Synthesis of pheophorbide-a conjugates with anticancer drugs as potential cancer diagnostic and therapeutic agents

Bioorganic and Medicinal Chemistry

Volumn 19, Issue 18, 2011, Pages 5383-5391

  You, Hyun ^a   Yoon, Hyo Eun ^b   Yoon, Jung Hoon ^b   Ko, Hyojin ^a   Kim, Yong Chul ^a  

^a Gwangju Institute of Science and Technology (GIST)   (South Korea)

^b Chosun University   (South Korea)

Author keywords

Cancer diagnosis; Conjugates; Doxorubicin; Paclitaxel; Pheophorbide a

Indexed keywords

ANTINEOPLASTIC AGENT; DOXORUBICIN; PACLITAXEL; PHEOPHORBIDE; PHEOPHORBIDE A; PHEOPHORBIDE A 2 HYDROXYCINNAMIC ACID; PHEOPHORBIDE A 2 HYDROXYCINNAMIC ACID DOXORUBICIN; PHEOPHORBIDE A 4 AMINOBENZYL ALCOHOL; PHEOPHORBIDE A 4 AMINOBENZYL ALCOHOL 4 NITROPHENYL FORMATE; PHEOPHORBIDE A 4 AMINOBENZYL ALCOHOL 4 NITROPHENYL FORMATE DOXORUBICIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL; CANCER DIAGNOSIS; CANCER THERAPY; CONTROLLED STUDY; DRUG INHIBITION; DRUG STRUCTURE; DRUG SYNTHESIS; EXCITATION; HUMAN; HUMAN CELL; INCUBATION TIME; NONHUMAN; TREATMENT RESPONSE;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL PROLIFERATION; CELL SURVIVAL; CHLOROPHYLL; DOSE-RESPONSE RELATIONSHIP, DRUG; DOXORUBICIN; DRUG SCREENING ASSAYS, ANTITUMOR; FLUORESCENCE; FLUORESCENT DYES; HELA CELLS; HUMANS; MICE; MICE, INBRED C3H; MICROSCOPY, CONFOCAL; MOLECULAR CONFORMATION; NEOPLASMS; PACLITAXEL; SPECTROMETRY, FLUORESCENCE; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TISSUE DISTRIBUTION; TUMOR CELLS, CULTURED;

EID: 80052557935     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2011.07.058     Document Type: Article

References (19)

1. R. Jarkko, K. Hanna, H. Tycho, O. Reza, O. Dooman, J. Tomi, and S. Jouko Nat. Rev. Drug Discov. 7 2008 225
2. M. Rubi, T. Wanyi, and C. Kun Adv. Drug Deliv. Rev. 63 2011 659
3. V. Sarika, M.W. Gregory, M. Zhiming, and H. Tayyaba Photochem. Photobiol. 83 2007 996
4. Z. Xiang, M. Janet, K.P. Suresh, C. Yihui, T. Erin, B. Heinz, R.M. Joseph, B. Carrie, J. Jennifer, A.B. David, W.H. Barbara, and K.P. Ravindra J. Med. Chem. 52 2009 4306
5. S. Karen, M. Nela, C. Nicole, H. Darel, L. Roger, E.L. Johan, G. John, and W.B. Ross Immunology 132 2010 256
6. H. Frank, S. Katja, S.B. Teodor, B. Stefan, and S. Ute Chem. Med. Chem. 3 2008 1185
7. F.G. Ana, F. Carlos, S. Narasimha, D. Darra, and R. Rahul J. Cell. Biochem. 99 2006 665
8. C. Xin, H. Li, A.F. David, and M.D. Charles Biochemistry 43 2004 10918
9. P. Arpana, D. Alok, and P.K. Gupta Cancer Chemother. Pharmacol. 68 2011 359
10. Y. Yoshiyuki, C.J.S. Sebastian, C. Katerina, M.M. Jenny, L. Ying, F.K. Gunnar, and D.J. Kim Bioorg. Med. Chem. Lett. 18 2008 1632
11. H. Yu-Fen, S. Dihua, L. Haipeng, A.P. Joseph, Z.Y.C. Xiaoling, and T. Weihong Chem. Biol. Chem. 10 2009 862
12. A.V. Paul, B.K. Stan, M. Rosemary, T. Chris, W. Peter, D. Ruth, H.T. Alison, S. Lilian, E.H. Tom, M. Tom, B. Sally, D. Fraier, E. Frigerio, C. Jim on behalf of the Cancer Research Campaign Phase I/II Committee Clin. Cancer Res. 5 1999 83
13. A.N.C. Vanangamudi, and F. Si-Shen J. Biomed. Mater. Res. A 94A 2010 730
14. B. Ritu, S. Nandana, S. Uma, and G. Girjesh J. Mol. Struct. 327 1994 201
15. W. Prapai, B. Arnold, W. Hui-Kang, F.B. Kenneth, and L. Kuo-Hsiung Bioorg. Med. Chem. 10 2002 583
16. P. Jong-Hwan, M. Yeon-Hee, B. Iel-Soo, K. Yong-Chul, K. Soo-A, A. Sang-Gun, and Y. Jung-Hoon Plant Cell Physiol. 50 2009 719
17. B.J. Graham, O.M. Miguel, S.W. James, V.D. Anthony, and J.B. Glenn Bioorg. Med. Chem. Lett. 10 2000 1987
18. G. Pickaert, M. Cesario, and R. Ziessel J. Org. Chem. 69 2004 5335
19. P. Skehan, R. Storeng, D. Scudiero, A. Monks, J. McMahon, D. Vistica, J.T. Warren, H. Bokesch, S. Kenney, and M.R. Boyd J. Natl. Cancer Inst. 82 1990 1107