The covalent modifier Nedd8 is critical for the activation of Smurf1 ubiquitin ligase in tumorigenesis

Nature Communications

Volumn 5, Issue , 2014, Pages

  Xie, Ping ^a,b   Zhang, Minghua ^a   He, Shan ^a   Lu, Kefeng ^a   Chen, Yuhan ^a   Xing, Guichun ^a   Lu, Yiming ^a   Liu, Ping ^c   Li, Yang ^a   Wang, Shaoxia ^a   Chai, Nan ^d   Wu, Jiawei ^d   Deng, Haiteng ^d   Wang, Hong Rui ^e   Cao, Yu ^a   Zhao, Fei ^a   Cui, Yu ^a   Wang, Jian ^a   He, Fuchu ^a   Zhang, Lingqiang ^a,b  

^a BEIJING INSTITUTE OF RADIATION MEDICINE   (China)

^b DALIAN MEDICAL UNIVERSITY   (China)

^c CHINESE PLA GENERAL HOSPITAL   (China)

^d TSINGHUA UNIVERSITY   (China)

^e XIAMEN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

NEDD8 PROTEIN; SMURF1 LIGASE; UBIQUITIN PROTEIN LIGASE; UNCLASSIFIED DRUG; ESCRT PROTEIN; NEDD8 PROTEIN, HUMAN; PROTEINASE; RSP5 PROTEIN, S CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEIN; SENP8 PROTEIN, HUMAN; SMURF1 PROTEIN, HUMAN; UBA3 PROTEIN, HUMAN; UBE2M PROTEIN, HUMAN; UBIQUITIN; UBIQUITIN CONJUGATING ENZYME;

AMINO ACID; CANCER; CATALYSIS; ENZYME ACTIVITY; GENE EXPRESSION; PROTEIN; PUBLIC HEALTH; TUMOR; YEAST;

ARTICLE; CANCER GROWTH; CANCER PROGNOSIS; CANCER STAGING; CARCINOGENESIS; CELL MIGRATION; CELL PROLIFERATION; COLORECTAL CANCER; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME SUBUNIT; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; MAJOR CLINICAL STUDY; MOLECULAR WEIGHT; NEDDYLATION; NONHUMAN; PROTEIN EXPRESSION; RNA INTERFERENCE; UBIQUITINATION; WESTERN BLOTTING; ANIMAL; CANCER TRANSPLANTATION; CARCINOMA; COLORECTAL TUMOR; DISEASE COURSE; GENE EXPRESSION REGULATION; GENETICS; HCT116 CELL LINE; METABOLISM; MOUSE; PATHOLOGY; PROGNOSIS; SACCHAROMYCES CEREVISIAE;

ANIMALS; CARCINOGENESIS; CARCINOMA; COLORECTAL NEOPLASMS; DISEASE PROGRESSION; ENDOPEPTIDASES; ENDOSOMAL SORTING COMPLEXES REQUIRED FOR TRANSPORT; GENE EXPRESSION REGULATION, NEOPLASTIC; HCT116 CELLS; HUMANS; MICE; NEOPLASM TRANSPLANTATION; PROGNOSIS; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; UBIQUITIN-ACTIVATING ENZYMES; UBIQUITIN-CONJUGATING ENZYMES; UBIQUITIN-PROTEIN LIGASE COMPLEXES; UBIQUITIN-PROTEIN LIGASES; UBIQUITINS;

EID: 84900399649     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms4733     Document Type: Article

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