Dual carbonic anhydrase/matrix metalloproteinase inhibitors incorporating bisphosphonic acid moieties targeting bone tumors

Bioorganic and Medicinal Chemistry Letters

Volumn 24, Issue 12, 2014, Pages 2617-2620

  Tauro, Marilena ^a   Loiodice, Fulvio ^a   Ceruso, Mariangela ^b   Supuran, Claudiu T ^b   Tortorella, Paolo ^a  

^a UNIVERSITY OF BARI   (Italy)

^b UNIVERSITY OF FLORENCE   (Italy)

Author keywords

Bisphosphonate; Bone resorption inhibitor; Carbonic anhydrase; Enzyme inhibitor; Matrix metalloproteinase inhibitor

Indexed keywords

ACETAZOLAMIDE; AMIDE; BISPHOSPHONIC ACID DERIVATIVE; CARBONATE DEHYDRATASE II; CARBONATE DEHYDRATASE INHIBITOR; CARBONATE DEHYDRATASE IX; CARBONATE DEHYDRATASE XII; CARBONATE DEHYDRATASE XIV; LYASE; MATRIX METALLOPROTEINASE INHIBITOR; SULFONAMIDE; UNCLASSIFIED DRUG; ZOLEDRONIC ACID; IMIDAZOLE DERIVATIVE; ANTINEOPLASTIC AGENT;

ARTICLE; BONE TUMOR; CARCINOGENESIS; CONTROLLED STUDY; HUMAN; METASTASIS; OSTEOCLAST; OSTEOLYSIS; TUMOR GROWTH; BONE NEOPLASMS; CELL LINE; CHEMICAL STRUCTURE; DRUG EFFECTS; ENZYME ACTIVATION; ENZYMOLOGY; IC50; ANIMAL CELL; BONE METASTASIS; CELL SURVIVAL; CELL VIABILITY; DRUG POTENCY; DRUG TARGETING; ENZYME INHIBITION; ENZYME INHIBITOR INTERACTION; MOUSE; NONHUMAN; OSTEOCLAST ACTIVITY;

BONE NEOPLASMS; CARBONIC ANHYDRASE INHIBITORS; CELL LINE; DIPHOSPHONATES; ENZYME ACTIVATION; HUMANS; IMIDAZOLES; INHIBITORY CONCENTRATION 50; MATRIX METALLOPROTEINASE INHIBITORS; MOLECULAR STRUCTURE;

EID: 84900809813     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2014.04.077     Document Type: Article

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