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Volumn 10, Issue 7, 2009, Pages 1067-1076

Epigenetic and microRNA-dependent control of cytochrome P450 expression: A gap between DNA and protein

Author keywords

Cytochrome P450; DNA methylation; Epigenetics; Histone modifications; miRNA

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; 5 AZA 2' DEOXYCYTIDINE; AROMATIC HYDROCARBON RECEPTOR; CYTOCHROME P450; CYTOCHROME P450 1A1; CYTOCHROME P450 1A2; CYTOCHROME P450 1B1; CYTOCHROME P450 2A6; CYTOCHROME P450 2C19; CYTOCHROME P450 2D6; CYTOCHROME P450 2E1; CYTOCHROME P450 2J2; CYTOCHROME P450 2R1; CYTOCHROME P450 2S1; CYTOCHROME P450 2W1; CYTOCHROME P450 3A; DNA; DNA METHYLTRANSFERASE 1; DNA METHYLTRANSFERASE 3A; DNA METHYLTRANSFERASE 3B; HISTONE H2A; HISTONE H2B; HISTONE H3; HYPOXIA INDUCIBLE FACTOR 1BETA; MICRORNA; POLYCYCLIC AROMATIC HYDROCARBON; TRANSCRIPTION FACTOR AP 1; TRANSCRIPTION FACTOR SP1; TRICHOSTATIN A; UNCLASSIFIED DRUG; UNINDEXED DRUG;

EID: 70449515534     PISSN: 14622416     EISSN: 17448042     Source Type: Journal    
DOI: 10.2217/pgs.09.56     Document Type: Conference Paper
Times cited : (48)

References (108)
  • 1
    • 36148976077 scopus 로고    scopus 로고
    • Influence of cytochrome P450 polymorphisms on drug therapies: Pharmacogenetic, pharmacoepigenetic and clinical aspects
    • DOI 10.1016/j.pharmthera.2007.09.004, PII S016372580700201X
    • Ingelman-Sundberg M, Sim SC, Gomez A et al.: Influence of cytochrome P450 polymorphisms on drug therapies: pharmacogenetic, pharmacoepigenetic and clinical aspects. Pharmacol. Ther. 116, 496-526 (2007). ■ In this review, we present that a number of the drug-metabolizing members of the CYP superfamily are potentially under DNA methylation control due to the presence of high density CpG islands in their promoters. (Pubitemid 350116943)
    • (2007) Pharmacology and Therapeutics , vol.116 , Issue.3 , pp. 496-526
    • Ingelman-Sundberg, M.1    Sim, S.C.2    Gomez, A.3    Rodriguez-Antona, C.4
  • 2
    • 33645116164 scopus 로고    scopus 로고
    • Cytochrome P450 pharmacogenetics and cancer
    • Rodríguez-Antona C, Ingelman-Sundberg M: Cytochrome P450 pharmacogenetics and cancer. Oncogene 25, 1679-1691 (2006).
    • (2006) Oncogene , vol.25 , pp. 1679-1691
    • Rodríguez-Antona, C.1    Ingelman-Sundberg, M.2
  • 3
    • 33644664657 scopus 로고    scopus 로고
    • Pharmacogenetics of drug-metabolizing enzymes: Implications for a safer and more effective drug therapy
    • Ingelman-Sundberg M, Rodríguez-Antona C: Pharmacogenetics of drug-metabolizing enzymes: implications for a safer and more effective drug therapy. Philos. Trans. R Soc. Lond. B Biol. Sci. 360, 1563-1570 (2005).
    • (2005) Philos. Trans. R Soc. Lond. B Biol. Sci. , vol.360 , pp. 1563-1570
    • Ingelman-Sundberg, M.1    Rodríguez-Antona, C.2
  • 4
    • 0345275779 scopus 로고    scopus 로고
    • A passion for P450s (rememberances of the early history of research on cytochrome P450)
    • Estabrook RW: A passion for P450s (rememberances of the early history of research on cytochrome P450). Drug Metab. Dispos. 31, 1461-1473 (2003).
    • (2003) Drug Metab. Dispos. , vol.31 , pp. 1461-1473
    • Estabrook, R.W.1
  • 5
    • 33645050104 scopus 로고    scopus 로고
    • Cytochrome P450s and other enzymes in drug metabolism and toxicity
    • Guengerich FP: Cytochrome P450s and other enzymes in drug metabolism and toxicity. AAPS J. 8, E101-E111 (2006).
    • (2006) AAPS J. , vol.8
    • Guengerich, F.P.1
  • 6
    • 34447301028 scopus 로고    scopus 로고
    • Effects of genetic polymorphism of cytochrome P450 enzymes on the pharmacokinetics of benzodiazepines
    • DOI 10.1111/j.1365-2710.2007.00829.x
    • Fukasawa T, Suzuki A, Otani K: Effects of genetic polymorphism of cytochrome P450 enzymes on the pharmacokinetics of benzodiazepines. J. Clin. Pharm. Ther. 32, 333-341 (2007). (Pubitemid 47063159)
    • (2007) Journal of Clinical Pharmacy and Therapeutics , vol.32 , Issue.4 , pp. 333-341
    • Fukasawa, T.1    Suzuki, A.2    Otani, K.3
  • 7
    • 0000783041 scopus 로고    scopus 로고
    • Evaluation of the genetic component of variability in CYP3A4 activity: A repeated drug administration method
    • DOI 10.1097/00008571-200007000-00001
    • Ozdemir V, Kalow W, Tang BK et al.: Evaluation of the genetic component of variability in CYP3A4 activity: a repeated drug administration method. Pharmacogenetics 10, 373-388 (2000). (Pubitemid 30433571)
    • (2000) Pharmacogenetics , vol.10 , Issue.5 , pp. 373-388
    • Ozdemir, V.1    Kalow, W.2    Tang, B.-K.3    Paterson, A.D.4    Walker, S.E.5    Endrenyi, L.6    Kashuba, A.D.M.7
  • 8
    • 34249279527 scopus 로고    scopus 로고
    • Stability and flexibility of epigenetic gene regulation in mammalian development
    • Reik W: Stability and flexibility of epigenetic gene regulation in mammalian development. Nature 447, 425-432 (2007).
    • (2007) Nature , vol.447 , pp. 425-432
    • Reik, W.1
  • 9
    • 32344450824 scopus 로고    scopus 로고
    • Genomic DNA methylation: The mark and its mediators
    • Klose RJ, Bird AP: Genomic DNA methylation: the mark and its mediators. Trends Biochem. Sci. 31, 89-97 (2006).
    • (2006) Trends Biochem. Sci. , vol.31 , pp. 89-97
    • Klose, R.J.1    Bird, A.P.2
  • 10
    • 0036312756 scopus 로고    scopus 로고
    • The impact of chromatin in human cancer: Linking DNA methylation to gene silencing
    • Ballestar E, Esteller M: The impact of chromatin in human cancer: linking DNA methylation to gene silencing. Carcinogenesis 23, 1103-1109 (2002). (Pubitemid 34814766)
    • (2002) Carcinogenesis , vol.23 , Issue.7 , pp. 1103-1109
    • Ballestar, E.1    Esteller, M.2
  • 11
    • 41649087986 scopus 로고    scopus 로고
    • Role of chromatin/epigenetic modifications on DNA accessibility
    • Georgel PT: Role of chromatin/epigenetic modifications on DNA accessibility. Drug News Perspect. 20, 549-556 (2007).
    • (2007) Drug News Perspect. , vol.20 , pp. 549-556
    • Georgel, P.T.1
  • 12
    • 4444285764 scopus 로고    scopus 로고
    • Beyond genetics - The emerging role of epigenetic changes in hematopoietic malignancies
    • DOI 10.1532/IJH97.04075
    • Galm O, Esteller M: Beyond genetics - the emerging role of epigenetic changes in hematopoietic malignancies. Int. J. Hematol. 80, 120-127 (2004). (Pubitemid 39201564)
    • (2004) International Journal of Hematology , vol.80 , Issue.2 , pp. 120-127
    • Galm, O.1    Esteller, M.2
  • 14
    • 34548138278 scopus 로고    scopus 로고
    • Epigenetics: A historical overview
    • Holliday R: Epigenetics: a historical overview. Epigenetics 1, 76-80 (2006).
    • (2006) Epigenetics , vol.1 , pp. 76-80
    • Holliday, R.1
  • 15
    • 39549093550 scopus 로고    scopus 로고
    • An epigenetic role for noncoding RNAs and intragenic DNA methylation
    • Flanagan JM, Wild L: An epigenetic role for noncoding RNAs and intragenic DNA methylation. Genome Biol. 8, 307 (2007).
    • (2007) Genome Biol. , vol.8 , pp. 307
    • Flanagan, J.M.1    Wild, L.2
  • 16
  • 17
    • 34249099120 scopus 로고    scopus 로고
    • Silencing by imprinted noncoding RNAs: Is transcription the answer?
    • Pauler FM, Koerner MV, Barlow DP: Silencing by imprinted noncoding RNAs: is transcription the answer? Trends Genet. 23, 284-292 (2007).
    • (2007) Trends Genet. , vol.23 , pp. 284-292
    • Pauler, F.M.1    Koerner, M.V.2    Barlow, D.P.3
  • 18
    • 33845474731 scopus 로고    scopus 로고
    • Non-coding RNAs: Lost in translation?
    • Costa FF: Non-coding RNAs: lost in translation? Gene 386, 1-10 (2007).
    • (2007) Gene , vol.386 , pp. 1-10
    • Costa, F.F.1
  • 20
    • 0035656688 scopus 로고    scopus 로고
    • Non-coding RNA genes and the modern RNA world
    • Eddy SR: Non-coding RNA genes and the modern RNA world. Nat. Rev. Genet. 2, 919-929 (2001).
    • (2001) Nat. Rev. Genet. , vol.2 , pp. 919-929
    • Eddy, S.R.1
  • 22
    • 23044514669 scopus 로고    scopus 로고
    • Epigenetic differences arise during the lifetime of monozygotic twins
    • Very important finding showing that in genetically similar monozygotic twins, phenotypic differences could occur through epigenetic means
    • Fraga MF, Ballestar E, Paz MF et al.: Epigenetic differences arise during the lifetime of monozygotic twins. Proc. Natl Acad. Sci. USA 102, 10604-10609 (2005). ■■ Very important finding showing that in genetically similar monozygotic twins, phenotypic differences could occur through epigenetic means.
    • (2005) Proc. Natl Acad. Sci. USA , vol.102 , pp. 10604-10609
    • Fraga, M.F.1    Ballestar, E.2    Paz, M.F.3
  • 23
    • 0037372003 scopus 로고    scopus 로고
    • Epigenetic regulation of gene expression: How the genome integrates intrinsic and environmental signals
    • DOI 10.1038/ng1089
    • Jaenisch R, Bird A: Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals. Nat. Genet. (Suppl. 33), 245-254 (2003). (Pubitemid 36278835)
    • (2003) Nature Genetics , vol.33 , Issue.SUPPL. , pp. 245-254
    • Jaenisch, R.1    Bird, A.2
  • 24
    • 34247473478 scopus 로고    scopus 로고
    • The epigenetic basis of twin discordance in age-related diseases
    • Poulsen P, Esteller M, Vaag A et al.: The epigenetic basis of twin discordance in age-related diseases. Pediatr. Res. 61, 38R-42R (2007).
    • (2007) Pediatr. Res. , vol.61
    • Poulsen, P.1    Esteller, M.2    Vaag, A.3
  • 25
    • 40849139208 scopus 로고    scopus 로고
    • Epigenetics in cancer
    • Esteller M: Epigenetics in cancer. N. Engl. J. Med. 358, 1148-1159 (2008).
    • (2008) N. Engl. J. Med. , vol.358 , pp. 1148-1159
    • Esteller, M.1
  • 26
    • 3342979802 scopus 로고    scopus 로고
    • Developmental plasticity and human health
    • Bateson P, Barker D, Clutton-Brock T et al.: Developmental plasticity and human health. Nature 430, 419-421 (2004).
    • (2004) Nature , vol.430 , pp. 419-421
    • Bateson, P.1    Barker, D.2    Clutton-Brock, T.3
  • 28
    • 41149142015 scopus 로고    scopus 로고
    • Epigenetics and complex disease: From etiology to new therapeutics
    • Ptak C, Petronis A: Epigenetics and complex disease: from etiology to new therapeutics. Annu. Rev. Pharmacol. Toxicol. 48, 257-276 (2008).
    • (2008) Annu. Rev. Pharmacol. Toxicol. , vol.48 , pp. 257-276
    • Ptak, C.1    Petronis, A.2
  • 29
    • 55949137722 scopus 로고    scopus 로고
    • Persistent epigenetic differences associated with prenatal exposure to famine in humans
    • Heijmans BT, Tobi EW, Stein AD et al.: Persistent epigenetic differences associated with prenatal exposure to famine in humans. Proc. Natl Acad. Sci. USA 105, 17046-17049 (2008).
    • (2008) Proc. Natl Acad. Sci. USA , vol.105 , pp. 17046-17049
    • Heijmans, B.T.1    Tobi, E.W.2    Stein, A.D.3
  • 30
    • 3342989681 scopus 로고    scopus 로고
    • Epigenetic programming by maternal behavior
    • Weaver IC, Cervoni N, Champagne FA et al.: Epigenetic programming by maternal behavior. Nat Neurosci. 7, 847-854 (2004).
    • (2004) Nat Neurosci. , vol.7 , pp. 847-854
    • Weaver, I.C.1    Cervoni, N.2    Champagne, F.A.3
  • 31
    • 33947310031 scopus 로고    scopus 로고
    • Environmental epigenomics and disease susceptibility
    • Jirtle RL, Skinner MK: Environmental epigenomics and disease susceptibility. Nat. Rev. Genet. 8, 253-262 (2007).
    • (2007) Nat. Rev. Genet. , vol.8 , pp. 253-262
    • Jirtle, R.L.1    Skinner, M.K.2
  • 32
    • 0033753779 scopus 로고    scopus 로고
    • The DNA methyltransferases of mammals
    • Bestor TH: The DNA methyltransferases of mammals. Hum. Mol. Genet. 9, 2395-2402 (2000).
    • (2000) Hum. Mol. Genet. , vol.9 , pp. 2395-2402
    • Bestor, T.H.1
  • 33
    • 0026708177 scopus 로고
    • Targeted mutation of the DNA methyltransferase gene results in embryonic lethality
    • Li E, Bestor TH, Jaenisch R: Targeted mutation of the DNA methyltransferase gene results in embryonic lethality. Cell 69, 915-926 (1992).
    • (1992) Cell , vol.69 , pp. 915-926
    • Li, E.1    Bestor, T.H.2    Jaenisch, R.3
  • 34
    • 34848911647 scopus 로고    scopus 로고
    • DNA methylation: The nuts and bolts of repression
    • Miranda TB, Jones PA: DNA methylation: the nuts and bolts of repression. J. Cell Physiol. 213, 384-390 (2007).
    • (2007) J. Cell Physiol. , vol.213 , pp. 384-390
    • Miranda, T.B.1    Jones, P.A.2
  • 35
    • 15744401773 scopus 로고    scopus 로고
    • Eukaryotic cytosine methyltransferases
    • Goll MG, Bestor TH: Eukaryotic cytosine methyltransferases. Annu. Rev. Biochem. 74, 481-514 (2005).
    • (2005) Annu. Rev. Biochem. , vol.74 , pp. 481-514
    • Goll, M.G.1    Bestor, T.H.2
  • 36
    • 0142247187 scopus 로고    scopus 로고
    • Mammalian DNA (cytosine-5) methyltransferases and their expression
    • DOI 10.1016/S1521-6616(03)00204-3
    • Pradhan S, Esteve PO: Mammalian DNA (cytosine-5) methyltransferases and their expression. Clin. Immunol. 109, 6-16 (2003). (Pubitemid 37324737)
    • (2003) Clinical Immunology , vol.109 , Issue.1 , pp. 6-16
    • Pradhan, S.1    Esteve, P.-O.2
  • 37
    • 41849101441 scopus 로고    scopus 로고
    • Carcinogenesis and microsatellite instability: The interrelationship between genetics and epigenetics
    • Imai K, Yamamoto H: Carcinogenesis and microsatellite instability: the interrelationship between genetics and epigenetics. Carcinogenesis 29, 673-680 (2008).
    • (2008) Carcinogenesis , vol.29 , pp. 673-680
    • Imai, K.1    Yamamoto, H.2
  • 38
    • 37149036252 scopus 로고    scopus 로고
    • IGFBP3 promoter methylation in colorectal cancer: Relationship with microsatellite instability, CpG island methylator phenotype, and p53
    • Kawasaki T, Nosho K, Ohnishi M et al.: IGFBP3 promoter methylation in colorectal cancer: relationship with microsatellite instability, CpG island methylator phenotype, and p53. Neoplasia 9, 1091-1098 (2007).
    • (2007) Neoplasia , vol.9 , pp. 1091-1098
    • Kawasaki, T.1    Nosho, K.2    Ohnishi, M.3
  • 39
    • 43049130760 scopus 로고    scopus 로고
    • LINE-1 hypomethylation is inversely associated with microsatellite instability and CpG island methylator phenotype in colorectal cancer
    • Ogino S, Kawasaki T, Nosho K et al.: LINE-1 hypomethylation is inversely associated with microsatellite instability and CpG island methylator phenotype in colorectal cancer. Int. J. Cancer 122, 2767-2773 (2008).
    • (2008) Int. J. Cancer , vol.122 , pp. 2767-2773
    • Ogino, S.1    Kawasaki, T.2    Nosho, K.3
  • 40
    • 33645958291 scopus 로고    scopus 로고
    • De novo methylation, long-term promoter silencing, methylation patterns in the human genome, and consequences of foreign DNA insertion
    • Doerfler W: De novo methylation, long-term promoter silencing, methylation patterns in the human genome, and consequences of foreign DNA insertion. Curr. Top. Microbiol. Immunol. 301, 125-175 (2006).
    • (2006) Curr. Top. Microbiol. Immunol. , vol.301 , pp. 125-175
    • Doerfler, W.1
  • 41
    • 33845608798 scopus 로고    scopus 로고
    • Classification of colorectal cancer based on correlation of clinical, morphological and molecular features
    • Jass JR: Classification of colorectal cancer based on correlation of clinical, morphological and molecular features. Histopathology 50, 113-130 (2007).
    • (2007) Histopathology , vol.50 , pp. 113-130
    • Jass, J.R.1
  • 42
    • 50949121524 scopus 로고    scopus 로고
    • Viral genome methylation as an epigenetic defense against geminiviruses
    • Raja P, Sanville BC, Buchmann RC et al.: Viral genome methylation as an epigenetic defense against geminiviruses. J. Virol. 82, 8997-9007 (2008).
    • (2008) J. Virol. , vol.82 , pp. 8997-9007
    • Raja, P.1    Sanville, B.C.2    Buchmann, R.C.3
  • 43
    • 34248373767 scopus 로고    scopus 로고
    • Epigenetic status of an adenovirus type 12 transgenome upon long-term cultivation in hamster cells
    • DOI 10.1128/JVI.02624-06
    • Hochstein N, Muiznieks I, Mangel L et al.: Epigenetic status of an adenovirus type 12 transgenome upon long-term cultivation in hamster cells. J. Virol. 81, 5349-5361 (2007). (Pubitemid 46744444)
    • (2007) Journal of Virology , vol.81 , Issue.10 , pp. 5349-5361
    • Hochstein, N.1    Muiznieks, I.2    Mangel, L.3    Brondke, H.4    Doerfler, W.5
  • 44
    • 0018250796 scopus 로고
    • Patterns of integration of viral DNA sequences in the genomes of adenovirus type 12-transformed hamster cells
    • Sutter D, Westphal M, Doerfler W: Patterns of integration of viral DNA sequences in the genomes of adenovirus type 12-transformed hamster cells. Cell 14, 569-585 (1978). (Pubitemid 9190236)
    • (1978) Cell , vol.14 , Issue.3 , pp. 569-585
    • Sutter, D.1    Westphal, M.2    Doerfler, W.3
  • 45
    • 0035962632 scopus 로고    scopus 로고
    • DNA methylation, chromatin inheritance, and cancer
    • Rountree MR, Bachman KE, Herman JG et al.: DNA methylation, chromatin inheritance, and cancer. Oncogene 20, 3156-3165 (2001).
    • (2001) Oncogene , vol.20 , pp. 3156-3165
    • Rountree, M.R.1    Bachman, K.E.2    Herman, J.G.3
  • 46
    • 2542545717 scopus 로고    scopus 로고
    • Transcriptional gene silencing promotes DNA hypermethylation through a sequential change in chromatin modifications in cancer cells
    • Stirzaker C, Song JZ, Davidson B et al.: Transcriptional gene silencing promotes DNA hypermethylation through a sequential change in chromatin modifications in cancer cells. Cancer Res. 64, 3871-3877 (2004).
    • (2004) Cancer Res. , vol.64 , pp. 3871-3877
    • Stirzaker, C.1    Song, J.Z.2    Davidson, B.3
  • 47
    • 0027535235 scopus 로고
    • Effects of DNA methylation on DNA-binding proteins and gene expression
    • Tate PH, Bird AP: Effects of DNA methylation on DNA-binding proteins and gene expression. Curr. Opin. Genet. Dev. 3, 226-231 (1993).
    • (1993) Curr. Opin. Genet. Dev. , vol.3 , pp. 226-231
    • Tate, P.H.1    Bird, A.P.2
  • 48
    • 18444361838 scopus 로고    scopus 로고
    • DNA methylation and chromatin structure: The puzzling CpG islands
    • DOI 10.1002/jcb.20325
    • Caiafa P, Zampieri M: DNA methylation and chromatin structure: the puzzling CpG islands. J. Cell Biochem. 94, 257-265 (2005). (Pubitemid 41420304)
    • (2005) Journal of Cellular Biochemistry , vol.94 , Issue.2 , pp. 257-265
    • Caiafa, P.1    Zampieri, M.2
  • 49
    • 0022545498 scopus 로고
    • DNA methylation affects the formation of active chromatin
    • Keshet I, Lieman-Hurwitz J, Cedar H: DNA methylation affects the formation of active chromatin. Cell 44, 535-543 (1986). (Pubitemid 16083696)
    • (1986) Cell , vol.44 , Issue.4 , pp. 535-543
    • Keshet, I.1    Lieman-Hurwitz, J.2    Cedar, H.3
  • 50
    • 18944390988 scopus 로고    scopus 로고
    • DNA methylation precedes chromatin modifications under the influence of the strain-specific modifier Ssm1
    • Padjen K, Ratnam S, Storb U: DNA methylation precedes chromatin modifications under the influence of the strain-specific modifier Ssm1. Mol. Cell Biol. 25, 4782-4791 (2005).
    • (2005) Mol. Cell Biol. , vol.25 , pp. 4782-4791
    • Padjen, K.1    Ratnam, S.2    Storb, U.3
  • 51
    • 23844451055 scopus 로고    scopus 로고
    • Cytochrome P450 1B1 is overexpressed and regulated by hypomethylation in prostate cancer
    • One of the most important papers in the field of P450 epigenetics showing the involvement of epigenetics, particularly DNA methylation, in the regulation of a CYP gene
    • Tokizane T, Shiina H, Igawa M et al.: Cytochrome P450 1B1 is overexpressed and regulated by hypomethylation in prostate cancer. Clin. Cancer Res. 11, 5793-5801 (2005). ■ One of the most important papers in the field of P450 epigenetics showing the involvement of epigenetics, particularly DNA methylation, in the regulation of a CYP gene.
    • (2005) Clin. Cancer Res. , vol.11 , pp. 5793-5801
    • Tokizane, T.1    Shiina, H.2    Igawa, M.3
  • 52
    • 0029806936 scopus 로고    scopus 로고
    • Preferential formation of benzo[a]pyrene adducts at lung cancer mutational hotspots in P53
    • DOI 10.1126/science.274.5286.430
    • Denissenko MF, Pao A, Tang M et al.: Preferential formation of benzo[α]pyrene adducts at lung cancer mutational hotspots in P53. Science 274, 430-432 (1996). (Pubitemid 26353359)
    • (1996) Science , vol.274 , Issue.5286 , pp. 430-432
    • Denissenko, M.F.1    Pao, A.2    Tang, M.-S.3    Pfeifer, G.P.4
  • 53
    • 0024326433 scopus 로고
    • Roles of individual human cytochrome P-450 enzymes in the bioactivation of benzo(α) pyrene, 7,8-dihydroxy-7,8-dihydrobenzo(α) pyrene, and other dihydrodiol derivatives of polycyclic aromatic hydrocarbons
    • Shimada T, Martin MV, Pruess-Schwartz D et al.: Roles of individual human cytochrome P-450 enzymes in the bioactivation of benzo(α) pyrene, 7,8-dihydroxy-7,8-dihydrobenzo(α) pyrene, and other dihydrodiol derivatives of polycyclic aromatic hydrocarbons. Cancer Res. 49, 6304-6312 (1989).
    • (1989) Cancer Res. , vol.49 , pp. 6304-6312
    • Shimada, T.1    Martin, M.V.2    Pruess-Schwartz, D.3
  • 54
    • 0027937066 scopus 로고
    • The role of 12 cDNA-expressed human, rodent, and rabbit cytochromes P450 in the metabolism of benzo[a]pyrene and benzo[a]pyrene trans-7,8-dihydrodiol
    • DOI 10.1002/mc.2940100307
    • Shou M, Korzekwa KR, Crespi CL et al.: The role of 12 cDNA-expressed human, rodent, and rabbit cytochromes P450 in the metabolism of benzo[a]pyrene and benzo[a] pyrene trans-7,8-dihydrodiol. Mol. Carcinog. 10, 159-168 (1994). (Pubitemid 24257511)
    • (1994) Molecular Carcinogenesis , vol.10 , Issue.3 , pp. 159-168
    • Shou, M.1    Korzekwa, K.R.2    Crespi, C.L.3    Gonzalez, F.J.4    Gelboin, H.V.5
  • 59
    • 0347320799 scopus 로고    scopus 로고
    • Methylation of cytochrome P4501A1 promoter in the lung is associated with tobacco smoking
    • Study showed that the environment, a very important factor in directing epigenetic changes, is instrumental in causing variation in drug response by affecting the expression of a CYP gene
    • Anttila S, Hakkola J, Tuominen P et al.: Methylation of cytochrome P4501A1 promoter in the lung is associated with tobacco smoking. Cancer Res. 63, 8623-8628 (2003). ■■ Study showed that the environment, a very important factor in directing epigenetic changes, is instrumental in causing variation in drug response by affecting the expression of a CYP gene.
    • (2003) Cancer Res. , vol.63 , pp. 8623-8628
    • Anttila, S.1    Hakkola, J.2    Tuominen, P.3
  • 60
    • 33747873674 scopus 로고    scopus 로고
    • Epigenetic inactivation of the dioxin-responsive Cytochrome P4501A1 gene in human prostate cancer
    • DOI 10.1158/0008-5472.CAN-06-0504
    • Okino ST, Pookot D, Li LC et al.: Epigenetic inactivation of the dioxin-responsive cytochrome P4501A1 gene in human prostate cancer. Cancer Res. 66, 7420-7428 (2006). (Pubitemid 44289194)
    • (2006) Cancer Research , vol.66 , Issue.15 , pp. 7420-7428
    • Okino, S.T.1    Pookot, D.2    Li, L.-C.3    Zhao, H.4    Urakami, S.5    Shiina, H.6    Igawa, M.7    Dahiya, R.8
  • 61
    • 0035036154 scopus 로고    scopus 로고
    • Regulation, function, and tissue-specific expression of cytochrome P450 CYP1B1
    • Murray GI, Melvin WT, Greenlee WF et al.: Regulation, function, and tissue-specific expression of cytochrome P450 CYP1B1. Annu. Rev. Pharmacol. Toxicol. 41, 297-316 (2001).
    • (2001) Annu. Rev. Pharmacol. Toxicol. , vol.41 , pp. 297-316
    • Murray, G.I.1    Melvin, W.T.2    Greenlee, W.F.3
  • 62
    • 0037450429 scopus 로고    scopus 로고
    • Functional role of AhR in the expression of toxic effects by TCDD
    • Mimura J, Fujii-Kuriyama Y: Functional role of AhR in the expression of toxic effects by TCDD. Biochim. Biophys. Acta 1619, 263-268 (2003).
    • (2003) Biochim. Biophys. Acta , vol.1619 , pp. 263-268
    • Mimura, J.1    Fujii-Kuriyama, Y.2
  • 63
    • 0030812372 scopus 로고    scopus 로고
    • Tumor-specific expression of cytochrome P450 CYP1B1
    • Murray GI, Taylor MC, McFadyen MC et al.: Tumor-specific expression of cytochrome P450 CYP1B1. Cancer Res. 57, 3026-3031 (1997).
    • (1997) Cancer Res. , vol.57 , pp. 3026-3031
    • Murray, G.I.1    Taylor, M.C.2    McFadyen, M.C.3
  • 64
    • 0032744286 scopus 로고    scopus 로고
    • Immunohistochemical localization of cytochrome P450 CYP1B1 in breast cancer with monoclonal antibodies specific for CYP1B1
    • McFadyen MC, Breeman S, Payne S et al.: Immunohistochemical localization of cytochrome P450 CYP1B1 in breast cancer with monoclonal antibodies specific for CYP1B1. J. Histochem. Cytochem. 47, 1457-1464 (1999).
    • (1999) J. Histochem. Cytochem. , vol.47 , pp. 1457-1464
    • McFadyen, M.C.1    Breeman, S.2    Payne, S.3
  • 65
    • 0034935458 scopus 로고    scopus 로고
    • Cytochrome P450 CYP1B1 over-expression in primary and metastatic ovarian cancer
    • McFadyen MC, Cruickshank ME, Miller ID et al.: Cytochrome P450 CYP1B1 over-expression in primary and metastatic ovarian cancer. Br. J. Cancer 85, 242-246 (2001).
    • (2001) Br. J. Cancer , vol.85 , pp. 242-246
    • McFadyen, M.C.1    Cruickshank, M.E.2    Miller, I.D.3
  • 66
    • 44949222437 scopus 로고    scopus 로고
    • Variation in CYP1A2 activity and its clinical implications: Influence of environmental factors and genetic polymorphisms
    • DOI 10.2217/14622416.9.5.625
    • Gunes A, Dahl ML: Variation in CYP1A2 activity and its clinical implications: influence of environmental factors and genetic polymorphisms. Pharmacogenomics 9, 625-637 (2008). (Pubitemid 351803920)
    • (2008) Pharmacogenomics , vol.9 , Issue.5 , pp. 625-637
    • Gunes, A.1    Dahl, M.-L.2
  • 67
    • 0024362285 scopus 로고
    • The human cytochrome CYP1A2 gene contains regulatory elements responsive to 3-methylcholanthrene
    • Quattrochi LC, Tukey RH: The human cytochrome CYP1A2 gene contains regulatory elements responsive to 3-methylcholanthrene. Mol. Pharmacol. 36, 66-71 (1989).
    • (1989) Mol. Pharmacol. , vol.36 , pp. 66-71
    • Quattrochi, L.C.1    Tukey, R.H.2
  • 69
    • 0035839057 scopus 로고    scopus 로고
    • The role of DNA methylation in mammalian epigenetics
    • Jones PA, Takai D: The role of DNA methylation in mammalian epigenetics. Science 293, 1068-1070 (2001).
    • (2001) Science , vol.293 , pp. 1068-1070
    • Jones, P.A.1    Takai, D.2
  • 70
    • 0026742792 scopus 로고
    • CpG islands as gene markers in the human genome
    • Larsen F, Gundersen G, Lopez R et al.: CpG islands as gene markers in the human genome. Genomics 13, 1095-1107 (1992).
    • (1992) Genomics , vol.13 , pp. 1095-1107
    • Larsen, F.1    Gundersen, G.2    Lopez, R.3
  • 71
    • 0023216891 scopus 로고
    • CpG islands in vertebrate genomes
    • Gardiner-Garden M, Frommer M: CpG islands in vertebrate genomes. J. Mol. Biol. 196, 261-282 (1987).
    • (1987) J. Mol. Biol. , vol.196 , pp. 261-282
    • Gardiner-Garden, M.1    Frommer, M.2
  • 72
    • 0037133565 scopus 로고    scopus 로고
    • Comprehensive ana lysis of CpG islands in human chromosomes 21 and 22
    • Takai D, Jones PA: Comprehensive ana lysis of CpG islands in human chromosomes 21 and 22. Proc. Natl Acad. Sci. USA 99, 3740-3745 (2002).
    • (2002) Proc. Natl Acad. Sci. USA , vol.99 , pp. 3740-3745
    • Takai, D.1    Jones, P.A.2
  • 73
    • 67349227175 scopus 로고    scopus 로고
    • Allele-specific expression and gene methylation in the control of CYP1A2 mRNA level in human livers
    • Ghotbi R, Gomez A, Milani L et al.: Allele-specific expression and gene methylation in the control of CYP1A2 mRNA level in human livers. Pharmacogenomics J. 9(3), 208-217 (2009).
    • (2009) Pharmacogenomics J. , vol.9 , Issue.3 , pp. 208-217
    • Ghotbi, R.1    Gomez, A.2    Milani, L.3
  • 74
    • 31444443707 scopus 로고    scopus 로고
    • Tumor-specific expression of the novel cytochrome P450 enzyme, CYP2W1
    • Karlgren M, Gomez A, Stark K et al.: Tumor-specific expression of the novel cytochrome P450 enzyme, CYP2W1. Biochem. Biophys. Res. Commun. 341, 451-458 (2006).
    • (2006) Biochem. Biophys. Res. Commun. , vol.341 , pp. 451-458
    • Karlgren, M.1    Gomez, A.2    Stark, K.3
  • 75
    • 36148931473 scopus 로고    scopus 로고
    • Expression of CYP2W1 in colon tumors: Regulation by gene methylation
    • DOI 10.2217/14622416.8.10.1315
    • Gomez A, Karlgren M, Edler D et al.: Expression of CYP2W1 in colon tumors: regulation by gene methylation. Pharmacogenomics 8, 1315-1325 (2007). ■ CYP2W1 has been shown to be expressed in the developing embryo and is re-expressed in colon tumor through aberrant changes in DNA methylation. (Pubitemid 350162848)
    • (2007) Pharmacogenomics , vol.8 , Issue.10 , pp. 1315-1325
    • Gomez, A.1    Karlgren, M.2    Edler, D.3    Bernal, M.L.4    Mkrtchian, S.5    Ingelman-Sundberg, M.6
  • 77
    • 0026506224 scopus 로고
    • Expression of CYP2E1 during human fetal development: Methylation of the CYP2E1 gene in human fetal and adult liver samples
    • Jones SM, Boobis AR, Moore GE et al.: Expression of CYP2E1 during human fetal development: methylation of the CYP2E1 gene in human fetal and adult liver samples. Biochem. Pharmacol. 43, 1876-1879 (1992).
    • (1992) Biochem. Pharmacol. , vol.43 , pp. 1876-1879
    • Jones, S.M.1    Boobis, A.R.2    Moore, G.E.3
  • 78
    • 0031789282 scopus 로고    scopus 로고
    • Expression of CYP2E1 in human lung and kidney during development and in full-term placenta: A differential methylation of the gene is involved in the regulation process
    • Vieira I, Pasanen M, Raunio H et al.: Expression of CYP2E1 in human lung and kidney during development and in full-term placenta: a differential methylation of the gene is involved in the regulation process. Pharmacol. Toxicol. 83, 183-187 (1998). (Pubitemid 28512134)
    • (1998) Pharmacology and Toxicology , vol.83 , Issue.5 , pp. 183-187
    • Vieira, I.1    Pasanen, M.2    Raunio, H.3    Cresteil, T.4
  • 79
    • 33749154491 scopus 로고    scopus 로고
    • Epigenetics of gene expression in human hepatoma cells: Expression profiling the response to inhibition of DNA methylation and histone deacetylation
    • Dannenberg LO, Edenberg HJ: Epigenetics of gene expression in human hepatoma cells: expression profiling the response to inhibition of DNA methylation and histone deacetylation. BMC Genomics 7, 181 (2006).
    • (2006) BMC Genomics , vol.7 , pp. 181
    • Dannenberg, L.O.1    Edenberg, H.J.2
  • 80
    • 0032574977 scopus 로고    scopus 로고
    • Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex
    • DOI 10.1038/30764
    • Nan X, Ng HH, Johnson CA et al.: Transcriptional repression by the methyl- CpG-binding protein MeCP2 involves a histone deacetylase complex. Nature 393, 386-389 (1998). (Pubitemid 28269714)
    • (1998) Nature , vol.393 , Issue.6683 , pp. 386-389
    • Nan, X.1    Ng, H.-H.2    Johnson, C.A.3    Laherty, C.D.4    Turner, B.M.5    Eisenman, R.N.6    Bird, A.7
  • 81
    • 53149134680 scopus 로고    scopus 로고
    • The controversial 30 nm chromatin fibre
    • Staynov DZ: The controversial 30 nm chromatin fibre. Bioessays 30, 1003-1009 (2008).
    • (2008) Bioessays , vol.30 , pp. 1003-1009
    • Staynov, D.Z.1
  • 82
    • 1842411320 scopus 로고    scopus 로고
    • Crystal structure of the nucleosome core particle at 2.8 A resolution
    • DOI 10.1038/38444
    • Luger K, Mäder AW, Richmond RK, Sargent DF, Richmond TJ: Crystal structure of the nucleosome core particle at 2.8 A resolution. Nature 389, 251-260 (1997). (Pubitemid 27406632)
    • (1997) Nature , vol.389 , Issue.6648 , pp. 251-260
    • Luger, K.1    Mader, A.W.2    Richmond, R.K.3    Sargent, D.F.4    Richmond, T.J.5
  • 83
    • 39449088572 scopus 로고    scopus 로고
    • Genome-wide approaches to studying chromatin modifications
    • Schones DE, Zhao K: Genome-wide approaches to studying chromatin modifications. Nat. Rev. Genet. 9, 179-191 (2008).
    • (2008) Nat. Rev. Genet. , vol.9 , pp. 179-191
    • Schones, D.E.1    Zhao, K.2
  • 84
    • 0034610814 scopus 로고    scopus 로고
    • The language of covalent histone modifications
    • Strahl BD, Allis CD: The language of covalent histone modifications. Nature 403, 41-45 (2000).
    • (2000) Nature , vol.403 , pp. 41-45
    • Strahl, B.D.1    Allis, C.D.2
  • 85
    • 59149103350 scopus 로고    scopus 로고
    • M-phase-specific phosphorylation of histone H1.5 at threonine 10 by GSK-3
    • Happel N, Stoldt S, Schmidt B et al.: M-phase-specific phosphorylation of histone H1.5 at threonine 10 by GSK-3. J. Mol. Biol. 386(2), 339-350 (2008).
    • (2008) J. Mol. Biol. , vol.386 , Issue.2 , pp. 339-350
    • Happel, N.1    Stoldt, S.2    Schmidt, B.3
  • 86
    • 59249095962 scopus 로고    scopus 로고
    • Histone ubiquitination associates with BRCA1- dependent DNA damage response
    • Wu J, Huen MS, Lu LY et al.: Histone ubiquitination associates with BRCA1- dependent DNA damage response. Mol. Cell Biol. 29, 849-860 (2009).
    • (2009) Mol. Cell Biol. , vol.29 , pp. 849-860
    • Wu, J.1    Huen, M.S.2    Lu, L.Y.3
  • 87
    • 33645879818 scopus 로고    scopus 로고
    • Histone sumoylation is a negative regulator in Saccharomyces cerevisiae and shows dynamic interplay with positive-acting histone modifications
    • Nathan D, Ingvarsdottir K, Sterner DE et al.: Histone sumoylation is a negative regulator in Saccharomyces cerevisiae and shows dynamic interplay with positive-acting histone modifications. Genes Dev. 20, 966-976 (2006).
    • (2006) Genes Dev. , vol.20 , pp. 966-976
    • Nathan, D.1    Ingvarsdottir, K.2    Sterner, D.E.3
  • 88
    • 60849099332 scopus 로고    scopus 로고
    • Histone hypercitrullination mediates chromatin decondensation and neutrophil extracellular trap formation
    • Wang Y, Li M, Stadler S et al.: Histone hypercitrullination mediates chromatin decondensation and neutrophil extracellular trap formation. J. Cell Biol. 184(2), 205-213 (2009).
    • (2009) J. Cell Biol. , vol.184 , Issue.2 , pp. 205-213
    • Wang, Y.1    Li, M.2    Stadler, S.3
  • 91
    • 0035839136 scopus 로고    scopus 로고
    • Translating the histone code
    • Jenuwein T, Allis CD: Translating the histone code. Science 293, 1074-1080 (2001).
    • (2001) Science , vol.293 , pp. 1074-1080
    • Jenuwein, T.1    Allis, C.D.2
  • 92
    • 34548631473 scopus 로고    scopus 로고
    • HDAC1 bound to the Cyp1a1 promoter blocks histone acetylation associated with Ah receptor-mediated trans-activation
    • DOI 10.1016/j.bbaexp.2007.07.002, PII S0167478107001236
    • Schnekenburger M, Peng L, Puga A: HDAC1 bound to the CYP1A1 promoter blocks histone acetylation associated with Ah receptor-mediated trans-activation. Biochim. Biophys. Acta 1769, 569-578 (2007). (Pubitemid 47404659)
    • (2007) Biochimica et Biophysica Acta - Gene Structure and Expression , vol.1769 , Issue.9-10 , pp. 569-578
    • Schnekenburger, M.1    Peng, L.2    Puga, A.3
  • 93
    • 1042266669 scopus 로고    scopus 로고
    • Chromium inhibits transcription from polycyclic aromatic hydrocarbon-inducible promoters by blocking the release of histone deacetylase and preventing the binding of p300 to chromatin
    • Wei YD, Tepperman K, Huang MY et al.: Chromium inhibits transcription from polycyclic aromatic hydrocarbon-inducible promoters by blocking the release of histone deacetylase and preventing the binding of p300 to chromatin. J. Biol. Chem. 279, 4110-4119 (2004).
    • (2004) J. Biol. Chem. , vol.279 , pp. 4110-4119
    • Wei, Y.D.1    Tepperman, K.2    Huang, M.Y.3
  • 94
    • 66049140973 scopus 로고    scopus 로고
    • Dynamic patterns of histone methylation are associated with ontogenic expression of the Cyp3a genes during mouse liver maturation
    • The developmental switch in the expression of Cyp3 members in mice was shown in this study to be due to histone modification changes in a locus-specific manner while DNA methylation did not change
    • Li Y, Cui Y, Hart SN, Klaassen CD, Zhong X: Dynamic patterns of histone methylation are associated with ontogenic expression of the Cyp3a genes during mouse liver maturation. Mol. Pharmacol. 75(5), 1171-1179 (2009). ■■ The developmental switch in the expression of Cyp3 members in mice was shown in this study to be due to histone modification changes in a locus-specific manner while DNA methylation did not change.
    • (2009) Mol. Pharmacol. , vol.75 , Issue.5 , pp. 1171-1179
    • Li, Y.1    Cui, Y.2    Hart, S.N.3    Klaassen, C.D.4    Zhong, X.5
  • 95
    • 4644309196 scopus 로고    scopus 로고
    • The functions of animal microRNAs
    • Ambros V: The functions of animal microRNAs. Nature 431, 350-355 (2004).
    • (2004) Nature , vol.431 , pp. 350-355
    • Ambros, V.1
  • 96
    • 26944495173 scopus 로고    scopus 로고
    • MicroRNA function in animal development
    • Wienholds E, Plasterk RH: MicroRNA function in animal development. FEBS Lett. 579, 5911-5922 (2005).
    • (2005) FEBS Lett. , vol.579 , pp. 5911-5922
    • Wienholds, E.1    Plasterk, R.H.2
  • 97
    • 33749487425 scopus 로고    scopus 로고
    • MicroRNA regulates the expression of human cytochrome P450 1B1
    • DOI 10.1158/0008-5472.CAN-06-1403
    • Tsuchiya Y, Nakajima M, Takagi S et al.: MicroRNA regulates the expression of human cytochrome P450 1B1. Cancer Res. 66, 9090-9098 (2006). (Pubitemid 44521128)
    • (2006) Cancer Research , vol.66 , Issue.18 , pp. 9090-9098
    • Tsuchiya, Y.1    Nakajima, M.2    Takagi, S.3    Taniya, T.4    Yokoi, T.5
  • 98
    • 57349134379 scopus 로고    scopus 로고
    • Differential expression of microRNAs in early-stage neoplastic transformation in the lungs of F344 rats chronically treated with the tobacco carcinogen 4-(methylnitrosamino)-1- (3-pyridyl)-1-butanone
    • The expression pattern of miRNAs in carcinogenesis could potentially lead to the expression of CYPs and even promote the carcinogenic process
    • Kalscheuer S, Zhang X, Zeng Y et al.: Differential expression of microRNAs in early-stage neoplastic transformation in the lungs of F344 rats chronically treated with the tobacco carcinogen 4-(methylnitrosamino)-1- (3-pyridyl)-1-butanone. Carcinogenesis 29, 2394-2399 (2008). ■■ The expression pattern of miRNAs in carcinogenesis could potentially lead to the expression of CYPs and even promote the carcinogenic process.
    • (2008) Carcinogenesis , vol.29 , pp. 2394-2399
    • Kalscheuer, S.1    Zhang, X.2    Zeng, Y.3
  • 99
    • 60549084170 scopus 로고    scopus 로고
    • MicroRNAs as modulators of smokinginduced gene expression changes in human airway epithelium
    • Schembri F, Sridhar S, Perdomo C et al.: MicroRNAs as modulators of smokinginduced gene expression changes in human airway epithelium. Proc. Natl Acad. Sci. USA 106(7), 2319-2324 (2009).
    • (2009) Proc. Natl Acad. Sci. USA , vol.106 , Issue.7 , pp. 2319-2324
    • Schembri, F.1    Sridhar, S.2    Perdomo, C.3
  • 100
    • 36048953756 scopus 로고    scopus 로고
    • CYP3A4 and pregnane X receptor humanized mice
    • Gonzalez FJ: CYP3A4 and pregnane X receptor humanized mice. J. Biochem. Mol. Toxicol. 21, 158-162 (2007).
    • (2007) J. Biochem. Mol. Toxicol. , vol.21 , pp. 158-162
    • Gonzalez, F.J.1
  • 101
    • 44349182094 scopus 로고    scopus 로고
    • Post-transcriptional regulation of human pregnane X receptor by micro-RNA affects the expression of cytochrome P450 3A4
    • Takagi S, Nakajima M, Mohri T et al.: Post-transcriptional regulation of human pregnane X receptor by micro-RNA affects the expression of cytochrome P450 3A4. J. Biol. Chem. 283, 9674-9680 (2008).
    • (2008) J. Biol. Chem. , vol.283 , pp. 9674-9680
    • Takagi, S.1    Nakajima, M.2    Mohri, T.3
  • 102
    • 0034734244 scopus 로고    scopus 로고
    • A nuclear receptor system constituted by RAR and RXR induces aromatase activity in MCF-7 human breast cancer cells
    • Mu YM, Yanase T, Nishi Y et al.: A nuclear receptor system constituted by RAR and RXR induces aromatase activity in MCF-7 human breast cancer cells. Mol. Cell Endocrinol. 166, 137-145 (2000).
    • (2000) Mol. Cell Endocrinol. , vol.166 , pp. 137-145
    • Mu, Y.M.1    Yanase, T.2    Nishi, Y.3
  • 104
    • 0034917318 scopus 로고    scopus 로고
    • Antineoplastic action of 5-aza-2′-deoxycytidine and histone deacetylase inhibitor and their effect on the expression of retinoic acid receptor β and estrogen receptor a genes in breast carcinoma cells
    • DOI 10.1007/s002800100294
    • Bovenzi V, Momparler RL: Antineoplastic action of 5-aza-2′- deoxycytidine and histone deacetylase inhibitor and their effect on the expression of retinoic acid receptor β and estrogen receptor a genes in breast carcinoma cells. Cancer Chemother. Pharmacol. 48, 71-76 (2001). (Pubitemid 32662439)
    • (2001) Cancer Chemotherapy and Pharmacology , vol.48 , Issue.1 , pp. 71-76
    • Bovenzi, V.1    Momparler, R.L.2
  • 105
    • 23844494772 scopus 로고    scopus 로고
    • Cytochrome P450-mediated metabolism of estrogens and its regulation in human
    • DOI 10.1016/j.canlet.2004.10.007, PII S030438350400802X
    • Tsuchiya Y, Nakajima M, Yokoi T: Cytochrome P450-mediated metabolism of estrogens and its regulation in human. Cancer Lett. 227, 115-124 (2005). (Pubitemid 41174580)
    • (2005) Cancer Letters , vol.227 , Issue.2 , pp. 115-124
    • Tsuchiya, Y.1    Nakajima, M.2    Yokoi, T.3
  • 106
    • 41549151941 scopus 로고    scopus 로고
    • Epigenetic regulation of the estrogen receptor a promoter in the cerebral cortex following ischemia in male and female rats
    • Westberry JM, Prewitt AK, Wilson ME: Epigenetic regulation of the estrogen receptor a promoter in the cerebral cortex following ischemia in male and female rats. Neuroscience 152, 982-989 (2008).
    • (2008) Neuroscience , vol.152 , pp. 982-989
    • Westberry, J.M.1    Prewitt, A.K.2    Wilson, M.E.3


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