Increased responsiveness to 5-hydroxytryptamine after antigenic challenge is inhibited by nifedipine and niflumic acid in rat trachea in vitro

Clinical and Experimental Pharmacology and Physiology

Volumn 32, Issue 12, 2005, Pages 1119-1123

  Moura, Carlos Tiago Martins ^a   Bezerra, Fernanda Carvalho ^a   De Moraes, Isabelle MacIel ^a   Magalhães, Pedro Jorge Caldas ^a   Capaz, Francisco Ruy ^a  

^a FEDERAL UNIVERSITY OF CEARÁ   (Brazil)

Author keywords

5 hydroxytryptamine; Asthma; Hyperresponsiveness; Rat airway; Serotonin; Voltage operated channel

Indexed keywords

ANTIGEN; CALCIUM CHANNEL BLOCKING AGENT; CALCIUM CHANNEL L TYPE; CALCIUM ION; CHLORIDE CHANNEL BLOCKING AGENT; NIFEDIPINE; NIFLUMIC ACID; OVALBUMIN; SEROTONIN; SODIUM CHLORIDE; CALCIUM; NONSTEROID ANTIINFLAMMATORY AGENT; SEROTONIN AGONIST; SEROTONIN ANTAGONIST;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTHMA; BATH; CONTROLLED STUDY; DRUG EFFECT; MALE; MUSCLE ISOMETRIC CONTRACTION; NONHUMAN; PROVOCATION TEST; RAT; RESPIRATORY TRACT ALLERGY; SENSITIZATION; TRACHEA; ANIMAL; DOSE RESPONSE; IMMUNOLOGY; IN VITRO STUDY; METABOLISM; MUSCLE CONTRACTION; PHYSIOLOGY; SMOOTH MUSCLE; WISTAR RAT;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ANTIGENS; CALCIUM; CALCIUM CHANNEL BLOCKERS; DOSE-RESPONSE RELATIONSHIP, DRUG; MALE; MUSCLE CONTRACTION; MUSCLE, SMOOTH; NIFEDIPINE; NIFLUMIC ACID; RATS; RATS, WISTAR; SEROTONIN; SEROTONIN AGONISTS; SEROTONIN ANTAGONISTS; TRACHEA;

EID: 33644983450     PISSN: 03051870     EISSN: 14401681     Source Type: Journal    
DOI: 10.1111/j.1440-1681.2005.04308.x     Document Type: Article

References (35)

1. Cockcroft DW Ruffin RE Dolovich J Hargreave FE. Allergen-induced increase in non-allergic bronchial reactivity. Clin. Allergy 1977 7 : 503 13.
2. Capaz FR Ruffie C Lefort J Manzini S Vargaftig BB Pretolani M. Effect of active sensitization on the bronchopulmonary responses to tachykinins in the guinea pig. Modulation by peptidase inhibitors. J. Pharmacol. Exp. Ther. 1993 266 : 812 19.
3. de Siqueira AL Russo M Steil AA Facincone S Mariano M Jancar S. A new murine model of pulmonary eosinophilic hypersensitivity: Contribution to experimental asthma. J. Allergy Clin. Immunol. 1997 100 : 383 8.
4. Steil AA Tavares de Lima W Jancar S. Modulation by lipid mediators of immune complex-induced lung inflammation in mice. Eur. J. Pharmacol. 1998 361 : 93 9.
5. Buchheit KH Hofmann A Manley P Pfannkuche HJ Quast U. Atypical effect of minoxidil sulphate on guinea pig airways. Naunyn Schmiedebergs Arch. Pharmacol. 2000 361 : 418 24.
6. Padrid P Snook S Finucane T et al. Persistent airway hyperresponsiveness and histologic alterations after chronic antigen challenge in cats. Am. J. Respir. Crit. Care Med. 1995 151 : 184 93.
7. 2+ and contraction in smooth muscle. Trends Pharmacol. Sci. 2004 25 : 388 93.
8. Horn R Marty A. Muscarinic activation of ionic currents measured by a new whole-cell recording method. J. Gen. Physiol. 1988 92 : 145 59.
9. Janssen LJ Sims SM. Acetylcholine activates non-selective cation and chloride conductances in canine and guinea-pig tracheal myocytes. J. Physiol. 1992 453 : 197 218.
10. + currents in guinea-pig tracheal myocytes: Convergence with muscarinic signalling pathway. J. Physiol. 1993 465 : 661 77.
11. Teixeira MCL Coelho RR Leal-Cardoso JH Criddle DN. Comparative effects of niflumic acid and nifedipine on 5-hydroxytryptamine- and acetylcholine-induced contraction of the rat trachea. Eur. J. Pharmacol. 2000 394 : 117 22.
12. Perpina M Palau M Cortijo J Fornas E Ortiz JL Morcillo E. Sources of calcium for the contraction induced by various agonists in trachealis muscle from normal and sensitized guinea pigs. Respiration 1989 55 : 105 12.
13. 45Ca movements in sensitized guinea-pig tracheal muscle. Eur. Respir. J. 1991 4 : 450 7.
14. Chand N Diamantis W Sofia RD. Induction of non-specific airway hyperreactivity by potassium channel blockade in rat isolated trachea. Br. J. Pharmacol. 1990 101 : 541 4.
15. Chapman ID Kristersson A Mathelin G et al. Effects of a potassium channel opener (SDZ PCO 4 00) on guinea-pig and human pulmonary airways. Br. J. Pharmacol. 1992 106 : 423 9.
16. 2+ influx: How many mechanisms for how many channels? Trends Pharmacol. Sci. 1994 15 : 77 83.
17. Yang CM Hsieh JT Yo YL Ong R Tsao HL. 5-Hydroxytryptamine-stimulated calcium mobilization in cultured canine tracheal smooth muscle cells. Cell Calcium 1994 16 : 194 204.
18. Van Rossum JM. Cumulative dose-response curves. II. Technique for the making of dose-response curves in isolated organs and the evaluation of the drug parameters. Arch. Int. Pharmacodyn. Ther. 1963 143 : 299 330.
19. Hossain S. Quantitative measurement of bronchial muscle in men with asthma. Am. Rev. Respir. Dis. 1973 107 : 99 109.
20. Antonissen LA Mitchell RW Kroeger EA Kepron W Tse KS Stephens NL. Mechanical alterations of airway smooth muscle in a canine asthmatic model. J. Appl. Physiol. 1979 46 : 681 7.
21. Macklem PT. A theoretical analysis of the effect of airway smooth muscle load on airway narrowing. Am. J. Respir. Crit. Care Med. 1996 153 : 83 9.
22. Romanin C Reinsprecht M Pecht I Schindler H. Immunologically activated chloride channels involved in degranulation of rat mucosal mast cells. EMBO J. 1991 10 : 3603 8.
23. Watts SW Cox DA Johnson BG Schoepp DD Cohen ML. Contractile serotonin-2A receptor signal transduction in guinea pig trachea. Importance of protein kinase C and extracellular and intracellular calcium but not phosphoinositide hydrolysis. J. Pharmacol. Exp. Ther. 1994 271 : 832 44.
24. Pauwels R. Relationship between bronchial reactivity and immediate hypersensitivity. Eur. J. Respir. Dis. Suppl. 1982 117 : 63 85.
25. 2+ concentration in bovine tracheal smooth muscle using aequorin. Am. J. Physiol. 1987 253 : C817 27.
26. 2+ signaling and crosstalk in stimulus secretion coupling. Biochim. Biophys. Acta 1993 1154 : 105 56.
27. Putney Jr JW. Capacitative calcium entry revisited. Cell Calcium 1990 11 : 611 24.
28. Hashimoto T Hirata M Ito Y. A role for inositol 1,4,5-trisphosphate in the initiation of agonist-induced contractions of dog tracheal smooth muscle. Br. J. Pharmacol. 1985 86 : 191 9.
29. Kotlikoff MI Herrera G Nelson MT. Calcium permeant ion channels in smooth muscle. Rev. Physiol. Biochem. Pharmacol. 1999 134 : 147 99.
30. Murray RK Kotlikoff MI. Receptor-activated calcium influx in human airway smooth muscle cells. J. Physiol. 1991 435 : 123 44.
31. Parekh AB Penner R. Store depletion and calcium influx. Physiol. Rev. 1997 77 : 901 30.
32. 2+ availability involved in antigen-induced airway hyperresponsiveness in rats. Eur. J. Pharmacol. 1995 278 : 79 82.
33. Coburn RF Yamaguchi T. Membrane potential-dependent and -independent tension in the canine tracheal muscle. J. Pharmacol. Exp. Ther. 1977 201 : 276 84.
34. - current in canine tracheal smooth muscle cells. Am. J. Physiol. 1995 269 : C163 9.
35. Song LQ Li Y Zhang LN Gao F Cheng JH Qi HW. The inhibiting effect of niflumic acid on airway hyperresponsiveness in asthmatic mice. Zhonghua Jie He He Hu Xi Za Zhi 2004 27 : 108 11 (in Chinese).