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Volumn 661, Issue , 2010, Pages 405-417

KCNQ potassium channels: New targets for pulmonary vasodilator drugs?

Author keywords

Flupirtine; K2P; KCNQ; Kv1.7; Membrane potential; Pulmonary arterial hypertension; Pulmonary artery; Retigabine

Indexed keywords

CALCIUM ION; DELAYED RECTIFIER POTASSIUM CHANNEL; FLUPIRTINE; POTASSIUM CHANNEL KCNQ; POTASSIUM CHANNEL KV1.7; RETIGABINE; SHAB POTASSIUM CHANNEL; SHAKER POTASSIUM CHANNEL; UNCLASSIFIED DRUG; VOLTAGE GATED CALCIUM CHANNEL; ISOPROTEIN; VASODILATOR AGENT;

EID: 77951250058     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-60761-500-2_26     Document Type: Conference Paper
Times cited : (14)

References (49)
  • 1
    • 0030685744 scopus 로고    scopus 로고
    • + channel α subunits in pulmonary artery smooth muscle cells
    • Wang J, Juhaszova M, Rubin LJ, Yuan XJ (1997) Hypoxia inhibits gene expression of voltagegated K+ channel a-subunits in pulmonary artery smooth muscle cells. J Clin Invest 100:2347-2353 (Pubitemid 27500159)
    • (1997) Journal of Clinical Investigation , vol.100 , Issue.9 , pp. 2347-2353
    • Wang, J.1    Juhaszova, M.2    Rubin, L.J.3    Yuan, X.-J.4
  • 2
    • 0031855521 scopus 로고    scopus 로고
    • Influence of chronic hypoxia on the contributions of non-inactivating and delayed rectifier K currents to the resting potential and tone of rat pulmonary artery smooth muscle
    • DOI 10.1038/sj.bjp.0702006
    • Osipenko ON, Alexander D, MacLean MR, Gurney AM (1998) Influence of chronic hypoxia on the contributions of non-inactivating and delayed rectifier K currents to the resting potential and tone of rat pulmonary artery smooth muscle. Br J Pharmacol 124:1335-1337 (Pubitemid 28360552)
    • (1998) British Journal of Pharmacology , vol.124 , Issue.7 , pp. 1335-1337
    • Osipenko, O.N.1    Alexander, D.2    MacLean, M.R.3    Gurney, A.M.4
  • 4
    • 40349110969 scopus 로고    scopus 로고
    • Potassium channels in the regulation of pulmonary artery smooth muscle cell proliferation and apoptosis: Pharmacotherapeutic implications
    • DOI 10.1038/sj.bjp.0707635, PII 0707635
    • Burg ED, Remillard CV, Yuan JX-J (2008) Potassium channels in the regulation of pulmonary artery smooth muscle cell proliferation and apoptosis: pharmacotherapeutic implications. Br J Pharmacol 153:S99-S111 (Pubitemid 351341007)
    • (2008) British Journal of Pharmacology , vol.153 , Issue.SUPPL. 1
    • Burg, E.D.1    Remillard, C.V.2    Yuan, J.X.-J.3
  • 6
    • 0030176194 scopus 로고    scopus 로고
    • The pulmonary vasodilator properties of potassium channel opening drugs
    • DOI 10.1016/0306-3623(95)02044-6
    • Wanstall JC (1996) The pulmonary vasodilator properties of potassium channel opening drugs. Gen Pharmacol 27:599-605 (Pubitemid 26233327)
    • (1996) General Pharmacology , vol.27 , Issue.4 , pp. 599-605
    • Wanstall, J.C.1
  • 8
    • 70350344951 scopus 로고    scopus 로고
    • The KV7 potassium channel activator flupirtine prevents pulmonary hypertension in two independent mouse models
    • Morecroft I, Murray A, Nilsen M, Gurney AM, MacLean MR (2009) The KV7 potassium channel activator flupirtine prevents pulmonary hypertension in two independent mouse models. Br J Pharmacol 157:1241-1249
    • (2009) Br J Pharmacol , vol.157 , pp. 1241-1249
    • Morecroft, I.1    Murray, A.2    Nilsen, M.3    Gurney, A.M.4    MacLean, M.R.5
  • 9
    • 79959557358 scopus 로고    scopus 로고
    • Guide to receptors and channels (GRAC)
    • Alexander SPH, Mathie A, Peters JA (2008) Guide to receptors and channels (GRAC). Br J Pharmacol 153:S130-S132
    • (2008) Br J Pharmacol , vol.153
    • Sph, A.1    Mathie, A.2    Peters, J.A.3
  • 10
    • 33750605037 scopus 로고    scopus 로고
    • + channels in determining pulmonary vascular tone, oxygen sensing, cell proliferation, and apoptosis: Implications in hypoxic pulmonary vasoconstriction and pulmonary arterial hypertension
    • DOI 10.1080/10739680600930222, PII W242N78126W69040
    • Moudgil R, Michelakis ED, Archer SL (2006) The role of K+ channels in determining pulmonary vascular tone, oxygen sensing, cell proliferation, and apoptosis: implications in hypoxic pulmonary vasoconstriction and pulmonary arterial hypertension. Microcirculation 13:615-632 (Pubitemid 44696118)
    • (2006) Microcirculation , vol.13 , Issue.8 , pp. 615-632
    • Moudgil, R.1    Michelakis, E.D.2    Archer, S.L.3
  • 13
    • 0030859539 scopus 로고    scopus 로고
    • + channel in oxygen-sensitive pulmonary artery myocytes
    • Patel AJ, Lazdunski M, Honoré E (1997) KV2.1/KV9.3, a novel ATP-dependent delayed-rectifier K+ channel in oxygen-sensitive pulmonary artery myocytes. EMBO J 16:6615-6625 (Pubitemid 27503474)
    • (1997) EMBO Journal , vol.16 , Issue.22 , pp. 6615-6625
    • Patel, A.J.1    Lazdunski, M.2    Honore, E.3
  • 14
    • 0034677792 scopus 로고    scopus 로고
    • Potential role for Kv3.1b Channels as oxygen sensors
    • Osipenko ON, Tate RJ, Gurney AM (2000) Potential role for KV3.1b channels as oxygen sensors. Circ Res 86:534-540 (Pubitemid 30165045)
    • (2000) Circulation Research , vol.86 , Issue.5 , pp. 534-540
    • Osipenko, O.N.1    Tate, R.J.2    Gurney, A.M.3
  • 15
    • 0035676069 scopus 로고    scopus 로고
    • Kv channel subunit expression in rat pulmonary arteries
    • DOI 10.1007/s004080000057
    • Davies AR, Kozlowski RZ (2001) KV channel subunit expression in rat pulmonary arteries. Lung 179:147-161 (Pubitemid 34033111)
    • (2001) Lung , vol.179 , Issue.3 , pp. 147-161
    • Davies, A.R.L.1    Kozlowski, R.Z.2
  • 16
    • 0035217758 scopus 로고    scopus 로고
    • Differential expression of KV channel a- and b-subunits in the bovine pulmonary arterial circulation
    • Coppock EA, Tamkun MM (2001) Differential expression of KV channel a- and b-subunits in the bovine pulmonary arterial circulation. Am J Physiol Lung Cell Mol Physiol 281:L1350-L1360
    • (2001) Am J Physiol Lung Cell Mol Physiol , vol.281
    • Coppock, E.A.1    Tamkun, M.M.2
  • 19
    • 63849294626 scopus 로고    scopus 로고
    • KCNQ modulators reveal a key role for KCNQ potassium channels in regulating the tone of rat pulmonary artery smooth muscle
    • Joshi S, Sedivy V, Hodyc D, Herget J, Gurney AM (2009) KCNQ modulators reveal a key role for KCNQ potassium channels in regulating the tone of rat pulmonary artery smooth muscle. J Pharmacol Exp Ther 329:368-376
    • (2009) J Pharmacol Exp Ther , vol.329 , pp. 368-376
    • Joshi, S.1    Sedivy, V.2    Hodyc, D.3    Herget, J.4    Gurney, A.M.5
  • 20
    • 33644810790 scopus 로고    scopus 로고
    • Pulmonary vasoconstrictor action of KCNQ potassium channel blockers
    • Joshi S, Balan P, Gurney AM (2006) Pulmonary vasoconstrictor action of KCNQ potassium channel blockers. Respir Res 7:31-41
    • (2006) Respir Res , vol.7 , pp. 31-41
    • Joshi, S.1    Balan, P.2    Gurney, A.M.3
  • 21
    • 0035941222 scopus 로고    scopus 로고
    • TREK-1 regulation by nitric oxide and cGMP-dependent protein kinase. An essential role in smooth muscle inhibitory neurotransmission
    • Koh SD, Monaghan K, Sergeant GP et al (2001) TREK-1 regulation by nitric oxide and cGMP-dependent protein kinase. An essential role in smooth muscle inhibitory neurotransmission. J Biol Chem 276:44338-44346
    • (2001) J Biol Chem , vol.276 , pp. 44338-44346
    • Koh, S.D.1    Monaghan, K.2    Sergeant, G.P.3
  • 23
  • 26
    • 33947330445 scopus 로고    scopus 로고
    • Functional expression of inward rectifier potassium channels in cultured human pulmonary smooth muscle cells: Evidence for a major role of Kir2.4 subunits
    • DOI 10.1007/s00232-006-0037-y
    • Tennant BP, Cui Y, Tinker A, Clapp LH (2006) Functional expression of inward rectifier potassium channels in cultured human pulmonary smooth muscle cells: evidence for a major role of Kir2.4 subunits. J Membr Biol 213:19-29 (Pubitemid 46440139)
    • (2006) Journal of Membrane Biology , vol.213 , Issue.1 , pp. 19-29
    • Tennant, B.P.1    Cui, Y.2    Tinker, A.3    Clapp, L.H.4
  • 27
    • 0017760003 scopus 로고
    • Excitation-contraction coupling in the smooth muscle cells of the rabbit main pulmonary artery
    • Casteels R, Kitamura K, Kuriyama H, Suzuki H (1977) Excitation- contraction coupling in the smooth muscle cells of the rabbit main pulmonary artery. J Physiol 271:63-79 (Pubitemid 8178788)
    • (1977) Journal of Physiology , vol.271 , Issue.1 , pp. 63-79
    • Casteels, R.1    Kitamura, K.2    Kuriyama, H.3    Suzuki, H.4
  • 29
    • 79959571732 scopus 로고    scopus 로고
    • Functional roles of ion channels in the regulation of membrane potential and pulmonary vascular tone
    • Yuan JX-J (ed) Dekker, New York
    • Gurney AM (2004) Functional roles of ion channels in the regulation of membrane potential and pulmonary vascular tone. In: Yuan JX-J (ed) Ion channels in the pulmonary vasculature (lung biology in health and disease). Dekker, New York, pp 447-461
    • (2004) Ion Channels in the Pulmonary Vasculature (Lung Biology in Health and Disease) , pp. 447-461
    • Gurney, A.M.1
  • 30
    • 0026214995 scopus 로고
    • Outward currents in rabbit pulmonary artery cells dissociated with a new technique
    • Clapp LH, Gurney AM (1991) Outward currents in rabbit pulmonary artery cells dissociated with a new technique. Exp Physiol 76:677-693
    • (1991) Exp Physiol , vol.76 , pp. 677-693
    • Clapp, L.H.1    Gurney, A.M.2
  • 31
    • 33745764874 scopus 로고    scopus 로고
    • The role of twin pore domain and other K+ channels in hypoxic pulmonary vasoconstriction
    • Gurney AM, Joshi S (2006) The role of twin pore domain and other K+ channels in hypoxic pulmonary vasoconstriction. Novartis Found Symp 272:218-228
    • (2006) Novartis Found Symp , vol.272 , pp. 218-228
    • Gurney, A.M.1    Joshi, S.2
  • 32
    • 0025756412 scopus 로고
    • Modulation of calcium movements by nitroprusside in isolated vascular smooth muscle cells
    • Clapp LH, Gurney AM (1991) Modulation of calcium movements by nitroprusside in isolated vascular smooth muscle cells. Pflügers Arch 418:462-470
    • (1991) Pflügers Arch , vol.418 , pp. 462-470
    • Clapp, L.H.1    Gurney, A.M.2
  • 33
    • 0032492407 scopus 로고    scopus 로고
    • + channel gene transcription in primary pulmonary hypertension
    • DOI 10.1016/S0140-6736(05)78495-6
    • Yuan XJ, Wang J, Juhaszova M, Gaine SP, Rubin LJ (1998) Attenuated K+ channel gene transcription in primary pulmonary hypertension. Lancet 351:726-727 (Pubitemid 28105348)
    • (1998) Lancet , vol.351 , Issue.9104 , pp. 726-727
    • Yuan, X.-J.1    Wang, J.2    Juhaszova, M.3    Gaine, S.P.4    Rubin, L.J.5
  • 34
    • 4043123181 scopus 로고    scopus 로고
    • + channels in resistance pulmonary arteries explains regional heterogeneity in hypoxic pulmonary vasoconstriction: Ionic diversity in smooth muscle cells
    • DOI 10.1161/01.RES.0000137173.42723.fb
    • Archer SL, Wu XC, Thébaud B et al (2004) Preferential expression and function of voltagegated, O2-sensitive K+ channels in resistance pulmonary arteries explains regional heterogeneity in hypoxic pulmonary vasoconstriction: ionic diversity in smooth muscle cells. Circ Res 95:308-318 (Pubitemid 39056292)
    • (2004) Circulation Research , vol.95 , Issue.3 , pp. 308-318
    • Archer, S.L.1    Wu, X.-C.2    Thebaud, B.3    Nsair, A.4    Bonnet, S.5    Tyrrell, B.6    McMurtry, M.S.7    Hashimoto, K.8    Harry, G.9    Michelakis, E.D.10
  • 36
    • 0031855521 scopus 로고    scopus 로고
    • Influence of chronic hypoxia on the contributions of non-inactivating and delayed rectifier K currents to the resting potential and tone of rat pulmonary artery smooth muscle
    • DOI 10.1038/sj.bjp.0702006
    • Osipenko ON, Alexander D, MacLean MR, Gurney AM (1998) Influence of chronic hypoxia on the contributions of non-inactivating and delayed rectifier K currents to the resting potential and tone of rat pulmonary artery smooth muscle. Br J Pharmacol 124:1335-1337 (Pubitemid 28360552)
    • (1998) British Journal of Pharmacology , vol.124 , Issue.7 , pp. 1335-1337
    • Osipenko, O.N.1    Alexander, D.2    MacLean, M.R.3    Gurney, A.M.4
  • 37
    • 0035430621 scopus 로고    scopus 로고
    • Impairment of hypoxic pulmonary vasoconstriction in mice lacking the voltage-gated potassium channel KV1.5
    • Archer SL, London B, Hampl V et al (2001) Impairment of hypoxic pulmonary vasoconstriction in mice lacking the voltage-gated potassium channel KV1.5. FASEB J 15:1801-1803
    • (2001) FASEB J , vol.15 , pp. 1801-1803
    • Archer, S.L.1    London, B.2    Hampl, V.3
  • 38
    • 60549114727 scopus 로고    scopus 로고
    • Two-pore potassium channels in the cardiovascular system
    • Gurney A, Manoury B (2009) Two-pore potassium channels in the cardiovascular system. Eur Biophys J 38:305-318
    • (2009) Eur Biophys J , vol.38 , pp. 305-318
    • Gurney, A.1    Manoury, B.2
  • 39
    • 18144428365 scopus 로고    scopus 로고
    • The use of small interfering RNA to elucidate the activity and function of ion channel genes in an intact tissue
    • DOI 10.1016/j.vascn.2004.08.012
    • Gurney AM, Hunter E (2005) The use of small interfering RNA to elucidate the activity and function of ion channel genes in an intact tissue. J Pharmacol Toxicol Methods 51:253-262 (Pubitemid 40615605)
    • (2005) Journal of Pharmacological and Toxicological Methods , vol.51 , Issue.3 SPEC. ISS. , pp. 253-262
    • Gurney, A.M.1    Hunter, E.2
  • 40
    • 33646816053 scopus 로고    scopus 로고
    • Impact of TASK-1 in human pulmonary artery smooth muscle cells
    • Olschewski A, Li Y, Tang B et al (2006) Impact of TASK-1 in human pulmonary artery smooth muscle cells. Circ Res 98:1072-1080
    • (2006) Circ Res , vol.98 , pp. 1072-1080
    • Olschewski, A.1    Li, Y.2    Tang, B.3
  • 41
    • 33644826285 scopus 로고    scopus 로고
    • Investigation of the role of TASK-2 channels in rat pulmonary arteries; pharmacological and functional studies following RNA interference procedures
    • DOI 10.1038/sj.bjp.0706649, PII 0706649
    • Gönczi M, Szentandrássy N, Johnson IT, Heagerty AM, Weston AH (2006) Investigation of the role of TASK-2 channels in rat pulmonary arteries; pharmacological and functional studies following RNA interference procedures. Br J Pharmacol 147:496-505 (Pubitemid 43355047)
    • (2006) British Journal of Pharmacology , vol.147 , Issue.5 , pp. 496-505
    • Gonczi, M.1    Szentandrassy, N.2    Johnson, I.T.3    Heagerty, A.M.4    Weston, A.H.5
  • 42
    • 33744823282 scopus 로고    scopus 로고
    • β-adrenoceptor mediated responses in rat pulmonary artery: Putative role of TASK-1 related K channels
    • DOI 10.1007/s00210-006-0060-7
    • Bieger D, Parai K, Ford CA, Tabrizchi R (2006) b-Adrenoceptor mediated responses in rat pulmonary artery: putative role of TASK-1 related K channels. Naunyn Schmiedebergs Arch Pharmacol 373:186-196 (Pubitemid 43829492)
    • (2006) Naunyn-Schmiedeberg's Archives of Pharmacology , vol.373 , Issue.3 , pp. 186-196
    • Bieger, D.1    Parai, K.2    Ford, C.A.3    Tabrizchi, R.4
  • 43
    • 70349084966 scopus 로고    scopus 로고
    • Endothelin-1 inhibits background two-pore domain channel TASK-1 in primary human pulmonary artery smooth muscle cells
    • Tang B, Li Y, Nagaraj C et al (2009) Endothelin-1 inhibits background two-pore domain channel TASK-1 in primary human pulmonary artery smooth muscle cells. Am J Respir Cell Mol Biol 41:467-483
    • (2009) Am J Respir Cell Mol Biol , vol.41 , pp. 467-483
    • Tang, B.1    Li, Y.2    Nagaraj, C.3
  • 44
    • 34547563267 scopus 로고    scopus 로고
    • + channels
    • DOI 10.1161/CIRCRESAHA.107.157412, PII 0000301220070720000004
    • Bryan RM Jr, Joseph BK, Lloyd E, Rusch NJ (2007) Starring TREK-1: the next generation of vascular K+ channels. Circ Res 101:119-121 (Pubitemid 47196578)
    • (2007) Circulation Research , vol.101 , Issue.2 , pp. 119-121
    • Bryan Jr., R.M.1    Joseph, B.K.2    Lloyd, E.3    Rusch, N.J.4
  • 45
    • 0029827405 scopus 로고    scopus 로고
    • Properties of a novel K+ current that is active at resting potential in rabbit pulmonary artery smooth muscle cells
    • Evans AM, Osipenko ON, Gurney AM (1996) Properties of a novel K+ current that is active at resting potential in rabbit pulmonary artery smooth muscle cells. J Physiol 496:407-420 (Pubitemid 26370913)
    • (1996) Journal of Physiology , vol.496 , Issue.2 , pp. 407-420
    • Evans, A.M.1    Osipenko, O.N.2    Gurney, A.M.3
  • 46
    • 29144466617 scopus 로고    scopus 로고
    • A cysteine-rich motif confers hypoxia sensitivity to mammalian large conductance voltageand Ca-activated K (BK) channel a-subunits
    • McCartney CE, McClafferty H, Huibant JM, Rowan EG, Shipston MJ, Rowe IC (2005) A cysteine-rich motif confers hypoxia sensitivity to mammalian large conductance voltageand Ca-activated K (BK) channel a-subunits. Proc Natl Acad Sci U S A 102:17870-17876
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 17870-17876
    • McCartney, C.E.1    McClafferty, H.2    Huibant, J.M.3    Rowan, E.G.4    Shipston, M.J.5    Rowe, I.C.6
  • 48
    • 34247252905 scopus 로고    scopus 로고
    • Randomized, multicenter, dose-ranging trial of retigabine for partial-onset seizures
    • DOI 10.1212/01.wnl.0000259034.45049.00, PII 0000611420070410000009
    • Porter RJ, Partiot A, Sachdeo R, Nohria V, Alves WM (2007) Randomized, multicenter, doseranging trial of retigabine for partial-onset seizures. Neurology 68:1197-1204 (Pubitemid 46608467)
    • (2007) Neurology , vol.68 , Issue.15 , pp. 1197-1204
    • Porter, R.J.1    Partiot, A.2    Sachdeo, R.3    Nohria, V.4    Alves, W.M.5
  • 49
    • 62349102834 scopus 로고    scopus 로고
    • Analgesic efficacy and tolerability of flupirtine vs. tramadol in patients with subacute low back pain: A double-blind multicentre trial
    • Li C, Ni J, Wang Z et al (2008) Analgesic efficacy and tolerability of flupirtine vs. tramadol in patients with subacute low back pain: a double-blind multicentre trial. Curr Med Res Opin 24:3523-3530
    • (2008) Curr Med Res Opin , vol.24 , pp. 3523-3530
    • Li, C.1    Ni, J.2    Wang, Z.3


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