Cyclotide structure-activity relationships: Qualitative and quantitative approaches linking cytotoxic and anthelmintic activity to the clustering of physicochemical forces

PLoS ONE

Volumn 9, Issue 3, 2014, Pages

  Park, Sungkyu ^a   Strömstedt, Adam A ^a   Göransson, Ulf ^a  

^a UPPSALA UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOTIDE; ANTHELMINTIC AGENT;

ANTHELMINTIC ACTIVITY; ARTICLE; CYSTINE KNOT MOTIF; DRUG CYTOTOXICITY; DRUG POTENCY; HAEMONCHUS CONTORTUS; HUMAN; HUMAN CELL; HYDROGEN BOND; IC 50; LIPOPHILICITY; NONHUMAN; PHYSICAL CHEMISTRY; QUALITATIVE ANALYSIS; QUANTITATIVE ANALYSIS; QUANTITATIVE STRUCTURE ACTIVITY RELATION; STATIC ELECTRICITY; AMINO ACID SEQUENCE; ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; CLUSTER ANALYSIS; DRUG EFFECTS; HAEMONCHUS; LARVA; MOLECULAR GENETICS; SEQUENCE ALIGNMENT; STRUCTURE ACTIVITY RELATION; TUMOR CELL LINE; U937 CELL LINE;

AMINO ACID SEQUENCE; ANIMALS; ANTHELMINTICS; CELL LINE, TUMOR; CLUSTER ANALYSIS; CYCLOTIDES; CYSTINE KNOT MOTIFS; HAEMONCHUS; HUMANS; HYDROGEN BONDING; LARVA; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PHYSICOCHEMICAL PROCESSES; SEQUENCE ALIGNMENT; STRUCTURE-ACTIVITY RELATIONSHIP; U937 CELLS;

EID: 84899865493     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0091430     Document Type: Article

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