KCNQ (Kv7) potassium channel activators as bronchodilators: Combination with a β2-adrenergic agonist enhances relaxation of rat airways

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 306, Issue 6, 2014, Pages

  Brueggemann, Lioubov I ^a   Haick, Jennifer M ^a   Neuburg, Samantha ^a   Tate, Shawn ^a   Randhawa, Devjit ^a   Cribbs, Leanne L ^a   Byron, Kenneth L ^a  

^a LOYOLA UNIVERSITY CHICAGO   (United States)

Author keywords

Airway smooth muscle; Bronchoconstrictor signal transduction; Bronchodilator therapy; KCNQ voltage activated potassium channel; Precision cut lung slice

Indexed keywords

10,10 BIS(4 PYRIDINYLMETHYL) 9(10H) ANTHRACENONE; BETA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; BRONCHODILATING AGENT; POTASSIUM CHANNEL KCNQ; POTASSIUM CHANNEL KCNQ ACTIVATOR; UNCLASSIFIED DRUG; 10,10-BIS(4-PYRIDINYLMETHYL)-9(10H)-ANTHRACENONE; 2,5 DIMETHYLCELECOXIB; 2,5-DIMETHYLCELECOXIB; ACETYLCHOLINE; AGENTS AFFECTING WATER, MOLECULE OR ION TRANSPORT; ANTHRACENE DERIVATIVE; BRONCHOCONSTRICTING AGENT; CARBAMIC ACID DERIVATIVE; ETHANOLAMINE DERIVATIVE; FORMOTEROL; KERATOLYTIC AGENT; METHACHOLINE CHLORIDE; ORGANOMETALLIC COMPOUND; PHENYLENEDIAMINE DERIVATIVE; POTASSIUM CHANNEL BLOCKING AGENT; PYRAZOLE DERIVATIVE; PYRIDINE DERIVATIVE; PYRITHIONE ZINC; RETIGABINE; SULFONAMIDE;

AIRWAY; AIRWAY DYNAMICS; AIRWAY RELAXATION; AIRWAY SMOOTH MUSCLE CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRONCHOCONSTRICTION; DRUG MECHANISM; ELECTROPHYSIOLOGY; MALE; NONHUMAN; PATCH CLAMP TECHNIQUE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SMOOTH MUSCLE FIBER; AIRWAY SMOOTH MUSCLE; ANIMAL; ASTHMA; BRONCHOCONSTRICTOR SIGNAL TRANSDUCTION; BRONCHODILATOR THERAPY; BRONCHUS; DRUG EFFECT; DRUG POTENTIATION; KCNQ VOLTAGE-ACTIVATED POTASSIUM CHANNEL; METABOLISM; PRECISION-CUT LUNG SLICE; SECRETION (PROCESS); SPRAGUE DAWLEY RAT;

AIRWAY SMOOTH MUSCLE; BRONCHOCONSTRICTOR SIGNAL TRANSDUCTION; BRONCHODILATOR THERAPY; KCNQ VOLTAGE-ACTIVATED POTASSIUM CHANNEL; PRECISION-CUT LUNG SLICE;

ACETYLCHOLINE; ADRENERGIC BETA-2 RECEPTOR AGONISTS; ANIMALS; ANTHRACENES; ASTHMA; BRONCHI; BRONCHOCONSTRICTION; BRONCHOCONSTRICTOR AGENTS; BRONCHODILATOR AGENTS; CARBAMATES; ETHANOLAMINES; KCNQ POTASSIUM CHANNELS; KERATOLYTIC AGENTS; MALE; MEMBRANE TRANSPORT MODULATORS; METHACHOLINE CHLORIDE; MYOCYTES, SMOOTH MUSCLE; ORGANOMETALLIC COMPOUNDS; PATCH-CLAMP TECHNIQUES; PHENYLENEDIAMINES; POTASSIUM CHANNEL BLOCKERS; PYRAZOLES; PYRIDINES; RATS; RATS, SPRAGUE-DAWLEY; SULFONAMIDES;

EID: 84900028256     PISSN: 10400605     EISSN: 15221504     Source Type: Journal    
DOI: 10.1152/ajplung.00253.2013     Document Type: Article

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