Disulfide locking a sodium channel voltage sensor reveals ion pair formation during activation

Proceedings of the National Academy of Sciences of the United States of America

Volumn 105, Issue 39, 2008, Pages 15142-15147

  DeCaen, Paul G ^a   Yarov Yarovoy, Vladimir ^a   Zhao, Yong ^a,b   Scheuer, Todd ^a   Catterall, William A ^a  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^b Cerep Inc   (United States)

Author keywords

Gating charge; Mutant cycle; Sliding helix; Voltage sensing

Indexed keywords

CYSTEINE; DISULFIDE; ION; SODIUM CHANNEL; BACTERIAL PROTEIN; NACHBAC PROTEIN, BACTERIA;

ARTICLE; BACTERIUM; CATALYSIS; CHANNEL GATING; COMPARATIVE STUDY; CONTROLLED STUDY; DISULFIDE BOND; ELECTRIC POTENTIAL; ENERGY; HYPERPOLARIZATION; KINETICS; MUTANT; NONHUMAN; PRIORITY JOURNAL; SENSOR; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; BACILLUS; DRUG POTENTIATION; GENETICS; METABOLISM; MOLECULAR GENETICS; MUTATION;

BACTERIA (MICROORGANISMS);

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; BACILLUS; BACTERIAL PROTEINS; CYSTEINE; DISULFIDES; ION CHANNEL GATING; MOLECULAR SEQUENCE DATA; MUTATION; SODIUM CHANNELS;

EID: 54449100445     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0806486105     Document Type: Article

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