Arylamino methylene bisphosphonate derivatives as bone seeking matrix metalloproteinase inhibitors

Bioorganic and Medicinal Chemistry

Volumn 21, Issue 21, 2013, Pages 6456-6465

  Tauro, Marilena ^a   Laghezza, Antonio ^a   Loiodice, Fulvio ^a   Agamennone, Mariangela ^b   Campestre, Cristina ^b   Tortorella, Paolo ^a  

^a UNIVERSITY OF BARI   (Italy)

^b UNIVERSITY OF CHIETI   (Italy)

Author keywords

Bisphosphonates; Bone targeting; Matrix metalloproteinase inhibitors; Zinc binding group

Indexed keywords

[(2,4 DICHLOROPHENYLAMINO)METHYL] 1,1 BISPHOSPHONIC ACID; [(3 BROMOPHENYLAMINO)METHYL] 1,1 BISPHOSPHONIC ACID; [(3 CHLOROPHENYLAMINO)METHYL] 1,1 BISPHOSPHONIC ACID; [(3 FLUOROPHENYLAMINO)METHYL] 1,1 BISPHOSPHONIC ACID; [(3 NITROPHENYLAMINO)METHYL] 1,1 BISPHOSPHONIC ACID; [(3 TRIFLUOROMETHYLPHENYLAMINO)METHYL] 1,1 BISPHOSPHONIC ACID; [(3,4 DICHLOROPHENYLAMINO)METHYL] 1,1 BISPHOSPHONIC ACID; [(4 BIPHENYLAMINO)METHYL] 1,1 BISPHOSPHONIC ACID; [(4 BROMOPHENYLAMINO)METHYL] 1,1 BISPHOSPHONIC ACID; [(4 CYANOPHENYLAMINO)METHYL] 1,1 BISPHOSPHONIC ACID; [(4 FLUORO 3 NITROPHENYLAMINO)METHYL] 1,1 BISPHOSPHONIC ACID; [(4 FLUOROPHENYLAMINO)METHYL] 1,1 BISPHOSPHONIC ACID; [(4 HYDROXYPHENYLAMINO)METHYL] 1,1 BISPHOSPHONIC ACID; [(4 METHYLPHENYLAMINO)METHYL] 1,1 BISPHOSPHONIC ACID; [(4 NITROPHENYLAMINO)METHYL] 1,1 BISPHOSPHONIC ACID; [(4 PHENOXYPHENYLAMINO)METHYL] 1,1 BISPHOSPHONIC ACID; [(4 TRIFLUOROMETHYLPHENYLAMINO)METHYL] 1,1 BISPHOSPHONIC ACID; [(PHENYLAMINO)METHYL] 1,1 BISPHOSPHONIC ACID; [[4 (4' BROMOPHENOXY)PHENYLAMINO]METHYL] 1,1 BISPHOSPHONIC ACID; [[4 (4' CHLOROPHENOXY)PHENYLAMINO]METHYL] 1,1 BISPHOSPHONIC ACID; ARYLAMINO METHYLENE BISPHOSPHONIC ACID DERIVATIVE; BISPHOSPHONIC ACID DERIVATIVE; GELATINASE A; GELATINASE B; HYDROXYAPATITE; MATRIX METALLOPROTEINASE 14; NEUTROPHIL COLLAGENASE; TILUDRONIC ACID; UNCLASSIFIED DRUG; UNINDEXED DRUG; ZOLEDRONIC ACID;

ARTICLE; BINDING AFFINITY; BONE CANCER; BONE DEVELOPMENT; CELL ASSAY; CELL SURVIVAL; CHEMICAL MODIFICATION; CONCENTRATION RESPONSE; DRUG BINDING; DRUG RESEARCH; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TARGETING; ENZYME ACTIVITY; ENZYME INHIBITION; IC 50; IN VITRO STUDY; OSTEOLYSIS; PHYSICAL CHEMISTRY; STRUCTURE ACTIVITY RELATION;

BISPHOSPHONATES; BONE TARGETING; MATRIX METALLOPROTEINASE INHIBITORS; ZINC BINDING GROUP;

ANIMALS; BINDING SITES; CELL LINE; CELL SURVIVAL; DIPHOSPHONATES; DURAPATITE; HEP G2 CELLS; HUMANS; MATRIX METALLOPROTEINASE 14; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE 8; MATRIX METALLOPROTEINASE 9; MATRIX METALLOPROTEINASE INHIBITORS; MATRIX METALLOPROTEINASES; MICE; MOLECULAR DOCKING SIMULATION; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84885189917     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2013.08.054     Document Type: Article

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