Transcription inhibition by the depsipeptide antibiotic salinamide A

eLife

Volumn 2014, Issue 3, 2014, Pages

  Degen, David ^a   Feng, Yu ^a   Zhang, Yu ^a   Ebright, Katherine Y ^a   Ebright, Yon W ^a   Gigliotti, Matthew ^a   Vahedian Movahed, Hanif ^a   Mandal, Sukhendu ^a   Talaue, Meliza ^b   Connell, Nancy ^b   Arnold, Eddy ^c   Fenical, William ^d   Ebright, Richard H ^a  

^a RUTGERS UNIVERSITY   (United States)

^b RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

^c RUTGERS UNIVERSITY   (United States)

^d UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

Allosteric inhibitor; Antibacterial agent; Antibacterial resistance; Antibiotic; Bridge helix; Bridge helix N terminal hinge; Bridge helix cap; CBR703; Crystal structure; F loop; Inhibitor; Link region; Lipiarmycin; Myxopyronin; Nucleotide addition; Resistance mutant; Resistance spectrum; Rifampin; Rifamycin; RNA polymerase; Salinamide A; Salinamide B; Salinamides; Streptolydigin; Transcription; Transcription elongation; Transcription initiation; Trigger loop

Indexed keywords

ANTIBIOTIC AGENT; DEPSIPEPTIDE; FIDAXOMICIN; HOLOENZYME; RIFAMPICIN; SALINAMIDE A; SALINAMIDE B; STREPTOLYDIGIN; UNCLASSIFIED DRUG; ANTIINFECTIVE AGENT; BROMINE; DNA DIRECTED RNA POLYMERASE; ENZYME INHIBITOR; NUCLEOTIDE; PROTEIN SUBUNIT;

ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERIAL GROWTH; BINDING SITE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CRYSTAL STRUCTURE; CRYSTALLIZATION; ESCHERICHIA COLI; GENE MUTATION; GENETIC COMPLEMENTATION; GENETIC TRANSCRIPTION; HYDROGEN BOND; KINETICS; MINIMUM INHIBITORY CONCENTRATION; MUTAGENESIS; NONHUMAN; POLYMERASE CHAIN REACTION; PROTEIN SYNTHESIS; STREPTOMYCES; AMINO ACID SEQUENCE; ANTAGONISTS AND INHIBITORS; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECTS; ENZYMOLOGY; GENETICS; METABOLISM; MOLECULAR GENETICS; MUTATION; PROTEIN SECONDARY STRUCTURE; PROTEIN SUBUNIT; X RAY CRYSTALLOGRAPHY;

AMINO ACID SEQUENCE; ANTI-BACTERIAL AGENTS; BROMINE; CRYSTALLOGRAPHY, X-RAY; DEPSIPEPTIDES; DNA-DIRECTED RNA POLYMERASES; ENZYME INHIBITORS; ESCHERICHIA COLI; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTATION; NUCLEOTIDES; PROTEIN STRUCTURE, SECONDARY; PROTEIN SUBUNITS; TRANSCRIPTION, GENETIC;

EID: 84899856701     PISSN: None     EISSN: 2050084X     Source Type: Journal    
DOI: 10.7554/eLife.02451     Document Type: Article

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