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Volumn 6, Issue 2, 2014, Pages 229-238

Personalized medicine and type 2 diabetes: Lesson from epigenetics

Author keywords

epigenetics; histone modifications; methylation; miRNA; personalized medicine; Type 2 diabetes

Indexed keywords

CYTOCHROME P450 1A1; CYTOCHROME P450 1A2; ORAL ANTIDIABETIC AGENT; ANTIDIABETIC AGENT; HISTONE;

EID: 84900431394     PISSN: 17501911     EISSN: 1750192X     Source Type: Journal    
DOI: 10.2217/epi.14.10     Document Type: Review
Times cited : (36)

References (95)
  • 1
    • 79960202841 scopus 로고    scopus 로고
    • Type 2 diabetes across generations: From pathophysiology to prevention and management
    • Nolan CJ, Damm P, Prentki M. Type 2 diabetes across generations: from pathophysiology to prevention and management. Lancet 378(9786), 169-181 (2011).
    • (2011) Lancet , vol.378 , Issue.9786 , pp. 169-181
    • Nolan, C.J.1    Damm, P.2    Prentki, M.3
  • 2
    • 84871281809 scopus 로고    scopus 로고
    • International Diabetes Federation (5th Edition)
    • International Diabetes Federation. Diabetes Atlas (5th Edition) (2012).www.idf.org/sites/default/files/5E-IDFAtlasPoster-2012-EN.pdf
    • (2012) Diabetes Atlas
  • 3
    • 77951630215 scopus 로고    scopus 로고
    • Individualizing therapies in Type 2 diabetes mellitus based on patient characteristics: What we know and what we need to know
    • Smith RJ, Nathan DM, Arslanian SA, Groop L, Rizza RA, Rotter JI. Individualizing therapies in Type 2 diabetes mellitus based on patient characteristics: what we know and what we need to know. J. Clin. Endocrinol. Metab. 95(4), 1566-1574 (2010).
    • (2010) J. Clin. Endocrinol. Metab. , vol.95 , Issue.4 , pp. 1566-1574
    • Smith, R.J.1    Nathan, D.M.2    Arslanian, S.A.3    Groop, L.4    Rizza, R.A.5    Rotter, J.I.6
  • 4
    • 79551489208 scopus 로고    scopus 로고
    • Personalized medicine in diabetes
    • Malandrino N, Smith RJ. Personalized medicine in diabetes. Clin. Chem. 57(2), 231-240 (2011).
    • (2011) Clin. Chem. , vol.57 , Issue.2 , pp. 231-240
    • Malandrino, N.1    Smith, R.J.2
  • 5
    • 84869503599 scopus 로고    scopus 로고
    • The genetic and epigenetic basis of Type 2 diabetes and obesity
    • Drong AW, Lindgren CM, McCarthy MI. The genetic and epigenetic basis of Type 2 diabetes and obesity. Clin. Pharmacol. Ther. 92(6), 707-715 (2012).
    • (2012) Clin. Pharmacol. Ther. , vol.92 , Issue.6 , pp. 707-715
    • Drong, A.W.1    Lindgren, C.M.2    McCarthy, M.I.3
  • 6
    • 79960016921 scopus 로고    scopus 로고
    • Type 2 diabetes and obesity: Genomics and the clinic
    • Travers ME, McCarthy MI. Type 2 diabetes and obesity: genomics and the clinic. Hum. Genet. 130(1), 41-58 (2011).
    • (2011) Hum. Genet. , vol.130 , Issue.1 , pp. 41-58
    • Travers, M.E.1    McCarthy, M.I.2
  • 7
  • 8
    • 84876784115 scopus 로고    scopus 로고
    • Epigenetic flexibility in metabolic regulation: Disease cause and prevention?
    • Kirchner H, Osler ME, Krook A, Zierath JR. Epigenetic flexibility in metabolic regulation: disease cause and prevention? Trends Cell Biol. 23(5), 203-209 (2013).
    • (2013) Trends Cell Biol. , vol.23 , Issue.5 , pp. 203-209
    • Kirchner, H.1    Osler, M.E.2    Krook, A.3    Zierath, J.R.4
  • 9
    • 84889099226 scopus 로고    scopus 로고
    • Genetic and epigenetic control of metabolic health
    • Schwenk RW, Vogel H, Schürmann A. Genetic and epigenetic control of metabolic health. Mol. Metab. 2(4), 337-347 (2013).
    • (2013) Mol. Metab. , vol.2 , Issue.4 , pp. 337-347
    • Schwenk, R.W.1    Vogel, H.2    Schürmann, A.3
  • 10
    • 84871158061 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor-γ activation enhances insulin-stimulated glucose disposal by reducing ped/pea-15 gene expression in skeletal muscle cells: Evidence for involvement of activator protein-1
    • Ungaro P, Mirra P, Oriente F et al. Peroxisome proliferator-activated receptor-γ activation enhances insulin-stimulated glucose disposal by reducing ped/pea-15 gene expression in skeletal muscle cells: evidence for involvement of activator protein-1. J. Biol. Chem. 287(51), 42951-42961 (2012).
    • (2012) J. Biol. Chem. , vol.287 , Issue.51 , pp. 42951-42961
    • Ungaro, P.1    Mirra, P.2    Oriente, F.3
  • 11
    • 57649183467 scopus 로고    scopus 로고
    • Molecular cloning and characterization of the human PED/PEA-15 gene promoter reveal antagonistic regulation by hepatocyte nuclear factor 4alpha and chicken ovalbumin upstream promoter transcription factor II
    • Ungaro P, Teperino R, Mirra P et al. Molecular cloning and characterization of the human PED/PEA-15 gene promoter reveal antagonistic regulation by hepatocyte nuclear factor 4alpha and chicken ovalbumin upstream promoter transcription factor II. J. Biol. Chem. 283(45), 30970-30979 (2008).
    • (2008) J. Biol. Chem. , vol.283 , Issue.45 , pp. 30970-30979
    • Ungaro, P.1    Teperino, R.2    Mirra, P.3
  • 12
    • 51349121084 scopus 로고    scopus 로고
    • Prep1 deficiency induces protection from diabetes and increased insulin sensitivity through a p160-mediated mechanism
    • Oriente F, Fernandez Diaz LC, Miele C et al. Prep1 deficiency induces protection from diabetes and increased insulin sensitivity through a p160-mediated mechanism. Mol. Cell. Biol. 28(18), 5634-5645 (2008).
    • (2008) Mol. Cell. Biol. , vol.28 , Issue.18 , pp. 5634-5645
    • Oriente, F.1    Fernandez Diaz, L.C.2    Miele, C.3
  • 13
    • 78751474014 scopus 로고    scopus 로고
    • Prep1 controls insulin glucoregulatory function in liver by transcriptional targeting of SHP1 tyrosine phosphatase
    • Oriente F, Iovino S, Cabaro S et al. Prep1 controls insulin glucoregulatory function in liver by transcriptional targeting of SHP1 tyrosine phosphatase. Diabetes 60(1), 138-147 (2011).
    • (2011) Diabetes , vol.60 , Issue.1 , pp. 138-147
    • Oriente, F.1    Iovino, S.2    Cabaro, S.3
  • 14
    • 84887947462 scopus 로고    scopus 로고
    • PREP1 deficiency downregulates hepatic lipogenesis and attenuates steatohepatitis in mice
    • Oriente F, Cabaro S, Liotti A et al. PREP1 deficiency downregulates hepatic lipogenesis and attenuates steatohepatitis in mice. Diabetologia 56(12), 2713-2722 (2013).
    • (2013) Diabetologia , vol.56 , Issue.12 , pp. 2713-2722
    • Oriente, F.1    Cabaro, S.2    Liotti, A.3
  • 15
    • 35448985442 scopus 로고    scopus 로고
    • The dynamic epigenome and its implications in toxicology
    • DOI 10.1093/toxsci/kfm177
    • Szyf M. The dynamic epigenome and its implications in toxicology. Toxicol. Sci. 100(1), 7-23 (2007). (Pubitemid 47617798)
    • (2007) Toxicological Sciences , vol.100 , Issue.1 , pp. 7-23
    • Szyf, M.1
  • 16
    • 78650694320 scopus 로고    scopus 로고
    • Epigenetics: Mechanisms and implications for diabetic complications
    • Cooper ME, El-Osta A. Epigenetics: mechanisms and implications for diabetic complications. Circ. Res. 107(12), 1403-1413 (2010).
    • (2010) Circ. Res. , vol.107 , Issue.12 , pp. 1403-1413
    • Cooper, M.E.1    El-Osta, A.2
  • 17
    • 84884562282 scopus 로고    scopus 로고
    • Epigenetic signatures and vascular risk in Type 2 diabetes: A clinical perspective
    • Paneni F, Costantino S, Volpe M, Lüscher TF, Cosentino F. Epigenetic signatures and vascular risk in Type 2 diabetes: a clinical perspective. Atherosclerosis 230(2), 191-197 (2013).
    • (2013) Atherosclerosis , vol.230 , Issue.2 , pp. 191-197
    • Paneni, F.1    Costantino, S.2    Volpe, M.3    Lüscher, T.F.4    Cosentino, F.5
  • 18
    • 77958596171 scopus 로고    scopus 로고
    • Chronic high-fat diet in fathers programs β-cell dysfunction in female rat offspring
    • Ng SF, Lin RC, Laybutt DR, Barres R, Owens JA, Morris MJ. Chronic high-fat diet in fathers programs β-cell dysfunction in female rat offspring. Nature 467(7318), 963-966 (2010).
    • (2010) Nature , vol.467 , Issue.7318 , pp. 963-966
    • Ng, S.F.1    Lin, R.C.2    Laybutt, D.R.3    Barres, R.4    Owens, J.A.5    Morris, M.J.6
  • 19
    • 84855400734 scopus 로고    scopus 로고
    • Genome-wide survey reveals predisposing diabetes Type 2-related DNA methylation variations in human peripheral blood
    • Toperoff G, Aran D, Kark JD et al. Genome-wide survey reveals predisposing diabetes Type 2-related DNA methylation variations in human peripheral blood. Hum. Mol. Genet. 21(2), 371-383 (2012).
    • (2012) Hum. Mol. Genet. , vol.21 , Issue.2 , pp. 371-383
    • Toperoff, G.1    Aran, D.2    Kark, J.D.3
  • 20
    • 79952113300 scopus 로고    scopus 로고
    • Nucleosome dynamics and epigenetic stability
    • Korber P, Becker PB. Nucleosome dynamics and epigenetic stability. Essays Biochem. 48(1), 63-74 (2010).
    • (2010) Essays Biochem. , vol.48 , Issue.1 , pp. 63-74
    • Korber, P.1    Becker, P.B.2
  • 21
    • 84863986133 scopus 로고    scopus 로고
    • Functions of DNA methylation: Islands, start sites, gene bodies and beyond
    • Jones PA. Functions of DNA methylation: islands, start sites, gene bodies and beyond. Nat. Rev. Genet. 13(7), 484-492 (2012).
    • (2012) Nat. Rev. Genet. , vol.13 , Issue.7 , pp. 484-492
    • Jones, P.A.1
  • 22
    • 0036241916 scopus 로고    scopus 로고
    • Molecular mechanisms of gene silencing mediated by DNA methylation
    • DOI 10.1128/MCB.22.9.3157-3173.2002
    • Curradi M, Izzo A, Badaracco G, Landsberger N. Molecular mechanisms of gene silencing mediated by DNA methylation. Mol. Cell. Biol. 22(9), 3157-3173 (2002). (Pubitemid 34437474)
    • (2002) Molecular and Cellular Biology , vol.22 , Issue.9 , pp. 3157-3173
    • Curradi, M.1    Izzo, A.2    Badaracco, G.3    Landsberger, N.4
  • 23
    • 33947536338 scopus 로고    scopus 로고
    • Simple histone acetylation plays a complex role in the regulation of gene expression
    • DOI 10.1093/bfgp/ell032
    • Fukuda H, Sano N, Muto S, Horikoshi M. Simple histone acetylation plays a complex role in the regulation of gene expression. Brief. Funct. Genomic Proteomic. 5(3), 190-208 (2006). (Pubitemid 46470220)
    • (2006) Briefings in Functional Genomics and Proteomics , vol.5 , Issue.3 , pp. 190-208
    • Fukuda, H.1    Sano, N.2    Muto, S.3    Horikoshi, M.4
  • 24
    • 0032030770 scopus 로고    scopus 로고
    • Histone acetylation and transcriptional regulatory mechanisms
    • Struhl K. Histone acetylation and transcriptional regulatory mechanisms. Genes Dev. 12(5), 599-606 (1998). (Pubitemid 28134293)
    • (1998) Genes and Development , vol.12 , Issue.5 , pp. 599-606
    • Struhl, K.1
  • 25
    • 33644910891 scopus 로고    scopus 로고
    • Exercise increases MEF2- and GEF DNA-binding activity in human skeletal muscle
    • DOI 10.1096/fj.05-4671fje
    • McGee SL, Sparling D, Olson AL, Hargreaves M. Exercise increases MEF2-and GEF DNA-binding activity in human skeletal muscle. FASEB J. 20(2), 348-349 (2006). (Pubitemid 46671167)
    • (2006) FASEB Journal , vol.20 , Issue.2 , pp. 348-349
    • McGee, S.L.1    Sparling, D.2    Olson, A.-L.3    Hargreaves, M.4
  • 26
    • 0035477471 scopus 로고    scopus 로고
    • Marathon running increases ERK1/2 and p38 MAP kinase signalling to downstream targets in human skeletal muscle
    • DOI 10.1111/j.1469-7793.2001.00273.x
    • Yu M, Blomstrand E, Chibalin AV, Krook A, Zierath JR. Marathon running increases ERK1/2 and p38 MAP kinase signalling to downstream targets in human skeletal muscle. J. Physiol. 536(Pt 1), 273-282 (2001). (Pubitemid 32952236)
    • (2001) Journal of Physiology , vol.536 , Issue.1 , pp. 273-282
    • Yu, M.1    Blomstrand, E.2    Chibalin, A.V.3    Krook, A.4    Zierath, J.R.5
  • 27
    • 55949134303 scopus 로고    scopus 로고
    • DNA methylomes, histone codes and miRNAs: Tying it all together
    • Guil S, Esteller M. DNA methylomes, histone codes and miRNAs: tying it all together. Int. J. Biochem. Cell. Biol. 41(1), 87-95 (2009).
    • (2009) Int. J. Biochem. Cell. Biol. , vol.41 , Issue.1 , pp. 87-95
    • Guil, S.1    Esteller, M.2
  • 28
    • 76749126233 scopus 로고    scopus 로고
    • A brief review on the mechanisms of miRNA regulation
    • Cai Y, Yu X, Hu S, Yu J. A brief review on the mechanisms of miRNA regulation. Genomics Proteomics Bioinformatics 7(4), 147-154 (2009).
    • (2009) Genomics Proteomics Bioinformatics , vol.7 , Issue.4 , pp. 147-154
    • Cai, Y.1    Yu, X.2    Hu, S.3    Yu, J.4
  • 29
    • 67749114140 scopus 로고    scopus 로고
    • Distinctive chromatin in human sperm packages genes for embryo development
    • Hammoud SS, Nix DA, Zhang H, Purwar J, Carrell DT, Cairns BR. Distinctive chromatin in human sperm packages genes for embryo development. Nature 460(7254), 473-478 (2009).
    • (2009) Nature , vol.460 , Issue.7254 , pp. 473-478
    • Hammoud, S.S.1    Nix, D.A.2    Zhang, H.3    Purwar, J.4    Carrell, D.T.5    Cairns, B.R.6
  • 30
    • 79956301666 scopus 로고    scopus 로고
    • Maternal high-fat diet effects on third-generation female body size via the paternal lineage
    • Dunn GA, Bale TL. Maternal high-fat diet effects on third-generation female body size via the paternal lineage. Endocrinology 152(6), 2228-2236 (2011).
    • (2011) Endocrinology , vol.152 , Issue.6 , pp. 2228-2236
    • Dunn, G.A.1    Bale, T.L.2
  • 31
    • 84863053794 scopus 로고    scopus 로고
    • Global DNA methylation is associated with insulin resistance: A monozygotic twin study
    • Zhao J, Goldberg J, Bremner JD, Vaccarino V. Global DNA methylation is associated with insulin resistance: a monozygotic twin study. Diabetes 61(2), 542-546 (2012).
    • (2012) Diabetes , vol.61 , Issue.2 , pp. 542-546
    • Zhao, J.1    Goldberg, J.2    Bremner, J.D.3    Vaccarino, V.4
  • 32
    • 41149172495 scopus 로고    scopus 로고
    • Epigenetic regulation of PPARGC1A in human Type 2 diabetic islets and effect on insulin secretion
    • Ling C, Del Guerra S, Lupi R et al. Epigenetic regulation of PPARGC1A in human Type 2 diabetic islets and effect on insulin secretion. Diabetologia 51(4), 615-622 (2008).
    • (2008) Diabetologia , vol.51 , Issue.4 , pp. 615-622
    • Ling, C.1    Del Guerra, S.2    Lupi, R.3
  • 33
    • 78951472134 scopus 로고    scopus 로고
    • Insulin promoter DNA methylation correlates negatively with insulin gene expression and positively with HbA(1c) levels in human pancreatic islets
    • Yang BT, Dayeh TA, Kirkpatrick CL et al. Insulin promoter DNA methylation correlates negatively with insulin gene expression and positively with HbA(1c) levels in human pancreatic islets. Diabetologia 54(2), 360-367 (2011).
    • (2011) Diabetologia , vol.54 , Issue.2 , pp. 360-367
    • Yang, B.T.1    Dayeh, T.A.2    Kirkpatrick, C.L.3
  • 34
    • 84858800629 scopus 로고    scopus 로고
    • DNA methylation profiling identifies epigenetic dysregulation in pancreatic islets from Type 2 diabetic patients
    • Volkmar M, Dedeurwaerder S, Cunha DA et al. DNA methylation profiling identifies epigenetic dysregulation in pancreatic islets from Type 2 diabetic patients. EMBO J. 31(6), 1405-1426 (2012).
    • (2012) EMBO J. , vol.31 , Issue.6 , pp. 1405-1426
    • Volkmar, M.1    Dedeurwaerder, S.2    Cunha, D.A.3
  • 35
    • 78649506925 scopus 로고    scopus 로고
    • Integrated genetic and epigenetic analysis identifies haplotype-specific methylation in the FTO Type 2 diabetes and obesity susceptibility locus
    • Bell CG, Finer S, Lindgren CM et al. Integrated genetic and epigenetic analysis identifies haplotype-specific methylation in the FTO Type 2 diabetes and obesity susceptibility locus. PLoS ONE 5(11), e14040 (2010).
    • (2010) PLoS ONE , vol.5 , Issue.11
    • Bell, C.G.1    Finer, S.2    Lindgren, C.M.3
  • 36
    • 84887391597 scopus 로고    scopus 로고
    • Restricted adipogenesis in hypertrophic obesity: The role of WISP2, WNT, and BMP4
    • Gustafson B, Hammarstedt A, Hedjazifar S, Smith U. Restricted adipogenesis in hypertrophic obesity: the role of WISP2, WNT, and BMP4. Diabetes 62(9), 2997-3004 (2013).
    • (2013) Diabetes , vol.62 , Issue.9 , pp. 2997-3004
    • Gustafson, B.1    Hammarstedt, A.2    Hedjazifar, S.3    Smith, U.4
  • 37
    • 77953503328 scopus 로고    scopus 로고
    • A chromatin perspective of adipogenesis
    • Musri MM, Gomis R, Párrizas M. A chromatin perspective of adipogenesis. Organogenesis 6(1), 15-23 (2010).
    • (2010) Organogenesis , vol.6 , Issue.1 , pp. 15-23
    • Musri, M.M.1    Gomis, R.2    Párrizas, M.3
  • 38
    • 79951774325 scopus 로고    scopus 로고
    • DNA methylation of genes in adipose tissue
    • Pinnick KE, Karpe F. DNA methylation of genes in adipose tissue. Proc. Nutr. Soc. 70(1), 57-63 (2011).
    • (2011) Proc. Nutr. Soc. , vol.70 , Issue.1 , pp. 57-63
    • Pinnick, K.E.1    Karpe, F.2
  • 39
    • 79953327099 scopus 로고    scopus 로고
    • Significance of serum microRNAs in pre-diabetes and newly diagnosed Type 2 diabetes: A clinical study
    • Kong L, Zhu J, Han W et al. Significance of serum microRNAs in pre-diabetes and newly diagnosed Type 2 diabetes: a clinical study. Acta Diabetol. (1), 61-69 (2011).
    • (2011) Acta Diabetol , vol.1 , pp. 61-69
    • Kong, L.1    Zhu, J.2    Han, W.3
  • 40
    • 77956863085 scopus 로고    scopus 로고
    • MicroRNA signature of the human developing pancreas
    • Rosero S, Bravo-Egana V, Jiang Z et al. MicroRNA signature of the human developing pancreas. BMC Genomics 11, 509 (2010).
    • (2010) BMC Genomics , vol.11 , pp. 509
    • Rosero, S.1    Bravo-Egana, V.2    Jiang, Z.3
  • 41
    • 65349144503 scopus 로고    scopus 로고
    • Epigenetic and microRNA-mediated regulation in diabetes
    • Muhonen P, Holthofer H. Epigenetic and microRNA-mediated regulation in diabetes. Nephrol. Dial. Transplant. 24(4), 1088-1096 (2009).
    • (2009) Nephrol. Dial. Transplant. , vol.24 , Issue.4 , pp. 1088-1096
    • Muhonen, P.1    Holthofer, H.2
  • 42
    • 61349122608 scopus 로고    scopus 로고
    • MicroRNA miR-7 is preferentially expressed in endocrine cells of the developing and adult human pancreas
    • Correa-Medina M, Bravo-Egana V, Rosero S et al. MicroRNA miR-7 is preferentially expressed in endocrine cells of the developing and adult human pancreas. Gene Expr. Patterns 9(4), 193-199 (2009).
    • (2009) Gene Expr. Patterns , vol.9 , Issue.4 , pp. 193-199
    • Correa-Medina, M.1    Bravo-Egana, V.2    Rosero, S.3
  • 43
    • 79952846843 scopus 로고    scopus 로고
    • Sirt1 and mir-9 expression is regulated during glucose-stimulated insulin secretion in pancreatic β-islets
    • Ramachandran D, Roy U, Garg S, Ghosh S, Pathak S, Kolthur-Seetharam U. Sirt1 and mir-9 expression is regulated during glucose-stimulated insulin secretion in pancreatic β-islets. FEBS J. 278(7), 1167-1174 (2011).
    • (2011) FEBS J. , vol.278 , Issue.7 , pp. 1167-1174
    • Ramachandran, D.1    Roy, U.2    Garg, S.3    Ghosh, S.4    Pathak, S.5    Kolthur-Seetharam, U.6
  • 44
    • 79951705428 scopus 로고    scopus 로고
    • The miR-30 family microRNAs confer epithelial phenotype to human pancreatic cells
    • Joglekar MV, Patil D, Joglekar VM et al. The miR-30 family microRNAs confer epithelial phenotype to human pancreatic cells. Islets 1(2), 137-147 (2009).
    • (2009) Islets , vol.1 , Issue.2 , pp. 137-147
    • Joglekar, M.V.1    Patil, D.2    Joglekar, V.M.3
  • 45
    • 65549144017 scopus 로고    scopus 로고
    • MicroRNAs induced during adipogenesis that accelerate fat cell development are downregulated in obesity
    • Xie H, Lim B, Lodish HF. MicroRNAs induced during adipogenesis that accelerate fat cell development are downregulated in obesity. Diabetes 58(5), 1050-1057 (2009).
    • (2009) Diabetes , vol.58 , Issue.5 , pp. 1050-1057
    • Xie, H.1    Lim, B.2    Lodish, H.F.3
  • 46
    • 77956276832 scopus 로고    scopus 로고
    • High glucose suppresses human islet insulin biosynthesis by inducing miR-133a leading to decreased polypyrimidine tract binding protein-expression
    • Fred RG, Bang-Berthelsen CH, Mandrup-Poulsen T, Grunnet LG, Welsh N. High glucose suppresses human islet insulin biosynthesis by inducing miR-133a leading to decreased polypyrimidine tract binding protein-expression. PLoS ONE 5(5), e10843 (2010).
    • (2010) PLoS ONE , vol.5 , Issue.5
    • Fred, R.G.1    Bang-Berthelsen, C.H.2    Mandrup-Poulsen, T.3    Grunnet, L.G.4    Welsh, N.5
  • 47
    • 65249093130 scopus 로고    scopus 로고
    • MiR-375 maintains normal pancreatic alpha-and beta-cell mass
    • Poy MN, Hausser J, Trajkovski M et al. miR-375 maintains normal pancreatic alpha-and beta-cell mass. Proc. Natl Acad. Sci. USA 106(14), 5813-5818 (2009).
    • (2009) Proc. Natl Acad. Sci. USA , vol.106 , Issue.14 , pp. 5813-5818
    • Poy, M.N.1    Hausser, J.2    Trajkovski, M.3
  • 48
    • 77957259803 scopus 로고    scopus 로고
    • Plasma microRNA profiling reveals loss of endothelial miR-126 and other microRNAs in Type 2 diabetes
    • Zampetaki A, Kiechl S, Drozdov I et al. Plasma microRNA profiling reveals loss of endothelial miR-126 and other microRNAs in Type 2 diabetes. Circ. Res. 107(6), 810-817 (2010).
    • (2010) Circ. Res. , vol.107 , Issue.6 , pp. 810-817
    • Zampetaki, A.1    Kiechl, S.2    Drozdov, I.3
  • 49
    • 80051766486 scopus 로고    scopus 로고
    • Pharmacogenomics of oral antidiabetic medications: Current data and pharmacoepigenomic perspective
    • Manolopoulos VG, Ragia G, Tavridou A. Pharmacogenomics of oral antidiabetic medications: current data and pharmacoepigenomic perspective. Pharmacogenomics 12(8), 1161-1191 (2011).
    • (2011) Pharmacogenomics , vol.12 , Issue.8 , pp. 1161-1191
    • Manolopoulos, V.G.1    Ragia, G.2    Tavridou, A.3
  • 50
    • 79251534433 scopus 로고    scopus 로고
    • Deregulation of microRNA-503 contributes to diabetes mellitus-induced impairment of endothelial function and reparative angiogenesis after limb ischemia
    • Caporali A, Meloni M, Völlenkle C et al. Deregulation of microRNA-503 contributes to diabetes mellitus-induced impairment of endothelial function and reparative angiogenesis after limb ischemia. Circulation 123(3), 282-291 (2011).
    • (2011) Circulation , vol.123 , Issue.3 , pp. 282-291
    • Caporali, A.1    Meloni, M.2    Völlenkle, C.3
  • 51
    • 77957820261 scopus 로고    scopus 로고
    • RNAi and small interfering RNAs in human disease therapeutic applications
    • Lares MR, Rossi JJ, Ouellet DL. RNAi and small interfering RNAs in human disease therapeutic applications. Trends Biotechnol. 28(11), 570-579 (2010).
    • (2010) Trends Biotechnol. , vol.28 , Issue.11 , pp. 570-579
    • Lares, M.R.1    Rossi, J.J.2    Ouellet, D.L.3
  • 53
    • 20344385787 scopus 로고    scopus 로고
    • Toxicology: Epigenetic transgenerational actions of endocrine disruptors and male fertility
    • DOI 10.1126/science.1108190
    • Anway MD, Cupp AS, Uzumcu M, Skinner MK. Epigenetic transgenerational actions of endocrine disruptors and male fertility. Science 308(5727), 1466-1469 (2005). Erratum in: Science 328(5979), 690 (2010). (Pubitemid 40791300)
    • (2005) Science , vol.308 , Issue.5727 , pp. 1466-1469
    • Anway, M.D.1    Cupp, A.S.2    Uzumcu, N.3    Skinner, M.K.4
  • 54
    • 0032751471 scopus 로고    scopus 로고
    • Epigenetic inheritance at the agouti locus in the mouse
    • DOI 10.1038/15490
    • Morgan HD, Sutherland HG, Martin DI, Whitelaw E. Epigenetic inheritance at the agouti locus in the mouse. Nat. Genet. 23(3), 314-318 (1999). (Pubitemid 29526429)
    • (1999) Nature Genetics , vol.23 , Issue.3 , pp. 314-318
    • Morgan, H.D.1    Sutherland, H.G.E.2    Martin, D.I.K.3    Whitelaw, E.4
  • 55
    • 0034928759 scopus 로고    scopus 로고
    • Maternal care, gene expression, and the transmission of individual differences in stress reactivity across generations
    • DOI 10.1146/annurev.neuro.24.1.1161
    • Meaney MJ. Maternal care, gene expression and the transmission of individual differences in stress reactivity across generations. Ann. Rev. Neurosci. 24, 1161-1192 (2001). (Pubitemid 32695257)
    • (2001) Annual Review of Neuroscience , vol.24 , pp. 1161-1192
    • Meaney, M.J.1
  • 56
    • 0033005713 scopus 로고    scopus 로고
    • Maternal care and the development of stress responses
    • DOI 10.1016/S0959-4388(99)80016-6
    • Francis DD, Meaney MJ. Maternal care and the development of stress responses. Curr. Opin. Neurobiol. 9(1), 128-134 (1999). (Pubitemid 29084099)
    • (1999) Current Opinion in Neurobiology , vol.9 , Issue.1 , pp. 128-134
    • Francis, D.D.1    Meaney, M.J.2
  • 59
    • 60749105468 scopus 로고    scopus 로고
    • Epigenetic regulation of glucocorticoid receptor in human brain associates with childhood abuse
    • McGowan PO, Sasaki A, D'Alessio AC et al. Epigenetic regulation of glucocorticoid receptor in human brain associates with childhood abuse. Nat. Neurosci. 12(3), 342-348 (2009).
    • (2009) Nat. Neurosci. , vol.12 , Issue.3 , pp. 342-348
    • McGowan, P.O.1    Sasaki, A.2    D'Alessio, A.C.3
  • 61
    • 46949090009 scopus 로고    scopus 로고
    • Rapid publication: The relationship of 5HTT (SLC6A4) methylation and genotype on mRNA expression and liability to major depression and alcohol dependence in subjects from the Iowa adoption studies
    • DOI 10.1002/ajmg.b.30657
    • Philibert RA, Sandhu H, Hollenbeck N, Gunter T, Adams W, Madan A. The relationship of 5HTT (SLC6A4) methylation and genotype on mRNA expression and liability to major depression and alcohol dependence in subjects from the Iowa Adoption Studies. Am. J. Med. Genet. B Neuropsychiatr. Genet. 147B(5), 543-549 (2008). (Pubitemid 351961655)
    • (2008) American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics , vol.147 , Issue.5 , pp. 543-549
    • Philibert, R.A.1    Sandhu, H.2    Hollenbeck, N.3    Gunter, T.4    Adams, W.5    Madan, A.6
  • 63
    • 69149087790 scopus 로고    scopus 로고
    • Non-CpG methylation of the PGC-1alpha promoter through DNMT3B controls mitochondrial density
    • Barrès R, Osler ME, Yan J et al. Non-CpG methylation of the PGC-1alpha promoter through DNMT3B controls mitochondrial density. Cell Metab. 10(3), 189-198 (2009).
    • (2009) Cell Metab. , vol.10 , Issue.3 , pp. 189-198
    • Barrès, R.1    Osler, M.E.2    Yan, J.3
  • 64
    • 79957851295 scopus 로고    scopus 로고
    • Gestational high fat diet programs hepatic phosphoenolpyruvate carboxykinase gene expression and histone modification in neonatal offspring rats
    • Strakovsky RS, Zhang X, Zhou D, Pan YX. Gestational high fat diet programs hepatic phosphoenolpyruvate carboxykinase gene expression and histone modification in neonatal offspring rats. J. Physiol. 589(Pt 11), 2707-2717 (2011).
    • (2011) J. Physiol. , vol.589 , Issue.PART 11 , pp. 2707-2717
    • Strakovsky, R.S.1    Zhang, X.2    Zhou, D.3    Pan, Y.X.4
  • 65
    • 84859221006 scopus 로고    scopus 로고
    • Vascular dysfunction induced in offspring by maternal dietary fat involves altered arterial polyunsaturated fatty acid biosynthesis
    • Kelsall CJ, Hoile SP, Irvine NA et al. Vascular dysfunction induced in offspring by maternal dietary fat involves altered arterial polyunsaturated fatty acid biosynthesis. PLoS ONE 7(4), e34492 (2012).
    • (2012) PLoS ONE , vol.7 , Issue.4
    • Kelsall, C.J.1    Hoile, S.P.2    Irvine, N.A.3
  • 66
    • 79955096234 scopus 로고    scopus 로고
    • Maternal diet and aging alter the epigenetic control of a promoter-enhancer interaction at the Hnf4a gene in rat pancreatic islets
    • Sandovici I, Smith NH, Nitert MD et al. Maternal diet and aging alter the epigenetic control of a promoter-enhancer interaction at the Hnf4a gene in rat pancreatic islets. Proc. Natl Acad. Sci. USA 108(13), 5449-5454 (2011).
    • (2011) Proc. Natl Acad. Sci. USA , vol.108 , Issue.13 , pp. 5449-5454
    • Sandovici, I.1    Smith, N.H.2    Nitert, M.D.3
  • 67
    • 84865080423 scopus 로고    scopus 로고
    • Protein restriction during gestation alters histone modifications at the glucose transporter 4 (GLUT4) promoter region and induces GLUT4 expression in skeletal muscle of female rat offspring
    • Zheng S, Rollet M, Pan YX. Protein restriction during gestation alters histone modifications at the glucose transporter 4 (GLUT4) promoter region and induces GLUT4 expression in skeletal muscle of female rat offspring. J. Nutr. Biochem. 23(9), 1064-1071 (2012).
    • (2012) J. Nutr. Biochem. , vol.23 , Issue.9 , pp. 1064-1071
    • Zheng, S.1    Rollet, M.2    Pan, Y.X.3
  • 68
    • 79951503905 scopus 로고    scopus 로고
    • Maternal protein restriction during pregnancy induces CCAAT/enhancer-binding protein (C/EBPβ) expression through the regulation of histone modification at its promoter region in female offspring rat skeletal muscle
    • Zheng S, Rollet M, Pan YX. Maternal protein restriction during pregnancy induces CCAAT/enhancer-binding protein (C/EBPβ) expression through the regulation of histone modification at its promoter region in female offspring rat skeletal muscle. Epigenetics 6(2), 161-170 (2011).
    • (2011) Epigenetics , vol.6 , Issue.2 , pp. 161-170
    • Zheng, S.1    Rollet, M.2    Pan, Y.X.3
  • 69
    • 80052664767 scopus 로고    scopus 로고
    • Perinatal undernutrition affects the methylation and expression of the leptin gene in adults: Implication for the understanding of metabolic syndrome
    • Jousse C, Parry L, Lambert-Langlais S et al. Perinatal undernutrition affects the methylation and expression of the leptin gene in adults: implication for the understanding of metabolic syndrome. FASEB J. 25(9), 3271-3278 (2011).
    • (2011) FASEB J. , vol.25 , Issue.9 , pp. 3271-3278
    • Jousse, C.1    Parry, L.2    Lambert-Langlais, S.3
  • 70
    • 84864402967 scopus 로고    scopus 로고
    • Feeding a protein-restricted diet during pregnancy induces altered epigenetic regulation of peroxisomal proliferator-activated receptor-α in the heart of the offspring
    • Slater-Jefferies JL, Lillycrop KA, Townsend PA et al. Feeding a protein-restricted diet during pregnancy induces altered epigenetic regulation of peroxisomal proliferator-activated receptor-α in the heart of the offspring. J. Dev. Orig. Health Dis. 2(4), 250-255 (2011).
    • (2011) J. Dev. Orig. Health Dis. , vol.2 , Issue.4 , pp. 250-255
    • Slater-Jefferies, J.L.1    Lillycrop, K.A.2    Townsend, P.A.3
  • 71
    • 84871323570 scopus 로고    scopus 로고
    • Increasing the folic acid content of maternal or post-weaning diets induces differential changes in phosphoenolpyruvate carboxykinase mRNA expression and promoter methylation in rats
    • Hoile SP, Lillycrop KA, Grenfell LR, Hanson MA, Burdge GC. Increasing the folic acid content of maternal or post-weaning diets induces differential changes in phosphoenolpyruvate carboxykinase mRNA expression and promoter methylation in rats. Br. J. Nutr. 108(5), 852-857 (2012).
    • (2012) Br. J. Nutr. , vol.108 , Issue.5 , pp. 852-857
    • Hoile, S.P.1    Lillycrop, K.A.2    Grenfell, L.R.3    Hanson, M.A.4    Burdge, G.C.5
  • 74
    • 55949137722 scopus 로고    scopus 로고
    • Persistent epigenetic differences associated with prenatal exposure to famine in humans
    • Heijmans BT, Tobi EW, Stein AD et al. Persistent epigenetic differences associated with prenatal exposure to famine in humans. Proc. Natl Acad. Sci. USA 105(44), 17046-17049 (2008).
    • (2008) Proc. Natl Acad. Sci. USA , vol.105 , Issue.44 , pp. 17046-17049
    • Heijmans, B.T.1    Tobi, E.W.2    Stein, A.D.3
  • 75
    • 70349999407 scopus 로고    scopus 로고
    • DNA methylation differences after exposure to prenatal famine are common and timing-and sex-specific
    • Tobi EW, Lumey LH, Talens RP et al. DNA methylation differences after exposure to prenatal famine are common and timing-and sex-specific. Hum. Mol. Genet. 18(21), 4046-4053 (2009).
    • (2009) Hum. Mol. Genet. , vol.18 , Issue.21 , pp. 4046-4053
    • Tobi, E.W.1    Lumey, L.H.2    Talens, R.P.3
  • 77
    • 84858636393 scopus 로고    scopus 로고
    • Hypermethylation at loci sensitive to the prenatal environment is associated with increased incidence of myocardial infarction
    • Talens RP, Jukema JW, Trompet S et al. Hypermethylation at loci sensitive to the prenatal environment is associated with increased incidence of myocardial infarction. Int. J. Epidemiol. 41(1), 106-115 (2012).
    • (2012) Int. J. Epidemiol. , vol.41 , Issue.1 , pp. 106-115
    • Talens, R.P.1    Jukema, J.W.2    Trompet, S.3
  • 79
    • 79957834770 scopus 로고    scopus 로고
    • Epigenetic gene promoter methylation at birth is associated with child's later adiposity
    • Godfrey KM, Sheppard A, Gluckman PD et al. Epigenetic gene promoter methylation at birth is associated with child's later adiposity. Diabetes 60(5), 1528-1534 (2011).
    • (2011) Diabetes , vol.60 , Issue.5 , pp. 1528-1534
    • Godfrey, K.M.1    Sheppard, A.2    Gluckman, P.D.3
  • 80
    • 0030951598 scopus 로고    scopus 로고
    • Physical activity and the risk of breast cancer
    • DOI 10.1056/NEJM199705013361801
    • Thune I, Brenn T, Lund E, Gaard M. Physical activity and the risk of breast cancer. N. Engl. J. Med. 336(18), 1269-1275 (1997). (Pubitemid 27187779)
    • (1997) New England Journal of Medicine , vol.336 , Issue.18 , pp. 1269-1275
    • Thune, I.1    Brenn, T.2    Lund, E.3    Gaard, M.4
  • 81
    • 84858055958 scopus 로고    scopus 로고
    • Acute exercise remodels promoter methylation in human skeletal muscle
    • Barrès R, Yan J, Egan B et al. Acute exercise remodels promoter methylation in human skeletal muscle. Cell Metab. 15(3), 405-411 (2012).
    • (2012) Cell Metab. , vol.15 , Issue.3 , pp. 405-411
    • Barrès, R.1    Yan, J.2    Egan, B.3
  • 82
    • 84879678934 scopus 로고    scopus 로고
    • A six months exercise intervention influences the genome-wide DNA methylation pattern in human adipose tissue
    • Rönn T, Volkov P, Davegårdh C et al. A six months exercise intervention influences the genome-wide DNA methylation pattern in human adipose tissue. PLoS Genet. 9(6), e1003572 (2013).
    • (2013) PLoS Genet. , vol.9 , Issue.6
    • Rönn, T.1    Volkov, P.2    Davegårdh, C.3
  • 83
    • 84870319843 scopus 로고    scopus 로고
    • Impact of an exercise intervention on DNA methylation in skeletal muscle from first-degree relatives of patients with Type 2 diabetes
    • Nitert MD, Dayeh T, Volkov P et al. Impact of an exercise intervention on DNA methylation in skeletal muscle from first-degree relatives of patients with Type 2 diabetes. Diabetes 61(12), 3322-3332 (2012).
    • (2012) Diabetes , vol.61 , Issue.12 , pp. 3322-3332
    • Nitert, M.D.1    Dayeh, T.2    Volkov, P.3
  • 84
    • 84876979205 scopus 로고    scopus 로고
    • Weight loss after gastric bypass surgery in human obesity remodels promoter methylation
    • Barres R, Kirchner H, Rasmussen M et al. Weight loss after gastric bypass surgery in human obesity remodels promoter methylation. Cell Rep. 3(4), 1020-1027 (2013).
    • (2013) Cell Rep. , vol.3 , Issue.4 , pp. 1020-1027
    • Barres, R.1    Kirchner, H.2    Rasmussen, M.3
  • 85
    • 84885598123 scopus 로고    scopus 로고
    • Lifestyle interventions for patients with and at risk for Type 2 diabetes: A systematic review and meta-analysis
    • Schellenberg ES, Dryden DM, Vandermeer B, Ha C, Korownyk C. Lifestyle interventions for patients with and at risk for Type 2 diabetes: a systematic review and meta-analysis. Ann. Intern. Med. 159(8), 543-551 (2013).
    • (2013) Ann. Intern. Med. , vol.159 , Issue.8 , pp. 543-551
    • Schellenberg, E.S.1    Dryden, D.M.2    Vandermeer, B.3    Ha, C.4    Korownyk, C.5
  • 86
    • 84871065589 scopus 로고    scopus 로고
    • Can diabetes prevention programmes be translated effectively into real-world settings and still deliver improved outcomes?
    • Johnson M, Jones R, Freeman C et al. Can diabetes prevention programmes be translated effectively into real-world settings and still deliver improved outcomes? A synthesis of evidence. Diabet. Med. 30(1), 3-15 (2013).
    • (2013) A Synthesis of Evidence. Diabet. Med. , vol.30 , Issue.1 , pp. 3-15
    • Johnson, M.1    Jones, R.2    Freeman, C.3
  • 87
    • 70449515534 scopus 로고    scopus 로고
    • Epigenetic and microRNA-dependent control of cytochrome P450 expression: A gap between DNA and protein
    • Gomez A, Ingelman-Sundberg M. Epigenetic and microRNA-dependent control of cytochrome P450 expression: a gap between DNA and protein. Pharmacogenomics 10(7), 1067-1076 (2009).
    • (2009) Pharmacogenomics , vol.10 , Issue.7 , pp. 1067-1076
    • Gomez, A.1    Ingelman-Sundberg, M.2
  • 89
    • 75849156338 scopus 로고    scopus 로고
    • Cytochrome P450 1B1 mRNA untranslated regions interact to inhibit protein translation
    • Devlin AH, Thompson P, Robson T, McKeown SR. Cytochrome P450 1B1 mRNA untranslated regions interact to inhibit protein translation. Mol. Carcinog. 49(2), 190-199 (2010).
    • (2010) Mol. Carcinog. , vol.49 , Issue.2 , pp. 190-199
    • Devlin, A.H.1    Thompson, P.2    Robson, T.3    McKeown, S.R.4
  • 90
    • 70349268327 scopus 로고    scopus 로고
    • MicroRNAs regulate CYP3A4 expression via direct and indirect targeting
    • Pan YZ, Gao W, Yu AM. MicroRNAs regulate CYP3A4 expression via direct and indirect targeting. Drug Metab. Dispos. 37(10), 2112-2117 (2009).
    • (2009) Drug Metab. Dispos. , vol.37 , Issue.10 , pp. 2112-2117
    • Pan, Y.Z.1    Gao, W.2    Yu, A.M.3
  • 91
    • 33749487425 scopus 로고    scopus 로고
    • MicroRNA regulates the expression of human cytochrome P450 1B1
    • DOI 10.1158/0008-5472.CAN-06-1403
    • Tsuchiya Y, Nakajima M, Takagi S, Taniya T, Yokoi T. MicroRNA regulates the expression of human cytochrome P450 1B1. Cancer Res. 66(18), 9090-9098 (2006). (Pubitemid 44521128)
    • (2006) Cancer Research , vol.66 , Issue.18 , pp. 9090-9098
    • Tsuchiya, Y.1    Nakajima, M.2    Takagi, S.3    Taniya, T.4    Yokoi, T.5
  • 92
    • 77956972960 scopus 로고    scopus 로고
    • In utero tobacco exposure epigenetically modifies placental CYP1A1 expression
    • Suter M, Abramovici A, Showalter L et al. In utero tobacco exposure epigenetically modifies placental CYP1A1 expression. Metabolism 59(10), 1481-1490 (2010).
    • (2010) Metabolism , vol.59 , Issue.10 , pp. 1481-1490
    • Suter, M.1    Abramovici, A.2    Showalter, L.3
  • 93
    • 79960001513 scopus 로고    scopus 로고
    • Nutritional status affects the epigenomic profile of peripheral blood cells
    • Zierath JR, Barrès RE. Nutritional status affects the epigenomic profile of peripheral blood cells. Epigenomics 3(3), 259-260 (2011).
    • (2011) Epigenomics , vol.3 , Issue.3 , pp. 259-260
    • Zierath, J.R.1    Barrès, R.E.2
  • 94
    • 84878756560 scopus 로고    scopus 로고
    • Pharmacogenetics and personalized treatment of Type 2 diabetes
    • Semiz S, Dujic T, Causevic A. Pharmacogenetics and personalized treatment of Type 2 diabetes. Biochem. Med. (Zagreb) 23(2), 154-171 (2013).
    • (2013) Biochem. Med. (Zagreb) , vol.23 , Issue.2 , pp. 154-171
    • Semiz, S.1    Dujic, T.2    Causevic, A.3


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