogenic factor. Science 1998;281:1683-1686.
22. Sweeney G. Cardiovascular effects of leptin. Nat Rev Cardiol 2010;7:22-29.
23. Sharma V, McNeill JH. The emerging roles of leptin and ghrelin in cardiovascular physiology and pathophysiology. Curr Vasc Pharmacol 2005;3:169-180.
24. Cheng KH, Chu CS, Lee KT, et al. Adipocytokines and proinflammatory mediators from abdominal and epicardial adipose tissue in patients with coronary artery disease. Int J Obes (Lond) 2008;32:268-274.
25. Knudson JD, Payne GA, Borbouse L, et al. Leptin and mechanisms of endothelial dysfunction and cardiovascular disease. Curr Hypertens Rep 2008;10:434-439.
26. Schulze PC, Kratzsch J, Linke A, et al. Elevated serumlevels of leptin and soluble leptin receptor in patients with advanced chronic heart failure. Eur J Heart Fail 2003;5:33-40.
27. Doehner W, Pflaum CD, Rauchhaus M, et al. Leptin, insulin sensitivity and growth hormone binding protein in chronic heart failure with and without cardiac cachexia. Eur J Endocrinol 2001;145:727-735.
28. Toth MJ, Gottlieb SS, Fisher ML, et al. Plasma leptin concentrations and energy expenditure in heart failure patients. Metabolism 1997;46:450-453.
29. Araujo JP, Lourenco P, Rocha-Goncalves F, et al. Adiponectin is increased in cardiac cachexia irrespective of body mass index. Eur J Heart Fail 2009;11:567-572.
30. Murdoch DR, Rooney E, Dargie HJ, et al. Inappropriately low plasma leptin concentration in the cachexia associated with chronic heart failure. Heart 1999;82:352-356.
31. Haynes WG, Morgan DA, Walsh SA, et al. Receptor-mediated regional sympathetic nerve activation by leptin. J Clin Invest 1997;100:270-278.
32. Atkinson LL, Fischer MA, Lopaschuk GD. Leptin activates cardiac fatty acid oxidation independent of changes in the AMP-activated protein kinase-acetyl-CoA carboxylase-malonyl-CoA axis. J Biol Chem 2002;277:29424-29430.
33. Schram K, De Girolamo S, Madani S, et al. Leptin regulates MMP-2, TIMP-1 and collagen synthesis via p38 MAPK in HL-1 murine cardiomyocytes. Cell Mol Biol Lett 2010;15:551-563.
34. Barouch LA, Gao D, Chen L, et al. Cardiac myocyte apoptosis is associated with increased DNA damage and decreased survival in murine models of obesity. Circ Res 2006;98:119-124.
35. McGaffin KR, Witham WG, Yester KA, et al. Cardiac-specific leptin receptor deletion exacerbates ischaemic heart failure in mice. Cardiovasc Res 2011;89:60-71.
36. Elliott DA. Body composition of the dog and cat. In: Ettinger SJ, Feldman EC, ed. Textbook of Veterinary Internal Medicine, 7th ed. St. Louis, MO: Saunders Elsevier; 2010:634-638.
37. Strickland KN. Pathophysiology and therapy of heart failure. In: Tilley LP, Smith FWK, Oyama MA, Sleeper MM, ed. Manual of Canine and Feline Cardiology. St Louis, MO: Saunders Elsevier; 2008:288-314.
38. Clements DN, Carter SD, Innes JF, et al. Analysis of normal and osteoarthritic canine cartilage mRNA expression by quantitative polymerase chain reaction. Arthritis Res Ther 2006;8:R158.
39. Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 2001;25:402-408.
40. Straburzynska-Migaj E, Gwizdala A, Siniawski A, et al. Leptin and inflammation in patients with chronic heart failure. Kardiol Pol 2010;68:1243-1247.
41. Brundel BJ, Melhnk P, Rivard L, Nattel S. The pathology of atrial fibrillation in dogs. J Vet Cardiol 2005;7:121-129.
42. Moro C, Grauzam S, Ormezzano O, et al. Inhibition of cardiac leptin expression after infarction reduces subsequent dysfunction. J Cell Mol Med 2011;15:1688-1694.
43. Martin LJ, Siliart B, Dumon HJ, et al. Hormonal disturbances associated with obesity in dogs. J Anim Physiol Anim Nutr (Berl) 2006;90:355-360.
44. Abel ED, Litwin SE, Sweeney G. Cardiac remodeling in obesity. Physiol Rev 2008;88:389-419.
45. Sagawa MM, Nakadomo F, Honjoh T, et al. Correlation between plasma leptin concentration and body fat content in dogs. Am J Vet Res 2002;63:7-10.
46. Appleton DJ, Rand JS, Sunvold GD. Plasma leptin concentrations in cats: Reference range, effect of weight gain and relationship with adiposity as measured by dual energy X-ray absorptiometry. J Feline Med Surg 2000;2:191-199.
47. German AJ, Ryan VH, German AC, et al. Obesity, its associated disorders and the role of inflammatory adipokines in companion animals. Vet J 2010;185:4-9.
48. Ishioka K, Soliman MM, Sagawa M, et al. Experimental and clinical studies on plasma leptin in obese dogs. J Vet Med Sci 2002;64:349-353.
49. Uddin S, Bu R, Ahmed M, et al. Leptin receptor expression and its association with PI3K/AKT signaling pathway in diffuse large B-cell lymphoma. Leuk Lymphoma 2010;51:1305-1314.