A glucagon-like endocrine pathway in Drosophila modulates both lipid and carbohydrate homeostasis

Journal of Experimental Biology

Volumn 211, Issue 19, 2008, Pages 3103-3110

  Bharucha, K N ^a   Tarr, P ^b   Zipursky, S L ^b  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

AKHR; Fat body; Obesity

Indexed keywords

AKHR PROTEIN, DROSOPHILA; DROSOPHILA PROTEIN; GLUCAGON RECEPTOR;

ANIMAL; ARTICLE; CARBOHYDRATE METABOLISM; DROSOPHILA; FAT BODY; GENE EXPRESSION REGULATION; GENETICS; HOMEOSTASIS; LIPID METABOLISM; METABOLISM; MOTOR ACTIVITY; PHENOTYPE; PHYSIOLOGY; SENSORY NERVE CELL; SIGNAL TRANSDUCTION; STARVATION; TASTE;

ANIMALS; CARBOHYDRATE METABOLISM; DROSOPHILA; DROSOPHILA PROTEINS; FAT BODY; HOMEOSTASIS; LIPID METABOLISM; MOTOR ACTIVITY; MUTAGENESIS, INSERTIONAL; NEURONS, AFFERENT; PHENOTYPE; RECEPTORS, GLUCAGON; SIGNAL TRANSDUCTION; STARVATION; TASTE;

MAMMALIA;

EID: 55549143025     PISSN: 00220949     EISSN: None     Source Type: Journal    
DOI: 10.1242/jeb.016451     Document Type: Article

References (51)

1. Aguila, J. R., Suszko, J., Gibbs, A. G. and Hoshizaki, D. K. (2007). The role of larval fat cells in adult Drosophila melanogaster. J. Exp. Biol. 210, 956-963.
2. Amrein, H. and Thorne, N. (2005). Gustatory perception and behavior in Drosophila melanogaster. Curr. Biol. 15, R673-R684.
3. Baker, K. D. and Thummel, C. S. (2007). Diabetic larvae and obese flies-emerging studies of metabolism in Drosophila. Cell Metab. 6, 257-266.
4. Baldal, E. A., Brakefield, P. M. and Zwaan, B. J. (2006). Multitrait evolution in lines of Drosophila melanogaster selected for increased starvation resistance: the role of metabolic rate and implications for the evolution of longevity. Evol. Int. J. Org. Evol. 60, 1435-1444.
5. Canavoso, L. E., Jouni, Z. E., Karnas, K. J., Pennington, J. E. and Wells, M. A. (2001). Fat metabolism in insects. Annu. Rev. Nutr. 21, 23-46.
6. Conarello, S. L., Jiang, G., Mu, J., Li, Z., Woods, J., Zycband, E., Ronan, J., Liu, F., Roy, R. S., Zhu, L. et al. (2007). Glucagon receptor knockout mice are resistant to diet-induced obesity and streptozotocin-mediated beta cell loss and hyperglycaemia. Diabetologia 50, 142-150.
7. De Robertis, E. M. and Sasai, Y. (1996). A common plan for dorsoventral patterning in Bilateria. Nature 380, 37-40.
8. Djawdan, M., Chippindale, A. K., Rose, M. R. and Bradley, T. J. (1998). Metabolic reserves and evolved stress resistance in Drosophila melanogaster. Physiol. Zool. 71, 584-594.
9. Drucker, D. J. (2001). Minireview: the glucagon-like peptides. Endocrinology 142, 521-527.
10. French, V., Feast, M. and Partridge, L. (1998). Body size and cell size in Drosophila: the developmental response to temperature. J. Insect Physiol. 44, 1081-1089.
11. Gade, G. and Auerswald, L. (2003). Mode of action of neuropeptides from the adipokinetic hormone family. Gen. Comp. Endocrinol. 132, 10-20.
12. Garofalo, R. S. (2002). Genetic analysis of insulin signaling in Drosophila. Trends Endocrinol. Metab. 13, 156-162.
13. Gelling, R. W., Du, X. Q., Dichmann, D. S., Romer, J., Huang, H., Cui, L., Obici, S., Tang, B., Holst, J. J., Fledelius, C. et al. (2003). Lower blood glucose, hyperglucagonemia, and pancreatic alpha cell hyperplasia in glucagon receptor knockout mice. Proc. Natl. Acad. Sci. USA 100, 1438-1443.
14. Geminard, C., Arquier, N., Layalle, S., Bourouis, M., Slaidina, M., Delanoue, R., Bjordal, M., Ohanna, M., Ma, M., Colombani, J. et al. (2006). Control of metabolism and growth through insulin-like peptides in Drosophila. Diabetes 55 Suppl. 2, S5-S8.
15. Goberdhan, D. C. and Wilson, C. (2003). The functions of insulin signaling: size isn't everything, even in Drosophila. Differentiation 71, 375-397.
16. Gronke, S., Mildner, A., Fellert, S., Tennagels, N., Petry, S., Muller, G., Jackle, H. and Kuhnlein, R. P. (2005). Brummer lipase is an evolutionary conserved fat storage regulator in Drosophila. Cell Metab. 1, 323-330.
17. Gronke, S., Muller, G., Hirsch, J., Fellert, S., Andreou, A., Haase, T., Jackle, H. and Kuhnlein, R. P. (2007). Dual lipolytic control of body fat storage and mobilization in Drosophila. PLoS Biol. 5, e137.
18. Hader, T., Muller, S., Aguilera, M., Eulenberg, K. G., Steuernagel, A., Ciossek, T., Kuhnlein, R. P., Lemaire, L., Fritsch, R., Dohrmann, C. et al. (2003). Control of triglyceride storage by a WD40/TPR-domain protein. EMBO Rep. 4, 511-516.
19. Hoffmann, A. A. and Harshman, L. G. (1999). Desiccation and starvation resistance in Drosophila: patterns of variation at the species, population and intrapopulation levels. Heredity 83, 637-643.
20. Hoffmann, A. A. and Weeks, A. R. (2007). Climatic selection on genes and traits after a 100 year-old invasion: a critical look at the temperate-tropical clines in Drosophila melanogaster from eastern Australia. Genetica 129, 133-147.
21. Isabel, G., Martin, J. R., Chidami, S., Veenstra, J. A. and Rosay, P. (2005). AKH-producing neuroendocrine cell ablation decreases trehalose and induces behavioral changes in Drosophila. Am. J. Physiol. Regul. Integr. Comp. Physiol. 288, R531-R538.
22. Jones, W. D., Cayirlioglu, P., Kadow, I. G. and Vosshall, L. B. (2007). Two chemosensory receptors together mediate carbon dioxide detection in Drosophila. Nature 445, 86-90.
23. Kim, S. K. and Rulifson, E. J. (2004). Conserved mechanisms of glucose sensing and regulation by Drosophila corpora cardiaca cells. Nature 431, 316-320.
24. Kulkarni, M. M. and Perrimon, N. (2005). Super-size flies. Cell Metab. 1, 288-290.
25. Lasko, P. (2002). Diabetic flies? Using Drosophila melanogaster to understand the causes of monogenic and genetically complex diseases. Clin. Genet. 62, 358-367.
26. Lazareva, A. A., Roman, G., Mattox, W., Hardin, P. E. and Dauwalder, B. (2007). A role for the adult fat body in Drosophila male courtship behavior. PLoS Genet. 3, e16.
27. Lee, G. and Park, J. H. (2004). Hemolymph sugar homeostasis and starvation-induced hyperactivity affected by genetic manipulations of the adipokinetic hormone-encoding gene in Drosophila melanogaster. Genetics 167, 311-323.
28. Leopold, P. and Perrimon, N. (2007). Drosophila and the genetics of the internal milieu. Nature 450, 186-188.
29. Libert, S., Chao, Y., Chu, X. and Pletcher, S. D. (2006). Trade-offs between longevity and pathogen resistance in Drosophila melanogaster are mediated by NFkappaB signaling. Aging Cell 5, 533-543.
30. Libert, S., Zwiener, J., Chu, X., Vanvoorhies, W., Roman, G. and Pletcher, S. D. (2007). Regulation of Drosophila life span by olfaction and food-derived odors. Science 315, 1133-1137.
31. Melcher, C. and Pankratz, M. J. (2005). Candidate gustatory interneurons modulating feeding behavior in the Drosophila brain. PLoS Biol. 3, e305.
32. Montooth, K. L., Marden, J. H. and Clark, A. G. (2003). Mapping determinants of variation in energy metabolism, respiration and flight in Drosophila. Genetics 165, 623-635.
33. Murphy, K. G. and Bloom, S. R. (2006). Gut hormones and the regulation of energy homeostasis. Nature 444, 854-859.
34. Neel, J. V. (1962). Diabetes mellitus: a "thrifty" genotype rendered detrimental by "progress"? Am. J. Hum. Genet. 14, 353-362.
35. Nern, A., Nguyen, L. V., Herman, T., Prakash, S., Clandinin, T. R. and Zipursky, S. L. (2005). An isoform-specific allele of Drosophila N-cadherin disrupts a late step of R7 targeting. Proc. Natl. Acad. Sci. USA 102, 12944-12949.
36. Orgad, S., Dudai, Y. and Cohen, P. (1987). The protein phosphatases of Drosophila melanogaster and their inhibitors. Eur. J. Biochem. 164, 31-38.
37. Park, Y., Kim, Y. J. and Adams, M. E. (2002). Identification of G protein-coupled receptors for Drosophila PRXamide peptides, CCAP, corazonin, and AKH supports a theory of ligand-receptor coevolution. Proc. Natl. Acad. Sci. USA 99, 11423-11428.
38. Parker, J. C., Andrews, K. M., Allen, M. R., Stock, J. L. and McNeish, J. D. (2002). Glycemic control in mice with targeted disruption of the glucagon receptor gene. Biochem. Biophys. Res. Commun. 290, 839-843.
39. Reaume, C. J. and Sokolowski, M. B. (2006). The nature of Drosophila melanogaster. Curr. Biol. 16, R623-R628.
40. Ruden, D. M., De Luca, M., Garfinkel, M. D., Bynum, K. L. and Lu, X. (2005). Drosophila nutrigenomics can provide clues to human gene-nutrient interactions. Annu. Rev. Nutr. 25, 499-522.
41. Rulifson, E. J., Kim, S. K. and Nusse, R. (2002). Ablation of insulin-producing neurons in flies: growth and diabetic phenotypes. Science 296, 1118-1120.
42. Ryder, E. and Russell, S. (2003). Transposable elements as tools for genomics and genetics in Drosophila. Brief. Funct. Genomic. Proteomic. 2, 57-71.
43. Schwartz, M. W. and Porte, D., Jr (2005). Diabetes, obesity, and the brain. Science 307, 375-379.
44. Scott, K. (2005). Taste recognition: food for thought. Neuron 48, 455-464.
45. Speakman, J. R. (2004). Obesity: the integrated roles of environment and genetics. J. Nutr. 134, 2090S-2105S.
46. Staubli, F., Jorgensen, T. J., Cazzamali, G., Williamson, M., Lenz, C., Sondergaard, L., Roepstorff, P. and Grimmelikhuijzen, C. J. (2002). Molecular identification of the insect adipokinetic hormone receptors. Proc. Natl. Acad. Sci. USA 99, 3446-3451.
47. Unson, C. G. (2002). Molecular determinants of glucagon receptor signaling. Biopolymers 66, 218-235.
48. Van der Horst, D. J. (2003). Insect adipokinetic hormones: release and integration of flight energy metabolism. Comp. Biochem. Physiol. B, Biochem. Mol. Biol. 136, 217-226.
49. Wang, Z., Singhvi, A., Kong, P. and Scott, K. (2004). Taste representations in the Drosophila brain. Cell 117, 981-991.
50. Wu, Q. and Brown, M. R. (2006). Signaling and function of insulin-like peptides in insects. Annu. Rev. Entomol. 51, 1-24.
51. Wu, Q., Zhao, Z. and Shen, P. (2005). Regulation of aversion to noxious food by Drosophila neuropeptide Y- and insulin-like systems. Nat. Neurosci. 8, 1350-1355.