Time-dependent effects of systemic lipopolysaccharide injection on regulators of antioxidant defence Nrf2 and PGC-1α in the neonatal rat brain

NeuroImmunoModulation

Volumn 20, Issue 4, 2013, Pages 185-193

  Correa, Fernando ^a   Ljunggren, Elin ^a   Patil, Jaspal ^a   Wang, Xiaoyang ^a   Hagberg, Henrik ^a   Mallard, Carina ^a   Sandberg, Mats ^a  

^a UNIVERSITY OF GOTHENBURG   (Sweden)

Author keywords

Antioxidant system; Neuroinflammation; Nuclear factor E2 related factor 2; Peroxisome proliferator activated receptor coactivator 1

Indexed keywords

KELCH LIKE ECH ASSOCIATED PROTEIN 1; LIPOPOLYSACCHARIDE; MANGANESE SUPEROXIDE DISMUTASE; MITOGEN ACTIVATED PROTEIN KINASE P38; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; PROTEIN KINASE B; TRANSCRIPTION FACTOR NRF2;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN HOMOGENATE; CONTROLLED STUDY; DOWN REGULATION; HISTONE ACETYLATION; MICROGLIA; NEUROPROTECTION; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT; SIGNAL TRANSDUCTION; SYSTEMIC THERAPY; UPREGULATION;

EID: 84876807588     PISSN: 10217401     EISSN: 14230216     Source Type: Journal    
DOI: 10.1159/000347161     Document Type: Article

References (33)

1. Coyle JT, Puttfarcken P: Oxidative stress, glutamate, and neurodegenerative disorders. Science 1993; 262: 689-695.
2. Frank-Cannon TC, Alto LT, McAlpine FE, Tansey MG: Does neuroinflammation fan the flame in neurodegenerative diseases? Mol Neurodegener 2009; 4: 47.
3. Innamorato NG, Rojo AI, Garcia-Yague AJ, Yamamoto M, de Ceballos ML, Cuadrado A: The transcription factor Nrf2 is a therapeutic target against brain inflammation. J Immunol 2008; 181: 680-689.
4. Chan K, Xiao-Dong H, Yuet Wai K: An important function of Nrf2 in combating oxidative stress: detoxification of acetaminophen. Proc Natl Acad Sci USA 2001; 98: 4611-4616.
5. Hubbs AF, Benkovic SA, Miller DB, O'Callaghan JP, Battelli L, Schwegler-Berry D, Ma Q: Vacuolar leukoencephalopathy with widespread astrogliosis in mice lacking transcription factor Nrf2. Am J Pathol 2007; 170: 2068-2076.
6. Zhao Z, Chen Y, Wang J, Sternberg P, Freeman ML, Grossniklaus HE, Cai J: Age-related retinopathy in NRF2-deficient mice. PLoS One 2011; 6:e19456.
7. Ramsey CP, Glass CA, Montgomery MB, Lindl KA, Ritson GP, Chia LA, Hamilton RL, Chu CT, Jordan-Sciutto KL: Expression of Nrf2 in neurodegenerative diseases. J Neuropathol Exp Neurol 2007; 66: 75-85.
8. Shih AY, Li P, Murphy TH: A small-molecule-inducible Nrf2-mediated antioxidant response provides effective prophylaxis against cerebral ischemia in vivo. J Neurosci 2005; 25: 10321-10335.
9. Zhao J, Kobori N, Aronowski J, Dash PK: Sulforaphane reduces infarct volume following focal cerebral ischemia in rodents. Neurosci Lett 2006; 393: 108-112.
10. Yang C, Zhang X, Fan H, Liu Y: Curcumin upregulates transcription factor Nrf2, HO-1 expression and protects rat brains against focal ischemia. Brain Res 2009; 1282: 133-141.
11. Shah ZA, Li RC, Ahmad AS, Kensler TW, Yamamoto M, Biswal S, Dore S: The flavanol (-)-epicatechin prevents stroke damage through the Nrf2/HO1 pathway. J Cereb Blood Flow Metab 2010; 30: 1951-1961.
12. Tanaka N, Ikeda Y, Ohta Y, Deguchi K, Tian F, Shang J, Matsuura T, Abe K: Expression of Keap1-Nrf2 system and antioxidative proteins in mouse brain after transient middle cerebral artery occlusion. Brain Res 2011; 1370: 246-253.
13. Ping Z, Liu W, Kang Z, Cai J, Wang Q, Cheng N, Wang S, Wang S, Zhang JH, Sun X: Sulforaphane protects brains against hypoxicischemic injury through induction of Nrf2-dependent phase 2 enzyme. Brain Res 2010; 1343: 178-185.
14. Wallin C, Puka-Sundvall M, Hagberg H, Weber SG, Sandberg M: Alterations in glutathione and amino acid concentrations after hypoxia-ischemia in the immature rat brain. Brain Res Dev Brain Res 2000; 125: 51-60.
15. Wang X, Svedin P, Nie C, Lapatto R, Zhu C, Gustavsson M, Sandberg M, Karlsson JO, Romero R, Hagberg H, Mallard C: N-acetylcysteine reduces lipopolysaccharide-sensitized hypoxic-ischemic brain injury. Ann Neurol 2007; 61: 263-271.
16. Eklind S, Mallard C, Arvidsson P, Hagberg H: Lipopolysaccharide induces both a primary and a secondary phase of sensitization in the developing rat brain. Pediatr Res 2005; 58: 112-116.
17. Correa F, Mallard C, Nilsson M, Sandberg M: Activated microglia decrease histone acetylation and Nrf2-inducible anti-oxidant defence in astrocytes: restoring effects of inhibitors of HDACs, p38 MAPK and GSK3beta. Neurobiol Dis 2011; 44: 142-151.
18. Clark J, Simon DK: Transcribe to survive: transcriptional control of antioxidant defence programs for neuroprotection in Parkinson's disease. Antioxid Redox Signal 2009; 11: 509-528.
19. Kifle Y, Monnier J, Chesrown SE, Raizada MK, Nick HS: Regulation of the manganese superoxide dismutase and inducible nitric oxide synthase gene in rat neuronal and glial cells. J Neurochem 1996; 66: 2128-2135.
20. Bordet R, Deplanque D, Maboudou P, Puisieux F, Pu Q, Robin E, Martin A, Bastide M, Leys D, Lhermitte M, Dupuis B: Increase in endogenous brain superoxide dismutase as a potential mechanism of lipopolysaccharideinduced brain ischemic tolerance. J Cereb Blood Flow Metab 2000; 20: 1190-1196.
21. Correa F, Ljunggren E, Mallard C, Nilsson M, Weber SG, Sandberg M: The Nrf2-inducible antioxidant defense in astrocytes can be both up-and down-regulated by activated micro glia: involvement of p38 MAPK. Glia 2011; 59: 785-799.
22. Mallard C, Hagberg H: Inflammation-induced preconditioning in the immature brain. Semin Fetal Neonatal Med 2007; 12: 280-286.
23. Park PH, Hur J, Kim YC, An RB, Sohn DH: Involvement of heme oxygenase-1 induction in inhibitory effect of ethyl gallate isolated from Galla Rhois on nitric oxide production in RAW 264.7 macrophages. Arch Pharm Res 2011; 34: 1545-1552.
24. Gustavsson M, Wilson MA, Mallard C, Rousset C, Johnston MV, Hagberg H: Global gene expression in the developing rat brain after hypoxic preconditioning: involvement of apoptotic mechanisms? Pediatr Res 2007; 61: 444-450.
25. Hong F, Freeman ML, Liebler DC: Identification of sensor cysteines in human Keap1 modified by the cancer chemopreventive agent sulforaphane. Chem Res Toxicol 2005; 18: 1917-1926.
26. Rahman I, Gilmour PS, Jimenez LA, MacNee W: Oxidative stress and TNF-alpha induce histone acetylation and NF-kappaB/AP-1 activation in alveolar epithelial cells: potential mechanism in gene transcription in lung inflammation. Mol Cell Biochem 2002; 234-235: 239-248.
27. El Gazzar M, Yoza BK, Chen X, Hu J, Hawkins GA, McCall CE: G9a and HP1 couple histone and DNA methylation to TNFalpha transcription silencing during endotoxin tolerance. J Biol Chem 2008; 283: 32198-32208.
28. Vakoc CR, Mandat SA, Olenchock BA, Blobel GA: Histone H3 lysine 9 methylation and HP1gamma are associated with transcription elongation through mammalian chromatin. Mol Cell 2005; 19: 381-391.
29. Kawai Y, Garduno L, Theodore M, Yang J, Arinze IJ: Acetylation-deacetylation of the transcription factor Nrf2 (nuclear factor erythroid 2-related factor 2) regulates its transcriptional activity and nucleocytoplasmic localization. J Biol Chem 2011; 286: 7629-7640.
30. Huang WC, Chen CC: Akt phosphorylation of p300 at Ser-1834 is essential for its histone acetyltransferase and transcriptional activity. Mol Cell Biol 2005; 25: 6592-6602.
31. Naidu S, Vijayan V, Santoso S, Kietzmann T, Immenschuh S: Inhibition and genetic deficiency of p38 MAPK up-regulates heme oxygenase-1 gene expression via Nrf2. J Immunol 2009; 182: 7048-7057.
32. Yu R, Chen C, Mo YY, Hebbar V, Owuor ED, Tan TH, Kong AN: Activation of mitogenactivated protein kinase pathways induces antioxidant response element-mediated gene expression via a Nrf2-dependent mechanism. J Biol Chem 2000; 275: 39907-39913.
33. Wang X, Zhu C, Qiu L, Hagberg H, Sandberg M, Blomgren K: Activation of ERK1/2 after neonatal rat cerebral hypoxia-ischaemia. J Neurochem 2003;86:351-362.