Design and synthesis of small molecule RhoA inhibitors: A new promising therapy for cardiovascular diseases?

Journal of Medicinal Chemistry

Volumn 54, Issue 13, 2011, Pages 4508-4522

  Deng, Jing ^a   Feng, Enguang ^b   Ma, Sheng ^c   Zhang, Yan ^c   Liu, Xiaofeng ^a   Li, Honglin ^a   Huang, Huang ^a   Zhu, Jin ^a   Zhu, Weiliang ^b   Shen, Xu ^a,b   Miao, Liyan ^c   Liu, Hong ^b   Jiang, Hualiang ^a,b   Li, Jian ^a  

^a EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

^c THE FIRST AFFILIATED HOSPITAL OF SOOCHOW UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

1,1' (6 NITROQUINOXALINE 2,3 DIYL)BIS(PIPERIDINE 3 CARBOXYLIC ACID); 1,1' (6 NITROQUINOXALINE 2,3 DIYL)BIS(PIPERIDINE 4 CARBOXYLIC ACID); 2 CHLORO 7 NITROQUINOXALINE; 2,3 BIS(4 METHYLPIPERIDIN 1 YL) 6 NITROQUINOXALINE; 2,3 BIS[4 (2,4 DIFLUOROPHENYL)PIPERAZIN 1 YL] 6 NITROQUINOXALINE; 2,3 BIS[4 (BENZO[D][1,3]DIOXOL 5 YL)PIPERAZIN 1 YL] 6 NITROQUINOXALINE; 2,3 DICHLORO 6 METHOXY QUINOXALINE; 2,3 DICHLORO 6 NITROQUINOXALINE; 2,3 DICHLORO 6 TRIFLUOROMETHYLQUINOXALINE; 2,3 IBS[4 (2 FLUOROPHENYL)PIPERIDIN 1 YL] 6 NITROQUINOXALINE; 3,3' (3,3' (6 NITROQUINOXALINE 2,3 DIYL)BIS(AZANEDIYL)BIS(3,1 PHENYLENE)DIACRYLIC ACID; 3,3' (3,3' (6 NITROQUINOXALINE 2,3 DIYL)BIS(AZANEDIYL)BIS(4,1 PHENYLENE)DIACRYLIC ACID; 3,3' [[[6 (TRIFLUOROMETHYL)QUINOXALINE 2,3 DIYL]BIS (AZANEDIYL)]BIS(4,1 PHENYLENE)]DIACRYLIC ACID; 4,4' (6 NITROQUINOXALINE 2,3 DIYL)DIMORPHOLINE; 6 METHOXY QUINOXALINE 2,3(1H,4H) DIONE; 6 NINTROQUINOXALIN 2 OL; 6 NITRO N 2,N 3 BIS(PYRIDIN 4 YLMETHYL)QUINOXALINE 2,3 DIAMINE; 6 NITRO QUINOXALINE 2,3(1H,4H) DIONE; 6 TRIFLUOROMETHYLQUINOXALINE 2,3(1H,4H) DIONE; 8 [3 [1,4 DIOXA 8 AZASPIRO[4.5]DECAN 8 YL] 7 NITROQUINOXALIN 2 YL] 1,4 DIOXA 8 AZASPIRO[4.5]DECANE; CARDIOVASCULAR AGENT; DIETHYL 1,1' (6 NITROQUINOXALINE 2,3 DIYL)BIS(PIPERIDINE 3 CARBOXYLATE); DIETHYL 1,1' (6 NITROQUINOXALINE 2,3 DIYL)BIS(PIPERIDINE 4 CARBOXYLATE); DIETHYL 3,3' [[(6 NITROQUINOXALINE 2,3 DIYL)BIS (4,1 PHENYLENE)]DIACRYLATE]; DIMETHYL 1,1' (6 NITROQUINOXALINE 2,3 DIYL)BIS(PIPERIDINE 4 CARBOXYLATE); N 1,N 1' (6 NITROQUINOXALINE 2,3 DIYL)BIS(N 2,N 2 DIETHYLETHANE 1,2 DIAMINE); N 2,N 3 BIS(3,4 DIMETHOXYPHENETHYL) 6 NITROQUINOXALINE 2,3 DIAMINE; N 2,N 3 BIS(4 METHYLBENZYL) 6 NITROQUINOXALINE 2,3 DIAMINE; PHENYLEPHRINE; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; UNCLASSIFIED DRUG;

ARTERY CONSTRICTION; ARTICLE; BINDING AFFINITY; BIOASSAY; CARDIOVASCULAR DISEASE; CONCENTRATION (PARAMETERS); DRUG ACTIVITY; DRUG DESIGN; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; MOLECULAR DOCKING; THORACIC AORTA;

ANIMALS; AORTA, THORACIC; BRAIN; CINNAMATES; DRUG DESIGN; HUMANS; MALE; MUSCLE CONTRACTION; MUSCLE, SMOOTH, VASCULAR; PHENYLEPHRINE; PROPANOLS; QUINOLINES; QUINOXALINES; RATS; RATS, SPRAGUE-DAWLEY; RHOA GTP-BINDING PROTEIN; SMALL MOLECULE LIBRARIES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; VASOCONSTRICTOR AGENTS; VASODILATOR AGENTS;

EID: 79960189765     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm200161c     Document Type: Article

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