Combating inflammaging through a Mediterranean whole diet approach: The NU-AGE project's conceptual framework and design

Mechanisms of Ageing and Development

Volumn 136-137, Issue , 2014, Pages 3-13

  Santoro, Aurelia ^a   Pini, Elisa ^a   Scurti, Maria ^a   Palmas, Giustina ^a   Berendsen, Agnes ^b   Brzozowska, Anna ^c   Pietruszka, Barbara ^c   Szczecinska, Anna ^c   Cano, Noël ^d   Meunier, Nathalie ^e   de Groot, C P G M ^b   Feskens, Edith ^b   Fairweather Tait, Susan ^f   Salvioli, Stefano ^a   Capri, Miriam ^a   Brigidi, Patrizia ^a   Franceschi, Claudio ^a   Fabbri, Cristina ^a   Bertarelli, Claudia ^a   Izzi, Massimo ^a   Mazzocchi, Mario ^a   Chardigny, Jean Michel ^g   Morio, Beatrice ^g   Rossi, Daniele ^h   Notarfonso, Maurizio ^h   O'Toole, Paul W ⁱ   Cashman, Kevin ⁱ   Carding, Simon R ^j   Nicoletti, Claudio ^j   Jacobs, Dirk ^k   Xipsiti, Maria ^k   Fernandez, Laura ^l   Wills, Josephine ^l   Irz, Xavier ^m   Kuosmanen, Natalia ^m   Gonos, Efstathios S ⁿ   Voutetakis, Konstantinos ⁿ   Salmon, Michael ^o   Toussaint, Olivier ^o   Traill, Bruce W ^p   Nocella, Giuseppe ^p   Caracciolo, Barbara ^q   Xu, Weili ^q   Mikko Ikonen, ^r   Tuure, Tuula ^r   Brummer, Robert ^s   Kadi, Fawzi ^s   Breton, Sylvie ^t   Triomphe, Marie ^t   Magario, Guido ^u   Villani, Filippo ^u   Pancrazio, Annibale ^v   Teufner, Brigitte ^w   Stocker, Josef ^w   Echevarría, Francisco Javier ^x   Iglesias, Jose Ramón ^x   Smrž, František ^y   Krejcirova, Lucie ^y   Koytsomitropoulou, Efthimia ^z   Georgakidis, Konstantinos ^z   Yornuk, Rezan ^aa   Ucar, Cihan ^aa   Van Ommen, Ben ^ab   Bouwman, Jildau ^ab   Collino, Sebastiano ^ac   Jankovics, Clara ^ad   Losó, Adrienn ^ad   de Vos, Willem ^b   Fuentes, Susana ^b   Commelin, Eric ^ae   more..

^a UNIVERSITY OF BOLOGNA   (Italy)

^b WAGENINGEN UNIVERSITY   (Netherlands)

^c WARSAW UNIVERSITY OF LIFE SCIENCES   (Poland)

^d UNIVERSITÉ CLERMONT AUVERGNE   (France)

^e UNIVERSITY HOSPITAL OF CLERMONT FERRAND   (France)

^f UNIVERSITY OF EAST ANGLIA   (United Kingdom)

^g UMR Peuplements Végétaux et Bio agresseurs en Milieu Tropical   (France)

^h Spread EuropeanSafetyGeie   (Italy)

ⁱ UNIVERSITY COLLEGE CORK   (Ireland)

^j INSTITUTE OF FOOD RESEARCH   (United Kingdom)

^k FoodDrinkEurope   (Belgium)

^l Institute of Food Research ^*  (Belgium)

^m Maa Ja Elintarviketalouden Tutkimuskeskus   (Finland)

ⁿ Ethniko Idrima Erevnon   (Greece)

^o STRATICELL   (Belgium)

^p UNIVERSITY OF READING   (United Kingdom)

^q KAROLINSKA INSTITUTE   (Sweden)

^r VALIO OY   (Finland)

^s ÖREBRO UNIVERSITY   (Sweden)

^t Lesieur SAS   (France)

^u Villani SpA   (Italy)

^v Pancrazio SpA   (Italy)

^w WiesbauerGourmet Gastro GmbH   (Austria)

^x Carrer de l' Institut S/n   (Spain)

^y Spol s ro   (Czech Republic)

^z Mevgal SA   (Greece)

^aa YorukSutUrunleriHayvancilikGida San Ve Tic Ltd ti   (Turkey)

^ab NederlandseOrganisatieVoorToegepast TNO   (Netherlands)

^ac NESTLÉ RESEARCH CENTER   (Switzerland)

^ad Mirelite Mirsa Zartkoruen Mukodo Reszvenytarsasag   (Hungary)

^ae EC6 Sarl   (France)

more..

Author keywords

Ageing; Elderly tailored foods; Gut microbiota; Inflammaging; Mediterranean diet

Indexed keywords

AGED; AGING; ARTICLE; CONCEPTUAL FRAMEWORK; CONTROLLED STUDY; ELDERLY CARE; EPIGENETICS; FEMALE; FOOD INDUSTRY; GERIATRIC NUTRITION; HEALTH STATUS; HUMAN; INFLAMMAGING; INFLAMMATION; MALE; MEDITERRANEAN DIET; MENTAL HEALTH; METABOLOMICS; METAGENOMICS; PRIORITY JOURNAL; QUALITY OF LIFE; RANDOMIZED CONTROLLED TRIAL; SINGLE BLIND PROCEDURE; STUDY DESIGN; SYSTEMS BIOLOGY; TRANSCRIPTOMICS; TREATMENT DURATION; BIOCHEMISTRY; CELL AGING; DIETARY INTAKE; ENERGY METABOLISM; IMMUNITY; NUTRITIONAL HEALTH; NUTRITIONAL VALUE; RISK FACTOR; SIGNAL TRANSDUCTION; DIET; DIET SUPPLEMENTATION; EUROPE; FEEDING BEHAVIOR; FOOD; INTERVENTION STUDY; INTESTINE; METHODOLOGY; MICROBIOLOGY; MITOCHONDRION; MULTICENTER STUDY (TOPIC); PATHOPHYSIOLOGY; PHYSIOLOGY; RANDOMIZED CONTROLLED TRIAL (TOPIC);

MICRORNA; MITOCHONDRIAL DNA; REACTIVE OXYGEN METABOLITE;

AGED; AGING; DIET; DIET, MEDITERRANEAN; EUROPE; FEMALE; FOOD; FOOD HABITS; FOOD INDUSTRY; FOOD, FORTIFIED; HEALTH STATUS; HUMANS; INFLAMMATION; INTERVENTION STUDIES; INTESTINES; MALE; MITOCHONDRIA; MULTICENTER STUDIES AS TOPIC; RANDOMIZED CONTROLLED TRIALS AS TOPIC; RESEARCH DESIGN; SYSTEMS BIOLOGY;

EID: 84899939543     PISSN: 00476374     EISSN: 18726216     Source Type: Journal    
DOI: 10.1016/j.mad.2013.12.001     Document Type: Article

References (75)

1. Bacalini G., Frisoc S., Olivieri F., Pirazzini C., Giuliani C., Capri M., Santoro A., Franceschi C., Garagniani P. Present and future of anti-ageing epigenetic diets. Mech. Ageing Dev. 2014, 136-137:101-115.
2. Beenakker K.G., Westendorp R.G., de Craen A.J., Slagboom P.E., van Heemst D., Maier A.B. Pro-inflammatory capacity of classically activated monocytes relates positively to muscle mass and strength. Aging Cell 2013, 12(4):682-689.
3. Berendsen A., Santoro A., Pini E., Cevenini E., Ostan R., Pietruszka B., Rolf K., Cano N., Caille A., Lyon-Belgy N., Fairweather-Tait S., Feskens E., Franceschi C., de Groot C.P.G.M. A parallel randomized trial on the effect of a healthful diet on inflammageing and its consequences in European elderly people: design of the NU-AGE dietary intervention study. Mech. Ageing Dev. 2013, 134(11-12):523-530.
4. Biagi E., Nylund L., Candela M., Ostan R., Bucci L., Pini E., Nikkïla J., Monti D., Satokari R., Franceschi C., Brigidi P., De Vos W. Through aging, and beyond: gut microbiota and inflammatory status in seniors and centenarians. PLoS One 2010, 5(5):e10667. (Erratum in: PLoS One 5 (6) (2010)).
5. Biagi E., Candela M., Fairweather-Tait S., Franceschi C., Brigidi P. Aging of the human metaorganism: the microbial counterpart. Age (Dordr.) 2012, 34(1):247-267.
6. Bonafè M., Storci G., Franceschi C. Inflamm-aging of the stem cell niche: breast cancer as a paradigmatic example: breakdown of the multi-shell cytokine network fuels cancer in aged people. Bioessays 2012, 34:40-49.
7. Boirie B., Morio B., Cano N.J. Nutrition and protein energy homeostasis in elderly. Mech. Ageing Dev. 2014, 136-137:76-84.
8. Bouwens M., van de Rest O., Dellschaft N., Bromhaar M.G., de Groot L.C., Geleijnse J.M., Müller M., Afman L.A. Fish-oil supplementation induces antiinflammatory gene expression profiles in human blood mononuclear cells. Am. J. Clin. Nutr. 2009, 90(2):415-424.
9. Burkle A., Caselli G., Franceschi C., Mariani E., Sansoni P., Santoni A., Vecchio G., Witkowski J.M., Caruso C. Pathophysiology of aging, longevity and age related diseases. Immun. Aging 2007, 4:4.
10. Calçada D., Vianello D., Giampieri E., Sala C., Castellani G., de Graaf A., Kremer B., van Ommen B., Feskens E., Santoro A., Franceschi C., Bouwman J. The role of low-grade inflammation and metabolic flexibility in aging and nutritional modulation thereof: a systems biology approach. Mech. Ageing Dev. 2014, 136-137:138-147.
11. Candela M., Biagi E., Brigidi P., O'Toole P., De Vos W.M. Maintenance of healthy trajectory of the intestinal microbiome during aging: a dietary approach. Mech. Ageing Dev. 2014, 136-137:70-75.
12. Caracciolo B., Weili X., Collins S., Fratiglioni L. Cognitive decline, dietary factors and gut-brain interactions. Mech. Ageing Dev. 2014, 136-137:59-69.
13. Cevenini E., Invidia L., Lescai F., Salvioli S., Tieri P., Castellani G., Franceschi C. Human models of aging and longevity. Expert Opin. Biol. Ther. 2008, 8(9):1393-1405.
14. Cevenini E., Caruso C., Candore G., Capri M., Nuzzo D., Duro G., Rizzo C., Colonna-Romano G., Lio D., Di Carlo D., Palmas M.G., Scurti M., Pini E., Franceschi C., Vasto S. Age-related inflammation: the contribution of different organs, tissues and systems. How to face it for therapeutic approaches?. Curr. Pharm. Des. 2010, 16(6):609-618.
15. Cevenini E., Monti D., Franceschi C. Inflammaging. Curr. Opin. Clin. Nutr. Metab. Care 2013, 16(1):14-20.
16. Claesson M.J., Jeffery I.B., Conde S., Power S.E., O'Connor E.M., Cusack S., Harris H.M., Coakley M., Lakshminarayanan B., O'Sullivan O., Fitzgerald G.F., Deane J., O'Connor M., Harnedy N., O'Connor K., O'Mahony D., van Sinderen D., Wallace M., Brennan L., Stanton C., Marchesi J.R., Fitzgerald A.P., Shanahan F., Hill C., Ross R.P., O'Toole P.W. Gut microbiota composition correlates with diet and health in the elderly. Nature 2012, 488(7410):178-184.
17. Collino S., Montoliu I., Martin F.P., Scherer M., Mari D., Salvioli S., Bucci L., Ostan R., Monti D., Biagi E., Brigidi P., Franceschi C., Rezzi S. Metabolic signatures of extreme longevity in northern italian centenarians reveal a complex remodeling of lipids, amino acids, and gut microbiota metabolism. PLoS One 2013, 8:e56564.
18. Collino S., Martin F.P., Karagounis L.G., Horcajada M.N., Moco S., Franceschi C., Kusmmann M., Offord E. Musculoskeletal system in the old age and the demand for healthy ageing biomarkers. Mech. Ageing Dev. 2013, 134(11-12):541-547.
19. Dall'Olio F., Vanhooren V., Chen C.C., Slagboom P.E., Wuhrer M., Franceschi C. N-glycomic biomarkers of biological aging and longevity: a link with inflammaging. Aging Res. Rev. 2012, 12(2):685-698.
20. De Martinis M., Franceschi C., Monti D., Ginaldi L. Inflammaging and lifelong antigenic load as major determinants of aging rate and longevity. FEBS Lett. 2005, 579(10):2035-2039.
21. De Martinis M., Franceschi C., Monti D., Ginaldi L. Inflammation markers predicting frailty and mortality in the elderly. Exp. Mol. Pathol. 2006, 80(3):219-227.
22. Dickinson J.M., Volpi E., Rasmussen B.B. Exercise and nutrition to target protein synthesis impairments in aging skeletal muscle. Exerc. Sport Sci. Rev. 2013, 41(4). 216Y223.
23. Donath M.Y., Shoelson S.E. Type 2 diabetes as an inflammatory disease. Nat. Rev. Immunol. 2011, 11(2):98-107.
24. Edward H., Sharman Sirtuins and mammalian aging and age-related disorders oxidative stress in applied basic. Res. Clin. Pract. Aging 2010, 91-117.
25. Eurostat, 2001. http://epp.eurostat.ec.europa.eu/cache/ITY_OFFPUB/KS-SF-08-072/EN/KS-SF-08-072-EN.PDF.
26. Fagundes C.P., Glaser R., Kiecolt-Glaser J.K. Stressful early life experiences and immune dysregulation across the lifespan. Brain Behav. Immun. 2013, 27(1):8-12.
27. Franceschi C., Valensin S., Bonafè M., Paolisso G., Yashin A.I., Monti D., De Benedictis G. The network and the remodeling theories of aging: historical background and new perspectives. Exp. Gerontol. 2000, 35(6-7):879-896.
28. Franceschi C., Bonafè M., Valensin S., Olivieri F., De Luca M., Ottaviani E., De Benedictis G. Inflamm-aging. An evolutionary perspective on immunosenescence. Ann. N. Y. Acad. Sci. 2000, 908:244-254.
29. Franceschi C., Capri M., Monti D., Giunta S., Olivieri F., Sevini F., Panourgia M.P., Invidia L., Celani L., Scurti M., Cevenini E., Castellani G.C., Salvioli S. Inflammaging and anti-inflammaging: a systemic perspective on aging and longevity emerged from studies in humans. Mech. Ageing Dev. 2007, 128(1):92-105.
30. Franceschi C. Inflammaging as a major characteristic of old people: can it be prevented or cured?. Nutr. Rev. 2007, 65(12 Pt 2):S173-S176.
31. Freund A., Orjalo A.V., Desprez P.Y., Campisi J. Inflammatory networks during cellular senescence: causes and consequences. Trends Mol. Med. 2010, 16:238-246.
32. Fried L.P., Tangen C.M., Walston J., Newman A.B., Hirsch C., Gottdiener J., Seeman T., Tracy R., Kop W.J., Burke G., McBurnie M.A. Frailty in older adults: evidence for a phenotype. J. Gerontol. A: Biol. Sci. Med. Sci. 2001, 56(3):M146-M156.
33. Gregor M.F., Hotamisligil G.S. Inflammatory mechanisms in obesity. Annu. Rev. Immunol. 2011, 29:415-445.
34. Grignolio A., Franceschi C. History of Research into Aging/Senescence. In: eLS. 2012, John Wiley & Sons, Chichester.
35. Guo W., Kong E., Meydani M. Dietary polyphenols, inflammation, and cancer. Nutr. Cancer 2009, 61(6):807-810.
36. Gurven M., Kaplan H., Winking J., Finch C., Crimmins E.M. Aging and inflammation in two epidemiological worlds. J. Gerontol. A: Biol. Sci. Med. Sci. 2008, 63(2):196-199.
37. Hughes V. Microbiome: cultural differences. Nature 2012, 492(7427):S14-S15.
38. Jacobs D.R., Steffen L.M. Nutrients, foods, and dietary patterns as exposures in research: a framework for food synergy. Am. J. Clin. Nutr. 2003, 78:508S-513S.
39. Jacques P.F., Tucker K.L. Are dietary patterns useful for understanding the role of diet in chronic disease?. Am. J. Clin. Nutr. 2001, 73:1-2.
40. Jeffery I.B., O'Toole P.W. Diet-microbiota interactions and their implications for healthy living. Nutrients 2013, 5(January (1)):234-252.
41. Lencel P., Magne D. Inflammaging: the driving force in osteoporosis?. Med. Hypotheses 2011, 76(3):317-321.
42. Martin O.A., Redon C.E., Dickey J.S., Nakamura A.J., Bonner W.M. Para-inflammation mediates systemic DNA damage in response to tumor growth. Commun. Integr. Biol. 2011, 4(1):78-81.
43. Meydani M. A Mediterranean-style diet and metabolic syndrome. Nutr. Rev. 2005, 63(9):312-314.
44. Metchnikoff E. The Nature of Man. Studies in Optimistic Philosophy 1903, G.P. Putnam and Sons, London.
45. Milaneschi Y., Bandinelli S., Corsi A.M., Lauretani F., Paolisso G., Dominguez L.J., Semba R.D., Tanaka T., Abbatecola A.M., Talegawkar S.A., Guralnik J.M., Ferrucci L. Mediterranean diet and mobility decline in older persons. Exp. Gerontol. 2011, 46(4):303-308.
46. Milaneschi Y., Bandinelli S., Penninx B.W., Vogelzangs N., Corsi A.M., Lauretani F., Kisialiou A., Vazzana R., Terracciano A., Guralnik J.M., Ferrucci L. Depressive symptoms and inflammation increase in a prospective study of older adults: a protective effect of a healthy (Mediterranean-style) diet. Mol. Psychiatry 2011, 16(6):589-590.
47. Olivieri F., Lazzarini R., Recchioni R., Marcheselli F., Rippo M.R., Di Nuzzo S., Albertini M.C., Graciotti L., Babini L., Mariotti S., Spada G., Abbatecola A.M., Antonicelli R., Franceschi C., Procopio A.D. MiR-146a as marker of senescence-associated pro-inflammatory status in cells involved in vascular remodelling. Age (Dordr.) 2012, 35(4):1157-1172.
48. Olivieri F., Spazzafumo L., Santini G., Lazzarini R., Albertini M.C., Rippo M.R., Galeazzi R., Abbatecola A.M., Marcheselli F., Monti D., Ostan R., Cevenini E., Antonicelli R., Franceschi C., Procopio A.D. Age-related differences in the expression of circulating microRNAs: miR-21 as a new circulating marker of inflammaging. Mech. Ageing Dev. 2012, 133(11-12):675-685.
49. Olivieri F., Rippo M.R., Monsurro V., Salvioli S., Capri M., Procopio A.D., Franceschi C. MicroRNAs linking inflamm-aging, cellular senescence and cancer. Aging Res. Rev. 2013, 12(4):1056-1068.
50. Ostan R., Bucci L., Capri M., Salvioli S., Scurti M., Pini E., Monti D., Franceschi C. Immunosenescence and immunogenetics of human longevity. Neuroimmunomodulation 2008, 15(4-6):224-240.
51. Pawelec G. Hallmarks of human "immunosenescence": adaptation or dysregulation?. Immun. Aging 2012, 9(1):15.
52. Pedersen B.K. The diseasome of physical inactivity - and the role of myokines in muscle - fat cross talk. J. Physiol. 2009, 587(December (Pt 23)):5559-5568.
53. Pinti, M., Cevenini, E., Nasi, M., De Biasi, S., Salvioli S., Monti D., Benatti S., Gibellini L., Cotichini, R., Stazi, M.A., Trenti, T., Franceschi, C., Cossarizza, A., submitted. Circulating mitochondrial DNA increases with age and is a familiar trait: implications for "inflamm-aging". Eur. J. Hum. Gen.
54. Ribarič S. Diet and aging. Oxid. Med. Cell Longev. 2012, 2012:741468.
55. Rodier F., Campisi J. Four faces of cellular senescence. J. Cell Biol. 2011, 192(February (4)):547-556.
56. Rose-John S. IL-6 trans-signaling via the soluble IL-6 receptor: importance for the pro-inflammatory activities of IL-6. Int. J. Biol. Sci. 2012, 8(9):1237-1247.
57. Salvioli S., Monti D., Lanzarini C., Conte M., Pirazzini C., Bacalini M.G., Garagnani P., Giuliani C., Fontanesi E., Ostan R., Bucci L., Sevini F., Yani S.L., Barbieri A., Lomartire L., Borelli V., Vianello D., Bellavista E., Martucci M., Cevenini E., Pini E., Scurti M., Biondi F., Santoro A., Capri M., Franceschi C. Immune system, cell senescence, aging and longevity-inflamm-aging reappraised. Curr. Pharm. Des. 2013, 19(9):1675-1679.
58. Sessa R., Seano G., di Blasio L., Gagliardi P.A., Isella C., Medico E., Cotelli F., Bussolino F., Primo L. The miR-126 regulates Angiopoietin-1 signaling and vessel maturation by targeting p85β. Biochim. Biophys. Acta 2012, 1823:1925-1935.
59. Spazzafumo L., Olivieri F., Abbatecola A.M., Castellani G., Monti D., Lisa R., Galeazzi R., Sirolla C., Testa R., Ostan R., Scurti M., Caruso C., Vasto S., Vescovini R., Ogliari G., Mari D., Lattanzio F., Franceschi C. Remodelling of biological parameters during human aging: evidence for complex regulation in longevity and in type 2 diabetes. Age (Dordr.) 2013, 35(2):419-429.
60. Swann J.R., Spagou K., Lewis M., Nicholson J.K., Glei D.A., Seeman T.E., Coe C.L., Goldman N., Ryff C.D., Weinstein M., Holmes E. Microbial-mammalian co-metabolites dominate the age-associated urinary metabolic phenotype in Taiwanese and American Populations. J. Proteome Res. 2013, 12(7):3166-3180.
61. Taekema D.G., Westendorp R.G., Frölich M., Gussekloo J. High innate production capacity of tumor necrosis factor-alpha and decline of handgrip strength in old age. Mech. Ageing Dev. 2007, 128(9):517-521.
62. Talegawkar S.A., Bandinelli S., Bandeen-Roche K., Chen P., Milaneschi Y., Tanaka T., Semba R.D., Guralnik J.M., Ferrucci L. A higher adherence to a Mediterranean-style diet is inversely associated with the development of frailty in community-dwelling elderly men and women. J. Nutr. 2012, 142(12):2161-2166.
63. Vanhooren V., Desmyter L., Liu X.E., Cardelli M., Franceschi C., Federico A., Libert C., Laroy W., Dewaele S., Contreras R., Chen C. N-glycomic changes in serum proteins during human aging. Rejuvenation Res. 2007, 10(4):521-531.
64. Vanhooren V., Dewaele S., Libert C., Engelborghs S., De Deyn P.P., Toussaint O., Debacq-Chainiaux F., Poulain M., Glupczynski Y., Franceschi C., Jaspers K., van der Pluijm I., Hoeijmakers J., Chen C.C. Serum N-glycan profile shift during human aging. Exp. Gerontol. 2010, 45(10):738-743.
65. van Ommen B., Bouwman J., Dragsted L.O., Drevon C.A., Elliott R., de Groot P., Kaput J., Mathers J.C., Müller M., Pepping F., Saito J., Scalbert A., Radonjic M., Rocca-Serra P., Travis A., Wopereis S., Evelo C.T. Challenges of molecular nutrition research 6: the nutritional phenotype database to store, share and evaluate nutritional systems biology studies. Genes Nutr. 2010, 5(February (3)):189-203.
66. Varadhan R., Yao W., Matteini A., Beamer B.A., Xue Q.L., Yang H., Manwani B., Reiner A., Jenny N., Parekh N., Fallin M.D., Newman A., Bandeen-Roche K., Tracy R., Ferrucci L., Walston J. Simple biologically informed inflammatory index of two serum cytokines predicts 10 year all-cause mortality in older adults. J. Gerontol. A: Biol. Sci. Med. Sci. 2013, (May). epub ahead of print.
67. Vescovini R., Biasini C., Fagnoni F.F., Telera A., Zanlari R., Pedrazzoni L., Bucci M., Monti L., Medici D., Chezzi M.C., Franceschi C., Sansoni C.P. Massive load of functional effector CD4+ and CD8+ T cells against cytomegalovirus in very old subjects. J. Immunol. 2007, 179(6):4283-4291.
68. Vescovini R., Biasini C., Telera A.R., Basaglia M., Stella A., Magalini F., Bucci L., Monti D., Lazzarotto T., Dal Monte P., Pedrazzoni M., Medici M.C., Chezzi C., Franceschi C., Fagnoni F.F., Sansoni P. Intense antiextracellular adaptive immune response to human cytomegalovirus in very old subjects with impaired health and cognitive and functional status. J. Immunol. 2010, 184(6):3242-3249.
69. Vitale G., Salvioli S., Franceschi C. Oxidative stress and the aging endocrine system. Nat. Rev. Endocrinol. 2013, 9(4):228-240.
70. Walrand S., Guillet C., Salles J., Cano N., Boirie Y. Physiopathological mechanism of sarcopenia. Clin. Geriatr. Med. 2011, 27:365-385.
71. Wang S., Aurora A.B., Johnson B.A., Qi X., McAnally J., Hill J.A., Richardson J.A., Bassel-Duby R., Olson E.N. The endothelial-specific microRNA miR-126 governs vascular integrity and angiogenesis. Dev. Cell 2008, 15:261-271.
72. Wijsman C.A., Maier A.B., de Craen A.J., van den Biggelaar A.H., Westendorp R.G. An unopposed proinflammatory response is beneficial for survival in the oldest old. Results of the Leiden 85-plus Study. J. Gerontol. A: Biol. Sci. Med. Sci. 2011, 66(4):393-399.
73. Wolf J., Weinberger B., Arnold C.R., Maier A.B., Westendorp R.G., Grubeck-Loebenstein B. The effect of chronological age on the inflammatory response of human fibroblasts. Exp. Gerontol. 2012, 47(9):749-753.
74. Zanni F., Vescovini R., Biasini C., Fagnoni F., Zanlari L., Telera A., Di Pede P., Passeri G., Pedrazzoni M., Passeri M., Franceschi C., Sansoni P. Marked increase with age of type 1 cytokines within memory and effector/cytotoxic CD8+ T cells in humans: a contribution to understand the relationship between inflammation and immunosenescence. Exp. Gerontol. 2003, 38(9):981-987.
75. Zhang Q., Raoof M., Chen Y., Sumi Y., Sursal T., Junger W., Brohi K., Itagaki K., Hauser C.J. Circulating mitochondrial damps cause inflammatory responses to injury. Nature 2010, 464:104-107.