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Volumn 103, Issue 2, 2014, Pages 59-67

Pheophytin a and chlorophyll a suppress neuroinflammatory responses in lipopolysaccharide and interferon-γ-stimulated BV2 microglia

Author keywords

BV2 cell; Chlorophyll a; Microglia; Neuroinflammation; Pheophytin a

Indexed keywords

BETA ACTIN; BETA INTERFERON; CHLOROPHYLL A; GAMMA INTERFERON; GAMMA INTERFERON INDUCIBLE PROTEIN 10; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERFERON REGULATORY FACTOR 1; INTERLEUKIN 1BETA; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; LUTEOLIN; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MITOGEN ACTIVATED PROTEIN KINASE; MONOCYTE CHEMOTACTIC PROTEIN 1; NITRIC OXIDE; PHEOPHYTIN; PHEOPHYTIN A; STAT1 PROTEIN; STRESS ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

EID: 84899945441     PISSN: 00243205     EISSN: 18790631     Source Type: Journal    
DOI: 10.1016/j.lfs.2014.04.003     Document Type: Article
Times cited : (32)

References (52)
  • 1
    • 33646004867 scopus 로고    scopus 로고
    • Manganese induces inducible nitric oxide synthase (iNOS) expression via activation of both MAP kinase and PI3K/Akt pathways in BV2 microglial cells
    • J.H. Bae, B.C. Jang, S.I. Suh, E. Ha, H.H. Baik, and S.S. Kim et al. Manganese induces inducible nitric oxide synthase (iNOS) expression via activation of both MAP kinase and PI3K/Akt pathways in BV2 microglial cells Neurosci Lett 398 2006 151 154
    • (2006) Neurosci Lett , vol.398 , pp. 151-154
    • Bae, J.H.1    Jang, B.C.2    Suh, S.I.3    Ha, E.4    Baik, H.H.5    Kim, S.S.6
  • 2
    • 10344228747 scopus 로고    scopus 로고
    • Resveratrol inhibits nitric oxide and TNF-alpha production by lipopolysaccharide-activated microglia
    • X.L. Bi, J.Y. Yang, Y.X. Dong, J.M. Wang, Y.H. Cui, and T. Ikeshima et al. Resveratrol inhibits nitric oxide and TNF-alpha production by lipopolysaccharide-activated microglia Int Immunopharmacol 5 2005 185 193
    • (2005) Int Immunopharmacol , vol.5 , pp. 185-193
    • Bi, X.L.1    Yang, J.Y.2    Dong, Y.X.3    Wang, J.M.4    Cui, Y.H.5    Ikeshima, T.6
  • 3
    • 47249120742 scopus 로고    scopus 로고
    • Neuron-microglia signaling: Chemokines as versatile messengers
    • K. Biber, J. Vinet, and H.W. Boddeke Neuron-microglia signaling: chemokines as versatile messengers J Neuroimmunol 198 2008 69 74
    • (2008) J Neuroimmunol , vol.198 , pp. 69-74
    • Biber, K.1    Vinet, J.2    Boddeke, H.W.3
  • 4
    • 0026738695 scopus 로고
    • Activated microglia mediate neuronal cell injury via a nitric oxide mechanism
    • C.C. Chao, S. Hu, T.W. Molitor, E.G. Shaskan, and P.K. Peterson Activated microglia mediate neuronal cell injury via a nitric oxide mechanism J Immunol 149 1992 2736 2741
    • (1992) J Immunol , vol.149 , pp. 2736-2741
    • Chao, C.C.1    Hu, S.2    Molitor, T.W.3    Shaskan, E.G.4    Peterson, P.K.5
  • 5
    • 0031703693 scopus 로고    scopus 로고
    • IP-10 gene transcription by virus in astrocytes requires cooperation of ISRE with adjacent kappaB site but not IRF-1 or viral transcription
    • [the official journal of the International Society for Interferon and Cytokine Research]
    • G. Cheng, A.S. Nazar, H.S. Shin, P. Vanguri, and M.L. Shin IP-10 gene transcription by virus in astrocytes requires cooperation of ISRE with adjacent kappaB site but not IRF-1 or viral transcription J Interf Cytokine Res 18 1998 987 997 [the official journal of the International Society for Interferon and Cytokine Research]
    • (1998) J Interf Cytokine Res , vol.18 , pp. 987-997
    • Cheng, G.1    Nazar, A.S.2    Shin, H.S.3    Vanguri, P.4    Shin, M.L.5
  • 6
    • 28844483688 scopus 로고    scopus 로고
    • Control of cytokine gene expression by PG101, a water-soluble extract prepared from Lentinus lepideus
    • J.J. Choi, M. Jin, J.K. Lee, W.Y. Lee, Y.I. Park, and Y.N. Han et al. Control of cytokine gene expression by PG101, a water-soluble extract prepared from Lentinus lepideus Biochem Biophys Res Commun 339 2006 880 887
    • (2006) Biochem Biophys Res Commun , vol.339 , pp. 880-887
    • Choi, J.J.1    Jin, M.2    Lee, J.K.3    Lee, W.Y.4    Park, Y.I.5    Han, Y.N.6
  • 7
    • 0027354484 scopus 로고
    • Microglia and cytokines in neurological disease, with special reference to AIDS and Alzheimer's disease
    • D.W. Dickson, S.C. Lee, L.A. Mattiace, S.H. Yen, and C. Brosnan Microglia and cytokines in neurological disease, with special reference to AIDS and Alzheimer's disease Glia 7 1993 75 83
    • (1993) Glia , vol.7 , pp. 75-83
    • Dickson, D.W.1    Lee, S.C.2    Mattiace, L.A.3    Yen, S.H.4    Brosnan, C.5
  • 10
    • 0037105422 scopus 로고    scopus 로고
    • Activation of monocytic cells through Fc gamma receptors induces the expression of macrophage-inflammatory protein (MIP)-1 alpha, MIP-1 beta, and RANTES
    • N. Fernandez, M. Renedo, C. Garcia-Rodriguez, and Crespo M. Sanchez Activation of monocytic cells through Fc gamma receptors induces the expression of macrophage-inflammatory protein (MIP)-1 alpha, MIP-1 beta, and RANTES J Immunol 169 2002 3321 3328
    • (2002) J Immunol , vol.169 , pp. 3321-3328
    • Fernandez, N.1    Renedo, M.2    Garcia-Rodriguez, C.3    Sanchez, C.M.4
  • 13
    • 3242855995 scopus 로고    scopus 로고
    • Histochemical and immunohistochemical detection of neurons that produce nitric oxide: Effect of different fixative parameters and immunoreactivity against non-neuronal NOS antisera
    • T. Gonzalez-Hernandez, M.A. Perez de la Cruz, and B. Mantolan-Sarmiento Histochemical and immunohistochemical detection of neurons that produce nitric oxide: effect of different fixative parameters and immunoreactivity against non-neuronal NOS antisera J Histochem Cytochem 44 1996 1399 1413
    • (1996) J Histochem Cytochem , vol.44 , pp. 1399-1413
    • Gonzalez-Hernandez, T.1    Perez De La Cruz, M.A.2    Mantolan-Sarmiento, B.3
  • 14
    • 0032942060 scopus 로고    scopus 로고
    • Microglia as mediators of inflammatory and degenerative diseases
    • F. Gonzalez-Scarano, and G. Baltuch Microglia as mediators of inflammatory and degenerative diseases Annu Rev Neurosci 22 1999 219 240
    • (1999) Annu Rev Neurosci , vol.22 , pp. 219-240
    • Gonzalez-Scarano, F.1    Baltuch, G.2
  • 15
    • 0027295562 scopus 로고
    • C/EBP, NF-kappa B, and c-Ets family members and transcriptional regulation of the cell-specific and inducible macrophage inflammatory protein 1 alpha immediate-early gene
    • M. Grove, and M. Plumb C/EBP, NF-kappa B, and c-Ets family members and transcriptional regulation of the cell-specific and inducible macrophage inflammatory protein 1 alpha immediate-early gene Mol Cell Biol 13 1993 5276 5289
    • (1993) Mol Cell Biol , vol.13 , pp. 5276-5289
    • Grove, M.1    Plumb, M.2
  • 16
    • 0037204864 scopus 로고    scopus 로고
    • P38 mitogen-activated protein kinase mediates lipopolysaccharide, not interferon-gamma, -induced inducible nitric oxide synthase expression in mouse BV2 microglial cells
    • I.O. Han, K.W. Kim, J.H. Ryu, and W.K. Kim p38 mitogen-activated protein kinase mediates lipopolysaccharide, not interferon-gamma, -induced inducible nitric oxide synthase expression in mouse BV2 microglial cells Neurosci Lett 325 2002 9 12
    • (2002) Neurosci Lett , vol.325 , pp. 9-12
    • Han, I.O.1    Kim, K.W.2    Ryu, J.H.3    Kim, W.K.4
  • 17
    • 38849199203 scopus 로고    scopus 로고
    • Shared principles in NF-kappaB signaling
    • M.S. Hayden, and S. Ghosh Shared principles in NF-kappaB signaling Cell 132 2008 344 362
    • (2008) Cell , vol.132 , pp. 344-362
    • Hayden, M.S.1    Ghosh, S.2
  • 18
    • 0034052904 scopus 로고    scopus 로고
    • Glial cells and Parkinson's disease
    • E.C. Hirsch Glial cells and Parkinson's disease J Neurol 247 Suppl. 2 2000 II58 II62
    • (2000) J Neurol , vol.247 , Issue.SUPPL. 2
    • Hirsch, E.C.1
  • 19
    • 70349736116 scopus 로고    scopus 로고
    • Cross-regulation of signaling pathways by interferon-gamma: Implications for immune responses and autoimmune diseases
    • X. Hu, and L.B. Ivashkiv Cross-regulation of signaling pathways by interferon-gamma: implications for immune responses and autoimmune diseases Immunity 31 2009 539 550
    • (2009) Immunity , vol.31 , pp. 539-550
    • Hu, X.1    Ivashkiv, L.B.2
  • 20
    • 84874516665 scopus 로고    scopus 로고
    • Anti-inflammatory activity of edible brown alga Saccharina japonica and its constituents pheophorbide a and pheophytin a in LPS-stimulated RAW 264.7 macrophage cells
    • M.N. Islam, I.J. Ishita, S.E. Jin, R.J. Choi, C.M. Lee, and Y.S. Kim et al. Anti-inflammatory activity of edible brown alga Saccharina japonica and its constituents pheophorbide a and pheophytin a in LPS-stimulated RAW 264.7 macrophage cells Food Chem Toxicol 55 2013 541 548
    • (2013) Food Chem Toxicol , vol.55 , pp. 541-548
    • Islam, M.N.1    Ishita, I.J.2    Jin, S.E.3    Choi, R.J.4    Lee, C.M.5    Kim, Y.S.6
  • 21
    • 7044235774 scopus 로고    scopus 로고
    • IFN-gamma/STAT1 acts as a proinflammatory signal in T cell-mediated hepatitis via induction of multiple chemokines and adhesion molecules: A critical role of IRF-1
    • B. Jaruga, F. Hong, W.H. Kim, and B. Gao IFN-gamma/STAT1 acts as a proinflammatory signal in T cell-mediated hepatitis via induction of multiple chemokines and adhesion molecules: a critical role of IRF-1 Am J Physiol Gastrointest Liver Physiol 287 2004 G1044 G1052
    • (2004) Am J Physiol Gastrointest Liver Physiol , vol.287
    • Jaruga, B.1    Hong, F.2    Kim, W.H.3    Gao, B.4
  • 22
    • 79955759334 scopus 로고    scopus 로고
    • Luteolin inhibits cytokine expression in endotoxin/cytokine-stimulated microglia
    • T.K. Kao, Y.C. Ou, S.Y. Lin, H.C. Pan, P.J. Song, and S.L. Raung et al. Luteolin inhibits cytokine expression in endotoxin/cytokine-stimulated microglia J Nutr Biochem 22 2011 612 624
    • (2011) J Nutr Biochem , vol.22 , pp. 612-624
    • Kao, T.K.1    Ou, Y.C.2    Lin, S.Y.3    Pan, H.C.4    Song, P.J.5    Raung, S.L.6
  • 23
    • 84857236125 scopus 로고    scopus 로고
    • Chemokines and cytokines in neuroinflammation leading to neuropathic pain
    • N. Kiguchi, Y. Kobayashi, and S. Kishioka Chemokines and cytokines in neuroinflammation leading to neuropathic pain Curr Opin Pharmacol 12 2012 55 61
    • (2012) Curr Opin Pharmacol , vol.12 , pp. 55-61
    • Kiguchi, N.1    Kobayashi, Y.2    Kishioka, S.3
  • 24
    • 1542298238 scopus 로고    scopus 로고
    • Importance of MAPK pathways for microglial pro-inflammatory cytokine IL-1 beta production
    • S.H. Kim, C.J. Smith, and L.J. Van Eldik Importance of MAPK pathways for microglial pro-inflammatory cytokine IL-1 beta production Neurobiol Aging 25 2004 431 439
    • (2004) Neurobiol Aging , vol.25 , pp. 431-439
    • Kim, S.H.1    Smith, C.J.2    Van Eldik, L.J.3
  • 25
    • 68149160164 scopus 로고    scopus 로고
    • Neuroprotective effect of epigallocatechin-3-gallate against beta-amyloid-induced oxidative and nitrosative cell death via augmentation of antioxidant defense capacity
    • C.Y. Kim, C. Lee, G.H. Park, and J.H. Jang Neuroprotective effect of epigallocatechin-3-gallate against beta-amyloid-induced oxidative and nitrosative cell death via augmentation of antioxidant defense capacity Arch Pharm Res 32 2009 869 881
    • (2009) Arch Pharm Res , vol.32 , pp. 869-881
    • Kim, C.Y.1    Lee, C.2    Park, G.H.3    Jang, J.H.4
  • 26
    • 0036644961 scopus 로고    scopus 로고
    • Cytokines, chemokines, and cytokine receptors in human microglia
    • Y.B. Lee, A. Nagai, and S.U. Kim Cytokines, chemokines, and cytokine receptors in human microglia J Neurosci Res 69 2002 94 103
    • (2002) J Neurosci Res , vol.69 , pp. 94-103
    • Lee, Y.B.1    Nagai, A.2    Kim, S.U.3
  • 27
    • 37449007512 scopus 로고    scopus 로고
    • Neuroprotective effect of curcumin is mainly mediated by blockade of microglial cell activation
    • H.S. Lee, K.K. Jung, J.Y. Cho, M.H. Rhee, S. Hong, and M. Kwon et al. Neuroprotective effect of curcumin is mainly mediated by blockade of microglial cell activation Pharmazie 62 2007 937 942
    • (2007) Pharmazie , vol.62 , pp. 937-942
    • Lee, H.S.1    Jung, K.K.2    Cho, J.Y.3    Rhee, M.H.4    Hong, S.5    Kwon, M.6
  • 28
    • 0042112656 scopus 로고    scopus 로고
    • The human immunodeficiency virus type 1 Tat protein up-regulates the promoter activity of the beta-chemokine monocyte chemoattractant protein 1 in the human astrocytoma cell line U-87 MG: Role of SP-1, AP-1, and NF-kappaB consensus sites
    • S.P. Lim, and A. Garzino-Demo The human immunodeficiency virus type 1 Tat protein up-regulates the promoter activity of the beta-chemokine monocyte chemoattractant protein 1 in the human astrocytoma cell line U-87 MG: role of SP-1, AP-1, and NF-kappaB consensus sites J Virol 74 2000 1632 1640
    • (2000) J Virol , vol.74 , pp. 1632-1640
    • Lim, S.P.1    Garzino-Demo, A.2
  • 30
    • 0027368278 scopus 로고
    • Macrophage nitric oxide synthase gene: Two upstream regions mediate induction by interferon gamma and lipopolysaccharide
    • C.J. Lowenstein, E.W. Alley, P. Raval, A.M. Snowman, S.H. Snyder, and S.W. Russell et al. Macrophage nitric oxide synthase gene: two upstream regions mediate induction by interferon gamma and lipopolysaccharide Proc Natl Acad Sci U S A 90 1993 9730 9734
    • (1993) Proc Natl Acad Sci U S A , vol.90 , pp. 9730-9734
    • Lowenstein, C.J.1    Alley, E.W.2    Raval, P.3    Snowman, A.M.4    Snyder, S.H.5    Russell, S.W.6
  • 31
    • 79957822241 scopus 로고    scopus 로고
    • Regulation of influenza A virus induced CXCL-10 gene expression requires PI3K/Akt pathway and IRF3 transcription factor
    • X. Lu, A. Masic, Q. Liu, and Y. Zhou Regulation of influenza A virus induced CXCL-10 gene expression requires PI3K/Akt pathway and IRF3 transcription factor Mol Immunol 48 2011 1417 1423
    • (2011) Mol Immunol , vol.48 , pp. 1417-1423
    • Lu, X.1    Masic, A.2    Liu, Q.3    Zhou, Y.4
  • 32
    • 33947543465 scopus 로고    scopus 로고
    • Inflammatory cell migration into the central nervous system: A few new twists on an old tale
    • S. Man, E.E. Ubogu, and R.M. Ransohoff Inflammatory cell migration into the central nervous system: a few new twists on an old tale Brain Pathol 17 2007 243 250
    • (2007) Brain Pathol , vol.17 , pp. 243-250
    • Man, S.1    Ubogu, E.E.2    Ransohoff, R.M.3
  • 33
    • 49449090948 scopus 로고    scopus 로고
    • Targeting multiple neurodegenerative diseases etiologies with multimodal-acting green tea catechins
    • S.A. Mandel, T. Amit, L. Kalfon, L. Reznichenko, and M.B. Youdim Targeting multiple neurodegenerative diseases etiologies with multimodal-acting green tea catechins J Nutr 138 2008 1578S 1583S
    • (2008) J Nutr , vol.138
    • Mandel, S.A.1    Amit, T.2    Kalfon, L.3    Reznichenko, L.4    Youdim, M.B.5
  • 34
    • 0028106830 scopus 로고
    • Role of interferon regulatory factor 1 in induction of nitric oxide synthase
    • E. Martin, C. Nathan, and Q.W. Xie Role of interferon regulatory factor 1 in induction of nitric oxide synthase J Exp Med 180 1994 977 984
    • (1994) J Exp Med , vol.180 , pp. 977-984
    • Martin, E.1    Nathan, C.2    Xie, Q.W.3
  • 35
    • 19744380563 scopus 로고    scopus 로고
    • Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo
    • A. Nimmerjahn, F. Kirchhoff, and F. Helmchen Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo Science 308 2005 1314 1318
    • (2005) Science , vol.308 , pp. 1314-1318
    • Nimmerjahn, A.1    Kirchhoff, F.2    Helmchen, F.3
  • 36
    • 77950202753 scopus 로고    scopus 로고
    • Obovatol attenuates microglia-mediated neuroinflammation by modulating redox regulation
    • J. Ock, H.S. Han, S.H. Hong, S.Y. Lee, Y. Han, B. Kwon, and K. Suk Obovatol attenuates microglia-mediated neuroinflammation by modulating redox regulation Br J Pharmacol 159 2010 1646 1662
    • (2010) Br J Pharmacol , vol.159 , pp. 1646-1662
    • Ock, J.1    Han, H.S.2    Hong, S.H.3    Lee, S.Y.4    Han, Y.5    Kwon, B.6    Suk, K.7
  • 37
    • 0027523467 scopus 로고
    • Cooperative interaction between interferon (IFN) stimulus response element and kappa B sequence motifs controls IFN gamma- and lipopolysaccharide- stimulated transcription from the murine IP-10 promoter
    • Y. Ohmori, and T.A. Hamilton Cooperative interaction between interferon (IFN) stimulus response element and kappa B sequence motifs controls IFN gamma- and lipopolysaccharide-stimulated transcription from the murine IP-10 promoter J Biol Chem 268 1993 6677 6688
    • (1993) J Biol Chem , vol.268 , pp. 6677-6688
    • Ohmori, Y.1    Hamilton, T.A.2
  • 39
    • 0032579949 scopus 로고    scopus 로고
    • Mitogen-activated protein kinases activated by lipopolysaccharide and beta-amyloid in cultured rat microglia
    • H. Pyo, I. Jou, S. Jung, S. Hong, and E.H. Joe Mitogen-activated protein kinases activated by lipopolysaccharide and beta-amyloid in cultured rat microglia Neuroreport 9 1998 871 874
    • (1998) Neuroreport , vol.9 , pp. 871-874
    • Pyo, H.1    Jou, I.2    Jung, S.3    Hong, S.4    Joe, E.H.5
  • 40
    • 0028865771 scopus 로고
    • Triggering of the human interleukin-6 gene by interferon-gamma and tumor necrosis factor-alpha in monocytic cells involves cooperation between interferon regulatory factor-1, NF kappa B, and Sp1 transcription factors
    • J. Sanceau, T. Kaisho, T. Hirano, and J. Wietzerbin Triggering of the human interleukin-6 gene by interferon-gamma and tumor necrosis factor-alpha in monocytic cells involves cooperation between interferon regulatory factor-1, NF kappa B, and Sp1 transcription factors J. Biol. Chem. 270 1995 27920 27931
    • (1995) J. Biol. Chem. , vol.270 , pp. 27920-27931
    • Sanceau, J.1    Kaisho, T.2    Hirano, T.3    Wietzerbin, J.4
  • 41
    • 33646179806 scopus 로고    scopus 로고
    • MAP kinase regulation of IP10/CXCL10 chemokine gene expression in microglial cells
    • Q. Shen, R. Zhang, and N.R. Bhat MAP kinase regulation of IP10/CXCL10 chemokine gene expression in microglial cells Brain Res 1086 2006 9 16
    • (2006) Brain Res , vol.1086 , pp. 9-16
    • Shen, Q.1    Zhang, R.2    Bhat, N.R.3
  • 42
    • 0025138248 scopus 로고
    • Involvement of a NF-kappa B-like transcription factor in the activation of the interleukin-6 gene by inflammatory lymphokines
    • H. Shimizu, K. Mitomo, T. Watanabe, S. Okamoto, and K. Yamamoto Involvement of a NF-kappa B-like transcription factor in the activation of the interleukin-6 gene by inflammatory lymphokines Mol Cell Biol 10 1990 561 568
    • (1990) Mol Cell Biol , vol.10 , pp. 561-568
    • Shimizu, H.1    Mitomo, K.2    Watanabe, T.3    Okamoto, S.4    Yamamoto, K.5
  • 43
    • 34548140134 scopus 로고    scopus 로고
    • How cells respond to interferons revisited: From early history to current complexity
    • G.R. Stark How cells respond to interferons revisited: from early history to current complexity Cytokine Growth Factor Rev 18 2007 419 423
    • (2007) Cytokine Growth Factor Rev , vol.18 , pp. 419-423
    • Stark, G.R.1
  • 44
    • 84863803531 scopus 로고    scopus 로고
    • Chlorophyll revisited: Anti-inflammatory activities of chlorophyll a and inhibition of expression of TNF-alpha gene by the same
    • A. Subramoniam, V.V. Asha, S.A. Nair, S.P. Sasidharan, P.K. Sureshkumar, and K.N. Rajendran et al. Chlorophyll revisited: anti-inflammatory activities of chlorophyll a and inhibition of expression of TNF-alpha gene by the same Inflammation 35 2012 959 966
    • (2012) Inflammation , vol.35 , pp. 959-966
    • Subramoniam, A.1    Asha, V.V.2    Nair, S.A.3    Sasidharan, S.P.4    Sureshkumar, P.K.5    Rajendran, K.N.6
  • 46
    • 0036222241 scopus 로고    scopus 로고
    • TLR4, but not TLR2, mediates IFN-beta-induced STAT1alpha/beta-dependent gene expression in macrophages
    • V. Toshchakov, B.W. Jones, P.Y. Perera, K. Thomas, M.J. Cody, and S. Zhang et al. TLR4, but not TLR2, mediates IFN-beta-induced STAT1alpha/beta- dependent gene expression in macrophages Nat Immunol 3 2002 392 398
    • (2002) Nat Immunol , vol.3 , pp. 392-398
    • Toshchakov, V.1    Jones, B.W.2    Perera, P.Y.3    Thomas, K.4    Cody, M.J.5    Zhang, S.6
  • 47
    • 33644938437 scopus 로고    scopus 로고
    • Nonparticipation of nuclear factor kappa B (NFkappaB) in the signaling cascade of c-Jun N-terminal kinase (JNK)- and p38 mitogen-activated protein kinase (p38MAPK)-dependent tumor necrosis factor alpha (TNFalpha) induction in lipopolysaccharide (LPS)-stimulated microglia
    • M. Uesugi, K. Nakajima, Y. Tohyama, S. Kohsaka, and T. Kurihara Nonparticipation of nuclear factor kappa B (NFkappaB) in the signaling cascade of c-Jun N-terminal kinase (JNK)- and p38 mitogen-activated protein kinase (p38MAPK)-dependent tumor necrosis factor alpha (TNFalpha) induction in lipopolysaccharide (LPS)-stimulated microglia Brain Res 1073-1074 2006 48 59
    • (2006) Brain Res , vol.1073-1074 , pp. 48-59
    • Uesugi, M.1    Nakajima, K.2    Tohyama, Y.3    Kohsaka, S.4    Kurihara, T.5
  • 48
    • 20044389119 scopus 로고    scopus 로고
    • C-Jun N-terminal kinases (JNKs) mediate pro-inflammatory actions of microglia
    • V. Waetzig, K. Czeloth, U. Hidding, K. Mielke, M. Kanzow, and S. Brecht et al. c-Jun N-terminal kinases (JNKs) mediate pro-inflammatory actions of microglia Glia 50 2005 235 246
    • (2005) Glia , vol.50 , pp. 235-246
    • Waetzig, V.1    Czeloth, K.2    Hidding, U.3    Mielke, K.4    Kanzow, M.5    Brecht, S.6
  • 49
    • 0027255749 scopus 로고
    • Promoter of the mouse gene encoding calcium-independent nitric oxide synthase confers inducibility by interferon gamma and bacterial lipopolysaccharide
    • Q.W. Xie, R. Whisnant, and C. Nathan Promoter of the mouse gene encoding calcium-independent nitric oxide synthase confers inducibility by interferon gamma and bacterial lipopolysaccharide J Exp Med 177 1993 1779 1784
    • (1993) J Exp Med , vol.177 , pp. 1779-1784
    • Xie, Q.W.1    Whisnant, R.2    Nathan, C.3
  • 50
    • 80052557935 scopus 로고    scopus 로고
    • Synthesis of pheophorbide a conjugates with anticancer drugs as potential cancer diagnostic and therapeutic agents
    • H. You, H.E. Yoon, J.H. Yoon, H. Ko, and Y.C. Kim Synthesis of pheophorbide-a conjugates with anticancer drugs as potential cancer diagnostic and therapeutic agents Bioorg Med Chem 19 2011 5383 5391
    • (2011) Bioorg Med Chem , vol.19 , pp. 5383-5391
    • You, H.1    Yoon, H.E.2    Yoon, J.H.3    Ko, H.4    Kim, Y.C.5
  • 51
    • 51549118941 scopus 로고    scopus 로고
    • TRIF and IRF-3 binding to the TNF promoter results in macrophage TNF dysregulation and steatosis induced by chronic ethanol
    • X.J. Zhao, Q. Dong, J. Bindas, J.D. Piganelli, A. Magill, and J. Reiser et al. TRIF and IRF-3 binding to the TNF promoter results in macrophage TNF dysregulation and steatosis induced by chronic ethanol J Immunol 181 2008 3049 3056
    • (2008) J Immunol , vol.181 , pp. 3049-3056
    • Zhao, X.J.1    Dong, Q.2    Bindas, J.3    Piganelli, J.D.4    Magill, A.5    Reiser, J.6
  • 52
    • 2642617812 scopus 로고    scopus 로고
    • IFN-gamma induction of the human monocyte chemoattractant protein (hMCP)-1 gene in astrocytoma cells: Functional interaction between an IFN-gamma-activated site and a GC-rich element
    • Z.H. Zhou, P. Chaturvedi, Y.L. Han, S. Aras, Y.S. Li, and P.E. Kolattukudy et al. IFN-gamma induction of the human monocyte chemoattractant protein (hMCP)-1 gene in astrocytoma cells: functional interaction between an IFN-gamma-activated site and a GC-rich element J Immunol 160 1998 3908 3916
    • (1998) J Immunol , vol.160 , pp. 3908-3916
    • Zhou, Z.H.1    Chaturvedi, P.2    Han, Y.L.3    Aras, S.4    Li, Y.S.5    Kolattukudy, P.E.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.