Inhibition of the unfolded protein response by ricin a-chain enhances its cytotoxicity in mammalian cells

Toxins

Volumn 3, Issue 5, 2011, Pages 453-468

  Wang, Chao Ting ^a   Jetzt, Amanda E ^a   Cheng, Ju Shun ^a   Cohick, Wendie S ^a  

^a RUTGERS UNIVERSITY   (United States)

Author keywords

Apoptosis; Caspase; Eif2 ; Epithelial cells; Er stress; Ire1 phosphorylation; Phosphorylation; Ricin; Rta; Unfolded protein response; X box binding protein1 splicing

Indexed keywords

CASPASE; DITHIOTHREITOL; INITIATION FACTOR 2ALPHA; MESSENGER RNA; PROTEIN IRE1; RICIN A; TUNICAMYCIN; X BOX BINDING PROTEIN 1;

ANIMAL CELL; ARTICLE; CELL LINE; CELL STRAIN MAC T; CONTROLLED STUDY; DRUG CYTOTOXICITY; ENZYME PHOSPHORYLATION; EPITHELIUM CELL; HELA CELL; HUMAN; HUMAN CELL; INHIBITION KINETICS; NONHUMAN; PROTEIN CLEAVAGE; PROTEIN PROCESSING; PROTEIN SYNTHESIS; UNFOLDED PROTEIN RESPONSE;

BLOTTING, WESTERN; CELL CULTURE TECHNIQUES; CELL SURVIVAL; DNA-BINDING PROTEINS; ENDOPLASMIC RETICULUM STRESS; ENDORIBONUCLEASES; HELA CELLS; HUMANS; MEMBRANE PROTEINS; PHOSPHORYLATION; PROTEIN SPLICING; PROTEIN-SERINE-THREONINE KINASES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RICIN; TRANSCRIPTION FACTORS; UNFOLDED PROTEIN RESPONSE;

EUKARYOTA; MAMMALIA;

EID: 79958039536     PISSN: None     EISSN: 20726651     Source Type: Journal    
DOI: 10.3390/toxins3050453     Document Type: Article

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