Correlation between simulated physicochemical properties and hemolycity of protegrin-like antimicrobial peptides: Predicting experimental toxicity

Peptides

Volumn 29, Issue 7, 2008, Pages 1085-1093

  Langham, Allison A ^a   Khandelia, Himanshu ^a   Schuster, Benjamin ^a   Waring, Alan J ^b   Lehrer, Robert I ^b   Kaznessis, Yiannis N ^a  

^a University of Minnesota   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Antimicrobial peptides; Molecular dynamics simulation; Protegrin; Quantitative structure activity relationship (QSAR); Toxicity prediction

Indexed keywords

POLYPEPTIDE ANTIBIOTIC AGENT; PROTEGRIN;

AQUEOUS SOLUTION; ARTICLE; ATOM; CYTOTOXICITY; ENERGY; HUMAN; HUMAN CELL; MOLECULAR DYNAMICS; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; PROTEIN INTERACTION; PROTEIN STRUCTURE; RADIUS; SIMULATION;

AMINO ACID SEQUENCE; ANTIMICROBIAL CATIONIC PEPTIDES; CERVIX UTERI; CHEMISTRY, PHYSICAL; COMPUTER SIMULATION; DOSE-RESPONSE RELATIONSHIP, DRUG; EPITHELIAL CELLS; ERYTHROCYTES; FEMALE; HEMOLYSIS; HUMANS; INHIBITORY CONCENTRATION 50; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PREDICTIVE VALUE OF TESTS; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; TEMPERATURE;

EID: 44649155678     PISSN: 01969781     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.peptides.2008.03.018     Document Type: Article

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