Epigenetics: Are there implications for personalised nutrition?

Current Opinion in Clinical Nutrition and Metabolic Care

Volumn 15, Issue 5, 2012, Pages 442-447

  Burdge, Graham C ^a   Hoile, Samuel P ^a   Lillycrop, Karen A ^b  

^a SOUTHAMPTON GENERAL HOSPITAL   (United Kingdom)

^b UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

Author keywords

epigenetics; epinutrigenomics; nutrition

Indexed keywords

FOLIC ACID;

BODY WEIGHT; BREAST CANCER; CALORIC INTAKE; CARBON METABOLISM; CPG ISLAND; DIETARY INTAKE; DNA METHYLATION; EPIGENETICS; EXERCISE; FAT INTAKE; GENE FUNCTION; GENETIC POLYMORPHISM; GENETIC VARIABILITY; HUMAN; INHERITANCE; MATERNAL NUTRITION; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; NUTRIGENOMICS; NUTRITION; NUTRITIONAL STATUS; OBESITY; PHENOTYPE; PHYSICAL ACTIVITY; PROTEIN INTAKE; PROTEIN RESTRICTION; REVIEW;

ANIMALS; BREAST NEOPLASMS; DIABETES MELLITUS, TYPE 2; DIET; DNA METHYLATION; EPIGENESIS, GENETIC; EXERCISE; FEMALE; FETAL DEVELOPMENT; GC RICH SEQUENCE; GENETIC LOCI; HUMANS; NUTRIGENOMICS; PREGNANCY; PRENATAL NUTRITIONAL PHYSIOLOGICAL PHENOMENA;

ANIMALIA;

EID: 84865477690     PISSN: 13631950     EISSN: 14736519     Source Type: Journal    
DOI: 10.1097/MCO.0b013e3283567dd2     Document Type: Review

References (55)

1. Rimbach G, Minihane AM. Nutrigenetics and personalised nutrition: how far have we progressed and are we likely to get there? Pro Nutr Soc 2009; 68:162-172.
2. Manolio TA, Collins FS, Cox NJ, et al. Finding the missing heritability of complex diseases. Nature 2009; 461:747-753.
3. Slatkin M. Epigenetic inheritance and the missing heritability problem. Genetics 2009; 182:845-850.
4. Goldberg AD, Allis CD, Bernstein E. Epigenetics: a landscape takes shape. Cell 2007; 128:635-638. (Pubitemid 46273578)
5. Bird A. DNA methylation patterns and epigenetic memory. Genes Dev 2002; 16:6-21. (Pubitemid 34049633)
6. Razin A, Szyf M. DNA methylation patterns. Formation and function. Biochim Biophys Acta 1984; 782:331-342. (Pubitemid 14038241)
7. Strahl BD, Ohba R, Cook RG, et al. Methylation of histone H3 at lysine 4 is highly conserved and correlates with transcriptionally active nuclei in Tetrahymena. Proc Natl Acad Sci USA 1999; 96:14967-21472.
8. Lachner M, O'Carroll D, Rea S, et al. Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins. Nature 2001; 410:116-120. (Pubitemid 32225847)
9. Zegerman P, Canas B, Pappin D, et al. Histone H3 lysine 4 methylation disrupts binding of nucleosome remodeling and deacetylase (NuRD) repressor complex. J Biol Chem 2002; 277:11621-11624. (Pubitemid 34952711)
10. Nakayama J, Rice JC, Strahl BD, et al. Role of histone H3 lysine 9 methylation in epigenetic control of heterochromatin assembly. Science 2001; 292:110-113. (Pubitemid 32289138)
11. Fuks F, Burgers WA, Brehm A, et al. DNA methyltransferase Dnmt1 associates with histone deacetylase activity. Nature Gen 2000; 24:88-91. (Pubitemid 30041428)
12. Rountree MR, Bachman KE, Baylin SB. DNMT1 binds HDAC2 and a new co-repressor, DMAP1, to form a complex at replication foci. Nature Gen 2000; 25:269-277. (Pubitemid 30437311)
13. Viré E, Brenner C, Deplus R, et al. The Polycomb group protein EZH2 directly controls DNA methylation. Nature 2006; 439:871-874. (Pubitemid 43255707)
14. Szyf M. The dynamic epigenome and its implications in toxicology. Toxicol Sci 2007; 100:7-23. (Pubitemid 47617798)
15. Gluckman PD, Hanson MA, Cooper C, et al. Effect of in utero and early-life conditions on adult health and disease. N Engl J Med 2008; 359:61-73.
16. Burdge GC, Lillycrop KA. Bridging the gap between epigenetics research and nutritional public health interventions. Genome Med 2010; 2:80.
17. Chen J-R, Zhang J, Lazarenko OP, et al. Inhibition of fetal bone development through epigenetic down-regulation of HoxA10 in obese rats fed high-fat diet. FASEB J 2012; 26:1131-1141.
18. Temple IK. Imprinting in human disease with special reference to transient neonatal diabetes and Beckwith-Wiedemann syndrome. Endo Dev 2007; 12:113-123.
19. Strakovsky RS, Zhang X, Zhou D, et al. Gestational high fat diet programs hepatic phosphoenolpyruvate carboxykinase gene expression and histone modification in neonatal offspring rats. J Physiol 2011; 589:2707-2717.
20. Kelsall C, Hoile SP, Irvine N, et al. Vascular dysfunction induced in offspring by maternal dietary fat involves altered arterial polyunsaturated fatty acid biosynthesis. PloS One 2012; 7:e34492.
21. Sandovici I, Smith NH, Nitert MD, et al. Maternal diet and aging alter the epigenetic control of a promoter-enhancer interaction at the Hnf4a gene in rat pancreatic islets. Proc Natl Acad Sci USA 2011; 108:5449-5454.
22. Zheng S, Rollet M, Pan Y-X. Protein restriction during gestation alters histone modifications at the glucose transporter 4 (GLUT4) promoter region and induces GLUT4 expression in skeletal muscle of female rat offspring. J Nutr Biochem 2011; 6:161-170.
23. Zheng S, Rollet M, Pan Y-X. Maternal protein restriction during pregnancy induces CCAAT/enhancer-binding protein (C/EBPb) expression through the regulation of histone modification at its promoter region in female offspring rat skeletal muscle. Epigenetics 2011; 6:161-170.
24. Jousse C, Parry L, Lambert-Langlais S, et al. Perinatal undernutrition affects the methylation and expression of the leptin gene in adults: implication for the understanding of metabolic syndrome. FASEB J 2011; 25:3271-3278.
25. Slater-Jefferies JL, Lillycrop KA, Townsend PA, et al. Feeding a proteinrestricted diet during pregnancy induces altered epigenetic regulation of peroxisomal proliferator-activated receptor-a in the heart of the offspring. J Dev Origins Health Dis 2011; 2:250-255.
26. McKay JA, Williams EA, Mathers JC. Effect of maternal and postweaning folate supply on gene-specific DNA methylation in the small intestine of weaning and adult apc and wild type mice. Frontiers Gen 2011; 2:23.
27. McKay JA, Wong YK, Relton CL, et al. Maternal folate supply and sex influence gene-specific DNA methylation in the fetal gut. Mol Nutr Food Res 2011; 55:1717-1723.
28. McKay JA, Waltham KJ, Williams EA, et al. Folate depletion during pregnancy and lactation reduces genomic DNA methylation in murine adult offspring. Genes Nutr 2011; 6:189-196.
29. Hoile SP, Lillycrop KA, Grenfell LR, et al. Increasing the folic acid content of maternal or postweaning diets induces differential changes in phosphoenolpyruvate carboxykinase mRNA expression and promoter methylation in rats. Br J Nutr 2011; 10.1017/S0007114511006155.
30. Schaible TD, Harris RA, Dowd SE, et al. Maternal methyl-donor supplementation induces prolonged murine offspring colitis susceptibility in association with mucosal epigenetic and microbiomic changes. Human Mol Gen 2011; 20:1687-1696.
31. Roseboom TJ, Van Der Meulen JH, Ravelli AC, et al. Effects of prenatal exposure to the Dutch famine on adult disease in later life: an overview. Mol Cell Endocrinol 2001; 185:93-98. (Pubitemid 33103957)
32. Heijmans BT, Tobi EW, Stein AD, et al. Persistent epigenetic differences associated with prenatal exposure to famine in humans. Proc Natl Acad Sci USA 2008; 105:17046-17049.
33. Tobi EW, Lumey LH, Talens RP, et al. DNA Methylation differences after exposure to prenatal famine are common and timing-and sex-specific. Hum Mol Genet 2009; 18:1460-2083.
34. Talens RP, Jukema JW, Trompet S, et al. Hypermethylation at loci sensitive to the prenatal environment is associated with increased incidence of myocardial infarction. Int J Epidemiol 2011; 41:106-115.
35. Godfrey KM, Sheppard A, Gluckman PD, et al. Epigenetic gene promoter methylation at birth is associated with child's later adiposity. Diabetes 2011; 60:1528-1534.
36. Harvey NC, Lillycrop KA, Garratt E, et al. Evaluation of methylation status of the eNOS promoter at birth in relation to childhood bone mineral content. Cal Tissue Int 2012; 90:120-127.
37. Relton CL, Groom A, St. Pourcain B, et al. DNA methylation patterns in cord blood DNA and body size in childhood. PLoS One 2012; 7:e31821.
38. Jablonka E, Raz G. Transgenerational epigenetic inheritance: prevalence, mechanisms, and implications for the study of heredity and evolution. Q Rev Biol 2009; 84:131-176.
39. BurdgeGC, Hoile SP, Uller T, et al. Progressive, transgenerational changes in offspring phenotype and epigenotype following nutritional transition. PLoS One 2011; 6:e28282.
40. Li CCY, Cropley JE, Cowley MJ, et al. A sustained dietary change increases epigenetic variation in isogenic mice. PLoS Gen 2011; 7:e1001380.
41. Ling C, Del Guerra S, Lupi R, et al. Epigenetic regulation of PPARGC1A in human type 2 diabetic islets and effect on insulin secretion. Diabetologia 2008; 51:615-622.
42. Toperoff G, Aran D, Kark JD, et al. Genome-wide survey reveals predisposing diabetes type 2-related DNA methylation variations in human peripheral blood. Human Mol Gen 2012; 21:371-383.
43. Bell CG, Finer S, Lindgren CM, et al. Integrated genetic and epigenetic analysis identifies haplotype-specific methylation in the FTO type 2 diabetes and obesity susceptibility locus. PloS One 2010; 5:e14040.
44. Yang BT, Dayeh TA, Kirkpatrick CL, et al. Insulin promoter DNA methylation correlates negatively with insulin gene expression and positively with HbA(1c) levels in human pancreatic islets. Diabetologia 2011; 54:360-367.
45. Volkmar M, Dedeurwaerder S, Cunha DA, et al. DNA methylation profiling identifies epigenetic dysregulation in pancreatic islets from type 2 diabetic patients. EMBO J 2012; 31:1405-1426.
46. Zhao J, Goldberg J, Bremner JD, et al. Global DNA methylation is associated with insulin resistance: a monozygotic twin study. Diabetes 2012; 61:542-546.
47. Zhang FF, Cardarelli R, Carroll J, et al. Physical activity and global genomic DNA methylation in a cancer-free population. Epigenetics 2011; 6:293-299
48. Barrès R, Yan J, Egan B, et al. Acute exercise remodels promoter methylation in human skeletal muscle. Cell Met 2012; 15:405-411.
49. Burdge GC, Lillycrop KA, Jackson AA. Nutrition in early life, and risk of cancer and metabolic disease: alternative endings in an epigenetic tale? Br J Nutr 2009; 101:619-630.
50. Wong EM, Southey MC, Fox SB, et al. Constitutional methylation of the BRCA1 promoter is specifically associated with BRCA1 mutation-associated pathology in early-onset breast cancer. Cancer Prev Res 2011; 4:23-33.
51. Papoutsis AJ, Borg JL, Selmin OI, et al. BRCA-1 promoter hypermethylation and silencing induced by the aromatic hydrocarbon receptor-ligand TCDD are prevented by resveratrol in MCF-7 Cells. J Nutr Biochem 2011; 10.1016/ j.jnutbio.2011.08.001.
52. Junaid MA, Kuizon S, Cardona J, et al. Folic acid supplementation dysregulates gene expression in lymphoblastoid cells-implications in nutrition. Biochem Biophys Res Comm 2011; 412:688-692.
53. Ceccarelli V, Racanicchi S, Martelli MP, et al. Eicosapentaenoic acid demethylates a single CpG that mediates expression of tumor suppressor CCAAT/enhancer-binding protein delta in U937 leukemia cells. J Biol Chem 2011; 286:27092-27102.
54. Piyathilake CJ, Macaluso M, Alvarez RD, et al. A higher degree of LINE-1 methylation in peripheral blood mononuclear cells, a one-carbon nutrient related epigenetic alteration, is associated with a lower risk of developing cervical intraepithelial neoplasia. Nutri 2011; 27:513-519.
55. Zeng H, Irwin ML, Lu L, et al. Physical activity and breast cancer survival: an epigenetic link through reduced methylation of a tumor suppressor gene L3MBTL1. Breast Cancer Res Treat 2012; 133:127-135.