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Volumn 20, Issue 16, 2012, Pages 5012-5016

Identification of new γ-hydroxybutenolides that preferentially inhibit the activity of mPGES-1

(8) De Simone, Rosa a Bruno, Ines a Riccio, Raffaele a Stadler, Katharina b Bauer, Julia b Schaible, Anja M c Laufer, Stefan b Werz, Oliver c

a UNIVERSITY OF SALERNO (Italy)

b UNIVERSITY OF TÜBINGEN (Germany)

c FRIEDRICH SCHILLER UNIVERSITY JENA (Germany)

Author keywords

Hydroxybutenolide; Anti inflammatory; Microsomal prostaglandin E2 synthase 1; Suzuki coupling

Indexed keywords

ARACHIDONIC ACID; BUTENOLIDE; DEXAMETHASONE; ENZYME INHIBITOR; GAMMA HYDROXYBUTENOLIDE DERIVATIVE; PROSTAGLANDIN E SYNTHASE 1; PROSTAGLANDIN E2 SYNTHASE 1; UNCLASSIFIED DRUG;

ARTICLE; CELL LINE; CONTROLLED STUDY; DRUG IDENTIFICATION; DRUG MECHANISM; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME INHIBITION; IC 50; MICROSOME; MICROWAVE RADIATION; PROTEIN EXPRESSION; SUZUKI REACTION;

4-BUTYROLACTONE; CELL LINE, TUMOR; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; HUMANS; INTRAMOLECULAR OXIDOREDUCTASES; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84864443266 PISSN: 09680896 EISSN: 14643391 Source Type: Journal
DOI: 10.1016/j.bmc.2012.06.032 Document Type: Article

Times cited : (13)

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