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Volumn 4, Issue 3, 2009, Pages 352-362

Synthesis, SAR, and biological evaluation of α-sulfonylphosphonic acids as selective matrix metalloproteinase inhibitors

(9) Rubino, Maria Teresa a Agamennone, Mariangela b Campestre, Cristina b Fracchiolla, Giuseppe a Laghezza, Antonio a Loiodice, Fulvio a Nuti, Elisa c Rossello, Armando c Tortorella, Paolo a

a UNIVERSITY OF BARI (Italy)

b UNIVERSITY OF CHIETI (Italy)

c UNIVERSITY OF PISA (Italy)

Author keywords

Inhibitors; Matrix metalloproteinases; Molecular modeling; Phosphonic acids; Zinc binding groups

Indexed keywords

[4 (PHENYLETHYNYL)PHENYLSULFONYL]METHYLPHOSPHONIC ACID; ALPHA SULFONYLPHOSPHONIC ACID DERIVATIVE; COLLAGENASE 3; GELATINASE A; GELATINASE B; GELATINASE INHIBITOR; MATRIX METALLOPROTEINASE 14; MATRIX METALLOPROTEINASE INHIBITOR; NEUTROPHIL COLLAGENASE; PHOSPHONIC ACID DERIVATIVE; STROMELYSIN; STROMELYSIN INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; DRUG ACTIVITY; DRUG EFFICACY; DRUG SELECTIVITY; DRUG SYNTHESIS; HUMAN; IC 50; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION;

COMPUTER SIMULATION; HUMANS; MATRIX METALLOPROTEINASES; PHOSPHONIC ACIDS; PROTEIN BINDING; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONIC ACIDS;

EID: 62749157590 PISSN: 18607179 EISSN: 18607187 Source Type: Journal
DOI: 10.1002/cmdc.200800324 Document Type: Article

Times cited : (36)

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