Novel anti-inflammatory activity of epoxyazadiradione against macrophage migration inhibitory factor: Inhibition of tautomerase and proinflammatory activities of macrophage migration inhibitory factor

Journal of Biological Chemistry

Volumn 287, Issue 29, 2012, Pages 24844-24861

  Alam, Athar ^a   Haldar, Saikat ^b   Thulasiram, Hirekodathakallu V ^b,c   Kumar, Rahul ^a   Goyal, Manish ^a   Iqbal, Mohd Shameel ^a   Pal, Chinmay ^a   Dey, Sumanta ^a   Bindu, Samik ^a   Sarkar, Souvik ^a   Pal, Uttam ^a   Maiti, Nakul C ^a   Bandyopadhyay, Uday ^a  

^a NATIONAL CHEMICAL LABORATORY   (India)

^b NATIONAL CHEMICAL LABORATORY   (India)

^c CSIR INSTITUTE OF GENOMICS AND INTEGRATIVE BIOLOGY   (India)

Author keywords

[No Author keywords available]

Indexed keywords

ANTI-INFLAMMATORY ACTIVITY; AZADIRACHTA INDICA; BACTERIAL INFECTIONS; BALB/C MICE; DISEASE STATE; DOCKING SIMULATIONS; IN-VITRO; IN-VIVO; KNOWLEDGE BASE; MALARIA PARASITE; METHYL ESTERS; MIGRATION INHIBITORY FACTORS; MOLECULAR BASIS; NITRIC-OXIDE SYNTHASE; PLASMODIUM FALCIPARUM; PROINFLAMMATORY; PROINFLAMMATORY CYTOKINES; TAUTOMERASE; THERAPEUTIC POTENTIALS; UP-REGULATION;

ACETIC ACID; DISEASES; MAMMALS; NITRIC OXIDE;

MACROPHAGES;

AZADIRACHTIN A; AZADIRACHTIN B; AZADIRADIONE; CYTOKINE; DOPACHROME TAUTOMERASE; EPOXYAZADIRADIONE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; INTERLEUKIN 6; LIMONOID; LIPOPOLYSACCHARIDE; MACROPHAGE MIGRATION INHIBITION FACTOR; NIMBIN; NITRIC OXIDE; PLANT MEDICINAL PRODUCT; SALANNIN; SULFORAPHANE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; AZADIRACHTA INDICA; BACTERIAL INFECTION; BAGG ALBINO MOUSE; CELL NUCLEUS; CELL STRAIN; CELL STRAIN RAW 264.7; CONTROLLED STUDY; CYTOKINE RELEASE; DRUG BINDING SITE; DRUG PROTEIN BINDING; DRUG STRUCTURE; ENZYME INHIBITION; ENZYME SYNTHESIS; HUMAN; IN VITRO STUDY; IN VIVO STUDY; MACROPHAGE MIGRATION; MALE; MOUSE; NONHUMAN; PLASMODIUM FALCIPARUM; PLASMODIUM YOELII; PRIORITY JOURNAL; PROTEIN TRANSPORT; SEPSIS; STRUCTURE ANALYSIS; UPREGULATION;

ANIMALS; ANTI-INFLAMMATORY AGENTS; AZADIRACHTA; CELL LINE; ELECTROPHORETIC MOBILITY SHIFT ASSAY; HUMANS; LIMONINS; MACROPHAGE MIGRATION-INHIBITORY FACTORS; MACROPHAGES; MALE; MICE; MICE, INBRED BALB C; NF-KAPPA B; NITRIC OXIDE; PLASMODIUM FALCIPARUM; PLASMODIUM YOELII;

AZADIRACHTA INDICA; BACTERIA (MICROORGANISMS); MUS; PLASMODIUM FALCIPARUM; PLASMODIUM YOELII;

EID: 84863795886     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.341321     Document Type: Article

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