Reduced KCNQ4-encoded voltage-dependent potassium channel activity underlies impaired β-adrenoceptor-mediated relaxation of renal arteries in hypertension

Hypertension

Volumn 59, Issue 4, 2012, Pages 877-884

  Chadha, Preet S ^a   Zunke, Friederike ^a   Zhu, Hai Lei ^b   Davis, Alison J ^a   Jepps, Thomas A ^a   Olesen, Søren P ^c   Cole, William C ^b   Moffatt, James D ^a   Greenwood, Iain A ^a  

^a ST GEORGE S HOSPITAL   (United Kingdom)

^b UNIVERSITY OF CALGARY   (Canada)

^c UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

adrenoceptor; KCNQ; Kv7 channels; renal artery; spontaneously hypertensive rat; vascular smooth muscle; vasodilation

Indexed keywords

BETA ADRENERGIC RECEPTOR; GIMERACIL PLUS OTERACIL POTASSIUM PLUS TEGAFUR; ISOPRENALINE; LINOPIRDINE; POTASSIUM CHANNEL KCNQ1; POTASSIUM CHANNEL KCNQ3; POTASSIUM CHANNEL KCNQ4; POTASSIUM CHANNEL KCNQ5; POTASSIUM CHANNEL KV7; POTASSIUM CHANNEL KV7.1; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; VOLTAGE GATED POTASSIUM CHANNEL;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ATTENUATION; CHANNEL GATING; CONTROLLED STUDY; GENE EXPRESSION; GENE TARGETING; HYPERTENSION; HYPOTHESIS; IMMUNOHISTOCHEMISTRY; INCUBATION TIME; KIDNEY ARTERY; KIDNEY BLOOD FLOW; MEDIATOR; MOLECULAR DYNAMICS; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; RAT; RENOVASCULAR DISEASE; SIGNAL TRANSDUCTION; SMOOTH MUSCLE FIBER; VASODILATATION;

ADRENERGIC BETA-AGONISTS; ANIMALS; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE KNOCKDOWN TECHNIQUES; HYPERTENSION; ISOPROTERENOL; KCNQ POTASSIUM CHANNELS; MALE; RATS; RATS, INBRED SHR; RATS, WISTAR; RECEPTORS, ADRENERGIC, BETA; RENAL ARTERY; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; VASODILATION;

EID: 84863413057     PISSN: 0194911X     EISSN: 15244563     Source Type: Journal    
DOI: 10.1161/HYPERTENSIONAHA.111.187427     Document Type: Article

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