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Volumn 12, Issue 4, 2014, Pages

Lowered Insulin Signalling Ameliorates Age-Related Sleep Fragmentation in Drosophila

Author keywords

[No Author keywords available]

Indexed keywords

ADIPOKINETIC HORMONE; DOPAMINE; DOPAMINE RECEPTOR; INSULIN; OCTOPAMINE; S6 KINASE; SOMATOMEDIN; TARGET OF RAPAMYCIN KINASE; TRANSCRIPTION FACTOR FOXO; AKHR PROTEIN, DROSOPHILA; DIAP2 PROTEIN, DROSOPHILA; DROSOPHILA PROTEIN; FORKHEAD TRANSCRIPTION FACTOR; FOXO PROTEIN, DROSOPHILA; GLUCAGON RECEPTOR; INHIBITOR OF APOPTOSIS PROTEIN; INSECT HORMONE; INSULIN RECEPTOR; OLIGOPEPTIDE; PYROGLUTAMIC ACID; RAPAMYCIN; RIBOSOMAL PROTEIN S6 KINASE, 70KD, POLYPEPTIDE 2;

EID: 84900443397     PISSN: 15449173     EISSN: 15457885     Source Type: Journal    
DOI: 10.1371/journal.pbio.1001824     Document Type: Article
Times cited : (71)

References (75)
  • 1
    • 68949150765 scopus 로고    scopus 로고
    • Sleep and its disorders in aging populations
    • doi:10.1016/J.Sleep.2009.07.004
    • Ancoli-Israel S, (2009) Sleep and its disorders in aging populations. Sleep Med 10: S7-S11 doi:10.1016/J.Sleep.2009.07.004.
    • (2009) Sleep Med , vol.10
    • Ancoli-Israel, S.1
  • 2
    • 67651097622 scopus 로고    scopus 로고
    • The genetic and molecular regulation of sleep: from fruit flies to humans
    • doi:10.1038/Nrn2683
    • Cirelli C, (2009) The genetic and molecular regulation of sleep: from fruit flies to humans. Nat Rev Neurosci 10: 549-560 doi:10.1038/Nrn2683.
    • (2009) Nat Rev Neurosci , vol.10 , pp. 549-560
    • Cirelli, C.1
  • 3
    • 21844480910 scopus 로고    scopus 로고
    • Dopaminergic modulation of arousal in Drosophila
    • doi:10.1016/J.Cub.2005.05.025
    • Andretic R, van Swinderen B, Greenspan RJ, (2005) Dopaminergic modulation of arousal in Drosophila. Curr Biol 15: 1165-1175 doi:10.1016/J.Cub.2005.05.025.
    • (2005) Curr Biol , vol.15 , pp. 1165-1175
    • Andretic, R.1    van Swinderen, B.2    Greenspan, R.J.3
  • 4
    • 23744439861 scopus 로고    scopus 로고
    • Dopamine is a regulator of arousal in the fruit fly
    • doi:10.1523/Jneurosci.2048-05.2005
    • Kume K, Kume S, Park SK, Hirsh J, Jackson FR, (2005) Dopamine is a regulator of arousal in the fruit fly. J Neurosci 25: 7377-7384 doi:10.1523/Jneurosci.2048-05.2005.
    • (2005) J Neurosci , vol.25 , pp. 7377-7384
    • Kume, K.1    Kume, S.2    Park, S.K.3    Hirsh, J.4    Jackson, F.R.5
  • 5
    • 33748802246 scopus 로고    scopus 로고
    • A Drosophila model for age-associated changes in sleep: wake cycles
    • doi:10.1073/Pnas.0605903103
    • Koh K, Evans JM, Hendricks JC, Sehgal A, (2006) A Drosophila model for age-associated changes in sleep: wake cycles. P Natl Acad Sci USA 103: 13843-13847 doi:10.1073/Pnas.0605903103.
    • (2006) P Natl Acad Sci USA , vol.103 , pp. 13843-13847
    • Koh, K.1    Evans, J.M.2    Hendricks, J.C.3    Sehgal, A.4
  • 6
    • 79251470797 scopus 로고    scopus 로고
    • The first long-lived mutants: discovery of the insulin/IGF-1 pathway for ageing
    • doi:10.1098/Rstb.2010.0276
    • Kenyon C, (2011) The first long-lived mutants: discovery of the insulin/IGF-1 pathway for ageing. Philos T R Soc B 366: 9-16 doi:10.1098/Rstb.2010.0276.
    • (2011) Philos T R Soc B , vol.366 , pp. 9-16
    • Kenyon, C.1
  • 7
    • 77951176737 scopus 로고    scopus 로고
    • Extending healthy life span-from yeast to humans
    • doi:10.1126/Science.1172539
    • Fontana L, Partridge L, Longo VD, (2010) Extending healthy life span-from yeast to humans. Science 328: 321-326 doi:10.1126/Science.1172539.
    • (2010) Science , vol.328 , pp. 321-326
    • Fontana, L.1    Partridge, L.2    Longo, V.D.3
  • 8
    • 79956016645 scopus 로고    scopus 로고
    • Impaired IGF1R signaling in cells expressing longevity-associated human IGF1R alleles
    • doi:10.1111/J.1474-9726.2011.00697.X
    • Tazearslan C, Huang J, Barzilai N, Suh Y, (2011) Impaired IGF1R signaling in cells expressing longevity-associated human IGF1R alleles. Aging Cell 10: 551-554 doi:10.1111/J.1474-9726.2011.00697.X.
    • (2011) Aging Cell , vol.10 , pp. 551-554
    • Tazearslan, C.1    Huang, J.2    Barzilai, N.3    Suh, Y.4
  • 9
    • 0027771804 scopus 로고
    • A C-elegans mutant that lives twice as long as wild-type
    • doi:10.1038/366461a0
    • Kenyon C, Chang J, Gensch E, Rudner A, Tabtiang R, (1993) A C-elegans mutant that lives twice as long as wild-type. Nature 366: 461-464 doi:10.1038/366461a0.
    • (1993) Nature , vol.366 , pp. 461-464
    • Kenyon, C.1    Chang, J.2    Gensch, E.3    Rudner, A.4    Tabtiang, R.5
  • 10
    • 0030657540 scopus 로고    scopus 로고
    • daf-16: an HNF-3/forkhead family member that can function to double the life-span of Caenorhabditis elegans
    • doi:10.1126/Science.278.5341.1319
    • Lin K, Dorman JB, Rodan A, Kenyon C, (1997) daf-16: an HNF-3/forkhead family member that can function to double the life-span of Caenorhabditis elegans. Science 278: 1319-1322 doi:10.1126/Science.278.5341.1319.
    • (1997) Science , vol.278 , pp. 1319-1322
    • Lin, K.1    Dorman, J.B.2    Rodan, A.3    Kenyon, C.4
  • 11
    • 0030659557 scopus 로고    scopus 로고
    • The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C-elegans
    • Ogg S, Paradis S, Gottlieb S, Patterson GI, Lee L, et al. (1997) The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C-elegans. Nature 389: 994-999.
    • (1997) Nature , vol.389 , pp. 994-999
    • Ogg, S.1    Paradis, S.2    Gottlieb, S.3    Patterson, G.I.4    Lee, L.5
  • 12
    • 79959559276 scopus 로고    scopus 로고
    • dFOXO-independent effects of reduced insulin-like signaling in Drosophila
    • doi:10.1111/J.1474-9726.2011.00707.X
    • Slack C, Giannakou ME, Foley A, Goss M, Partridge L, (2011) dFOXO-independent effects of reduced insulin-like signaling in Drosophila. Aging Cell 10: 735-748 doi:10.1111/J.1474-9726.2011.00707.X.
    • (2011) Aging Cell , vol.10 , pp. 735-748
    • Slack, C.1    Giannakou, M.E.2    Foley, A.3    Goss, M.4    Partridge, L.5
  • 13
    • 32044465506 scopus 로고    scopus 로고
    • TOR signaling in growth and metabolism
    • doi:10.1016/J.Cell.2006.01.016
    • Wullschleger S, Loewith R, Hall MN, (2006) TOR signaling in growth and metabolism. Cell 127: 5-19 doi:10.1016/J.Cell.2006.01.016.
    • (2006) Cell , vol.127 , pp. 5-19
    • Wullschleger, S.1    Loewith, R.2    Hall, M.N.3
  • 14
    • 4043171462 scopus 로고    scopus 로고
    • Upstream and downstream of mTOR
    • doi:10.1101/Gad.1212704
    • Hay N, Sonenberg N, (2004) Upstream and downstream of mTOR. Gene Dev 18: 1926-1945 doi:10.1101/Gad.1212704.
    • (2004) Gene Dev , vol.18 , pp. 1926-1945
    • Hay, N.1    Sonenberg, N.2
  • 15
    • 20344406240 scopus 로고    scopus 로고
    • Autophagy in metazoans: cell survival in the land of plenty
    • doi:10.1038/Nrm1660
    • Lum JJ, DeBerardinis RJ, Thompson CB, (2005) Autophagy in metazoans: cell survival in the land of plenty. Nat Rev Mol Cell Bio 6: 439-448 doi:10.1038/Nrm1660.
    • (2005) Nat Rev Mol Cell Bio , vol.6 , pp. 439-448
    • Lum, J.J.1    DeBerardinis, R.J.2    Thompson, C.B.3
  • 16
    • 67650944993 scopus 로고    scopus 로고
    • Rapamycin fed late in life extends lifespan in genetically heterogeneous mice
    • doi:10.1038/Nature08221
    • Harrison DE, Strong R, Sharp ZD, Nelson JF, Astle CM, et al. (2009) Rapamycin fed late in life extends lifespan in genetically heterogeneous mice. Nature 460: 392-U108 doi:10.1038/Nature08221.
    • (2009) Nature , vol.460 , pp. 108-392
    • Harrison, D.E.1    Strong, R.2    Sharp, Z.D.3    Nelson, J.F.4    Astle, C.M.5
  • 17
    • 72649091698 scopus 로고    scopus 로고
    • Mechanisms of life span extension by Rapamycin in the fruit fly Drosophila melanogaster
    • doi:10.1016/J.Cmet.2009.11.010
    • Bjedov I, Toivonen JM, Kerr F, Slack C, Jacobson J, et al. (2010) Mechanisms of life span extension by Rapamycin in the fruit fly Drosophila melanogaster. Cell Metab 11: 35-46 doi:10.1016/J.Cmet.2009.11.010.
    • (2010) Cell Metab , vol.11 , pp. 35-46
    • Bjedov, I.1    Toivonen, J.M.2    Kerr, F.3    Slack, C.4    Jacobson, J.5
  • 18
    • 52449086907 scopus 로고    scopus 로고
    • The insulin paradox: aging, proteotoxicity and neurodegeneration
    • doi:10.1038/nrn2474
    • Cohen E, Dillin A, (2008) The insulin paradox: aging, proteotoxicity and neurodegeneration. Nat Rev Neurosci 9: 759-767 doi:10.1038/nrn2474.
    • (2008) Nat Rev Neurosci , vol.9 , pp. 759-767
    • Cohen, E.1    Dillin, A.2
  • 19
    • 59849091257 scopus 로고    scopus 로고
    • Insulin/IGF-like signalling, the central nervous system and aging
    • doi:10.1042/Bj20082102
    • Broughton S, Partridge L, (2009) Insulin/IGF-like signalling, the central nervous system and aging. Biochem J 418: 1-12 doi:10.1042/Bj20082102.
    • (2009) Biochem J , vol.418 , pp. 1-12
    • Broughton, S.1    Partridge, L.2
  • 20
    • 77950229880 scopus 로고    scopus 로고
    • Neural mechanisms of ageing and cognitive decline
    • doi:10.1038/Nature08983
    • Bishop NA, Lu T, Yankner BA, (2010) Neural mechanisms of ageing and cognitive decline. Nature 464: 529-535 doi:10.1038/Nature08983.
    • (2010) Nature , vol.464 , pp. 529-535
    • Bishop, N.A.1    Lu, T.2    Yankner, B.A.3
  • 21
    • 77649195357 scopus 로고    scopus 로고
    • Molecular evolution and functional characterization of drosophila insulin-like peptides
    • doi:10.1371/Journal.Pgen.1000857
    • Gronke S, Clarke DF, Broughton S, Andrews TD, Partridge L, (2010) Molecular evolution and functional characterization of drosophila insulin-like peptides. PLoS Genet 6: e1000857 doi:10.1371/Journal.Pgen.1000857.
    • (2010) PLoS Genet , vol.6
    • Gronke, S.1    Clarke, D.F.2    Broughton, S.3    Andrews, T.D.4    Partridge, L.5
  • 22
    • 72449141605 scopus 로고    scopus 로고
    • The endosymbiont Wolbachia increases insulin/IGF-like signalling in Drosophila
    • doi:10.1098/Rspb.2009.0778
    • Ikeya T, Broughton S, Alic N, Grandison R, Partridge L, (2009) The endosymbiont Wolbachia increases insulin/IGF-like signalling in Drosophila. P R Soc B 276: 3799-3807 doi:10.1098/Rspb.2009.0778.
    • (2009) P R Soc B , vol.276 , pp. 3799-3807
    • Ikeya, T.1    Broughton, S.2    Alic, N.3    Grandison, R.4    Partridge, L.5
  • 23
    • 0034106011 scopus 로고    scopus 로고
    • Rest in Drosophila is a sleep-like state
    • doi:10.1016/S0896-6273(00)80877-6
    • Hendricks JC, Finn SM, Panckeri KA, Chavkin J, Williams JA, et al. (2000) Rest in Drosophila is a sleep-like state. Neuron 25: 129-138 doi:10.1016/S0896-6273(00)80877-6.
    • (2000) Neuron , vol.25 , pp. 129-138
    • Hendricks, J.C.1    Finn, S.M.2    Panckeri, K.A.3    Chavkin, J.4    Williams, J.A.5
  • 24
    • 84155177082 scopus 로고    scopus 로고
    • Insomniac and Cullin-3 regulate sleep and wakefulness in Drosophila
    • doi:10.1016/j.neuron.2011.12.003
    • Stavropoulos N, Young MW, (2011) Insomniac and Cullin-3 regulate sleep and wakefulness in Drosophila. Neuron 72: 964-976 doi:10.1016/j.neuron.2011.12.003.
    • (2011) Neuron , vol.72 , pp. 964-976
    • Stavropoulos, N.1    Young, M.W.2
  • 25
    • 0034629130 scopus 로고    scopus 로고
    • Correlates of sleep and waking in Drosophila melanogaster
    • doi:10.1126/Science.287.5459.1834
    • Shaw PJ, Cirelli C, Greenspan RJ, Tononi G, (2000) Correlates of sleep and waking in Drosophila melanogaster. Science 287: 1834-1837 doi:10.1126/Science.287.5459.1834.
    • (2000) Science , vol.287 , pp. 1834-1837
    • Shaw, P.J.1    Cirelli, C.2    Greenspan, R.J.3    Tononi, G.4
  • 27
    • 27644457084 scopus 로고    scopus 로고
    • Hypothalamic regulation of sleep and circadian rhythms
    • doi:10.1038/nature04284
    • Saper CB, Scammell TE, Lu J, (2005) Hypothalamic regulation of sleep and circadian rhythms. Nature 437: 1257-1263 doi:10.1038/nature04284.
    • (2005) Nature , vol.437 , pp. 1257-1263
    • Saper, C.B.1    Scammell, T.E.2    Lu, J.3
  • 28
    • 4644242353 scopus 로고    scopus 로고
    • Conserved mechanisms of glucose sensing and regulation by Drosophila corpora cardiaca cells
    • doi:10.1038/Nature02897
    • Kim SK, Rulifson EJ, (2004) Conserved mechanisms of glucose sensing and regulation by Drosophila corpora cardiaca cells. Nature 431: 316-320 doi:10.1038/Nature02897.
    • (2004) Nature , vol.431 , pp. 316-320
    • Kim, S.K.1    Rulifson, E.J.2
  • 29
    • 41449108530 scopus 로고    scopus 로고
    • Opposing effects of dietary protein and sugar regulate a transcriptional target of Drosophila insulin-like peptide signaling
    • doi:10.1016/j.cmet.2008.02.012
    • Buch S, Melcher C, Bauer M, Katzenberger J, Pankratz MJ, (2008) Opposing effects of dietary protein and sugar regulate a transcriptional target of Drosophila insulin-like peptide signaling. Cell Metab 7: 321-332 doi:10.1016/j.cmet.2008.02.012.
    • (2008) Cell Metab , vol.7 , pp. 321-332
    • Buch, S.1    Melcher, C.2    Bauer, M.3    Katzenberger, J.4    Pankratz, M.J.5
  • 30
    • 12344305171 scopus 로고    scopus 로고
    • AKH-producing neuroendocrine cell ablation decreases trehalose and induces behavioral changes in Drosophila
    • doi:10.1152/Ajpregu.00158.2004
    • Isabel G, Martin JR, Chidami S, Veenstra JA, Rosay P, (2005) AKH-producing neuroendocrine cell ablation decreases trehalose and induces behavioral changes in Drosophila. Am J Physiol-Reg I 288: R531-R538 doi:10.1152/Ajpregu.00158.2004.
    • (2005) Am J Physiol-Reg I , vol.288
    • Isabel, G.1    Martin, J.R.2    Chidami, S.3    Veenstra, J.A.4    Rosay, P.5
  • 31
    • 33746614739 scopus 로고    scopus 로고
    • Differential receptor activation by cockroach adipokinetic hormones produces differential effects on ion currents, neuronal activity, and locomotion (vol 95, pg 2314, 2006)
    • Wicher D, Agricola HJ, Sohler S, Gundel M, Heinemann SH, et al. (2006) Differential receptor activation by cockroach adipokinetic hormones produces differential effects on ion currents, neuronal activity, and locomotion (vol 95, pg 2314, 2006). J Neurophysiol 96: 965-965.
    • (2006) J Neurophysiol , vol.96 , pp. 965
    • Wicher, D.1    Agricola, H.J.2    Sohler, S.3    Gundel, M.4    Heinemann, S.H.5
  • 32
    • 58149328456 scopus 로고    scopus 로고
    • Octopamine regulates sleep in Drosophila through protein kinase A-dependent mechanisms
    • doi:10.1523/Jneurosci.3072-08a.2008
    • Crocker A, Sehgal A, (2008) Octopamine regulates sleep in Drosophila through protein kinase A-dependent mechanisms. J Neurosci 28: 9377-9385 doi:10.1523/Jneurosci.3072-08a.2008.
    • (2008) J Neurosci , vol.28 , pp. 9377-9385
    • Crocker, A.1    Sehgal, A.2
  • 33
    • 22244485006 scopus 로고    scopus 로고
    • Identification and characterization of a novel family of Drosophila beta-adrenergic-like octopamine G-protein coupled receptors
    • doi:10.1111/J.1471-4159.2005.03251.X
    • Maqueira B, Chatwin H, Evans PD, (2005) Identification and characterization of a novel family of Drosophila beta-adrenergic-like octopamine G-protein coupled receptors. J Neurochem 94: 547-560 doi:10.1111/J.1471-4159.2005.03251.X.
    • (2005) J Neurochem , vol.94 , pp. 547-560
    • Maqueira, B.1    Chatwin, H.2    Evans, P.D.3
  • 34
    • 84859778293 scopus 로고    scopus 로고
    • mTOR signaling in growth control and disease
    • doi:10.1016/J.Cell.2012.03.017
    • Laplante M, Sabatini DM, (2012) mTOR signaling in growth control and disease. Cell 149: 274-293 doi:10.1016/J.Cell.2012.03.017.
    • (2012) Cell , vol.149 , pp. 274-293
    • Laplante, M.1    Sabatini, D.M.2
  • 35
    • 30944458446 scopus 로고    scopus 로고
    • Extension of chronological life span in yeast by decreased TOR pathway signaling
    • doi:10.1101/Gad.1381406
    • Powers RW, Kaeberlein M, Caldwell SD, Kennedy BK, Fields S, (2006) Extension of chronological life span in yeast by decreased TOR pathway signaling. Gene Dev 20: 174-184 doi:10.1101/Gad.1381406.
    • (2006) Gene Dev , vol.20 , pp. 174-184
    • Powers, R.W.1    Kaeberlein, M.2    Caldwell, S.D.3    Kennedy, B.K.4    Fields, S.5
  • 36
    • 84860461929 scopus 로고    scopus 로고
    • TOR signaling and Rapamycin influence longevity by regulating SKN-1/Nrf and DAF-16/FoxO
    • doi:10.1016/J.Cmet.2012.04.007
    • Robida-Stubbs S, Glover-Cutter K, Lamming DW, Mizunuma M, Narasimhan SD, et al. (2012) TOR signaling and Rapamycin influence longevity by regulating SKN-1/Nrf and DAF-16/FoxO. Cell Metab 15: 713-724 doi:10.1016/J.Cmet.2012.04.007.
    • (2012) Cell Metab , vol.15 , pp. 713-724
    • Robida-Stubbs, S.1    Glover-Cutter, K.2    Lamming, D.W.3    Mizunuma, M.4    Narasimhan, S.D.5
  • 37
    • 0015867426 scopus 로고
    • The effects of protein synthesis inhibition on sleep in mice
    • Pegram V, Hammond D, Bridgers W, (1973) The effects of protein synthesis inhibition on sleep in mice. Behav Biol 9: 377-382.
    • (1973) Behav Biol , vol.9 , pp. 377-382
    • Pegram, V.1    Hammond, D.2    Bridgers, W.3
  • 38
    • 70449753456 scopus 로고    scopus 로고
    • Two different forms of arousal in Drosophila are oppositely regulated by the dopamine D1 receptor ortholog DopR via distinct neural circuits
    • doi:10.1016/J.Neuron.2009.09.031
    • Lebestky T, Chang JSC, Dankert H, Zelnik L, Kim YC, et al. (2009) Two different forms of arousal in Drosophila are oppositely regulated by the dopamine D1 receptor ortholog DopR via distinct neural circuits. Neuron 64: 522-536 doi:10.1016/J.Neuron.2009.09.031.
    • (2009) Neuron , vol.64 , pp. 522-536
    • Lebestky, T.1    Chang, J.S.C.2    Dankert, H.3    Zelnik, L.4    Kim, Y.C.5
  • 39
    • 84866556851 scopus 로고    scopus 로고
    • Interaction between sleep and metabolism in Drosophila with altered octopamine signaling
    • doi:10.1074/jbc.M112.360875
    • Erion R, DiAngelo JR, Crocker A, Sehgal A, (2012) Interaction between sleep and metabolism in Drosophila with altered octopamine signaling. J Biol Chem 287: 32406-32414 doi:10.1074/jbc.M112.360875.
    • (2012) J Biol Chem , vol.287 , pp. 32406-32414
    • Erion, R.1    DiAngelo, J.R.2    Crocker, A.3    Sehgal, A.4
  • 40
    • 84855849923 scopus 로고    scopus 로고
    • High calorie diet augments age-associated sleep impairment in Drosophila
    • doi:10.1016/J.Bbrc.2011.12.041
    • Yamazaki M, Tomita J, Takahama K, Ueno T, Mitsuyoshi M, et al. (2012) High calorie diet augments age-associated sleep impairment in Drosophila. Biochem Bioph Res Co 417: 812-816 doi:10.1016/J.Bbrc.2011.12.041.
    • (2012) Biochem Bioph Res Co , vol.417 , pp. 812-816
    • Yamazaki, M.1    Tomita, J.2    Takahama, K.3    Ueno, T.4    Mitsuyoshi, M.5
  • 41
    • 84863508216 scopus 로고    scopus 로고
    • Re-patterning sleep architecture in Drosophila through gustatory perception and nutritional quality
    • doi:10.1371/Journal.Pgen.1002668
    • Linford NJ, Chan TP, Pletcher SD, (2012) Re-patterning sleep architecture in Drosophila through gustatory perception and nutritional quality. PLoS Genet 8: e1002668 doi:10.1371/Journal.Pgen.1002668.
    • (2012) PLoS Genet , vol.8
    • Linford, N.J.1    Chan, T.P.2    Pletcher, S.D.3
  • 42
    • 84861658629 scopus 로고    scopus 로고
    • Diet promotes sleep duration and quality
    • doi:10.1016/J.Nutres.2012.03.009
    • Peuhkuri K, Sihvola N, Korpela R, (2012) Diet promotes sleep duration and quality. Nutr Res 32: 309-319 doi:10.1016/J.Nutres.2012.03.009.
    • (2012) Nutr Res , vol.32 , pp. 309-319
    • Peuhkuri, K.1    Sihvola, N.2    Korpela, R.3
  • 43
    • 43749090685 scopus 로고    scopus 로고
    • Meta-analysis of short sleep duration and obesity in children and adults
    • Cappuccio FP, Taggart FM, Kandala NB, Currie A, Peile E, et al. (2008) Meta-analysis of short sleep duration and obesity in children and adults. Sleep 31: 619-626.
    • (2008) Sleep , vol.31 , pp. 619-626
    • Cappuccio, F.P.1    Taggart, F.M.2    Kandala, N.B.3    Currie, A.4    Peile, E.5
  • 44
    • 67651180846 scopus 로고    scopus 로고
    • Effects of poor and short sleep on glucose metabolism and obesity risk
    • doi:10.1038/Nrendo.2009.23
    • Spiegel K, Tasali E, Leproult R, Van Cauter E, (2009) Effects of poor and short sleep on glucose metabolism and obesity risk. Nat Rev Endocrinol 5: 253-261 doi:10.1038/Nrendo.2009.23.
    • (2009) Nat Rev Endocrinol , vol.5 , pp. 253-261
    • Spiegel, K.1    Tasali, E.2    Leproult, R.3    Van Cauter, E.4
  • 45
    • 57149117828 scopus 로고    scopus 로고
    • A PI3-kinase-mediated negative feedback regulates neuronal excitability
    • doi:10.1371/journal.pgen.1000277
    • Howlett E, Lin CC, Lavery W, Stern M, (2008) A PI3-kinase-mediated negative feedback regulates neuronal excitability. PLoS Genet 4: e1000277 doi:10.1371/journal.pgen.1000277.
    • (2008) PLoS Genet , vol.4
    • Howlett, E.1    Lin, C.C.2    Lavery, W.3    Stern, M.4
  • 46
    • 77649170707 scopus 로고    scopus 로고
    • Identification of a neural circuit that underlies the effects of octopamine on sleep:wake behavior
    • doi:10.1016/j.neuron.2010.01.032
    • Crocker A, Shahidullah M, Levitan IB, Sehgal A, (2010) Identification of a neural circuit that underlies the effects of octopamine on sleep:wake behavior. Neuron 65: 670-681 doi:10.1016/j.neuron.2010.01.032.
    • (2010) Neuron , vol.65 , pp. 670-681
    • Crocker, A.1    Shahidullah, M.2    Levitan, I.B.3    Sehgal, A.4
  • 47
    • 79251547590 scopus 로고    scopus 로고
    • Autoregulatory and paracrine control of synaptic and behavioral plasticity by octopaminergic signaling
    • doi:10.1038/Nn.2716
    • Koon AC, Ashley J, Barria R, DasGupta S, Brain R, et al. (2011) Autoregulatory and paracrine control of synaptic and behavioral plasticity by octopaminergic signaling. Nat Neurosci 14: 190-U275 doi:10.1038/Nn.2716.
    • (2011) Nat Neurosci , vol.14 , pp. 190-275
    • Koon, A.C.1    Ashley, J.2    Barria, R.3    DasGupta, S.4    Brain, R.5
  • 48
    • 0037052544 scopus 로고    scopus 로고
    • Ablation of insulin-producing neurons in flies: growth and diabetic phenotypes
    • doi:10.1126/Science.1070058
    • Rulifson EJ, Kim SK, Nusse R, (2002) Ablation of insulin-producing neurons in flies: growth and diabetic phenotypes. Science 296: 1118-1120 doi:10.1126/Science.1070058.
    • (2002) Science , vol.296 , pp. 1118-1120
    • Rulifson, E.J.1    Kim, S.K.2    Nusse, R.3
  • 49
    • 55549143025 scopus 로고    scopus 로고
    • A glucagon-like endocrine pathway in Drosophila modulates both lipid and carbohydrate homeostasis
    • doi:10.1242/Jeb.016451
    • Bharucha KN, Tarr P, Zipursky SL, (2008) A glucagon-like endocrine pathway in Drosophila modulates both lipid and carbohydrate homeostasis. J Exp Biol 211: 3103-3110 doi:10.1242/Jeb.016451.
    • (2008) J Exp Biol , vol.211 , pp. 3103-3110
    • Bharucha, K.N.1    Tarr, P.2    Zipursky, S.L.3
  • 50
    • 2942590660 scopus 로고    scopus 로고
    • Hemolymph sugar homeostasis and starvation-induced hyperactivity affected by genetic manipulations of the adipokinetic hormone-encoding gene in Drosophila melanogaster
    • doi:10.1534/Genetics.167.1.311
    • Lee GH, Park JH, (2004) Hemolymph sugar homeostasis and starvation-induced hyperactivity affected by genetic manipulations of the adipokinetic hormone-encoding gene in Drosophila melanogaster. Genetics 167: 311-323 doi:10.1534/Genetics.167.1.311.
    • (2004) Genetics , vol.167 , pp. 311-323
    • Lee, G.H.1    Park, J.H.2
  • 51
    • 77956854713 scopus 로고    scopus 로고
    • The perilipin homologue, lipid storage droplet 2, regulates sleep homeostasis and prevents learning impairments following sleep loss
    • doi:10.1371/Journal.Pbio.1000466
    • Thimgan MS, Suzuki Y, Seugnet L, Gottschalk L, Shaw PJ, (2010) The perilipin homologue, lipid storage droplet 2, regulates sleep homeostasis and prevents learning impairments following sleep loss. PLoS Biol 8: e1000466 doi:10.1371/Journal.Pbio.1000466.
    • (2010) PLoS Biol , vol.8
    • Thimgan, M.S.1    Suzuki, Y.2    Seugnet, L.3    Gottschalk, L.4    Shaw, P.J.5
  • 52
    • 79959559899 scopus 로고    scopus 로고
    • Genome-wide dFOXO targets and topology of the transcriptomic response to stress and insulin signalling
    • doi:10.1038/Msb.2011.36
    • Alic N, Andrews TD, Giannakou ME, Papatheodorou I, Slack C, et al. (2011) Genome-wide dFOXO targets and topology of the transcriptomic response to stress and insulin signalling. Mol Syst Biol 7doi:10.1038/Msb.2011.36.
    • (2011) Mol Syst Biol , vol.7
    • Alic, N.1    Andrews, T.D.2    Giannakou, M.E.3    Papatheodorou, I.4    Slack, C.5
  • 53
    • 79251589096 scopus 로고    scopus 로고
    • Fighting the famine with an amine: synaptic strategies for smart search
    • doi:10.1038/Nn0211-124
    • Sigrist SJ, Andlauer TFM, (2011) Fighting the famine with an amine: synaptic strategies for smart search. Nat Neurosci 14: 124-126 doi:10.1038/Nn0211-124.
    • (2011) Nat Neurosci , vol.14 , pp. 124-126
    • Sigrist, S.J.1    Andlauer, T.F.M.2
  • 54
    • 24944498730 scopus 로고    scopus 로고
    • Regulation of hunger-driven behaviors by neural ribosomal S6 kinase in Drosophila
    • doi:10.1073/Pnas.0501914102
    • Wu Q, Zhang Y, Xu J, Shen P, (2005) Regulation of hunger-driven behaviors by neural ribosomal S6 kinase in Drosophila. P Natl Acad Sci USA 102: 13289-13294 doi:10.1073/Pnas.0501914102.
    • (2005) P Natl Acad Sci USA , vol.102 , pp. 13289-13294
    • Wu, Q.1    Zhang, Y.2    Xu, J.3    Shen, P.4
  • 55
    • 75749114797 scopus 로고    scopus 로고
    • mTOR signaling: at the crossroads of plasticity, memory and disease
    • doi:10.1016/J.Tins.2009.11.003
    • Hoeffer CA, Klann E, (2010) mTOR signaling: at the crossroads of plasticity, memory and disease. Trends Neurosci 33: 67-75 doi:10.1016/J.Tins.2009.11.003.
    • (2010) Trends Neurosci , vol.33 , pp. 67-75
    • Hoeffer, C.A.1    Klann, E.2
  • 56
    • 84865525400 scopus 로고    scopus 로고
    • Chronic inhibition of mammalian target of rapamycin by rapamycin modulates cognitive and non-cognitive components of behavior throughout lifespan in mice
    • doi:10.1016/J.Neuroscience.2012.06.054
    • Halloran J, Hussong SA, Burbank R, Podlutskaya N, Fischer KE, et al. (2012) Chronic inhibition of mammalian target of rapamycin by rapamycin modulates cognitive and non-cognitive components of behavior throughout lifespan in mice. Neuroscience 223: 102-113 doi:10.1016/J.Neuroscience.2012.06.054.
    • (2012) Neuroscience , vol.223 , pp. 102-113
    • Halloran, J.1    Hussong, S.A.2    Burbank, R.3    Podlutskaya, N.4    Fischer, K.E.5
  • 57
    • 69449084089 scopus 로고    scopus 로고
    • Rapamycin activation of 4E-BP prevents parkinsonian dopaminergic neuron loss
    • doi:10.1038/Nn.2372
    • Tain LS, Mortiboys H, Tao RN, Ziviani E, Bandmann O, et al. (2009) Rapamycin activation of 4E-BP prevents parkinsonian dopaminergic neuron loss. Nat Neurosci 12: 1129-U13 doi:10.1038/Nn.2372.
    • (2009) Nat Neurosci , vol.12 , pp. 1113-1129
    • Tain, L.S.1    Mortiboys, H.2    Tao, R.N.3    Ziviani, E.4    Bandmann, O.5
  • 59
    • 0347948474 scopus 로고    scopus 로고
    • Extensive and divergent effects of sleep and wakefulness on brain gene expression
    • doi:10.1016/S0896-6273(03)00814-6
    • Cirelli C, Gutierrez CM, Tononi G, (2004) Extensive and divergent effects of sleep and wakefulness on brain gene expression. Neuron 41: 35-43 doi:10.1016/S0896-6273(03)00814-6.
    • (2004) Neuron , vol.41 , pp. 35-43
    • Cirelli, C.1    Gutierrez, C.M.2    Tononi, G.3
  • 60
    • 34247560334 scopus 로고    scopus 로고
    • Multiple mechanisms limit the duration of wakefulness in Drosophila brain
    • doi:10.1152/Physiolgenomics.00030.2006
    • Zimmerman JE, Rizzo W, Shockley KR, Raizen DM, Naidoo N, et al. (2006) Multiple mechanisms limit the duration of wakefulness in Drosophila brain. Physiol Genomics 27: 337-350 doi:10.1152/Physiolgenomics.00030.2006.
    • (2006) Physiol Genomics , vol.27 , pp. 337-350
    • Zimmerman, J.E.1    Rizzo, W.2    Shockley, K.R.3    Raizen, D.M.4    Naidoo, N.5
  • 61
    • 36248934760 scopus 로고    scopus 로고
    • Macromolecule biosynthesis: a key function of sleep
    • doi:10.1152/physiolgenomics.00275.2006
    • Mackiewicz M, Shockley KR, Romer MA, Galante RJ, Zimmerman JE, et al. (2007) Macromolecule biosynthesis: a key function of sleep. Physiol Genomics 31: 441-457 doi:10.1152/physiolgenomics.00275.2006.
    • (2007) Physiol Genomics , vol.31 , pp. 441-457
    • Mackiewicz, M.1    Shockley, K.R.2    Romer, M.A.3    Galante, R.J.4    Zimmerman, J.E.5
  • 62
    • 37849005927 scopus 로고    scopus 로고
    • Administration of the protein synthesis inhibitor, anisomycin, has distinct sleep-promoting effects in lateral preoptic and perifornical hypothalamic sites in rats
    • doi:10.1016/J.Neuroscience.2007.09.051
    • Methippara MM, Alam MN, Kumar S, Bashir T, Szymusiak R, et al. (2008) Administration of the protein synthesis inhibitor, anisomycin, has distinct sleep-promoting effects in lateral preoptic and perifornical hypothalamic sites in rats. Neuroscience 151: 1-11 doi:10.1016/J.Neuroscience.2007.09.051.
    • (2008) Neuroscience , vol.151 , pp. 1-11
    • Methippara, M.M.1    Alam, M.N.2    Kumar, S.3    Bashir, T.4    Szymusiak, R.5
  • 63
    • 67349284303 scopus 로고    scopus 로고
    • Enhanced dopamine D1 and D2 receptor gene expression in the hippocampus of hypoglycaemic and diabetic rats
    • doi:10.1007/S10571-008-9328-4
    • Robinson R, Krishnakumar A, Paulose CS, (2009) Enhanced dopamine D1 and D2 receptor gene expression in the hippocampus of hypoglycaemic and diabetic rats. Cell Mol Neurobiol 29: 365-372 doi:10.1007/S10571-008-9328-4.
    • (2009) Cell Mol Neurobiol , vol.29 , pp. 365-372
    • Robinson, R.1    Krishnakumar, A.2    Paulose, C.S.3
  • 64
    • 0035283399 scopus 로고    scopus 로고
    • Dopaminergic role in stimulant-induced wakefulness
    • Wisor JP, Nishino S, Sora I, Uhl GH, Mignot E, et al. (2001) Dopaminergic role in stimulant-induced wakefulness. J Neurosci 21: 1787-1794.
    • (2001) J Neurosci , vol.21 , pp. 1787-1794
    • Wisor, J.P.1    Nishino, S.2    Sora, I.3    Uhl, G.H.4    Mignot, E.5
  • 66
    • 0037221587 scopus 로고    scopus 로고
    • Selective decreases in amphetamine self-administration and regulation of dopamine transporter function in diabetic rats
    • Galici R, Galli A, Jones DJ, Sanchez TA, Saunders C, et al. (2003) Selective decreases in amphetamine self-administration and regulation of dopamine transporter function in diabetic rats. Neuroendocrinology 77: 132-140.
    • (2003) Neuroendocrinology , vol.77 , pp. 132-140
    • Galici, R.1    Galli, A.2    Jones, D.J.3    Sanchez, T.A.4    Saunders, C.5
  • 67
    • 22344431879 scopus 로고    scopus 로고
    • Akt is essential for insulin modulation of amphetamine-induced human dopamine transporter cell-surface redistribution
    • doi:10.1124/mol.104.009092
    • Garcia BG, Wei Y, Moron JA, Lin RZ, Javitch JA, et al. (2005) Akt is essential for insulin modulation of amphetamine-induced human dopamine transporter cell-surface redistribution. Mol Pharmacol 68: 102-109 doi:10.1124/mol.104.009092.
    • (2005) Mol Pharmacol , vol.68 , pp. 102-109
    • Garcia, B.G.1    Wei, Y.2    Moron, J.A.3    Lin, R.Z.4    Javitch, J.A.5
  • 68
    • 35648964732 scopus 로고    scopus 로고
    • Hypoinsulinemia regulates amphetamine-induced reverse transport of dopamine
    • doi:10.1371/journal.pbio.0050274
    • Williams JM, Owens WA, Turner GH, Saunders C, Dipace C, et al. (2007) Hypoinsulinemia regulates amphetamine-induced reverse transport of dopamine. PLoS Biol 5: e274 doi:10.1371/journal.pbio.0050274.
    • (2007) PLoS Biol , vol.5
    • Williams, J.M.1    Owens, W.A.2    Turner, G.H.3    Saunders, C.4    Dipace, C.5
  • 69
    • 78650757798 scopus 로고    scopus 로고
    • Inhibition of the mammalian target of rapamycin pathway by rapamycin blocks cocaine-induced locomotor sensitization
    • doi:10.1016/J.Neuroscience.2010.10.041
    • Wu J, McCallum SE, Glick SD, Huang Y, (2011) Inhibition of the mammalian target of rapamycin pathway by rapamycin blocks cocaine-induced locomotor sensitization. Neuroscience 172: 104-109 doi:10.1016/J.Neuroscience.2010.10.041.
    • (2011) Neuroscience , vol.172 , pp. 104-109
    • Wu, J.1    McCallum, S.E.2    Glick, S.D.3    Huang, Y.4
  • 71
    • 4344563878 scopus 로고    scopus 로고
    • Role and regulation of starvation-induced autophagy in the Drosophila fat body
    • doi:10.1016/j.devcel.2004.07.009
    • Scott RC, Schuldiner O, Neufeld TP, (2004) Role and regulation of starvation-induced autophagy in the Drosophila fat body. Dev Cell 7: 167-178 doi:10.1016/j.devcel.2004.07.009.
    • (2004) Dev Cell , vol.7 , pp. 167-178
    • Scott, R.C.1    Schuldiner, O.2    Neufeld, T.P.3
  • 72
    • 34250306022 scopus 로고    scopus 로고
    • Dual lipolytic control of body fat storage and mobilization in Drosophila
    • doi:10.1371/journal.pbio.0050137
    • Gronke S, Muller G, Hirsch J, Fellert S, Andreou A, et al. (2007) Dual lipolytic control of body fat storage and mobilization in Drosophila. PLoS Biol 5: e137 doi:10.1371/journal.pbio.0050137.
    • (2007) PLoS Biol , vol.5
    • Gronke, S.1    Muller, G.2    Hirsch, J.3    Fellert, S.4    Andreou, A.5
  • 73
    • 34248592705 scopus 로고    scopus 로고
    • Monitoring and analyzing Drosophila circadian locomotor activity
    • doi:10.1007/978-1-59745-257-1_4
    • Zordan MA, Benna C, Mazzotta G, (2007) Monitoring and analyzing Drosophila circadian locomotor activity. Methods Mol Biol 362: 67-81 doi:_10.1007/978-1-59745-257-1_4.
    • (2007) Methods Mol Biol , vol.362 , pp. 67-81
    • Zordan, M.A.1    Benna, C.2    Mazzotta, G.3
  • 74
    • 27644525016 scopus 로고    scopus 로고
    • Sulphonylurea sensitivity and enriched expression implicate inward rectifier K+ channels in Drosophila melanogaster renal function
    • doi:10.1242/jeb.01829
    • Evans JM, Allan AK, Davies SA, Dow JA, (2005) Sulphonylurea sensitivity and enriched expression implicate inward rectifier K+ channels in Drosophila melanogaster renal function. J Exp Biol 208: 3771-3783 doi:10.1242/jeb.01829.
    • (2005) J Exp Biol , vol.208 , pp. 3771-3783
    • Evans, J.M.1    Allan, A.K.2    Davies, S.A.3    Dow, J.A.4
  • 75
    • 0014662714 scopus 로고
    • Absence of a life-shortening effect of amino-acid analogues on adult Drosophila
    • Dingley F, Smith JM, (1969) Absence of a life-shortening effect of amino-acid analogues on adult Drosophila. Exp Gerontol 4: 145-149.
    • (1969) Exp Gerontol , vol.4 , pp. 145-149
    • Dingley, F.1    Smith, J.M.2


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