QSAR analysis of antimicrobial and haemolytic effects of cyclic cationic antimicrobial peptides derived from protegrin-1

Bioorganic and Medicinal Chemistry

Volumn 14, Issue 17, 2006, Pages 6065-6074

  Frecer, Vladimir ^a,b  

^a CANCER RESEARCH INSTITUTE   (Slovakia)

^b UNIDO   (Italy)

Author keywords

Cationic antimicrobial peptides; Genetic function approximation algorithm; Molecular properties; Optimisation of antimicrobial and haemolytic effects; QSAR analysis

Indexed keywords

AMINO ACID; POLYPEPTIDE ANTIBIOTIC AGENT; PROTEGRIN; PROTEGRIN 1; UNCLASSIFIED DRUG;

ANTIMICROBIAL ACTIVITY; ARTICLE; BETA SHEET; CELL DESTRUCTION; CONTROLLED STUDY; DRUG ACTIVITY; DRUG DETERMINATION; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; GENETIC ALGORITHM; HEMOLYSIS; LIPOPHILICITY; MINIMUM INHIBITORY CONCENTRATION; MOLECULAR MODEL; NONHUMAN; QUANTITATIVE STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; SUBSTITUTION REACTION;

ANTI-BACTERIAL AGENTS; ANTIMICROBIAL CATIONIC PEPTIDES; ERYTHROCYTES; ESCHERICHIA COLI; HEMOLYSIS; HUMANS; MICROBIAL SENSITIVITY TESTS; MODELS, MOLECULAR; PROTEIN CONFORMATION; PROTEINS; PSEUDOMONAS AERUGINOSA; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; STAPHYLOCOCCUS AUREUS;

SUIDAE;

EID: 33746075554     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2006.05.005     Document Type: Article

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