Marathon running increases ERK1/2 and p38 MAP kinase signalling to downstream targets in human skeletal muscle

Journal of Physiology

Volumn 536, Issue 1, 2001, Pages 273-282

  Yu, Mei ^a,b   Blomstrand, Eva ^b,c   Chibalin, Alexander V ^a,b   Krook, Anna ^a,b   Zierath, Juleen R ^a,b  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^b KAROLINSKA INSTITUTE   (Sweden)

^c University College of Physical Education and Sports   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

GLYCOGEN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE ACTIVATED PROTEIN KINASE 2; PHOSPHOTRANSFERASE; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; STRESS ACTIVATED PROTEIN KINASE 1;

ADULT; ANTIBODY SPECIFICITY; ANTIGEN ANTIBODY COMPLEX; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; ENZYME SUBSTRATE; GENETIC TRANSCRIPTION; GLYCOGEN ANALYSIS; HUMAN; HUMAN EXPERIMENT; HUMAN TISSUE; HYPOTHESIS; IMMUNOASSAY; IMMUNOBLOTTING; MALE; MARATHON RUNNER; MUSCLE BIOPSY; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; SKELETAL MUSCLE; SPECTROPHOTOMETRY; TIME; VASTUS LATERALIS MUSCLE;

ADULT; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; EXERCISE; GLYCOGEN; HUMANS; MALE; MAP KINASE SIGNALING SYSTEM; MIDDLE AGED; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MITOGEN-ACTIVATED PROTEIN KINASES; MUSCLE, SKELETAL; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; RIBOSOMAL PROTEIN S6 KINASES; RIBOSOMAL PROTEIN S6 KINASES, 90-KDA; RUNNING;

EID: 0035477471     PISSN: 00223751     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1469-7793.2001.00273.x     Document Type: Article

References (49)

1. PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase in vitro and in vivo
2. Contractile activity stimulates the c-Jun NH2-terminal kinase pathway in rat skeletal muscle
3. Exercise stimulates the mitogenic-activated protein kinase pathway in human skeletal muscle
4. The p38/RK mitogen-activated protein kinase pathway regulates interleukin-6 synthesis response to tumor necrosis factor
5. Signal transduction via the MAP kinases: Proceed at your own RSK
6. Molecular and cellular adaptations of muscle in response to exercise: Perspectives of various models
7. 2-terminal kinase activity in human skeletal muscle
8. 2-terminal kinase and p38γ activities in human skeletal muscle
9. Mammalian MAP kinase modules: How to transduce specific signals
10. Parallel signal processing among mammalian MAPKs
11. Exercise-induced changes in expression and activity of proteins involved in insulin signal transduction in skeletal muscle: Differential effects on insulin receptor substrates 1 and 2
12. A comparison of the substrate specificity of MAPKAP kinase-2 and MAPKAP kinase-3 and their activation by cytokines and cellular stress
13. The search for physiological substrates of MAP and SAP kinases in mammalian cells
14. Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells
15. Ras-dependent activation of MAP kinase pathway mediated by G-proteinβγ subunits
16. Activation of stress-activated protein kinase-3 (SAPK3) by cytokines and cellular stresses is mediated via SAPKK3 (MKK6); comparison of the specificities of SAPK3 and SAPK2 (RK/p38)
17. SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1
18. The mitogen-activated protein kinase signal transduction pathway
19. Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB
20. Interleukin-1 activates a novel protein kinase cascade that results in the phosphorylation of Hsp27
21. An osmosensing signal transduction pathway in mammalian cells
22. Activation of the novel stress-activated protein kinase SAPK4 by cytokines and cellular stresses is mediated by SKK3 (MKK6); comparison of its substrate specificity with that of other SAP kinases
23. Effects of exercise and insulin on mitogen-activated protein kinase signaling pathways in rat skeletal muscle
24. Effects of contractile activity on tyrosine phosphorylation and PI 3-kinase activity in rat skeletal muscle
25. A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells
26. Skeletal muscle contractile activity in vitro stimulates mitogen-activated protein kinase signaling
27. p38/RK is essential for stress-induced nuclear responses: JNK/SAPKs and c-Jun/ATF-2 phosphorylation are insufficient
28. Effects of endurance training on gene expression of insulin signal transduction pathway
29. Effect of long-term exercise on gene expression of insulin signaling pathway intermediates in skeletal muscle
30. Acute and chronic effects of strenuous exercise on glucose metabolism in isolated, incubated soleus muscle of exercise-trained rats
31. The primary structure of p38γ: A new member of p38 group of MAP kinase
32. The MEF2A isoform is required for striated muscle-specific expression of the insulin-responsive GLUT4 glucose transporter
33. Evidence that interleukin-6 is produced in human skeletal muscle during prolonged running
34. The p38 and ERK MAP kinase pathways cooperate to activate ternary complex factors and c-fos transcription in response to UV light
35. Rapid stimulation by insulin of a serine/threonine kinase in 3T3-L1 adipocytes that phosphorylates microtubule-associated protein 2 in vitro
36. Characterization of insulin-stimulated microtubule-associated protein kinase. Rapid isolation and stabilization of a novel serine/threonine kinase from 3T3-L1 cells
37. Effect of contraction on mitogen-activated protein kinase signal transduction in skeletal muscle: Involvement of the mitogen- and stress-activated protein kinase 1
38. Role of SAPK/ERK kinase-1 in the stress-activated pathway regulating transcription factor c-Jun
39. The MAPK signaling cascade
40. S6K, and Akt by contraction and insulin in rat skeletal muscle
41. Insulin-stimulated MAP-2 kinase phosphorylates and activates ribosomal protein S6 kinase II
42. Myocyte enhancer factor 2 (MEF2)-binding site is required for GLUT4 gene expression in transgenic mice. Regulation of MEF2 DNA binding activity in insulin-deficient diabetes
43. Receptor-tyrosine-kinase- and Gβγ-mediated MAP kinase activation by a common signaling pathway
44. o-protein α-subunits activates mitogen-activated protein kinase via a novel protein kinase C-dependent mechanism
45. Divergent effects of exercise on metabolic and mitogenic signaling pathways in human skeletal muscle
46. Differential regulation of MAP kinase by contraction and insulin in skeletal muscle: Metabolic implications
47. Coupling of the RAS-MAPK pathway to gene activation by RSK2, a growth factor-regulated CREB kinase
48. p38 mitogen-activated protein kinase pathway promotes skeletal muscle differentiation: Participation of the MEF2C transcription factor
49. Regulation and interaction of pp90(RSK) isoforms with mitogen-activated protein kinase