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Volumn 36, Issue 5, 2013, Pages 385-392

Regulation of SIRT1 by microRNAs

Author keywords

Aging; Deacetylase; NAD; NAMPT; Obesity; Therapeutics

Indexed keywords

MICRORNA; MICRORNA 34A; NICOTINAMIDE ADENINE DINUCLEOTIDE; NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE; SIRTUIN; SIRTUIN 1;

EID: 84900423595     PISSN: 10168478     EISSN: 02191032     Source Type: Journal    
DOI: 10.1007/s10059-013-0297-1     Document Type: Short Survey
Times cited : (70)

References (81)
  • 9
    • 80052008851 scopus 로고    scopus 로고
    • Circulating microRNAs in patients with chronic hepatitis C and non-alcoholic fatty liver disease
    • Cermelli, S., Ruggieri, A., Marrero, J.A., Ioannou, G.N., and Beretta, L. (2011). Circulating microRNAs in patients with chronic hepatitis C and non-alcoholic fatty liver disease. PLoS One 6, e23937.
    • (2011) PLoS One , vol.6
    • Cermelli, S.1    Ruggieri, A.2    Marrero, J.A.3    Ioannou, G.N.4    Beretta, L.5
  • 11
    • 77955434383 scopus 로고    scopus 로고
    • Fibroblast growth factor 21 regulates energy metabolism by activating the AMPK-SIRT1-PGC-1alpha pathway
    • Chau, M.D., Gao, J., Yang, Q., Wu, Z., and Gromada, J. (2010). Fibroblast growth factor 21 regulates energy metabolism by activating the AMPK-SIRT1-PGC-1alpha pathway. Proc. Natl. Acad. Sci. USA 107, 12553-12558.
    • (2010) Proc. Natl. Acad. Sci. USA , vol.107 , pp. 12553-12558
    • Chau, M.D.1    Gao, J.2    Yang, Q.3    Wu, Z.4    Gromada, J.5
  • 13
    • 84888131014 scopus 로고    scopus 로고
    • Elevated micro-RNA-34a in obesity reduces NAD+ levels and SIRT1 activity by directly targeting NAMPT
    • Epub ahead of print
    • Choi, S.E., Fu, T., Seok, S., Kim, D.H., Yu, E., Lee, KW., Kang, Y., Li, X., Kemper, B., and Kemper, J.K. (2013). Elevated micro-RNA-34a in obesity reduces NAD+ levels and SIRT1 activity by directly targeting NAMPT. Aging Cell [Epub ahead of print].
    • (2013) Aging Cell
    • Choi, S.E.1    Fu, T.2    Seok, S.3    Kim, D.H.4    Yu, E.5    Lee, K.W.6    Kang, Y.7    Li, X.8    Kemper, B.9    Kemper, J.K.10
  • 17
    • 67949102053 scopus 로고    scopus 로고
    • Recent progress in the biology and physiology of sirtuins
    • Finkel, T., Deng, C.X., and Mostoslavsky, R. (2009). Recent progress in the biology and physiology of sirtuins. Nature 460, 587-591.
    • (2009) Nature , vol.460 , pp. 587-591
    • Finkel, T.1    Deng, C.X.2    Mostoslavsky, R.3
  • 18
    • 33744466971 scopus 로고    scopus 로고
    • Mammalian Sir2 homolog SIRT7 is an activator of RNA polymerase I transcription
    • Ford, E., Voit, R., Liszt, G., Magin, C., Grummt, I., and Guarente, L. (2006). Mammalian Sir2 homolog SIRT7 is an activator of RNA polymerase I transcription. Genes Dev. 20, 1075-1080.
    • (2006) Genes Dev. , vol.20 , pp. 1075-1080
    • Ford, E.1    Voit, R.2    Liszt, G.3    Magin, C.4    Grummt, I.5    Guarente, L.6
  • 19
    • 84867068010 scopus 로고    scopus 로고
    • Aberrantly elevated microRNA-34a in obesity attenuates hepatic responses to FGF19 by targeting a membrane coreceptor beta-Klotho
    • Fu, T., Choi, S.E., Kim, D.H., Seok, S., Suino-Powell, K.M., Xu, H.E., and Kemper, J.K. (2012). Aberrantly elevated microRNA-34a in obesity attenuates hepatic responses to FGF19 by targeting a membrane coreceptor beta-Klotho. Proc. Natl. Acad. Sci. USA 109, 16137-16142.
    • (2012) Proc. Natl. Acad. Sci. USA , vol.109 , pp. 16137-16142
    • Fu, T.1    Choi, S.E.2    Kim, D.H.3    Seok, S.4    Suino-Powell, K.M.5    Xu, H.E.6    Kemper, J.K.7
  • 20
    • 33845868198 scopus 로고    scopus 로고
    • Sirtuins as potential targets for metabolic syndrome
    • Guarente, L. (2006). Sirtuins as potential targets for metabolic syndrome. Nature 444, 868-874.
    • (2006) Nature , vol.444 , pp. 868-874
    • Guarente, L.1
  • 22
    • 84860228592 scopus 로고    scopus 로고
    • In mammalian muscle, SIRT3 is present in mitochondria and not in the nucleus; and SIRT3 is upregulated by chronic muscle contraction in an adenosine monophosphate-activated protein kinase-independent manner
    • Gurd, B.J., Holloway, G.P., Yoshida, Y., and Bonen, A. (2012). In mammalian muscle, SIRT3 is present in mitochondria and not in the nucleus; and SIRT3 is upregulated by chronic muscle contraction in an adenosine monophosphate-activated protein kinase-independent manner. Metabolism 61, 733-741.
    • (2012) Metabolism , vol.61 , pp. 733-741
    • Gurd, B.J.1    Holloway, G.P.2    Yoshida, Y.3    Bonen, A.4
  • 23
    • 77949887506 scopus 로고    scopus 로고
    • Mammalian sirtuins: Biological insights and disease relevance
    • Haigis, M.C., and Sinclair, D.A. (2010). Mammalian sirtuins: biological insights and disease relevance. Annu. Rev. Pathol. 5, 253-295.
    • (2010) Annu. Rev. Pathol. , vol.5 , pp. 253-295
    • Haigis, M.C.1    Sinclair, D.A.2
  • 25
    • 41349096445 scopus 로고    scopus 로고
    • Gene regulation by transcription factors and microRNAs
    • Hobert, O. (2008). Gene regulation by transcription factors and microRNAs. Science 319, 1785-1786.
    • (2008) Science , vol.319 , pp. 1785-1786
    • Hobert, O.1
  • 28
    • 63849252078 scopus 로고    scopus 로고
    • Therapeutic potential of SIRT1 and NAMPT-mediated NAD biosynthesis in type 2 diabetes
    • Imai, S., and Kiess, W. (2009). Therapeutic potential of SIRT1 and NAMPT-mediated NAD biosynthesis in type 2 diabetes. Front Biosci. 14, 2983-95.
    • (2009) Front Biosci. , vol.14 , pp. 2983-2995
    • Imai, S.1    Kiess, W.2
  • 29
    • 0034677535 scopus 로고    scopus 로고
    • Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase
    • DOI 10.1038/35001622
    • Imai, S., Armstrong, C.M., Kaeberlein, M., and Guarente, L. (2000). Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase. Nature 403, 795-800. (Pubitemid 30111843)
    • (2000) Nature , vol.403 , Issue.6771 , pp. 795-800
    • Imai, S.-I.1    Armstrong, C.M.2    Kaeberlein, M.3    Guarente, L.4
  • 30
    • 84871852995 scopus 로고    scopus 로고
    • SIRT3 functions in the nucleus in the control of stress-related gene expression
    • Iwahara, T., Bonasio, R., Narendra, V., and Reinberg, D. (2012). SIRT3 functions in the nucleus in the control of stress-related gene expression. Mol. Cell. Biol. 32, 5022-5034.
    • (2012) Mol. Cell. Biol. , vol.32 , pp. 5022-5034
    • Iwahara, T.1    Bonasio, R.2    Narendra, V.3    Reinberg, D.4
  • 31
    • 77955417245 scopus 로고    scopus 로고
    • MicroRNA-34a regulation of endothelial senescence
    • Ito, T., Yagi, S., and Yamakuchi, M. (2010). MicroRNA-34a regulation of endothelial senescence. Biochem. Biophys. Res. Commun. 398, 735-740.
    • (2010) Biochem. Biophys. Res. Commun. , vol.398 , pp. 735-740
    • Ito, T.1    Yagi, S.2    Yamakuchi, M.3
  • 32
    • 70350606061 scopus 로고    scopus 로고
    • FXR acetylation is normally dynamically regulated by p300 and SIRT1 but constitutively elevated in metabolic disease states
    • Kemper, J.K., Xiao, Z., Ponugoti, B., Miao, J., Fang, S., Kanamaluru, D., Tsang, S., Wu, S., Chiang, C.M., and Veenstra, T.D. (2009). FXR acetylation is normally dynamically regulated by p300 and SIRT1 but constitutively elevated in metabolic disease states. Cell Metab. 10, 392-404.
    • (2009) Cell Metab. , vol.10 , pp. 392-404
    • Kemper, J.K.1    Xiao, Z.2    Ponugoti, B.3    Miao, J.4    Fang, S.5    Kanamaluru, D.6    Tsang, S.7    Wu, S.8    Chiang, C.M.9    Veenstra, T.D.10
  • 33
    • 84873868477 scopus 로고    scopus 로고
    • Sirtuin 1 deacetylase: A key regulator of hepatic lipid metabolism
    • Kemper, J.K., Choi, S.E., and Kim, D.H. (2013). Sirtuin 1 deacetylase: a key regulator of hepatic lipid metabolism. Vitam. Horm. 91, 385-404.
    • (2013) Vitam. Horm. , vol.91 , pp. 385-404
    • Kemper, J.K.1    Choi, S.E.2    Kim, D.H.3
  • 34
    • 80051604377 scopus 로고    scopus 로고
    • Gain of survival signaling by downregulation of three key miRNAs in brain of calorie-restricted mice
    • Khanna, A., Muthusamy, S., Liang, R., Sarojini, H., and Wang, E. (2011). Gain of survival signaling by downregulation of three key miRNAs in brain of calorie-restricted mice. Aging 3, 223-236.
    • (2011) Aging , vol.3 , pp. 223-236
    • Khanna, A.1    Muthusamy, S.2    Liang, R.3    Sarojini, H.4    Wang, E.5
  • 35
    • 84874487252 scopus 로고    scopus 로고
    • Sirtuin7 oncogenic potential in human hepatocellular carcinoma and its regulation by the tumor suppressors MiR-125a-5p and MiR-125b
    • Kim, J.K., Noh, J.H., Jung, K.H., Eun, J.W., Bae, H.J., Kim, M.G., Chang, Y.G., Shen, Q., Park, W.S., Lee, J.Y., et al. (2013). Sirtuin7 oncogenic potential in human hepatocellular carcinoma and its regulation by the tumor suppressors MiR-125a-5p and MiR-125b. Hepatology 57, 1055-1067.
    • (2013) Hepatology , vol.57 , pp. 1055-1067
    • Kim, J.K.1    Noh, J.H.2    Jung, K.H.3    Eun, J.W.4    Bae, H.J.5    Kim, M.G.6    Chang, Y.G.7    Shen, Q.8    Park, W.S.9    Lee, J.Y.10
  • 36
    • 27744518040 scopus 로고    scopus 로고
    • FoxO1 protects against pancreatic beta cell failure through NeuroD and MafA induction
    • Kitamura, Y.I., Kitamura, T., Kruse, J.P., Raum, J.C., Stein, R., Gu, W., and Accili, D. (2005). FoxO1 protects against pancreatic beta cell failure through NeuroD and MafA induction. Cell Metab. 2, 153-163.
    • (2005) Cell Metab. , vol.2 , pp. 153-163
    • Kitamura, Y.I.1    Kitamura, T.2    Kruse, J.P.3    Raum, J.C.4    Stein, R.5    Gu, W.6    Accili, D.7
  • 37
    • 77955347446 scopus 로고    scopus 로고
    • Sirtuin 3, a new target of PGC-1α, plays an important role in the suppression of ROS and mitochondrial biogenesis
    • Kong, X., Wang, R., Xue, Y., Liu, X., Zhang, H., Chen, Y., Fang, F., and Chang, Y. (2010). Sirtuin 3, a new target of PGC-1α, plays an important role in the suppression of ROS and mitochondrial biogenesis. PLoS One 5, e11707.
    • (2010) PLoS One , vol.5
    • Kong, X.1    Wang, R.2    Xue, Y.3    Liu, X.4    Zhang, H.5    Chen, Y.6    Fang, F.7    Chang, Y.8
  • 39
    • 79952109655 scopus 로고    scopus 로고
    • Controlling SIRT1 expression by microRNAs in health and metabolic disease
    • Lee, J., and Kemper, J.K. (2010). Controlling SIRT1 expression by microRNAs in health and metabolic disease. Aging 2, 527-534.
    • (2010) Aging , vol.2 , pp. 527-534
    • Lee, J.1    Kemper, J.K.2
  • 40
    • 77951210885 scopus 로고    scopus 로고
    • A pathway involving farnesoid X receptor and small heterodimer partner positively regulates hepatic sirtuin 1 levels via microRNA-34a inhibition
    • Lee, J., Padhye, A., Sharma, A., Song, G., Miao, J., Mo, Y.Y., Wang, L., and Kemper, J.K. (2010). A pathway involving farnesoid X receptor and small heterodimer partner positively regulates hepatic sirtuin 1 levels via microRNA-34a inhibition. J. Biol. Chem. 285, 12604-126011.
    • (2010) J. Biol. Chem. , vol.285 , pp. 12604-126011
    • Lee, J.1    Padhye, A.2    Sharma, A.3    Song, G.4    Miao, J.5    Mo, Y.Y.6    Wang, L.7    Kemper, J.K.8
  • 41
    • 79955957616 scopus 로고    scopus 로고
    • Poly(ADP-Ribose) regulates stress responses and microRNA activity in the cytoplasm
    • Leung, A.K., Vyas, S., Rood, J.E., Bhutkar, A., Sharp, P.A., and Chang, P. (2011). Poly(ADP-Ribose) regulates stress responses and microRNA activity in the cytoplasm. Mol. Cell 42, 489-499.
    • (2011) Mol. Cell , vol.42 , pp. 489-499
    • Leung, A.K.1    Vyas, S.2    Rood, J.E.3    Bhutkar, A.4    Sharp, P.A.5    Chang, P.6
  • 42
    • 0346094457 scopus 로고    scopus 로고
    • Prediction of Mammalian MicroRNA Targets
    • DOI 10.1016/S0092-8674(03)01018-3
    • Lewis, B.P., Shih, I.H., Jones-Rhoades, M.W., Bartel, D.P., and Burge, C.B. (2003) Prediction of mammalian microRNA targets. Cell 115, 787-798. (Pubitemid 38058492)
    • (2003) Cell , vol.115 , Issue.7 , pp. 787-798
    • Lewis, B.P.1    Shih, I.-H.2    Jones-Rhoades, M.W.3    Bartel, D.P.4    Burge, C.B.5
  • 43
    • 70349393847 scopus 로고    scopus 로고
    • Differential expression of micro-RNAs in mouse liver under aberrant energy metabolic status
    • Li, S., Chen, X., Zhang, H., Liang, X., Xiang, Y., Yu, C., Zen, K., Li, Y., and Zhang, C.Y. (2009). Differential expression of micro-RNAs in mouse liver under aberrant energy metabolic status. J. Lipid Res. 50, 1756-1765.
    • (2009) J. Lipid Res. , vol.50 , pp. 1756-1765
    • Li, S.1    Chen, X.2    Zhang, H.3    Liang, X.4    Xiang, Y.5    Yu, C.6    Zen, K.7    Li, Y.8    Zhang, C.Y.9
  • 44
    • 79952742806 scopus 로고    scopus 로고
    • Increased expression of miR-34a and miR-93 in rat liver during aging, and their impact on the expression of Mgst1 and Sirt1
    • Li, N., Muthusamy, S., Liang, R., Sarojini, H., and Wang, E. (2011). Increased expression of miR-34a and miR-93 in rat liver during aging, and their impact on the expression of Mgst1 and Sirt1. Mech. Ageing Dev. 132, 75-85.
    • (2011) Mech. Ageing Dev. , vol.132 , pp. 75-85
    • Li, N.1    Muthusamy, S.2    Liang, R.3    Sarojini, H.4    Wang, E.5
  • 47
  • 51
    • 65249087389 scopus 로고    scopus 로고
    • SIRT5 Deacetylates carbamoyl phosphate synthetase 1 and regulates the urea cycle
    • Nakagawa, T., Lomb, D.J., Haigis, M.C., and Guarente, L. (2009). SIRT5 Deacetylates carbamoyl phosphate synthetase 1 and regulates the urea cycle. Cell 137, 560-570.
    • (2009) Cell , vol.137 , pp. 560-570
    • Nakagawa, T.1    Lomb, D.J.2    Haigis, M.C.3    Guarente, L.4
  • 52
  • 53
    • 51549106674 scopus 로고    scopus 로고
    • Small RNA regulators of gene expression
    • Neilson, J.R., and Sharp, P.A. (2008). Small RNA regulators of gene expression. Cell 134, 899-902.
    • (2008) Cell , vol.134 , pp. 899-902
    • Neilson, J.R.1    Sharp, P.A.2
  • 55
    • 30044443515 scopus 로고    scopus 로고
    • + depletion and reduced Sir2alpha deacetylase activity
    • DOI 10.1074/jbc.M506162200
    • Pillai, J.B., Isbatan, A., Imai, S., and Gupta, M.P. (2005). Poly(ADP-ribose) polymerase-1-dependent cardiac myocyte cell death during heart failure is mediated by NAD+ depletion and reduced Sir2alpha deacetylase activity. J. Biol. Chem. 280, 43121-43130. (Pubitemid 43049278)
    • (2005) Journal of Biological Chemistry , vol.280 , Issue.52 , pp. 43121-43130
    • Pillai, J.B.1    Isbatan, A.2    Imai, S.-I.3    Gupta, M.P.4
  • 58
    • 80051590849 scopus 로고    scopus 로고
    • Restitution of tumor suppressor microRNAs using a systemic nanovector inhibits pancreatic cancer growth in mice
    • Pramanik, D., Campbell, N.R., Karikari, C., Chivukula, R., Kent, O. A., Mendell, J.T., and Maitra, A. (2011). Restitution of tumor suppressor microRNAs using a systemic nanovector inhibits pancreatic cancer growth in mice. Mol. Cancer Ther. 10, 1470-1480.
    • (2011) Mol. Cancer Ther. , vol.10 , pp. 1470-1480
    • Pramanik, D.1    Campbell, N.R.2    Karikari, C.3    Chivukula, R.4    Kent, O.A.5    Mendell, J.T.6    Maitra, A.7
  • 59
    • 84864615516 scopus 로고    scopus 로고
    • Brown remodeling of white adipose tissue by SirT1-dependent deacetylation of Pparaγ
    • Qiang, L., Wang, L., Kon, N., Zhao, W., Lee, S., Zhang, Y., Rosenbaum, M., Zhao, Y., Gu, W., Farmer, S.R., et al. (2012). Brown remodeling of white adipose tissue by SirT1-dependent deacetylation of Pparaγ. Cell 150, 620-632.
    • (2012) Cell , vol.150 , pp. 620-632
    • Qiang, L.1    Wang, L.2    Kon, N.3    Zhao, W.4    Lee, S.5    Zhang, Y.6    Rosenbaum, M.7    Zhao, Y.8    Gu, W.9    Farmer, S.R.10
  • 60
    • 79952846843 scopus 로고    scopus 로고
    • Sirt1 and mir-9 expression is regulated during glucose-stimulated insulin secretion in pancreatic β-islets
    • Ramachandran, D., Roy, U., Garg, S., Ghosh, S., Pathak, S., and Kolthur-Seetharam, U. (2011). Sirt1 and mir-9 expression is regulated during glucose-stimulated insulin secretion in pancreatic β-islets. FEBS J. 278, 1167-1174.
    • (2011) FEBS J. , vol.278 , pp. 1167-1174
    • Ramachandran, D.1    Roy, U.2    Garg, S.3    Ghosh, S.4    Pathak, S.5    Kolthur-Seetharam, U.6
  • 64
    • 14544282413 scopus 로고    scopus 로고
    • Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1
    • DOI 10.1038/nature03354
    • Rodgers, J.T., Lerin, C., Haas, W., Gygi, S.P., Spiegelman, B.M., and Puigserver, P. (2005). Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1. Nature 434, 113-118. (Pubitemid 40349395)
    • (2005) Nature , vol.434 , Issue.7029 , pp. 113-118
    • Rodgers, J.T.1    Lerin, C.2    Haas, W.3    Gygi, S.P.4    Spiegelman, B.M.5    Puigserver, P.6
  • 67
    • 84880068090 scopus 로고    scopus 로고
    • The role of SIRT6 protein in aging and reprogramming of human induced pluripotent stem cells
    • Sharma, A., Diecke, S., Zhang, W.Y., Lan, F., He, C., Mordwinkin, N.M., Chua, K.F., and Wu, J.C. (2013). The role of SIRT6 protein in aging and reprogramming of human induced pluripotent stem cells. J. Biol. Chem. 288, 18439-18447.
    • (2013) J. Biol. Chem. , vol.288 , pp. 18439-18447
    • Sharma, A.1    Diecke, S.2    Zhang, W.Y.3    Lan, F.4    He, C.5    Mordwinkin, N.M.6    Chua, K.F.7    Wu, J.C.8
  • 68
    • 70350436694 scopus 로고    scopus 로고
    • MicroRNA 132 regulates nutritional stressinduced chemokine production through repression of SirT1
    • Strum, J.C., Johnson, J.H., Ward, J., Xie, H., Field, J., Hester, A., Alford, A., and Waters, K.M. (2009). MicroRNA 132 regulates nutritional stressinduced chemokine production through repression of SirT1. Mol. Endocrinol. 23, 1876-1884.
    • (2009) Mol. Endocrinol. , vol.23 , pp. 1876-1884
    • Strum, J.C.1    Johnson, J.H.2    Ward, J.3    Xie, H.4    Field, J.5    Hester, A.6    Alford, A.7    Waters, K.M.8
  • 70
    • 41449083867 scopus 로고    scopus 로고
    • Sirt7 increases stress resistance of cardiomyocytes and prevents apoptosis and inflammatory cardiomyopathy in mice
    • DOI 10.1161/CIRCRESAHA.107.164558
    • Vakhrusheva, O., Smolka, C., Gajawada, P., Kostin, S., Boettger, T., Kubin, T., Braun, T., and Bober, E. (2008). Sirt7 increases stress resistance of cardiomyocytes and prevents apoptosis and inflammatory cardiomyopathy in mice. Circ. Res. 102, 703-710. (Pubitemid 351457857)
    • (2008) Circulation Research , vol.102 , Issue.6 , pp. 703-710
    • Vakhrusheva, O.1    Smolka, C.2    Gajawada, P.3    Kostin, S.4    Boettger, T.5    Kubin, T.6    Braun, T.7    Bober, E.8
  • 71
    • 79251581020 scopus 로고    scopus 로고
    • The art of microRNA research
    • Van Rooji, E. (2011). The art of microRNA research. Circ. Res. 108, 219-234.
    • (2011) Circ. Res. , vol.108 , pp. 219-234
    • Van Rooji, E.1
  • 73
    • 65549144017 scopus 로고    scopus 로고
    • MicroRNAs induced during adipogenesis that accelerate fat cell development are downregulated in obesity
    • Xie, H., Lim, B., and Lodish, H.F. (2009). MicroRNAs induced during adipogenesis that accelerate fat cell development are downregulated in obesity. Diabetes 58, 1050-1057.
    • (2009) Diabetes , vol.58 , pp. 1050-1057
    • Xie, H.1    Lim, B.2    Lodish, H.F.3
  • 75
    • 34547413569 scopus 로고    scopus 로고
    • Sirtuin functions in health and disease
    • DOI 10.1210/me.2007-0079
    • Yamamoto, H., Schoonjans, K., and Auwerx, J. (2007). Sirtuin functions in health and disease Mol. Endocrinol. 21, 1745-1755. (Pubitemid 47173788)
    • (2007) Molecular Endocrinology , vol.21 , Issue.8 , pp. 1745-1755
    • Yamamoto, H.1    Schoonjans, K.2    Auwerx, J.3
  • 76
    • 80052996141 scopus 로고    scopus 로고
    • Alternative miRNA biogenesis pathways and the interpretation of core miRNA pathway mutants
    • Yang, J.S., and Lai, E.C. (2011). Alternative miRNA biogenesis pathways and the interpretation of core miRNA pathway mutants. Mol. Cell 43, 892-903.
    • (2011) Mol. Cell , vol.43 , pp. 892-903
    • Yang, J.S.1    Lai, E.C.2
  • 77
    • 80053920774 scopus 로고    scopus 로고
    • Nicotinamide mononucleotide, a key NAD(+) intermediate, treats the pathophysiology of diet- and age-induced diabetes in mice
    • Yoshino, J., Mills, K.F., Yoon, M.J., and Imai, S. (2011). Nicotinamide mononucleotide, a key NAD(+) intermediate, treats the pathophysiology of diet- and age-induced diabetes in mice. Cell Metab. 14, 528-536.
    • (2011) Cell Metab. , vol.14 , pp. 528-536
    • Yoshino, J.1    Mills, K.F.2    Yoon, M.J.3    Imai, S.4
  • 79
    • 84880844549 scopus 로고    scopus 로고
    • Nicotinamide phosphoribosyl transferase (Nampt) is a target of MicroRNA-26b in colorectal cancer cells
    • Zhang, C., Tong, J., and Huang, G. (2013). Nicotinamide phosphoribosyl transferase (Nampt) is a target of MicroRNA-26b in colorectal cancer cells. PLoS One 8, e69963.
    • (2013) PLoS One , vol.8
    • Zhang, C.1    Tong, J.2    Huang, G.3
  • 80
    • 84866362817 scopus 로고    scopus 로고
    • Downregulation of miR-181a upregulates sirtuin-1 (SIRT1) and improves hepatic insulin sensitivity
    • Zhou, B., Li, C., Qi, W., Zhang, Y., Zhang, F., Wu, J.X., Hu, Y.N., Wu, D.M., Liu, Y., Yan, T.T., et al. (2012). Downregulation of miR-181a upregulates sirtuin-1 (SIRT1) and improves hepatic insulin sensitivity. Diabetologia 55, 2032-2043.
    • (2012) Diabetologia , vol.55 , pp. 2032-2043
    • Zhou, B.1    Li, C.2    Qi, W.3    Zhang, Y.4    Zhang, F.5    Wu, J.X.6    Hu, Y.N.7    Wu, D.M.8    Liu, Y.9    Yan, T.T.10


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.