Combined x-ray and NMR analysis of the stability of the cyclotide cystine knot fold that underpins its insecticidal activity and potential use as a drug scaffold

Journal of Biological Chemistry

Volumn 284, Issue 16, 2009, Pages 10672-10683

  Wang, Conan K ^a   Shu Hong, Hu ^a   Martin, Jennifer L ^a   Sjögren, Tove ^b   Hajdu, Janos ^b   Bohlin, Lars ^b   Claeson, Per ^b   Göransson, Ulf ^b   Rosengren, K Johan ^a,b   Tang, Jun ^c   Ning Hua, Tan ^c   Craik, David J ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

^b UPPSALA UNIVERSITY   (Sweden)

^c KUNMING INSTITUTE OF BOTANY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING ORIENTATION; BIOLOGICAL INSIGHT; BIOPHYSICAL PARAMETERS; CYCLOTIDES; DRUG DESIGN; ENZYMATIC TREATMENTS; HYDROGEN BOND NETWORKS; INSECTICIDAL ACTIVITY; NMR ANALYSIS; PLANT DEFENSE; SELF-ASSOCIATION; SOLUTION STATE NMR; STRUCTURAL BASIS; STRUCTURAL FEATURE; STRUCTURAL RIGIDITY; X RAY DATA;

AMINES; ASSOCIATION REACTIONS; BINDING SITES; HYDROGEN; HYDROGEN BONDS; NUCLEAR MAGNETIC RESONANCE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY;

CRYSTAL STRUCTURE;

CYCLOTIDE; CYSTEINE; DODECYLPHOSPHORYLCHOLINE; GLUTAMIC ACID; UNCLASSIFIED DRUG; VARV F PROTEIN; INSECTICIDE; VARV F;

ARTICLE; HYDROGEN BOND; INSECTICIDAL ACTIVITY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FOLDING; PROTEIN FUNCTION; PROTEIN STABILITY; PROTEIN STRUCTURE; REGULATORY MECHANISM; VIOLACEAE; X RAY ANALYSIS; AMINO ACID SEQUENCE; ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; CYSTINE KNOT MOTIF; DRUG DESIGN; GENETICS; HUMAN; METABOLISM; MOLECULAR GENETICS; PROTEIN CONFORMATION; SEQUENCE ALIGNMENT; X RAY CRYSTALLOGRAPHY;

HEXAPODA; VIOLA ARVENSIS;

AMINO ACID SEQUENCE; ANIMALS; CRYSTALLOGRAPHY, X-RAY; CYCLOTIDES; CYSTINE KNOT MOTIFS; DRUG DESIGN; HUMANS; HYDROGEN BONDING; INSECTICIDES; MOLECULAR SEQUENCE DATA; MOLECULAR STRUCTURE; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PROTEIN CONFORMATION; PROTEIN FOLDING; SEQUENCE ALIGNMENT;

EID: 67449106989     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M900021200     Document Type: Article

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