Mitochondrial sirtuins and metabolic homeostasis

Best Practice and Research: Clinical Endocrinology and Metabolism

Volumn 26, Issue 6, 2012, Pages 759-770

  Pirinen, Eija ^a,b   Lo Sasso, Giuseppe ^a   Auwerx, Johan ^a  

^a EPFL   (Switzerland)

^b UNIVERSITY OF EASTERN FINLAND   (Finland)

Author keywords

deacetylase; energy homeostasis; metabolism; mitochondria; sirtuins

Indexed keywords

INSULIN; LIPID; SIRTUIN; SIRTUIN 1; SIRTUIN 3; SIRTUIN 4; SIRTUIN 5;

ARTICLE; GENE EXPRESSION; GLUCONEOGENESIS; GLUCOSE METABOLISM; GLUCOSE TRANSPORT; GLUCOSE UTILIZATION; HUMAN; INSULIN RELEASE; KETOGENESIS; LIPID METABOLISM; METABOLIC STRESS; METABOLISM; MITOCHONDRION; NONHUMAN; UREA CYCLE;

EID: 84869464949     PISSN: 1521690X     EISSN: 15321908     Source Type: Journal    
DOI: 10.1016/j.beem.2012.05.001     Document Type: Review

References (106)

1. D.C. Wallace, W. Fan, and V. Procaccio Mitochondrial energetics and therapeutics Annual Review of Pathology 5 2010 297 348
2. D. Shore, M. Squire, and K.A. Nasmyth Characterization of two genes required for the position-effect control of yeast mating-type genes European Molecular Biology Organization Journal 3 1984 2817 2823
3. M. Kaeberlein, M. McVey, and L. Guarente The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms Genes and Development 13 1999 2570 2580
4. S. Imai, C.M. Armstrong, and M. Kaeberlein Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase Nature 403 2000 795 800
5. H. Yamamoto, K. Schoonjans, and J. Auwerx Sirtuin functions in health and disease Molecular Endocrinology 21 2007 1745 1755
6. K.A. Moynihan, A.A. Grimm, and M.M. Plueger Increased dosage of mammalian Sir2 in pancreatic beta cells enhances glucose-stimulated insulin secretion in mice Cell Metabolism 2 2005 105 117
7. R. Mostoslavsky, K.F. Chua, and D.B. Lombard Genomic instability and aging-like phenotype in the absence of mammalian SIRT6 Cell 124 2006 315 329
8. E. Ford, R. Voit, and G. Liszt Mammalian Sir2 homolog SIRT7 is an activator of RNA polymerase I transcription Genes and Development 20 2006 1075 1080
9. A. Vaquero, M.B. Scher, and D.H. Lee SirT2 is a histone deacetylase with preference for histone H4 Lys 16 during mitosis Genes and Development 20 2006 1256 1261
10. L. Zhong, and R. Mostoslavsky Fine tuning our cellular factories: sirtuins in mitochondrial biology Cell Metabolism 13 2011 621 626
11. + -dependent Sir2 histone/protein deacetylases Proceedings of the National Academy of Sciences of the United States of America 101 2004 8563 8568
12. M.C. Haigis, R. Mostoslavsky, and K.M. Haigis SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells Cell 126 2006 941 954
13. G. Liszt, E. Ford, and M. Kurtev Mouse Sir2 homolog SIRT6 is a nuclear ADP-ribosyltransferase Journal of Biological Chemistry 280 2005 21313 21320
14. E. Michishita, R.A. McCord, and E. Berber SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin Nature 452 2008 492 496
15. C. Peng, Z. Lu, and Z. Xie The first identification of lysine malonylation substrates and its regulatory enzyme Molecular and Cellular Proteomics 10 2011 M111.012658
16. J. Du, Y. Zhou, and X. Su Sirt5 is a NAD-dependent protein lysine demalonylase and desuccinylase Science 334 2011 806 809
17. + ? Pharmacological Reviews 64 2012 166 187
18. R.H. Houtkooper, E. Pirinen, and J. Auwerx Sirtuins as regulators of metabolism and healthspan Nature Reviews Molecular Cell Biology 13 2012 225 238
19. + : an old metabolite controlling new metabolic signaling pathways Endocrine Reviews 31 2010 194 223
20. E. Nisoli, C. Tonello, and A. Cardile Calorie restriction promotes mitochondrial biogenesis by inducing the expression of eNOS Science 310 2005 314 317
21. C. Canto, Z. Gerhart-Hines, and J.N. Feige AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity Nature 458 2009 1056 1060
22. C. Canto, L.Q. Jiang, and A.S. Deshmukh Interdependence of AMPK and SIRT1 for metabolic adaptation to fasting and exercise in skeletal muscle Cell Metabolism 11 2010 213 219
23. P. Bai, C. Canto, and H. Oudart PARP-1 inhibition increases mitochondrial metabolism through SIRT1 activation Cell Metabolism 13 2011 461 468
24. M.T. Barbosa, S.M. Soares, and C.M. Novak The enzyme CD38 (a NAD glycohydrolase, EC 3.2.2.5) is necessary for the development of diet-induced obesity Federation of the American Societies for Experimental Biology Journal 21 2007 3629 3639
25. S. Nemoto, M.M. Fergusson, and T. Finkel Nutrient availability regulates SIRT1 through a forkhead-dependent pathway Science 306 2004 2105 2108
26. + -dependent protein deacetylase, via activation of PPARalpha in mice Molecular and Cellular Biochemistry 339 2010 285 292
27. M. Okazaki, Y. Iwasaki, and M. Nishiyama PPARbeta/delta regulates the human SIRT1 gene transcription via Sp1 Endocrine Journal 57 2010 403 413
28. L.G. Noriega, J.N. Feige, and C. Canto CREB and ChREBP oppositely regulate SIRT1 expression in response to energy availability European Molecular Biology Organization Reports 12 2011 1069 1076
29. L. Han, R. Zhou, and J. Niu SIRT1 is regulated by a PPAR{gamma}-SIRT1 negative feedback loop associated with senescence Nucleic Acids Research 38 2010 7458 7471
30. W.Y. Chen, D.H. Wang, and R.C. Yen Tumor suppressor HIC1 directly regulates SIRT1 to modulate p53-dependent DNA-damage responses Cell 123 2005 437 448
31. P. Bai, C. Canto, and A. Brunyanszki PARP-2 regulates SIRT1 expression and whole-body energy expenditure Cell Metabolism 13 2011 450 460
32. J. Lee, A. Padhye, and A. Sharma A pathway involving farnesoid X receptor and small heterodimer partner positively regulates hepatic sirtuin 1 levels via microRNA-34a inhibition Journal of Biological Chemistry 285 2010 12604 12611
33. S. Rane, M. He, and D. Sayed Downregulation of miR-199a derepresses hypoxia-inducible factor-1alpha and Sirtuin 1 and recapitulates hypoxia preconditioning in cardiac myocytes Circulation Research 104 2009 879 886
34. T. Sasaki, B. Maier, and K.D. Koclega Phosphorylation regulates SIRT1 function Public Library of Science One 3 2008 e4020
35. + Molecular Cell 44 2011 851 863
36. N. Nasrin, V.K. Kaushik, and E. Fortier JNK1 phosphorylates SIRT1 and promotes its enzymatic activity Public Library of Science One 4 2009 e8414
37. X. Guo, J.G. Williams, and T.T. Schug DYRK1A and DYRK3 promote cell survival through phosphorylation and activation of SIRT1 Journal of Biological Chemistry 285 2010 13223 13232
38. K.T. Howitz, K.J. Bitterman, and H.Y. Cohen Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan Nature 425 2003 191 196
39. J.H. Um, S.J. Park, and H. Kang AMP-activated protein kinase-deficient mice are resistant to the metabolic effects of resveratrol Diabetes 59 2010 554 563
40. S.J. Park, F. Ahmad, and A. Philp Resveratrol ameliorates aging-related metabolic phenotypes by inhibiting cAMP phosphodiesterases Cell 148 2012 421 433
41. J.A. Baur, K.J. Pearson, and N.L. Price Resveratrol improves health and survival of mice on a high-calorie diet Nature 444 2006 337 342
42. M. Lagouge, C. Argmann, and Z. Gerhart-Hines Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha Cell 127 2006 1109 1122
43. S. Timmers, E. Konings, and L. Bilet Calorie restriction-like effects of 30 days of resveratrol supplementation on energy metabolism and metabolic profile in obese humans Cell Metabolism 14 2011 612 622
44. J.C. Milne, P.D. Lambert, and S. Schenk Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes Nature 450 2007 712 716
45. J.N. Feige, M. Lagouge, and C. Canto Specific SIRT1 activation mimics low energy levels and protects against diet-induced metabolic disorders by enhancing fat oxidation Cell Metabolism 8 2008 347 358
46. M. Pacholec, J.E. Bleasdale, and B. Chrunyk SRT1720, SRT2183, SRT1460, and resveratrol are not direct activators of SIRT1 Journal of Biological Chemistry 285 2010 8340 8351
47. J. Zheng, and V.D. Ramirez Inhibition of mitochondrial proton F0F1-ATPase/ATP synthase by polyphenolic phytochemicals British Journal of Pharmacology 130 2000 1115 1123
48. L. Vetterli, T. Brun, and L. Giovannoni Resveratrol potentiates glucose-stimulated insulin secretion in INS-1E beta-cells and human islets through a SIRT1-dependent mechanism Journal of Biological Chemistry 286 2011 6049 6060
49. T. Shi, F. Wang, and E. Stieren SIRT3, a mitochondrial sirtuin deacetylase, regulates mitochondrial function and thermogenesis in brown adipocytes Journal of Biological Chemistry 280 2005 13560 13567
50. M.D. Hirschey, T. Shimazu, and E. Jing SIRT3 deficiency and mitochondrial protein hyperacetylation accelerate the development of the metabolic syndrome Molecular Cell 44 2011 177 190
51. W.C. Hallows, S. Lee, and J.M. Denu Sirtuins deacetylate and activate mammalian acetyl-CoA synthetases Proceedings of the National Academy of Sciences United States of America 103 2006 10230 10235
52. B.J. Gurd, G.P. Holloway, and Y. Yoshida In mammalian muscle, SIRT3 is present in mitochondria and not in the nucleus; and SIRT3 is upregulated by chronic muscle contraction in an adenosine monophosphate-activated protein kinase-independent manner Metabolism 61 2012 733 741
53. H.Y. Cohen, C. Miller, and K.J. Bitterman Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase Science 305 2004 390 392
54. A. Giralt, E. Hondares, and J.A. Villena Peroxisome proliferator- activated receptor-gamma coactivator-1alpha controls transcription of the Sirt3 gene, an essential component of the thermogenic brown adipocyte phenotype Journal of Biological Chemistry 286 2011 16958 16966
55. X. Kong, R. Wang, and Y. Xue Sirtuin 3, a new target of PGC-1alpha, plays an important role in the suppression of ROS and mitochondrial biogenesis Public Library of Science One 5 2010 e11707
56. H. Schirmer, T.C. Pereira, and E.P. Rico Modulatory effect of resveratrol on SIRT1, SIRT3, SIRT4, PGC1alpha and NAMPT gene expression profiles in wild-type adult zebrafish liver Molecular Biology Reports 39 2011 3281 3289
57. C.S. Lieber, M.A. Leo, and X. Wang Alcohol alters hepatic FoxO1, p53, and mitochondrial SIRT5 deacetylation function Biochemical and Biophysical Research Communications 373 2008 246 252
58. B.D. Shepard, and P.L. Tuma Alcohol-induced protein hyperacetylation: mechanisms and consequences World Journal of Gastroenterology 15 2009 1219 1230
59. D.B. Lombard, F.W. Alt, and H.L. Cheng Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation Molecular Cellular Biology 27 2007 8807 8814
60. C. Schlicker, M. Gertz, and P. Papatheodorou Substrates and regulation mechanisms for the human mitochondrial sirtuins Sirt3 and Sirt5 Journal of Molecular Biology 382 2008 790 801
61. T. Nakagawa, D.J. Lomb, and M.C. Haigis SIRT5 deacetylates carbamoyl phosphate synthetase 1 and regulates the urea cycle Cell 137 2009 560 570
62. E. Jing, B. Emanuelli, and M.D. Hirschey Sirtuin-3 (Sirt3) regulates skeletal muscle metabolism and insulin signaling via altered mitochondrial oxidation and reactive oxygen species production Proceedings of the National Academy of Sciences of the United States of America 108 2011 14608 14613
63. J.T. Rodgers, C. Lerin, and W. Haas Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1 Nature 434 2005 113 118
64. J.H. Lim, Y.M. Lee, and Y.S. Chun Sirtuin 1 modulates cellular responses to hypoxia by deacetylating hypoxia-inducible factor 1alpha Molecular Cell 38 2010 864 878
65. C.J. Hu, S. Iyer, and A. Sataur Differential regulation of the transcriptional activities of hypoxia-inducible factor 1 alpha (HIF-1alpha) and HIF-2alpha in stem cells Molecular Cellular Biology 26 2006 3514 3526
66. J.W. Kim, I. Tchernyshyov, and G.L. Semenza HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia Cell Metabolism 3 2006 177 185
67. X. Qiu, K. Brown, and M.D. Hirschey Calorie restriction reduces oxidative stress by SIRT3-mediated SOD2 activation Cell Metabolism 12 2010 662 667
68. S. Someya, W. Yu, and W.C. Hallows Sirt3 mediates reduction of oxidative damage and prevention of age-related hearing loss under caloric restriction Cell 143 2010 802 812
69. L.W. Finley, A. Carracedo, and J. Lee SIRT3 opposes reprogramming of cancer cell metabolism through HIF1alpha destabilization Cancer Cell 19 2011 416 428
70. N. Shulga, R. Wilson-Smith, and J.G. Pastorino Sirtuin-3 deacetylation of cyclophilin D induces dissociation of hexokinase II from the mitochondria Journal of Cell Science 123 2010 894 902
71. P.J. Fernandez-Marcos, and J. Auwerx Regulation of PGC-1alpha, a nodal regulator of mitochondrial biogenesis American Journal of Clinical Nutrition 93 2011 884S 890S
72. B.H. Ahn, H.S. Kim, and S. Song A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis Proceedings of the National Academy of Sciences of the United States of America 105 2008 14447 14452
73. L.W. Finley, W. Haas, and V. Desquiret-Dumas Succinate dehydrogenase is a direct target of sirtuin 3 deacetylase activity Public Library of Sciences One 6 2011 e23295
74. H. Cimen, M.J. Han, and Y. Yang Regulation of succinate dehydrogenase activity by SIRT3 in mammalian mitochondria Biochemistry 49 2010 304 311
75. Y. Yang, H. Cimen, and M.J. Han NAD+-dependent deacetylase SIRT3 regulates mitochondrial protein synthesis by deacetylation of the ribosomal protein MRPL10 The Journal of Biological Chemistry 285 2010 7417 7429
76. I.K. Law, L. Liu, and A. Xu Identification and characterization of proteins interacting with SIRT1 and SIRT3: implications in the anti-aging and metabolic effects of sirtuins Proteomics 9 2009 2444 2456
77. T. Finkel, C.X. Deng, and R. Mostoslavsky Recent progress in the biology and physiology of sirtuins Nature 460 2009 587 591
78. N. Ahuja, B. Schwer, and S. Carobbio Regulation of insulin secretion by SIRT4, a mitochondrial ADP-ribosyltransferase Journal of Biological Chemistry 282 2007 33583 33592
79. S. Eaton Control of mitochondrial beta-oxidation flux Progress in Lipid Research 41 2002 197 239
80. H. Yamamoto, E.G. Williams, and L. Mouchiroud NCoR1 is a conserved physiological modulator of muscle mass and oxidative function Cell 147 2011 827 839
81. C. Handschin, and B.M. Spiegelman Peroxisome proliferator-activated receptor gamma coactivator 1 coactivators, energy homeostasis, and metabolism Endocrine Reviews 27 2006 728 735
82. A. Coste, J.F. Louet, and M. Lagouge The genetic ablation of SRC-3 protects against obesity and improves insulin sensitivity by reducing the acetylation of PGC-1{alpha} Proceedings of the National Academy Sciences of the United States of America 105 2008 17187 17192
83. C. Canto, and J. Auwerx AMP-activated protein kinase and its downstream transcriptional pathways Cellular and Molecular Life Sciences 67 2010 3407 3423
84. S. Jager, C. Handschin, and J. St-Pierre AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1alpha Proceedings of National Academy of Sciences of the United States of America 104 2007 12017 12022
85. A.A. Gonzalez, R. Kumar, and J.D. Mulligan Effects of aging on cardiac and skeletal muscle AMPK activity: basal activity, allosteric activation, and response to in vivo hypoxemia in mice American Journal of Physiology. Regulatory, Integrative and Computer Physiology 287 2004 R1270 R1275
86. S. Schenk, C.E. McCurdy, and A. Philp Sirt1 enhances skeletal muscle insulin sensitivity in mice during caloric restriction The Journal of Clinical Investigation 121 2011 4281 4288
87. O.M. Palacios, J.J. Carmona, and S. Michan Diet and exercise signals regulate SIRT3 and activate AMPK and PGC-1alpha in skeletal muscle Aging (Albany NY) 1 2009 771 783
88. A. Philp, A. Chen, and D. Lan Sirtuin 1 (SIRT1) deacetylase activity is not required for mitochondrial biogenesis or peroxisome proliferator-activated receptor-{gamma} coactivator-1{alpha} (PGC-1{alpha}) deacetylation following endurance exercise Journal of Biological Chemistry 286 2011 30561 30570
89. N. Nasrin, X. Wu, and E. Fortier SIRT4 regulates fatty acid oxidation and mitochondrial gene expression in liver and muscle cells Journal of Biological Chemistry 285 2010 31995 32002
90. M.D. Hirschey, T. Shimazu, and E. Goetzman SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation Nature 464 2010 121 125
91. F. Hokari, E. Kawasaki, and A. Sakai Muscle contractile activity regulates Sirt3 protein expression in rat skeletal muscles Journal of Applied Physiology 109 2010 332 340
92. A. Purushotham, T.T. Schug, and Q. Xu Hepatocyte-specific deletion of SIRT1 alters fatty acid metabolism and results in hepatic steatosis and inflammation Cell Metabolism 9 2009 327 338
93. R.H. Wang, C. Li, and C.X. Deng Liver steatosis and increased ChREBP expression in mice carrying a liver specific SIRT1 null mutation under a normal feeding condition International Journal of Biological Sciences 6 2010 682 690
94. F. Xu, Z. Gao, and J. Zhang Lack of SIRT1 (Mammalian Sirtuin 1) activity leads to liver steatosis in the SIRT1+/- mice: a role of lipid mobilization and inflammation Endocrinology 151 2010 2504 2514
95. J.M. Ajmo, X. Liang, and C.Q. Rogers Resveratrol alleviates alcoholic fatty liver in mice American Journal of Physiology, Gastrointestinal and Liver Physiology 295 2008 G833 G842
96. Y. Yamazaki, I. Usui, and Y. Kanatani Treatment with SRT1720, a SIRT1 activator, ameliorates fatty liver with reduced expression of lipogenic enzymes in MSG mice American Journal of Physiology, Endocrinology and Metabolism 2009
97. A.K. Walker, F. Yang, and K. Jiang Conserved role of SIRT1 orthologs in fasting-dependent inhibition of the lipid/cholesterol regulator SREBP Genes and Development 24 2010 1403 1417
98. B. Ponugoti, D.H. Kim, and Z. Xiao SIRT1 deacetylates and inhibits SREBP-1C activity in regulation of hepatic lipid metabolism Journal of Biological Chemistry 285 2010 33959 33970
99. Y. Ikeda, J. Yamamoto, and M. Okamura Transcriptional regulation of the murine acetyl-CoA synthetase 1 gene through multiple clustered binding sites for sterol regulatory element-binding proteins and a single neighboring site for Sp1 Journal of Biological Chemistry 276 2001 34259 34269
100. T. Fujino, J. Kondo, and M. Ishikawa Acetyl-CoA synthetase 2, a mitochondrial matrix enzyme involved in the oxidation of acetate Journal of Biological Chemistry 276 2001 11420 11426
101. B. Schwer, J. Bunkenborg, and R.O. Verdin Reversible lysine acetylation controls the activity of the mitochondrial enzyme acetyl-CoA synthetase 2 Proceedings of National Academy of Sciences of the United States of America 103 2006 10224 10229
102. T. Shimazu, M.D. Hirschey, and L. Hua SIRT3 deacetylates mitochondrial 3-hydroxy-3-methylglutaryl CoA synthase 2 and regulates ketone body production Cell Metabolism 12 2010 654 661
103. M. Mullins Von Dreele, and R.O. Banks Urea synthesis in the canine kidney Renal Physiology 8 1985 73 79
104. M. Watford The urea cycle: a two-compartment system Essays in Biochemistry 26 1991 49 58
105. W.C. Hallows, W. Yu, and B.C. Smith Sirt3 promotes the urea cycle and fatty acid oxidation during dietary restriction Molecular Cell 41 2011 139 149
106. P.J. Fernandez-Marcos, E.H. Jeninga, and C. Canto Muscle or liver-specific Sirt3 deficiency induces hyperacetylation of mitochondrial proteins without affecting global metabolic homeostasis Scientific Reports 2 2012 425